Abstract: Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed.

Abstract: A modular system and method for improving the receiving, processing, storing, and transloading of bulk materials such as organic waste. A system includes at least a receiving module to receive material, a storage module, a discharge module, and a control system. A liquid capture system captures and retains liquid from the organic material. Systems can be adapted with additional modules, such as processing modules and transfer modules, depending on the site and materials to be handled. The storage module has a levelling component for levelling out the organic material stored therein, including a levelling conveyor in a top region, and a removal component for discharging the organic material. A control system interfaces with the modular components and local operators, and provides remote reporting and monitoring.

Abstract: In a handrail including a carcass, a stretch inhibitor within the carcass, and a sliding layer bonded to the carcass, at least a portion of the carcass has a gas phase dispersed in a solid polymer matrix. The gas phase can reduce a density of the carcass by at least 5% or 10%, or about 15%, as compared to a density of the polymer matrix. The carcass can have a generally uniform distribution of gas bubbles in the polymer matrix, which can define a generally closed cell structure in the polymer matrix. The gas phase can be formed of particles of a syntactic foam dispersed in the polymer matrix. The handrail can further include a cover. The carcass and the cover can be formed of thermoplastic materials, and the cover can represent between 10 and 30% of the overall TPU required for the handrail.

Abstract: In an example embodiment, an apparatus for making pouch products includes a conveyor system. The conveyor system includes a first receiving location along a path of the conveyor system, and a dosing location along the path of the conveyor system. The apparatus also includes a first material dispensing station configured to transfer a first material to the first receiving location. The first material includes a first elastic layer and a first support layer. The first material dispensing station includes a dispenser roller configured to hold a roll of the first material, a plurality of rollers configured to convey the first material from the dispenser roller to the first receiving location, and a stripper plate configured remove at least a portion of the first support layer from a portion of the first elastic layer.

Abstract: A clearance control assembly for a gas turbine engine that defines an axial direction and a radial direction and includes a stage of rotor blades and a shroud hanger. The assembly includes a case configured to be positioned outward along the radial direction from the stage of rotor blades when installed in the gas turbine engine. The case is further configured to be engaged with the shroud hanger at a first location when installed in the gas turbine engine. The assembly also includes a baffle positioned outward along the radial direction from the case to define a chamber therebetween. The baffle has a forward end and an aft end. The forward end of the baffle is engaged with the case to form a first seal and the aft end of the baffle is engaged with the case to form a second seal. The baffle, the case, or both define an inlet to allow a fluid to enter the chamber and the case defines an outlet to allow the fluid to exit the chamber.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Methods, systems, and devices are described for providing network access services to mobile users via mobile terminals over a satellite system. In embodiments, dynamic multiplexing of traffic from fixed terminals and mobile users on the same satellite beam can take advantage of statistical multiplexing of large numbers of users and on different usage patterns between fixed terminals and mobile users. In embodiments, quality-of-service (QoS) is controlled for mobile devices at a per-user level. Mobile users may be provisioned on the satellite system according to a set of traffic policies based on their service level agreement (SLA). System resources of the satellite may be allocated to mobile users based on the demand of each mobile user and the set of traffic polices associated with each mobile user, regardless of which mobile terminal is used to access the system.

Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.

Abstract: In an aspect, a device includes a body structure including a core and a sleeve disposed around at least a portion of the core, the core defining a channel through the core extending from a first end of the core to a second end of the core, the sleeve including a flange adjacent the second end of the core; and a deployable portion coupled to the body structure adjacent the first end of the core, the deployable portion having a wired structure transitionable between a retained configuration and a deployed configuration, wherein a top portion of the wired structure extends beyond the first end of the core in a longitudinal direction when the wired structure is in the retained configuration, and wherein first end of the core extends beyond the top portion of the wired structure when the wired structure is in the deployed configuration.

Abstract: A method is provided that can include activating at least two wireless communication channels in parallel, between a first wireless transceiver and a second wireless transceiver. Each of the at least two wireless communication channels can operate at a different radio carrier frequency, and the first wireless transceiver may be part of a first vehicle. The method can also include transmitting, by the first wireless transceiver, common information in parallel on the at least two wireless communication channels to the second wireless transceiver and deactivating the at least two wireless communication channels.

Abstract: In an example embodiment, an apparatus for making pouch products includes a conveyor system. The conveyor system includes a first receiving location along a path of the conveyor system, and a dosing location along the path of the conveyor system. The apparatus also includes a first material dispensing station configured to transfer a first material to the first receiving location. The first material includes a first elastic layer and a first support layer. The first material dispensing station includes a dispenser roller configured to hold a roll of the first material, a plurality of rollers configured to convey the first material from the dispenser roller to the first receiving location, and a stripper plate configured remove at least a portion of the first support layer from a portion of the first elastic layer.

