Patents by Inventor J. Kevin Judice

J. Kevin Judice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyacid glycopeptide derivatives
    Publication number: 20020055464
    Abstract: Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO2H) groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Application
    Filed: May 1, 2001
    Publication date: May 9, 2002
    Inventors: Martin S. Linsell, J. Kevin Judice
  • Multivalent polymyxin antibiotics
    Patent number: 6380356
    Abstract: Disclosed are multibinding compounds which are antibiotics effective against bacterial infections, in particular, Gram-negative bacterial infections. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a polymyxin, circulin or octapeptin antibiotic or other suitable compound which binds to the LPS present in bacteria, in particular, Gram-negative bacteria. The multibinding compounds of this invention are useful for the prophylaxis and treatment of various bacterial infections caused by bacteria.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: April 30, 2002
    Assignee: Advanced Medicine, Inc.
    Inventors: John H. Griffin, J. Kevin Judice
  • Polyhudroxy glycopeptide derivatives
    Publication number: 20020049156
    Abstract: Disclosed are polyhydroxy derivatives of glycopeptides and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Application
    Filed: May 1, 2001
    Publication date: April 25, 2002
    Inventors: Guang Yang, Donald E. Schmidt, J. Kevin Judice
  • Glycopeptide carboxy-saccharide derivatives
    Publication number: 20020028770
    Abstract: Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Application
    Filed: May 1, 2001
    Publication date: March 7, 2002
    Inventors: Martin S. Linsell, Paul R. Fatheree, Michael R. Leadbetter, Yan Zhu, J. Kevin Judice
  • Local anesthetic compounds and uses
    Patent number: 6337423
    Abstract: Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: January 8, 2002
    Assignee: Advanced Medicine, Inc.
    Inventors: Sabine M. Axt, Timothy J. Church, Witold Hruzewicz, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, J. Kevin Judice
  • Constrained helical peptides and methods of making same
    Patent number: 6271198
    Abstract: Provided are cyclized peptides with a constrained region(s) having an &agr;-helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use in preparing antibodies that prevent viral membrane fusion. Also provided are methods for making such cyclized peptides.
    Type: Grant
    Filed: November 5, 1997
    Date of Patent: August 7, 2001
    Assignee: Genentech, Inc.
    Inventors: Andrew C. Braisted, J. Kevin Judice, Robert S. McDowell, J. Christopher Phelan, Melissa A. Starovasnik, James A. Wells