Abstract: Embodiments of a metal oxide intercalated ink-jettable compound are disclosed.

Abstract: Compositions, methods of using the compositions, and solid freeform fabrication (SFF) systems for producing three-dimensional objects are disclosed. One exemplary composition, among others, includes a basic component, an acidic component, at least one monoacrylate component, a light sensitive initiator, and a polar binder. A polymerization reaction between the at least one monoacrylate component and the light sensitive initiator occurs upon exposure to optical energy. The polar binder includes a viscosity modifier and a surface tension modifier. The polar binder is capable of stimulating a crosslinking reaction between the basic component and the acidic component.

Abstract: A method for solid free-form fabrication of a three-dimensional object includes depositing a particulate blend in a defined region, the particulate blend including reactive glass ionomer particulates, cross-linkable polyacid particulates including polyvinyl pyrrolidone-co-polyacrylic acid, and nanocomposites, ink-jetting an aqueous phase binder onto a predetermined area of the particulate blend to form hydrated cement in the predetermined area, and hardening the hydrated cement.

Abstract: The present invention is drawn toward compositions, methods, and systems for solid free-form fabrication of three-dimensional objects. In one embodiment, a system for solid free-form fabrication of three-dimensional objects can comprise a particulate composition, a substrate configured for supporting at least a layer of the particulate composition in a defined region, and a liquid phase binder configured for being jetted in the defined region to polymerize at least a portion of the particulate composition to form a polymeric cement. Using this system in a layer by layer deposition process, three-dimensional objects can be formed. The particulate composition can include from 70 wt % to 99.9 wt % of polymeric particulates, and from 0.1 wt % to 10 wt % of a polymerization initiator. The liquid phase binder can include from 70 wt % to 90 wt % of polymerizable monomers and from 0.1 wt % to 10 wt % of a polymerization accelerator.

Abstract: Implantable medical devices such as stents, methods of making medical devices, and systems for making medical devices are disclosed herein. In one exemplary embodiment, medical device includes a stent that is coated at least on a portion of one surface by an ink-jet device.

Abstract: A solution is provided that includes a non-aqueous organic solvent within which a solute has been dissolved. A thermal-fluid ejection mechanism is provided that has fluid-ejection nozzles and that is capable of thermally ejecting the solution. A device medium is provided that has a three-dimensional surface on which the solution is to be ejected. The fluid-ejection nozzles of the thermal fluid-ejection mechanism are controlled to eject the solution onto the three-dimensional surface of the device medium in accordance with a desired pattern.

Abstract: Various embodiments and methods relating to dispensing fluid are disclosed.

Abstract: A method for solid free-form fabrication of a three-dimensional object includes depositing a particulate blend in a defined region, the particulate blend including a calcium phosphate source, a reaction retardant, and a layered double hydroxide, and selectively ink-jetting a solubilizing binder onto a predetermined volume of the particulate blend to form a pre-ceramic object in the predetermined volume, wherein the solubilizing binder includes wetting agents, humectants, pH modifiers, and surfactants.

Abstract: Chemical compositions are disclosed. One exemplary composition, among others, includes: a basic component, an acidic component, at least one acrylate component, oxidizing agent, reducing agent, and a binder. The binder includes a viscosity modifier and a surface tension modifier. The binder is capable of stimulating a reaction between the basic component and the acidic component. A portion of the binder is capable of undergoing a polymerization reaction between at least one acrylate component, the oxidizing agent, and the reducing agent. The polymerization reaction being initiated by the redox reaction between the oxidizing agent and the reducing agent.

Abstract: The present invention is directed to a particulate pharmaceutical composition. The particulate pharmaceutical composition can comprise a water-soluble or partially water-soluble polymer matrix; and a plurality of nano-sized particles of active agent which are sparingly water-soluble to water-insoluble dispersed in the water-soluble or partially water-soluble polymer matrix. The particulate pharmaceutical composition can be micronized or in the form of a film that can be rolled up. If micronized, the individual micron-sized particles can have a plurality of nano-sized particles present in the micron-sized particles.

