Abstract: In various embodiments, a goods to operator workstation is provided. The goods to operator workstation include an upper level. The upper level includes an upper level conveyor and one or more upper level container bays configured to receive and present one of the one or more upper level containers. The goods to operator workstation also includes at least one connector panel extending from the upper level. The goods to operator workstation further includes a lower level coupled to the at least one connector panel. The lower level is configured to receive one or more lower level containers.

Abstract: Techniques for NAT-based steering of traffic in cloud-based networks. The techniques may include establishing, by a frontend node of a network, a connection with a client device. The frontend node may receive, via the connection, a packet including an indication of an identity of a service hosted on a backend node of the network. Based at least in part on the indication, the frontend node may establish a second connection with the backend node. Additionally, the frontend node may store a mapping indicating that packets received from the client device are to be sent to the backend node. The techniques may also include receiving another packet at the frontend node or another frontend node of the network. Based at least in part on the mapping, the frontend node or other frontend node may alter one or more network addresses of the other packet and forward it to the backend node.

Abstract: This disclosure describes techniques and mechanisms for using a domain-specific language (DSL) to express and compile serverless network functions, and optimizing the deployment location for the serverless network functions on network devices. In some examples, the serverless network functions may be expressed entirely in the DSL (e.g., via a text-based editor, a graphics-based editor, etc.), where the DSL is a computer language specialized to a particular domain, such as a network function domain. In additional examples, the serverless network functions may be expressed and compiled using a DSL in combination with a general-purpose language (GSL). Once the serverless network function have been expressed and/or compiled, the techniques of this disclosure further include determining an optimized network component on which the serverless network function is to execute, and deploying the serverless function to the optimized network component.

Abstract: The present invention relates, inter alia, to a method of preventing or treating skin cancer or skin precancer, the method comprising locally administering to the skin of a subject in need thereof an effective amount of a compound of Formula (I) or a pro-drug thereof, Formula (I) wherein the subject is being administered an immunosuppressant agent that binds to FKBP12. The agent that binds to FKBP12 may be tacrolimus. The invention also relates to methods of preventing or treating a skin condition, disorder or disease associated with administration of an immunosuppressant agent that binds to FKBP12, and to uses of the compound of Formula (I) in treating skin cancer or skin precancer, or a skin condition, disorder or disease associated with administration of an immunosuppressant agent that binds to FKBP12.

Abstract: Examples described herein include systems and methods for dynamically displaying features in a GUI of a portal application that facilitates access to other applications. An example method can include receiving a push notification, from a notification service, at a user device upon which the portal application is installed. The push notification can indicate that a new feature is available for the portal application executing on the user device. The example method can include requesting, from the management server, at least one command for modifying the GUI of the portal application. The management server can provide the command or provide instructions for the user device to retrieve the command. The method can include receiving at least one command. The method can also include modifying the GUI of the portal application based on the received command and displaying the modified GUI.

Abstract: Provided herein are protein biosensors, fusion proteins, compositions, and methods that are useful in detecting SARS-CoV-2 viruses in a sample from a subject. The viral detection assays described herein are solution-based, rapid, and quantitative. The protein biosensors and fusion proteins herein are able to bind to SARS-CoV-2 viral proteins. Use of the fusion proteins in proximity assays (e.g., split reporter assays) allows sensitive detection of SARS-CoV-2 virus in samples.

Abstract: Techniques are described for using observability to allocate and deploy workloads for execution by computing resources in a cloud network. The workloads may be allocated and deployed to the computing resources based on metrics. The workloads may be deployed to the computing resources, based on the computing resources providing a number of types of observability that matches the number of metrics. The workloads may be deployed to the computing resources, further based on each of the computing resources matching a corresponding one of the metrics. Deployment of the workloads may be further based on availability of the computing resources. The workloads may be redeployed to other computing resources that provide different types of observability associated with the metrics, in comparison to the initial computing resources. The workloads may be allocated and deployed based on intent based descriptions indicating characteristics utilized to determine types of metrics for providing observability.

Abstract: This disclosure describes techniques for performing application-based tagging. An example method is performed by a virtual socket of a device. The method includes receiving non-packetized data from an application, generating a label based on the application, and providing the non-packetized data and the label to a kernel of the device.

Abstract: In various embodiments, a goods to operator workstation is provided. The goods to operator workstation include an upper level. The upper level includes an upper level conveyor and one or more upper level container bays configured to receive and present one of the one or more upper level containers. The goods to operator workstation also includes at least one connector panel extending from the upper level. The goods to operator workstation further includes a lower level coupled to the at least one connector panel. The lower level is configured to receive one or more lower level containers. A gap is defined between the upper level and lower level that is sized to allow the one or more lower containers to be placed on the lower level. A method of operating the goods to operator workstation is also included.

