Patents by Inventor Igor I. Slukvin

Igor I. Slukvin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDUCTION OF ARTERIAL-TYPE OF HEMOGENIC ENDOTHELIUM (AHE) AND ENHANCEMENT OF T CELL PRODUCTION FROM PSCS THROUGH OVEREXPRESSION OF ETS FACTORS OR MODULATING MAPK/ERK SIGNALLING PATHWAYS
    Publication number: 20220306988
    Abstract: The present invention is a method of creating a population of hemogenic endothelial cells with arterial specification. In one embodiment, the method uses ETS transgene induction at the mesodermal stage of differentiation. In another embodiment, the method activates ERK signaling at the mesodermal stage of differentiation.
    Type: Application
    Filed: May 27, 2022
    Publication date: September 29, 2022
    Inventors: Igor I. Slukvin, Mi Ae Park, Akhilesh Kumar
  • Induction of arterial-type of hemogenic endothelium (AHE) and enhancement of T cell production from PSCs through overexpression of ETS factors or modulating MAPK/ERK signalling pathways
    Patent number: 11345895
    Abstract: The present invention is a method of creating a population of hemogenic endothelial cells with arterial specification and enhanced T cell potential. In one embodiment, the method uses ETS transgene induction at the mesodermal stage of differentiation. In another embodiment, the method activates ERK and NOTCH signaling at the mesodermal stage of differentiation.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: May 31, 2022
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Igor I. Slukvin, Mi Ae Park, Akhilesh Kumar
  • DERIVATION OF HUMAN MICROGLIA FROM PLURIPOTENT STEM CELLS
    Publication number: 20220033773
    Abstract: The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.
    Type: Application
    Filed: August 18, 2021
    Publication date: February 3, 2022
    Inventors: James A. Thomson, Nicholas E. Propson, Michael P. Schwartz, Zhonggang Hou, Gene I. Uenishi, Igor I Slukvin, William L. Murphy, Jue Zhang
  • Derivation of human microglia from pluripotent stem cells
    Patent number: 11124765
    Abstract: The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: September 21, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James A. Thomson, Nicholas E. Propson, Michael P. Schwartz, Zhonggang Hou, Gene I. Uenishi, Igor I. Slukvin, William L. Murphy, Jue Zhang
  • Method for the Induction of Arterial-Type of Hemogenic Endothelium from hPSCS
    Publication number: 20210261923
    Abstract: This invention discloses a method for the induction of arterial-type of hemogenic endothelium and method of differentiating T cells from hemogenic endothelial cells.
    Type: Application
    Filed: April 19, 2021
    Publication date: August 26, 2021
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Igor I. SLUKVIN, Gene Uenishi
  • Method for the induction of arterial-type of hemogenic endothelium from hPSCS
    Patent number: 10982192
    Abstract: This invention discloses a method for the induction of arterial-type of hemogenic endothelium.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: April 20, 2021
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Igor I. Slukvin, Gene Uenishi
  • GENERATION OF FUNCTIONAL NEUTROPHILS AND MACROPHAGES FROM INDUCED PLURIPOTENT STEM CELLS IN CHEMICALLY DEFINED CONDITIONS USING TRANSIENT EXPRESSION OF ETV2
    Publication number: 20200385676
    Abstract: The present invention provides methods of producing in vitro derived neutrophils or macrophages in xenogen- and serum-free conditions from pluripotent stem cells and in vitro derived populations of neutrophils and macrophages. Methods of treatment using in vitro derived neutrophils or macrophages are also contemplated.
    Type: Application
    Filed: June 5, 2020
    Publication date: December 10, 2020
    Inventors: Igor I. Slukvin, Vera Sergeyevna Brok Volchanskaya, Kran Suknuntha, Anna Huttenlocher, David Alfred Bennin, Lucas Klemm
  • Erythroid cells producing adult-type beta-hemoglobin generated from human embryonic stem cells
    Patent number: 10724002
    Abstract: Methods and compositions of erythroid cells that produce adult ?-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: July 28, 2020
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • EXPANSION OF HPSC-DERIVED GRANULOCYTIC AND LYMPHOID PROGENITORS WITH UM171
    Publication number: 20200063104
    Abstract: The present invention provides methods of amplifying or expanding CD34+CD43+CD45+CD41loCD235+/? hematopoietic progenitor cells enriched in granulocytic progenitors (G-CFCs). In another embodiment, the present invention provides methods of producing CD34+CD7+CD41a? lymphoid progenitor cells are enriched in NK progenitors.
