Patents by Inventor Igor Rukhman

Igor Rukhman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of valsartan and intermediates thereof
    Publication number: 20050059827
    Abstract: Provided are process for the preparation of valsartan and the precursors thereof.
    Type: Application
    Filed: April 21, 2004
    Publication date: March 17, 2005
    Inventors: Igor Rukhman, Ben-Zion Dolitzky, Evgeni Flyaks
  • Process for the preparation of valsartan
    Publication number: 20050010053
    Abstract: Provided is a process for preparing valsartan and precursors thereof.
    Type: Application
    Filed: April 21, 2004
    Publication date: January 13, 2005
    Inventors: Zvi Harel, Igor Rukhman
  • Polymorphs of valsartan
    Publication number: 20040242661
    Abstract: Provided are crystalline and amorphous form of valsartan, and processes for their preparation.
    Type: Application
    Filed: March 17, 2004
    Publication date: December 2, 2004
    Inventors: Igor Rukhman, Evgeni Flyaks, Tamas Koltai, Judith Aronhime
  • Novel synthesis of 2-butyl-3-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspiro[4.4]-non-ene-4-one
    Publication number: 20040242894
    Abstract: Provided is a novel method of making 2-butyl-3-[[2′(1-trityl-1H-tetrazol-5-yl)biphen-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-ene-4-one, which can be converted to irbesartan. Also provided are methods of making irbesartan.
    Type: Application
    Filed: February 5, 2004
    Publication date: December 2, 2004
    Inventors: Ben-Zion Dolitzky, Julia Kaftanov, Boris Pertsikov, Igor Rukhman, Gennady Nisnevich
  • Novel synthesis of irbesartan
    Publication number: 20040192713
    Abstract: Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4′-bromobenzyl)-1,3-diazaspiro[4,4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.
    Type: Application
    Filed: January 16, 2004
    Publication date: September 30, 2004
    Inventors: Gennady Nisnevich, Igor Rukhman, Boris Pertsikov, Julia Kaftanov, Ben-Zion Dolitzky
  • Amorphous and crystalline forms of losartan potassium and process for their preparation
    Publication number: 20040006237
    Abstract: This invention relates to novel amorphous losartan potassium, novel losartan potassium in a crystalline form that is a hydrate, novel crystalline losartan potassium Form IV and solvates thereof, novel crystalline losartan potassium Form V and solvates thereof, to processes for their preparation, to compositions containing them and to their use in medicine. This invention further relates to a novel process for preparing crystalline losartan potassium Form I and Form II.
    Type: Application
    Filed: November 13, 2002
    Publication date: January 8, 2004
    Applicant: Teva Pharmaceutical Industries Ltd.
    Inventors: Ben Zion Dolitzky, Shlomit Wizel, Gennady Nisnevich, Igor Rukhman, Julia Kaftanov
  • Novel process and intermediates for production of cabergoline and related compounds
    Publication number: 20020177709
    Abstract: A process for preparation of N-(ergoline-8&bgr;-carbonyl)ureas of the formula [I] their stereoisomers as well as acid addition salts thereof which process comprises silylating an ergoline-8&bgr;-carboxamide of the formula [2], 1
    Type: Application
    Filed: April 16, 2001
    Publication date: November 28, 2002
    Inventors: Arie L. Gutman, Gennadiy Nisnevich, Igor Rukhman, Boris Tishin, Alex Vilensky, Boris Pertsikov