Patents by Inventor Jamal Temsamani

Jamal Temsamani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amphipathic linear peptides and formulations containing said peptides
    Publication number: 20030186890
    Abstract: Peptides containing or composed of an antibiotic peptide derivative by (i) modifying the cysteine residues such that the peptide is free of disulphide bridges, (ii) substituting 1 to 18 and, preferentially, 1 to 6 amino acids and/or permuting at least one amino acid pair, the substitutions and/or permutation being such that the peptide is amphipathic in nature, and a compound formed from at least one of the peptides bound directly or indirectly to at least one active substance.
    Type: Application
    Filed: January 3, 2003
    Publication date: October 2, 2003
    Applicant: SYNT:EM S.A.
    Inventors: Guillaume Drin, Jerome Gomar, Jamal Temsamani, Anthony R. Rees
  • Use of cyclodextrins to modulate gene expression with reduced immunostimulatory response
    Publication number: 20030148981
    Abstract: The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen-mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by administering the phosphorothioate oligonucleotide in a therapeutic formulation which includes at least one cyclodextrin to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.
    Type: Application
    Filed: October 23, 2002
    Publication date: August 7, 2003
    Inventors: Qiuyan Zhao, Jamal Temsamani, Sudhir Agrawal
  • Method of modulating gene expression with reduced immunostimulatory response
    Patent number: 5968909
    Abstract: The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen-mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by modifying at least one chemical structure within the phosphorothioate oligonucleotide to produce an immunostimulatory response-reducing phosphorothioate oligonucleotide, which is then administered to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.
    Type: Grant
    Filed: August 4, 1995
    Date of Patent: October 19, 1999
    Assignee: Hybridon, Inc.
    Inventors: Sudhir Agrawal, Jamal Temsamani, Qiuyan Zhao
  • Detection of synthetic oligonucleotides extracted from body fluids or tissues
    Patent number: 5693466
    Abstract: The invention provides a method for detecting specific synthetic oligonucleotides that are present in body fluid or tissue samples taken from an animal or human patient to whom oligonucleotides have been administered.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: December 2, 1997
    Assignee: Hybridon, Inc.
    Inventors: Jamal Temsamani, Sudhir Agrawal
  • Detection of synthetic oligonucleotides extracted from body fluids or tissues
    Patent number: 5558992
    Abstract: The invention provides a method for detecting specific synthetic oligonucleotides that are present in body fluid or tissue samples taken from an animal or human patient to whom oligonucleotides have been administered.
    Type: Grant
    Filed: May 11, 1994
    Date of Patent: September 24, 1996
    Assignee: Hybridon, Inc.
    Inventors: Jamal Temsamani, Sudhir Agrawal