    Type: Application
    Filed: August 22, 2019
    Publication date: February 27, 2020
    Inventors: Igor I. Slukvin, Walatta-Tseyon Mesquitta
  • Angiohematopoietic progenitor cells
    Patent number: 10260047
    Abstract: A purified human cell population of subsets of angiohematopoietic progenitor cells, wherein the population is at least 94% pure and wherein the cells are selected with cell markers selected from the group of KDR, APLNR, VE-cadherin, PDGFR?, CD31, CD235a, CD73, CD43, and CD41a.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: April 16, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, Maksym A. Vodyanyk, Kyung-Dal Choi
  • DERIVATION OF HUMAN MICROGLIA FROM PLURIPOTENT STEM CELLS
    Publication number: 20190078054
    Abstract: The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.
    Type: Application
    Filed: September 21, 2018
    Publication date: March 14, 2019
    Inventors: James A. Thomson, Nicholas E. Propson, Michael P. Schwartz, Zhonggang Hou, Gene I. Uenishi, Igor I. Slukvin, William L. Murphy, Jue Zhang
  • Method for the induction of arterial-type of hemogenic endothelium from hPSCS
    Publication number: 20180291349
    Abstract: This invention discloses a method for the induction of arterial-type of hemogenic endothelium.
    Type: Application
    Filed: February 16, 2018
    Publication date: October 11, 2018
    Inventors: Igor I. Slukvin, Gene Uenishi
  • Derivation of human microglia from pluripotent stem cells
    Patent number: 10081792
    Abstract: The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: September 25, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James A. Thomson, Nicholas E. Propson, Michael P. Schwartz, Zhonggang Hou, Gene I. Uenishi, Igor I. Slukvin, William L. Murphy, Jue Zhang
  • ERYTHROID CELLS PRODUCING ADULT-TYPE BETA-HEMOGLOBIN GENERATED FROM HUMAN EMBRYONIC STEM CELLS
    Publication number: 20180230430
    Abstract: Methods and compositions of erythroid cells that produce adult ?-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions.
    Type: Application
    Filed: April 5, 2018
    Publication date: August 16, 2018
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • INDUCTION OF ARTERIAL-TYPE OF HEMOGENIC ENDOTHELIUM (AHE) AND ENHANCEMENT OF T CELL PRODUCTION FROM PSCS THROUGH OVEREXPRESSION OF ETS FACTORS OR MODULATING MAPK/ERK SIGNALLING PATHWAYS
    Publication number: 20180142207
    Abstract: The present invention is a method of creating a population of hemogenic endothelial cells with arterial specification and enhanced T cell potential. In one embodiment, the method uses ETS transgene induction at the mesodermal stage of differentiation. In another embodiment, the method activates ERK and NOTCH signaling at the mesodermal stage of differentiation.
    Type: Application
    Filed: November 17, 2017
    Publication date: May 24, 2018
    Inventors: Igor I. Slukvin, Mi Ae Park, Akhilesh Kumar
  • Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions
    Patent number: 9938499
    Abstract: Methods and compositions for differentiating pluripotent stem cells into cells of endothelial and hematopoietic lineages are disclosed.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: April 10, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, Gene Ichiro Uenishi
  • Method of making primate cells expressing apelin receptor that have mesangioblast potential
    Patent number: 9771561
    Abstract: Methods for obtaining multipotent Apelin receptor-positive lateral plate mesoderm cells, mesenchymal stem cells, and mesangioblasts under serum-free conditions are disclosed.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: September 26, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Maksym A. Vodyanyk, Igor I. Slukvin
  • Multipotent lymphohematopoietic progenitor cells
    Patent number: 9624470
    Abstract: This invention relates to hematopoietic precursors derived from human embryonic stem cells. In the culture of differentiated cells from human ES cells, the fully committed hematopoietic precursors are CD34+ and CD43+ but not CD45+. If the cells are cultured until they express CD45, then the cells lose the ability to produce differentiated cells of the lymphoid lineages.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: April 18, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, Maksym A. Vodyanyk, James A. Thomson
  • Angiohematopoietic Progenitor Cells
    Publication number: 20160194610
    Abstract: A purified human cell population of subsets of angiohematopoietic progenitor cells, wherein the population is at least 94% pure and wherein the cells are selected with cell markers selected from the group of KDR, APLNR, VE-cadherin, PDGFR?, CD31, CD235a, CD73, CD43, and CD41a.
    Type: Application
    Filed: December 1, 2015
    Publication date: July 7, 2016
    Inventors: Igor I. Slukvin, Maksym A. Vodyanyk, Kyung-Dal Choi
  • Induced pluripotent stem cell model of chronic myeloid leukemia revealed olfactomedin 4 as a novel therapeutic target in leukemia stem cells
    Patent number: 9381210
    Abstract: Disclosed herein are compositions and methods to treat and reduce therapeutic resistance in chronic myelogenous leukemia. Also disclosed herein are methods to generate leukemia stem cell like cells (iLSCs) generated from CML patient-derived iPSCs, and methods for utilizing iLSCs in screens to identify modulators of CML drug resistance and gene targets that underlie CML drug resistance.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: July 5, 2016
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, Kran Suknuntha