Abstract: This disclosure describes techniques and mechanisms for using a domain-specific language (DSL) to express and compile serverless network functions, and optimizing the deployment location for the serverless network functions on network devices. In some examples, the serverless network functions may be expressed entirely in the DSL (e.g., via a text-based editor, a graphics-based editor, etc.), where the DSL is a computer language specialized to a particular domain, such as a network function domain. In additional examples, the serverless network functions may be expressed and compiled using a DSL in combination with a general-purpose language (GSL). Once the serverless network function have been expressed and/or compiled, the techniques of this disclosure further include determining an optimized network component on which the serverless network function is to execute, and deploying the serverless function to the optimized network component.

Abstract: The disclosure is related to antibodies and antibody fragments that specifically bind the CUB domain-containing protein 1 (CDCP1) and their methods and uses in treating and detecting cancers.

Abstract: Techniques for load balancing communication sessions in a networked computing environment are described herein. The techniques may include establishing a first communication session between a client device and a first computing resource of a networked computing environment. Additionally, the techniques may include storing, in a data store, data indicating that the first communication session is associated with the first computing resource. The techniques may further include receiving, at a second computing resource of the networked computing environment, traffic associated with a second communication session that was sent by the client device, and based at least in part on accessing the data stored in the data store, establishing a traffic redirect such that the traffic and additional traffic associated with the second communication session is sent from the second computing resource to the first computing resource.

Abstract: The present disclosure provides a system that enables precise temporal control of the serum half-life a therapeutic moiety by inducing the association or disassociation of the therapeutic moiety with an Fc domain by a small molecule. The present disclosure also provides a system that enables precise control of the serum half- life a T cell engager domain by incorporating a chemically induced dimerizer (CID). One half of the CID is fused to a T cell engager, and the other half of the CID is fused to a HSA binding domain. Addition or removal of a small molecule induces association or dissociation of the T cell engager with HSA, thereby enabling precise temporal control of the serum half-life the T cell engager.

Abstract: This disclosure describes techniques for performing application-based tagging. An example method is performed by a virtual socket of a device. The method includes receiving non-packetized data from an application, generating a label based on the application, and providing the non-packetized data and the label to a kernel of the device.

Abstract: This disclosure describes techniques for providing a distributed scalable architecture for Network Address Translation (NAT) systems with high availability and mitigations for flow breakage during failover events. The NAT servers may include functionality to serve as fast-path servers and/or slow-path servers. A fast-path server may include a NAT worker that includes a cache of NAT mappings to perform stateful network address translation and to forward packets with minimal latency. A slow-path server may include a mapping server that creates new NAT mappings, depreciates old ones, and answers NAT worker state requests. The NAT system may use virtual mapping servers (VMSs) running on primary physical servers with state duplicated VMSs on different physical failover servers.

Abstract: The present disclosure relates to self-test circuitry for a system that includes one or more current control subsystems, each current control subsystem having a load terminal for coupling the current control subsystem to a load. The self-test circuitry comprises: a signal path associated with each current control subsystem, each signal path configured to selectively couple a measurement node to the load terminal of the current control subsystem, wherein the measurement node is common to all of the signal paths; voltage detection circuitry; and test voltage source circuitry configured to provide a test voltage to the measurement node. The voltage detection circuitry is operable to output a signal indicative of a fault condition if a voltage detected at the measurement node differs from the test voltage when the measurement node is coupled to the load terminal.

Abstract: Techniques for transferring address rights (e.g., internet protocol address(es), media access control address(es), etc.) amongst devices in a data center network fabric. A data center (DC) authority (e.g., network controller and/or a service controller) of a data center network fabric may determine that a device in the network is to communicate on an address in the network. The DC authority may create and sign a token that indicates a verifiable authorization to communicate on the address. The token may allow any device that posses the token to communicate on the address, following verification from an associated network switch. Additionally, the token may be signed by a device in the network in possession of the token, and delegated to another device in the data center network fabric following a migration of a service from one server to another, for example.

Abstract: The present invention provides antibody-based chemically induced dimerizers (AbCIDs) comprising an antibody domain that recognizes a chemical epitope created by the binding of an IMiD to a binding partner, such as cereblon, and methods to rapidly generate such AbCIDs. Several aspects described herein relate to systems, compositions, and methods including components of a chemically induced dimerizer (CID), such as an antibody chemically induced dimerizer (AbCID).

Abstract: In various embodiments, a goods to operator workstation is provided. The goods to operator workstation include an upper level. The upper level includes an upper level conveyor and one or more upper level container bays configured to receive and present one of the one or more upper level containers. The goods to operator workstation also includes at least one connector panel extending from the upper level. The goods to operator workstation further includes a lower level coupled to the at least one connector panel. The lower level is configured to receive one or more lower level containers. A gap is defined between the upper level and lower level that is sized to allow the one or more lower containers to be placed on the lower level. A method of operating the goods to operator workstation is also included.