Patents by Inventor Igor Rukhman

Igor Rukhman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of valsartan
    Patent number: 7378531
    Abstract: Provided is a process for preparing valsartan and precursors thereof.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: May 27, 2008
    Assignee: Teva Pharmaceutical Industries Ltd
    Inventors: Zvi Harel, Igor Rukhman
  • Amorphous and Crystalline Forms of Losartan Potassium and Process For Their Preparation
    Publication number: 20080096945
    Abstract: This invention relates to novel amorphous losartan potassium, novel losartan potassium in a crystalline form that is a hydrate, novel crystalline losartan potassium Form IV and solvates thereof, novel crystalline losartan potassium Form V and solvates thereof, to processes for their preparation, to compositions containing them and to their use in medicine. This invention further relates to a novel process for preparing crystalline losartan potassium Form I and Form II.
    Type: Application
    Filed: December 21, 2007
    Publication date: April 24, 2008
    Inventors: Ben DOLITZKY, Shlomit WIZEL, Gennady NISNEVICH, Igor RUKHMAN, Julia KAFTANOV
  • Amorphous and crystalline forms of losartan potassium and process for their preparation
    Patent number: 7332612
    Abstract: This invention relates to novel amorphous losartan potassium, novel losartan potassium in a crystalline form that is a hydrate, novel crystalline losartan potassium Form IV and solvates thereof, novel crystalline losartan potassium Form V and solvates thereof, to processes for their preparation, to compositions containing them and to their use in medicine. This invention further relates to a novel process for preparing crystalline losartan potassium Form I and Form II.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: February 19, 2008
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Ben Zion Dolitzky, Shlomit Wizel, Gennady Nisnevich, Igor Rukhman, Julia Kaftanov
  • Synthesis of 2-butyl-3-(1-trityl-1H-tetrazol-5-YL)biphenyl-4-YL)-1,3-diazaspiro[4,4]- non-ene-4-one
    Patent number: 7312340
    Abstract: Provided is a novel method of making 2-butyl-3-[[2?(1-trityl-1H-tetrazol-5-yl)biphen-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-ene-4-one, which can be converted to irbesartan. Also provided are methods of making irbesartan.
    Type: Grant
    Filed: January 9, 2006
    Date of Patent: December 25, 2007
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Ben-Zion Dolitzky, Julia Kaftanov, Boris Pertsikov, Igor Rukhman, Gennady Nisnevich
  • Intermediates for the synthesis of irbesartan
    Patent number: 7301035
    Abstract: Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4?-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: November 27, 2007
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Gennady Nisnevich, Igor Rukhman, Boris Pertsikov, Julia Kaftanov, Ben-Zion Dolitzky
  • Novel synthesis of irbesartan
    Publication number: 20070213539
    Abstract: Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4?-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.
    Type: Application
    Filed: May 4, 2007
    Publication date: September 13, 2007
    Inventors: Gennady Nisnevich, Igor Rukhman, Boris Pertsikov, Julia Kaftanov, Ben-Zion Dolitzky
  • Synthesis of irbesartan
    Patent number: 7227026
    Abstract: Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4?-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: June 5, 2007
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Gennady Nisnevich, Igor Rukhman, Boris Pertsikov, Julia Kaftanov, Ben-Zion Dolitzky
  • Synthesis of irbesartan
    Patent number: 7217825
    Abstract: Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4?-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: May 15, 2007
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Gennady Nisnevich, Igor Rukhman, Boris Pertsikov, Julia Kaftanov, Ben-Zion Dolitzky
  • Process for the preparation of valsartan and intermediates thereof
    Publication number: 20070093542
    Abstract: Provided are process for the preparation of valsartan and the precursors thereof.
    Type: Application
    Filed: December 14, 2006
    Publication date: April 26, 2007
    Inventors: Igor Rukhman, Ben-Zion Dolitzky, Evgeni Flyaks
  • Process for the preparation of valsartan and intermediates thereof
    Patent number: 7199144
    Abstract: Provided are process for the preparation of valsartan and the precursors thereof.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: April 3, 2007
    Assignee: Teva Pharmaceuticals Industries, Ltd.