Abstract: A foam earplug for reception at least partially within the ear canal and including a body portion formed of resilient foam plastic material having a multiple open cell structure and having a size and shape for at least partial reception within the ear canal. A transdermal material having a particular beneficial action, and with an outer layer of the foam earplug infused with the transdermal material so that the benefits of the transdermal material is in transdermal contact with the ear canal. One example is a humectant material and, specifically, a moisturizer/lubricating material, for providing an increase to the lubrication and moisturizing in the car canal. A second example is where the beneficial action is provided by systemic distribution such as a sleep aid, i.e., Melatonin, so that when the earplugs are worn during sleep, the earplugs will provide a sleep aid to the wearer.

Abstract: According to an aspect, an inflatable penile prosthesis includes a fluid reservoir configured to hold fluid, an inflatable member, and a pump assembly configured to transfer the fluid between the fluid reservoir and the inflatable member. The pump assembly includes a pump bulb, a valve body, a valve disposed within the valve body, a first fluid port configured to be fluidly coupled to the fluid reservoir, and a second fluid port configured to be fluidly coupled to the inflatable member. The valve is configured to move between an inflation position and a deflation position. The valve includes a first member and second member, the first member being configured to move with respect to the second member.

Abstract: Methods and systems for a device connectivity services system. A method for using the device connectivity services includes receiving a request to connect with a device to perform one or more tasks at the device, processing the request with respect to connectivity factors related to the request and the device, scheduling the request based on the connectivity factors, instantiating a controller to execute the one or more tasks at the device, sending commands to the device over a connection to perform the one or more tasks, and receiving responses from the device over the connection after completing the one or more tasks.

Abstract: Provided herein is a method of characterising a target polynucleotide as it moves with respect to a nanopore using a motor protein. Also provided are polynucleotide adapters and kits comprising such adapters. The methods, kits and adapters find use in characterising polynucleotides, for example in sequencing.

Abstract: A system and method for ordering, ranking, producing, marking, and shipping limited run or limited availability/edition items, such as clothing items, is provided. A web-based or other ordering system is used to process an order. Upon payment, a sequential and ranked Sequence ID is generated for the purchased item. This Sequence ID expresses an ordered ranking within the item's ordering and/or production timeline. The unique, ranked Sequence ID may be applied to a patch or otherwise printed directly onto the limited-edition item and included as a prominent feature for visual appeal or other benefit. A certificate of authenticity may be generated with the limited-edition, ranked item.

Abstract: Systems and methods are provided for using an algorithm and data structure for efficient and accurate classification of data items into recovery classes. When a target recovery time (TRT) is specified for a data set, a system may obtain version metadata regarding data items in the data set. The metadata may be obtained in reverse chronological order such that the latest record representing a version or other storage operation is first, followed by the second latest record, and so on. The system may use a bidirectional doubly linked list to efficiently store version data for a particular data item in memory. As version metadata records are read and added to the data structure in reverse chronological order, classification determinations may be triggered when certain conditions are met.

Abstract: A method of controlling an aeronautical gas turbine engine may be performed with an electronic controller. The method may include determining an airfoil pitch control command for at least one of a plurality of airfoils of the aeronautical gas turbine engine based at least in part on an excitation load acting upon the aeronautical gas turbine engine, and outputting the airfoil pitch control command to one or more actuators actuatable to change a pitch angle of the at least one of the plurality of airfoils. The airfoil pitch control command may be configured to augment and/or compensate for the excitation load acting upon the aeronautical gas turbine engine. The method may be embodied by a non-transitory computer-readable medium that includes computer-executable instructions, which when executed by a processor associated with the electronic controller, cause the electronic controller to perform the method.

Abstract: A quality of service management system includes a rules engine that receives information associated with a communication path having an assigned quality of service (QoS) to be provided for a customer communication device, and identifies one or more network elements assigned to provide the communication path. Each network element having a plurality of queues configured to provide varying QoS levels relative to one another. For each of the network elements, the rules engine determines at least one queue that is configured to provide the communication path at the assigned quality of service, and transmits queue information associated with the determined queue to its respective network element, the network element conveying the communication path through the determined queue.

Abstract: An open rotor aeronautical engine may include a core engine, a plurality of unducted airfoils, and a pitch change assembly. The pitch change assembly may include an ensemble actuator assembly and a unitary actuator assembly. The ensemble actuator assembly may have one or more ensemble actuators and a unison ring that is movable by actuation of the one or more ensemble actuators to collectively change a pitch angle of the plurality of unducted airfoils. The unitary actuator assembly comprising a plurality of unitary actuators respectively coupled to a corresponding one of the plurality of unducted airfoils, the plurality of unitary actuators respectively movable to change the pitch angle of the corresponding one of the plurality of unducted airfoils.