Patents by Inventor Jack Newman
Jack Newman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080092829Abstract: A fuel composition comprises at least a C5 isoprenoid compound or its derivative and a conventional fuel additive. The C5 isoprenoid compound or its derivative can be used as a fuel component or as a fuel additive in the fuel composition. The fuel composition may further comprise a conventional fuel component selected from a diesel fuel, jet fuel, kerosene or gasoline. Methods of making and using the fuel composition are also disclosed.Type: ApplicationFiled: May 25, 2007Publication date: April 24, 2008Applicant: Amyris Biotechnologies, Inc.Inventors: Neil Renninger, Jack Newman, Keith Reiling
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Publication number: 20070264632Abstract: The present invention provides a method of identifying an enzyme, the method generally involving contacting a sample containing an enzyme with a selected enzyme substrate, where the contacting provides for covalent binding of the substrate to an amino acid of the enzyme to form a covalently modified enzyme; and determining the amino acid sequence of at least a portion of the covalently modified enzyme, using any available peptide sequencing technology, such as tandem mass spectrometry. The present invention further provides methods of identifying a nucleic acid encoding an enzyme, the methods generally involving identifying an enzyme; and, based on the amino acid sequence of at least a portion of the enzyme, designing nucleic acid probes or primers that hybridize to the nucleic acid encoding the enzyme.Type: ApplicationFiled: December 8, 2004Publication date: November 15, 2007Inventors: Jack Newman, Neil Renninger, Vincent Martin, Jay Keasling, Keith Reiling
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Publication number: 20070166782Abstract: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the mevalonate pathway and at least one heterologous nucleic acid sequence, each sequence coding for an enzyme in the mevalonate pathway necessary for converting the intermediate into isopentenyl pyrophosphate. The invention also provides nucleic acid sequences, enzymes, expression vectors, and transformed host cells for carrying out the methods.Type: ApplicationFiled: September 1, 2006Publication date: July 19, 2007Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: JAY KEASLING, VINCENT MARTIN, DOUGLAS PITERA, SEON-WON KIM, SYDNOR WITHERS, YASUO YOSHIKUNI, JACK NEWMAN, ARTEM KHLEBNIKOV
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Publication number: 20070141574Abstract: The present invention provides isolated, genetically modified host cells, where a host cell is genetically modified with a nucleic acid that includes a nucleotide sequence encoding a biosynthetic pathway enzyme. Synthesis of the enzyme in the host cell results in conversion of a substrate for the enzyme into a biosynthetic pathway intermediate, which intermediate is produced in an amount effective to inhibit growth of the genetically modified host cell. The present invention further provides compositions and kits comprising a subject genetically modified host cell. Subject host cells are useful for identifying a gene product having activity in a biosynthetic pathway. The present invention further provides methods of identifying a gene product having activity in a biosynthetic pathway.Type: ApplicationFiled: September 29, 2004Publication date: June 21, 2007Inventors: Jay Keasling, Jack Newman, Douglas Pitera, Sydnor Withers, Keith Reiling, Vincent Martin
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Publication number: 20070099261Abstract: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the mevalonate pathway and at least one heterologous nucleic acid sequence, each sequence coding for an enzyme in the mevalonate pathway necessary for converting the intermediate into isopentenyl pyrophosphate. The invention also provides nucleic acid sequences, enzymes, expression vectors, and transformed host cells for carrying out the methods.Type: ApplicationFiled: December 13, 2006Publication date: May 3, 2007Inventors: Jay KEASLING, Vincent Martin, Douglas Pitera, Seon-Won Kim, Sydnor Withers, Yasuo Yoshikuni, Jack Newman, Artem Khlebnikov
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Publication number: 20070092931Abstract: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the mevalonate pathway and at least one heterologous nucleic acid sequence, each sequence coding for an enzyme in the mevalonate pathway necessary for converting the intermediate into isopentenyl pyrophosphate. The invention also provides nucleic acid sequences, enzymes, expression vectors, and transformed host cells for carrying out the methods.Type: ApplicationFiled: December 14, 2006Publication date: April 26, 2007Inventors: Jay KEASLING, Vincent Martin, Douglas Pitera, Seon-Won Kim, Sydnor Withers, Yasuo Yoshikuni, Jack Newman, Artem Khlebnikov
