Patents by Inventor Irun R. Cohen

Irun R. Cohen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens
    Patent number: 11965885
    Abstract: Methods and kits for diagnosing or monitoring systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to a specific antibody reactivity profile useful in diagnosing or monitoring SLE in a subject.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: April 23, 2024
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Rachel Sorek, Keren Jakobi, Pennina Safer, Anat Reiner-Benaim, Irun R. Cohen
  • Use of AKT phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
    Patent number: 11852634
    Abstract: The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogues and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: December 26, 2023
    Assignees: Yeda Research and Development Co. Ltd., Universitätsklinikum Hamburg-Eppendorf
    Inventors: Eran Ovadia, Irun R. Cohen, Johannes Herkel, Raanan Margalit, Meirav Pevsner-Fischer
  • Diagnosis of systemic lupus erythematosus using oligonucleotides antigens
    Patent number: 11846636
    Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: December 19, 2023
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. Cohen, Eytan Domany, Noam Shental, Ittai Fattal
  • DIAGNOSIS OF AUTOIMMUNE DISEASE
    Publication number: 20230045855
    Abstract: Assays and methods for diagnosing and treating autoimmune diseases. Particularly, the invention provides methods for differential diagnosis of specific autoimmune diseases, including autoimmune rheumatic disorders.
    Type: Application
    Filed: September 29, 2022
    Publication date: February 16, 2023
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Rachel SOREK, Keren JAKOBI-BROOK, Pennina SAFER, Irun R. COHEN
  • Diagnosis of autoimmune diseases
    Patent number: 11480568
    Abstract: Assays and methods for diagnosing and treating autoimmune diseases. Particularly, the invention provides methods for differential diagnosis of specific autoimmune diseases, including autoimmune rheumatic disorders.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: October 25, 2022
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Rachel Sorek, Keren Jakobi-Brook, Pennina Safer, Irun R. Cohen
  • DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS USING PROTEIN, PEPTIDE AND OLIGONUCLEOTIDE ANTIGENS
    Publication number: 20220003762
    Abstract: Methods and kits for diagnosing or monitoring systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to a specific antibody reactivity profile useful in diagnosing or monitoring SLE in a subject.
    Type: Application
    Filed: May 27, 2021
    Publication date: January 6, 2022
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Rachel SOREK, Keren JAKOBI, Pennina SAFER, Anat REINER-BENAIM, Irun R. COHEN
  • Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens
    Patent number: 11047855
    Abstract: Methods and kits for diagnosing or monitoring systemic lupus erythematosus (SLE) in a subject are provided. Particularly, provided is a specific antibody reactivity profile useful in diagnosing or monitoring SLE in a subject.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: June 29, 2021
    Assignees: IMMUNARRAY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Rachel Sorek, Keren Jakobi, Pennina Safer, Anat Reiner-Benaim, Irun R. Cohen
  • Identifying antigen clusters for monitoring a global state of an immune system
    Patent number: 11002735
    Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: May 11, 2021
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. Cohen, Eytan Domany, Francisco Javier Quintana, Guy Hed, Gad Getz
  • USE OF AKT PHOSPHORYLATION AS A BIOMARKER FOR PROGNOSING NEURODEGENERATIVE DISEASES AND TREATING SAME
    Publication number: 20210041455
    Abstract: The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogues and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.
    Type: Application
    Filed: October 27, 2020
    Publication date: February 11, 2021
    Applicants: Yeda Research and Development Co. Ltd., Universitätsklinikum Hamburg-Eppendorf
    Inventors: Eran OVADIA, Irun R. COHEN, Johannes HERKEL, Raanan MARGALIT, Meirav PEVSNER-FISCHER
  • DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS USING OLIGONUCLEOTIDES ANTIGENS
    Publication number: 20200264172
    Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.
    Type: Application
    Filed: January 24, 2020
    Publication date: August 20, 2020
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. COHEN, Eytan DOMANY, Noam SHENTAL, Ittai FATTAL
  • SLE DISEASE MANAGEMENT
    Publication number: 20200225222
    Abstract: Assays, kits and methods useful in the field of systemic lupus erythematosus (SLE) diagnosis and management for determining and providing SLE treatment adjustment include methods for detecting SLE resolution and for adjusting treatment in a subject hitherto diagnosed as having SLE.
