Patents by Inventor J. Kevin Judice

J. Kevin Judice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
    Patent number: 8158580
    Abstract: Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: April 17, 2012
    Assignee: Theravance, Inc.
    Inventors: J. Kevin Judice, Jeng-Pyng Shaw, YongQi Mu, Michael W. Conner, John L. Pace
  • Glycopeptide derivatives and pharmaceutical compositions containing the same
    Patent number: 7723470
    Abstract: Disclosed are compounds of the formula: or a trifluoroacetic acid salt thereof, wherein A, B and Fmoc are as defined herein. Such compounds are useful as synthetic intermediates for preparing glycopeptides antibiotics.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: May 25, 2010
    Assignee: Theravance, Inc.
    Inventors: J. Kevin Judice, Paul Ross Fatheree, Bernice M. T. Lam, Michael R. Leadbetter, Martin S. Linsell, YongQi Mu, Sean Gary Trapp, Guang Yang, Yan Zhu
  • PHARMACEUTICAL COMPOSITIONS CONTAINING A GLYCOPEPTIDE ANTIBIOTIC AND A CYCLODEXTRIN
    Publication number: 20100081609
    Abstract: Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.
    Type: Application
    Filed: April 29, 2009
    Publication date: April 1, 2010
    Inventors: J. Kevin Judice, Jeng-Pyng Shaw, YongQi Mu, Michael W. Conner, John L. Pace
  • GLYCOPEPTIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
    Publication number: 20090215982
    Abstract: Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb-(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Application
    Filed: May 8, 2009
    Publication date: August 27, 2009
    Inventors: J. Kevin Judice, Paul Ross Fatheree, Bernice M.T. Lam, Michael R. Leadbetter, Martin S. Linsell, YongQi Mu, Sean Gary Trapp, Guang Yang, Yan Zhu
  • Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
    Patent number: 7544364
    Abstract: Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: June 9, 2009
    Assignee: Theravance, Inc.
    Inventors: J. Kevin Judice, Jeng-Pyng Shaw, YongQi Mu, Michael W. Conner, John L. Pace
  • Novel antibacterial agents
    Publication number: 20090111737
    Abstract: This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall.
    Type: Application
    Filed: April 11, 2008
    Publication date: April 30, 2009
    Inventors: Burton G. Christensen, Edmund J. Moran, John H. Griffin, J. Kevin Judice, YongQi Mu, John L. Pace, Mathai Mammen, James Aggen
  • Methods of treating coagulapathic or thrombotic disorders
    Patent number: 7354585
    Abstract: The invention provides for the isolation, identification, synthesis, expression and purification of antibodies reactive with factor IX (FIX)/factor IXa (IXa). In particular aspects, the invention provides human antibodies reactive with the human FIX Gla domain. The invention further provides compositions especially pharmaceutical compositions, articles of manufacture, and methods of inhibiting the activation of FIX and inhibiting FIX/IXa dependent coagulation.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: April 8, 2008
    Assignee: Genentech, Inc.
    Inventors: Camellia W. Adams, Brigitte Devaux, Dan L. Eaton, Philip E. Hass, J. Kevin Judice, Daniel Kirchhofer, Shelley Suggett
  • Glycopeptide carboxy-saccharide derivatives
    Patent number: 7265086
    Abstract: Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: September 4, 2007
    Assignee: Theravance, Inc.
    Inventors: Martin S. Linsell, Paul R. Fatheree, Michael R. Leadbetter, Yan Zhu, J. Kevin Judice
  • Polyacid glycopeptide derivatives
    Patent number: 7244705
    Abstract: Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO2H) groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: July 17, 2007
    Assignee: Theravance, Inc.
    Inventors: Martin S. Linsell, J. Kevin Judice
  • Glycopeptide carboxy-saccharide derivatives
    Patent number: 7157554
    Abstract: Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: January 2, 2007
    Assignee: Theravance, Inc.
    Inventors: Martin S. Linsell, Paul R. Fatheree, Michael R. Leadbetter, Yan Zhu, J. Kevin Judice
  • Polyacid glycopeptide derivatives
    Patent number: 7074760
    Abstract: Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO2H) groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: July 11, 2006
    Assignee: Theravance, Inc.
    Inventors: Martin S. Linsell, J. Kevin Judice
  • Pharmaceutical compositions containing a gycopeptide antibiotic and a cyclodextrin
    Patent number: 7067483
    Abstract: Disclosed are pharmaceutical composition containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering said pharmaceutical composition.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: June 27, 2006
    Assignee: Theravance, Inc.
    Inventors: J. Kevin Judice, Jeng Pyng Shaw, YongQi Mu, Michael W. Conner, John L. Pace
  • Human anti-factor IX/IXa antibodies
    Patent number: 7049411
    Abstract: The invention provides for the isolation, identification, synthesis, expression and purification of antibodies reactive with factor IX (FIX)/factor IXa (IXa). In particular aspects, the invention provides human antibodies reactive with the human FIX Gla domain. The invention further provides compositions especially pharmaceutical compositions, articles of manufacture, and methods of inhibiting the activation of FIX and inhibiting FIX/IXa dependent coagulation.
    Type: Grant
    Filed: July 8, 2003
    Date of Patent: May 23, 2006
    Assignee: Genentech, Inc.
    Inventors: Camellia W. Adams, Brigitte Devaux, Dan L. Eaton, Philip E. Hass, J. Kevin Judice, Daniel Kirchhofer, Shelley Suggett
  • Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
    Patent number: 7026288
    Abstract: Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: April 11, 2006
    Assignee: Theravance, Inc.
    Inventors: J. Kevin Judice, Jeng Pyng Shaw, YongQi Mu, Michael W. Conner, John L. Pace
  • Glycopeptide derivatives and pharmaceutical compositions containing the same
    Patent number: 6962970
    Abstract: Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: November 8, 2005
    Assignee: Theravance, Inc.
    Inventors: J. Kevin Judice, Paul Ross Fatheree, Bernice M. T. Lam, Michael R. Leadbetter, Martin S. Linsell, YongQi Mu, Sean Gary Trapp, Guang Yang, Yan Zhu
  • Polyacid glycopeptide derivatives
    Patent number: 6906031
    Abstract: Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO2H) groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: June 14, 2005
    Assignee: Theravance, Inc.
    Inventors: Martin S. Linsell, J. Kevin Judice
  • Glycopeptide carboxy-saccharide derivatives
    Patent number: 6903070
    Abstract: Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Grant
    Filed: June 23, 2003
    Date of Patent: June 7, 2005
    Assignee: Theravance, Inc.
    Inventors: Martin S. Linsell, Paul R. Fatheree, Michael R. Leadbetter, Yan Zhu, J. Kevin Judice
  • Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
    Patent number: 6858584
    Abstract: Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: February 22, 2005
    Assignee: Theravance, Inc.
    Inventors: J. Kevin Judice, Jeng-Pyng Shaw, YongQi Mu, Michael W. Conner, John L. Pace
  • Polyhydroxy glycopeptide derivatives
    Patent number: 6828299
    Abstract: Disclosed are polyhydroxy derivatives of glycopeptides and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: December 7, 2004
    Assignee: Theravance, Inc.
    Inventors: Guang Yang, Donald E. Schmidt, Jr., J. Kevin Judice
  • Polyacid glycopeptide derivatives
    Publication number: 20040229775
    Abstract: Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO2H) groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Application
    Filed: June 25, 2004
    Publication date: November 18, 2004
    Inventors: Martin S. Linsell, J. Kevin Judice