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Publication number: 20070077616Abstract: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the mevalonate pathway and at least one heterologous nucleic acid sequence, each sequence coding for an enzyme in the mevalonate pathway necessary for converting the intermediate into isopentenyl pyrophosphate. The invention also provides nucleic acid sequences, enzymes, expression vectors, and transformed host cells for carrying out the methods.Type: ApplicationFiled: December 14, 2006Publication date: April 5, 2007Inventors: Jay KEASLING, Vincent Martin, Douglas Pitera, Seon-Won Kim, Sydnor Withers, Yasuo Yoshikuni, Jack Newman, Artem Khlebnikov
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Patent number: 7192751Abstract: Methods for synthesizing amorpha-4,11-diene synthase from isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. Amorpha-4,11-diene synthase is then produced using an optimized amorpha-4,11-diene synthase gene. The invention also provides nucleic acid sequences, enzymes, expression vectors, and transformed host cells for carrying out the methods.Type: GrantFiled: April 9, 2003Date of Patent: March 20, 2007Assignee: The Regents of the University of CaliforniaInventors: Jay Keasling, Vincent Martin, Douglas Pitera, Sydnor T. Withers, III, Jack Newman
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Patent number: 7172886Abstract: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the mevalonate pathway and at least one heterologous nucleic acid sequence, each sequence coding for an enzyme in the mevalonate pathway necessary for converting the intermediate into isopentenyl pyrophosphate. The invention also provides nucleic acid sequences, enzymes, expression vectors, and transformed host cells for carrying out the methods.Type: GrantFiled: December 6, 2001Date of Patent: February 6, 2007Assignee: The Regents of the University of CaliforniaInventors: Jay Keasling, Vincent Martin, Douglas Pitera, Seon-Won Kim, Sydnor T. Withers, III, Yasuo Yoshikuni, Jack Newman, Artem Valentinovich Khlebnikov
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Publication number: 20060079476Abstract: The present invention provides methods of producing an isoprenoid or an isoprenoid precursor in a genetically modified host cell. The methods generally involve modulating the level of hydroxymethylglutaryl-CoA (HMG-CoA) in the cell, such that the level of HMG-CoA is not toxic to the cell and/or does not substantially inhibit cell growth, but is maintained at a level that provides for high-level production of mevalonate, IPP, and other downstream products of an isoprenoid or isoprenoid pathway, e.g., polyprenyl diphosphates and isoprenoid compounds. The present invention further provides genetically modified host cells that are suitable for use in a subject method. The present invention further provides recombinant nucleic acid constructs for use in generating a subject genetically modified host cell, including recombinant nucleic acid constructs comprising nucleotide sequences encoding one or more mevalonate pathway enzymes, and recombinant vectors (e.g., recombinant expression vectors) comprising same.Type: ApplicationFiled: May 20, 2005Publication date: April 13, 2006Inventors: Jay Keasling, Jack Newman, Douglas Pitera
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Publication number: 20040005678Abstract: Methods for synthesizing amorpha-4,11-diene synthase from isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. Amorpha-4,11-diene synthase is then produced using an optimized amorpha-4,11-diene synthase gene. The invention also provides nucleic acid sequences, enzymes, expression vectors, and transformed host cells for carrying out the methods.Type: ApplicationFiled: April 9, 2003Publication date: January 8, 2004Inventors: Jay Keasling, Vincent Martin, Douglas Pitera, Sydnor T. Withers, Jack Newman
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Publication number: 20030148479Abstract: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the mevalonate pathway and at least one heterologous nucleic acid sequence, each sequence coding for an enzyme in the mevalonate pathway necessary for converting the intermediate into isopentenyl pyrophosphate. The invention also provides nucleic acid sequences, enzymes, expression vectors, and transformed host cells for carrying out the methods.Type: ApplicationFiled: December 6, 2001Publication date: August 7, 2003Inventors: Jay Keasling, Vincent Martin, Douglas Pitera, Seon-Won Kim, Sydnor T. Withers, Yasuo Yoshikuni, Jack Newman, Artem Valentinovich Khlebnikov
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Patent number: 6151575Abstract: A source-adapted model for use in speech recognition is generated by defining a linear relationship between a first element of an initial model and a first element of the source-adapted model. Thereafter, speech data that corresponds to the first element of the initial model is assembled from a set of speech data for a particular source associated with the source-adapted model. A linear transform that maps between the assembled speech data and the first element of the initial model is then determined. Finally, a first element of the source-adapted model is produced from the first element of the initial model using the linear transform.Type: GrantFiled: October 28, 1997Date of Patent: November 21, 2000Assignee: Dragon Systems, Inc.Inventors: Michael Jack Newman, Laurence S. Gillick, Venkatesh Nagesha