    Type: Application
    Filed: September 17, 2018
    Publication date: July 16, 2020
    Inventors: Rachel SOREK, Keren JAKOBI-BROOK, Pennina SAFER, Irun R. COHEN
  • IDENTIFYING ANTIGEN CLUSTERS FOR MONITORING A GLOBAL STATE OF AN IMMUNE SYSTEM
    Publication number: 20200225223
    Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.
    Type: Application
    Filed: January 21, 2020
    Publication date: July 16, 2020
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. COHEN, Eytan DOMANY, Francisco Javier QUINTANA, Guy HED, Gad GETZ
  • METHODS OF TREATMENT OF HLA-B27 RELATED INFLAMMATORY DISEASES AND COMPOSITIONS RELATED TO SAME
    Publication number: 20200114022
    Abstract: The present disclosure provides methods and compositions for treatment of an HLA-B27-associated autoimmune inflammatory disorder by administration of nucleic acid encoding HSP90 or an active fragment thereof.
    Type: Application
    Filed: March 28, 2018
    Publication date: April 16, 2020
    Inventors: Irun R. Cohen, Denis Ravel, Raanan Margalit, Binah Baum
  • Diagnosis of systemic lupus erythematosus using oligonucleotides antigens
    Patent number: 10545144
    Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: January 28, 2020
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Irun R. Cohen, Eytan Domany, Noam Shental, Ittai Fattal
  • USE OF AKT PHOSPHORYLATION AS A BIOMARKER FOR PROGNOSING NEURODEGENERATIVE DISEASES AND TREATING SAME
    Publication number: 20190204340
    Abstract: The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogues and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.
    Type: Application
    Filed: March 14, 2019
    Publication date: July 4, 2019
    Applicants: Yeda Research and Development Co. Ltd., Universitätsklinikum Hamburg-Eppendorf
    Inventors: Eran OVADIA, Irun R. COHEN, Johannes HERKEL, Raanan MARGALIT, Meirav PEVSNER-FISCHER
  • Use of AKT phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
    Patent number: 10288622
    Abstract: The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogs and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: May 14, 2019
    Assignees: Yeda Research and Development Co. Ltd., Universitätsklinikum Hamburg-Eppendorf
    Inventors: Eran Ovadia, Irun R. Cohen, Johannes Herkel, Raanan Margalit, Meirav Pevsner-Fischer
  • DNA vaccines encoding heat shock proteins
    Patent number: 10226517
    Abstract: A method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding heat shock protein 90 (HSP 90), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences. The disease is other than insulin dependent diabetes mellitus (IDDM) or rheumatoid arthritis. The administering of the immunogenic composition results in a shift of the immune response to a Th2 response, thereby treating the disease.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: March 12, 2019
    Assignee: Alma Bio Therapeutics
    Inventors: Irun R. Cohen, Francisco J. Quintana, Pnina Carmi, Felix Mor
  • IDENTIFYING ANTIGEN CLUSTERS FOR MONITORING A GLOBAL STATE OF AN IMMUNE SYSTEM
    Publication number: 20190004045
    Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.
    Type: Application
    Filed: September 6, 2018
    Publication date: January 3, 2019
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. COHEN, Eytan DOMANY, Francisco Javier QUINTANA, Guy HED, Gad GETZ
  • Identifying antigen clusters for monitoring a global state of an immune system
    Patent number: 10082503
    Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: September 25, 2018
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. Cohen, Eytan Domany, Francisco Javier Quintana, Guy Hed, Gad Getz
  • DNA Vaccines Encoding Heat Shock Proteins
    Publication number: 20180236052
    Abstract: A method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding heat shock protein 90 (HSP 90), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences. The disease is other than insulin dependent diabetes mellitus (IDDM) or rheumatoid arthritis. The administering of the immunogenic composition results in a shift of the immune response to a Th2 response, thereby treating the disease.
    Type: Application
    Filed: April 19, 2018
    Publication date: August 23, 2018
    Inventors: Irun R. Cohen, Francisco J. Quintana, Pnina Carmi, Felix Mor