Abstract: The present invention provides pharmaceutical compositions. In one aspect, a pharmaceutical composition is provided having a plurality of polymeric film layers heat sealed together as a multilayer structure and having an active agent dispersed within the multilayer structure. The multilayer structure is configured to release the active agent upon administration to a subject, either in a controlled release or immediate release manner.

Abstract: A solid freeform fabrication system includes a powdered build material deposited as a layer in a fabrication bin; a binding powder deposited as a layer over the layer of powdered build material; and an activating fluid that is selectively dispensed from an ejection head to activate the binding powder. The activated binding powder then selectively binds the build material into a cross-section of an object being fabricated.

Abstract: A slurry is prepared in which nanoparticles of a pharmaceutical ingredient have been formed within a solvent. A solid formulation of the nanoparticles of the pharmaceutical ingredient is prepared from the slurry, without employing electrostatic collection. The solid formulation of the nanoparticles includes at least micron-sized particles.

Abstract: A pharmaceutical ingredient is dissolved within a solvent. The solvent is evaporated until nanoparticles of the pharmaceutical ingredient are at least partially formed without employing a substrate for them. A portion of the solvent remains, within which the nanoparticles are located.

Abstract: A method for solid free-form fabrication of a three-dimensional metal object includes depositing a particulate blend in a defined region, the particulate blend including a number of metal or metal alloy particulates and a peroxide, and selectively ink-jetting a binder system onto a predetermined area of the particulate blend to form a green part, wherein the liquid phase binder includes a water soluble monofunctional acrylate-based monomer, a water soluble difunctional acrylate-based monomer, an amine, and water.

Abstract: Methods of preparing organic nanoparticles are provided. Such methods can include generating a mixture of an organic material, a first liquid, and a second liquid, wherein the organic material is more soluble in the second liquid than in the first liquid. The methods can also include adding a third liquid to the mixture which causes the mixture to form an emulsion. Such an emulsion can have a continuous phase including the first liquid and a discontinuous phase including the organic material and the second liquid. The organic material can be precipitated to form organic nanoparticles and the second liquid can diffuse into the continuous phase.

Abstract: A printing device is provided, wherein the printing device is configured to print a printing fluid onto a printing medium. The printing device includes a printing fluid reservoir configured to hold a volume of the printing fluid, a print head assembly configured to transfer the printing fluid to the printing medium, wherein the print head assembly is fluidically connected to the printing fluid reservoir, and a printing fluid detector configured to detect a characteristic of the printing fluid. The printing fluid detector includes a first electrode and a second electrode configured to be in contact with the printing fluid, wherein at least one of the first electrode and the second electrode includes an electrically conductive coating disposed over an electrically conductive substrate.

Abstract: Implantable medical devices such as stents, methods of making medical devices, and systems for making medical devices are disclosed herein. In one exemplary embodiment, medical device includes a stent that is coated at least on a portion of one surface by an ink-jet device.

Abstract: Solid freeform fabrication systems, powder supply bins for solid freeform fabrication systems, and methods of solid freeform fabrication are disclosed. One exemplary solid freeform fabrication system includes a removable powder supply bin, a build bin, a roller, and a print head disposed above the build bin that deposits a binder onto the powder in the build bin in a preselected pattern.

Abstract: A spray-dryable cement composition comprises unreacted cement particles and a salt of a poly-acid. The composition can be used in a method for solid free-form fabrication of a three-dimensional object, in which a slurry comprising unreacted cement particles and a poly acid in a liquid carrier is spray-dried so as to substantially remove the carrier and form dry cement particles, the cement particles are deposited in a defined region and a liquid binder is applied to a predetermined area within the defined region such that upon contact of the liquid binder with the cement particles a hydrated cement forms in the predetermined area, and the steps of depositing the cement and applying the binder are repeated so as to form a three dimensional object.