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Patent number: 5946654Abstract: A speech model is produced for use in determining whether a speaker associated with the speech model produced an unidentified speech sample. First a sample of speech of a particular speaker is obtained. Next, the contents of the sample of speech are identified using speech recognition. Finally, a speech model associated with the particular speaker is produced using the sample of speech and the identified contents thereof. The speech model is produced without using an external mechanism to monitor the accuracy with which the contents were identified.Type: GrantFiled: February 21, 1997Date of Patent: August 31, 1999Assignee: Dragon Systems, Inc.Inventors: Michael Jack Newman, Laurence S. Gillick, Yoshiko Ito
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Patent number: 5710254Abstract: A method of improving the therapeutic activity of von Willebrand Factor obtained from materials comprising on Willebrand Factor comprising incubating said Factor at a temperature of about 20.degree. C. to about 55.degree. C. for about 1 to about 30 hours, most preferably at from about 45.degree. C. to about 55.degree. C. for about 1 to about 5 hours.Type: GrantFiled: June 7, 1995Date of Patent: January 20, 1998Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.Inventors: Jack Newman, David Farb
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Patent number: 5674482Abstract: A biologically active polymeric compound comprising an alkylaryl or heteroalkylaryl backbone having about 5 to about 50 repeating aromatic ring-containing units and which, according to the computer program marketed as SYBYL.RTM. version 5.2 running on a DEC VAX.RTM. 11/750 computer, is capable of forming a linear backbone having a helical secondary structure, and wherein the maximum diameter of the helical structure, as measured by the alkylaryl or heteroalkylaryl backbone, is less than 3 times greater than the maximum diameter of the aryl group of the alkylaryl or heteroalkylaryl backbone.Type: GrantFiled: August 9, 1991Date of Patent: October 7, 1997Assignee: Rhone-Poulenc Rorer Pharmaceuticals, Inc.Inventors: John R. Regan, Michael N. Chang, Jack Newman, Schmuel Ben-Sasson
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Patent number: 5571506Abstract: This invention relates to aromatic oligomeric compounds useful in the treatment of cardiovascular, bone metabolic, hypolipidaemic, neuronal, gastrointestinal and elastase-mediated connective tissue degradation disorders and disorders which may be treated by agents effective in binding DNA, to processes for preparation of such oligomeric compounds, to pharmaceutical compositions including such oligomeric compounds, and to their use in the treatment of such disorders.Type: GrantFiled: September 10, 1993Date of Patent: November 5, 1996Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.Inventors: John R. Regan, Daniel G. McGarry, Michael N. Chang, Jeffrey N. Barton, Jack Newman, Schmuel Ben-Sasson
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Patent number: 5506341Abstract: A method of improving the therapeutic activity of von Willebrand Factor obtained from materials comprising said Factor comprising incubating said Factor at a temperature of about 20.degree. C. to about 55.degree. C. for about 1 to about 30 hours.Type: GrantFiled: May 16, 1994Date of Patent: April 9, 1996Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.Inventors: Jack Newman, David L. Farb
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Patent number: 5009637Abstract: A device to introduce a liquid into the hypoderma, the device includes a reservoir which receives a gas under pressure, the gas is delivered via a valve to an interacting piston and cylinder. When the gas is delivered to the piston, the piston moves to eject a liquid from a capsule mounted within the device. The liquid contained in the capsule is then ejected through a nozzle located against the skin of the user.Type: GrantFiled: November 16, 1988Date of Patent: April 23, 1991Assignee: Sy-Quest International LimitedInventors: Jack Newman, James A. Monroe
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Patent number: 5006642Abstract: A method of preparing von Willebrand Factor by disassociating it from a chaotropic agent in solution therewith and preferably treating the same under controlled temperature either in liquid or lyophilized form.Type: GrantFiled: June 13, 1988Date of Patent: April 9, 1991Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.Inventors: Jack Newman, David L. Farb