Patents by Inventor Igor I. Slukvin

Igor I. Slukvin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DERIVATION OF HUMAN MICROGLIA FROM PLURIPOTENT STEM CELLS
    Publication number: 20160186137
    Abstract: The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.
    Type: Application
    Filed: December 31, 2015
    Publication date: June 30, 2016
    Inventors: James A. Thomson, Nicholas E. Propson, Michael P. Schwartz, Zhonggang Hou, Gene I. Uenishi, Igor I. Slukvin, William L. Murphy, Jue Zhang
  • MULTIPOTENT CELLS HAVING MESENCHYMAL AND ENDOTHELIAL LINEAGE POTENTIAL
    Publication number: 20150175971
    Abstract: Methods for obtaining multipotent Apelin receptor-positive lateral plate mesoderm cells, mesenchymal stem cells, and mesangioblasts under serum-free conditions are disclosed.
    Type: Application
    Filed: December 12, 2014
    Publication date: June 25, 2015
    Inventors: Maksym A. Vodyanyk, Igor I. Slukvin
  • INDUCED PLURIPOTENT STEM CELL MODEL OF CHRONIC MYELOID LEUKEMIA REVEALED OLFACTOMEDIN 4 AS A NOVEL THERAPEUTIC TARGET IN LEUKEMIA STEM CELLS
    Publication number: 20150005361
    Abstract: Disclosed herein are compositions and methods to treat and reduce therapeutic resistance in chronic myelogenous leukemia. Also disclosed herein are methods to generate leukemia stem cell like cells (iLSCs) generated from CML patient-derived iPSCs, and methods for utilizing iLSCs in screens to identify modulators of CML drug resistance and gene targets that underlie CML drug resistance.
    Type: Application
    Filed: April 11, 2014
    Publication date: January 1, 2015
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, Kran Suknuntha
  • Generation of mature myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived linCD34CD43CD45progenitors
    Patent number: 8846395
    Abstract: A method for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, dendritic cells an Langerhans cells from human embryonic stem cells is disclosed.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: September 30, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, Kyung-Dal Choi, Maksym A. Vodyanyk
  • Methods and Materials for Hematoendothelial Differentiation of Human Pluripotent Stem Cells Under Defined Conditions
    Publication number: 20140273211
    Abstract: Methods and compositions for differentiating pluripotent stem cells into cells of endothelial and hematopoietic lineages are disclosed.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, Gene Ichiro Uenishi
  • ERYTHROID CELLS PRODUCING ADULT-TYPE BETA-HEMOGLOBIN GENERATED FROM HUMAN EMBRYONIC STEM CELLS
    Publication number: 20140248699
    Abstract: Methods and compositions of erythroid cells that produce adult ?-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions.
    Type: Application
    Filed: March 13, 2012
    Publication date: September 4, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Method of forming dendritic cells from embryonic stem cells
    Patent number: 8785189
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: July 22, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Method of Forming Dendritic Cells from Embryonic Stem Cells
    Publication number: 20130230917
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Application
    Filed: April 9, 2013
    Publication date: September 5, 2013
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Method of forming dendritic cells from embryonic stem cells
    Patent number: 8435785
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: May 7, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Method Of Forming Dendritic Cells From Embryonic Stem Cells
    Publication number: 20120142106
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Application
    Filed: February 1, 2012
    Publication date: June 7, 2012
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Erythroid cells producing adult-type ?-hemoglobin generated from human embryonic stem cells
    Patent number: 8158422
    Abstract: Methods and compositions of erythroid cells that produce adult ?-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions.
    Type: Grant
    Filed: February 8, 2007
    Date of Patent: April 17, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Method of forming myeloid precursor cells from human embryonic stem cells
    Patent number: 8133732
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: March 13, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Multipotent Lymphohematopoietic Progenitor Cells
    Publication number: 20120040362
    Abstract: This invention relates to hematopoietic precursors derived from human embryonic stem cells. In the culture of differentiated cells from human ES cells, the fully committed hematopoietic precursors are CD34+ and CD43+ but not CD45+. If the cells are cultured until they express CD45, then the cells lose the ability to produce differentiated cells of the lymphoid lineages.
    Type: Application
    Filed: July 29, 2011
    Publication date: February 16, 2012
    Inventors: Igor I. Slukvin, Maksym A. Vodyanyk, James A. Thomson
  • Multipotent lymphohematopoietic progenitor cells
    Patent number: 8034613
    Abstract: This invention relates to hematopoietic precursors derived from human embryonic stem cells. In the culture of differentiated cells from human ES cells, the fully committed hematopoietic precursors are CD34+ and CD43+ but not CD45+. If the cells are cultured until they express CD45, then the cells lose the ability to produce differentiated cells of the lymphoid lineages.
    Type: Grant
    Filed: September 14, 2006
    Date of Patent: October 11, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, Maksym A. Vodyanyk, James A. Thomson
  • Method of Forming Dendritic Cells from Embryonic Stem Cells
    Publication number: 20110117135
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Application
    Filed: September 7, 2010
    Publication date: May 19, 2011
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • GENERATION OF CLONAL MESENCHYMAL PROGENITORS AND MESENCHYMAL STEM CELL LINES UNDER SERUM-FREE CONDITIONS
    Publication number: 20100261274
    Abstract: Methods for obtaining multipotent Apelin receptor-positive lateral plate mesoderm cells, mesenchymal stem cells, and mesangioblasts under serum-free conditions are disclosed.
    Type: Application
    Filed: March 18, 2010
    Publication date: October 14, 2010
    Inventors: Maksym A. Vodyanyk, Igor I. Slukvin
  • Method of forming dendritic cells from embryonic stem cells
    Patent number: 7811821
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: October 12, 2010
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Generation of mature myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34+CD43+CD45+progenitors
    Publication number: 20100081199
    Abstract: A method for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, dendritic cells an Langerhans cells from human embryonic stem cells is disclosed.
    Type: Application
    Filed: September 24, 2009
    Publication date: April 1, 2010
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, Kyung-Dal Choi, Maksym A. Vodyanyk
  • Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions
    Patent number: 7615374
    Abstract: Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: November 10, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Maksym A. Vodyanyk, Junying Yu, James A. Thomson, Igor I. Slukvin
  • GENERATION OF CLONAL MESENCHYMAL PROGENITORS AND MESENCHYMAL STEM CELL LINES UNDER SERUM-FREE CONDITIONS
    Publication number: 20090081784
    Abstract: Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed.
    Type: Application
    Filed: February 1, 2008
    Publication date: March 26, 2009
    Inventors: Maksym A. Vodyanyk, Junying Yu, James A. Thomson, Igor I. Slukvin