    Inventors: Igor Rukhman, Ben-Zion Dolitzky, Evgeni Flyaks
  • Polymorphs of valsartan
    Patent number: 7105557
    Abstract: Provided are crystalline and amorphous form of valsartan, and processes for their preparation.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: September 12, 2006
    Assignee: Teva Pharmaceutical Industries, Ltd.
    Inventors: Igor Rukhman, Evgeni Flyaks, Tamas Koltai, Judith Aronhime
  • Novel synthesis of irbesartan
    Publication number: 20060135780
    Abstract: Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4?-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.
    Type: Application
    Filed: February 6, 2006
    Publication date: June 22, 2006
    Inventors: Gennady Nisnevich, Igor Rukhman, Boris Pertsikov, Julia Kaftanov, Ben-Zion Dolitzky
  • Novel synthesis of irbesartan
    Publication number: 20060135544
    Abstract: Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4?-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.
    Type: Application
    Filed: February 6, 2006
    Publication date: June 22, 2006
    Inventors: Gennady Nisnevich, Igor Rukhman, Boris Pertsikov, Julia Kaftanov, Ben-Zion Dolitzky
  • Novel synthesis of 2-Butyl-3-(1-trityl-1H-tetrazol-5-YL)biphenyl-4-YL)-1,3-diazaspiro[4,4]- non-ene-4-one
    Publication number: 20060128967
    Abstract: Provided is a novel method of making 2-butyl-3-[[2?(1-trityl-1H-tetrazol-5-yl)biphen-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-ene-4-one, which can be converted to irbesartan. Also provided are methods of making irbesartan.
    Type: Application
    Filed: January 9, 2006
    Publication date: June 15, 2006
    Inventors: Ben-Zion Dolitzky, Julia Kaftanov, Boris Pertsikov, Igor Rukhman, Gennady Nisnevich
  • Novel synthesis of irbesartan
    Publication number: 20060128968
    Abstract: Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4?-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.
    Type: Application
    Filed: February 6, 2006
    Publication date: June 15, 2006
    Inventors: Gennady Nisnevich, Igor Rukhman, Boris Pertsikov, Julia Kaftanov, Ben-Zion Dolitzky
  • Synthesis of 2-butyl-3-(2?-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspiro[4.4]-non-ene-4-one
    Patent number: 7038060
    Abstract: Provided is a novel method of making 2-butyl-3-[[2?(1-trityl-1H-tetrazol-5-yl)biphen-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-ene-4-one, which can be converted to irbesartan. Also provided are methods of making irbesartan.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: May 2, 2006
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Ben-Zion Dolitzky, Julia Kaftanov, Boris Pertsikov, Igor Rukhman, Gennady Nisnevich
  • Synthesis of irbesartan
    Patent number: 7019148
    Abstract: Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4?-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: March 28, 2006
    Assignee: Teva Pharmaceutical Industries, Ltd.
    Inventors: Gennady Nisnevich, Igor Rukhman, Boris Pertsikov, Julia Kaftanov, Ben-Zion Dolitzky
  • Methods for making thebaine or its acid salts
    Patent number: 6958398
    Abstract: Methods for making thebaine and an acid salt of thebaine are disclosed herein. In one embodiment, an acid salt of thebaine is made from codeinone or an acid salt of one or more of the following: 8-methoxy-?6-dihydrothebaine, codeinone dimethyl ketal, and neopinone dimethyl ketal.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: October 25, 2005
    Assignee: Euro-Celtique S.A.
    Inventors: Robert J. Kupper, Arie Gutman, Igor Rukhman, Lev Yudovich, Gennady A. Nisnevich
  • Polymorphs of valsartan
    Publication number: 20050222233
    Abstract: Provided are crystalline and amorphous form of valsartan, and processes for their preparation.
    Type: Application
    Filed: May 27, 2005
    Publication date: October 6, 2005
    Inventors: Igor Rukhman, Evgeni Flyaks, Tamas Koltai, Judith Aronhime
  • Novel synthesis of irbesartan
    Publication number: 20050176794
    Abstract: Provided is a novel synthesis of irbesartan employing a phase transfer catalyst. Also provided is irbesartan having a fine particle size.
    Type: Application
    Filed: July 16, 2003
    Publication date: August 11, 2005
    Inventors: Ben-Zion Dolitzky, Gennady Nisnevich, Igor Rukhman, Boris Pertsikov, Julia Kaftanov