Abstract: Techniques for load balancing communication sessions in a networked computing environment are described herein. The techniques may include establishing a first communication session between a client device and a first computing resource of a networked computing environment. Additionally, the techniques may include storing, in a data store, data indicating that the first communication session is associated with the first computing resource. The techniques may further include receiving, at a second computing resource of the networked computing environment, traffic associated with a second communication session that was sent by the client device, and based at least in part on accessing the data stored in the data store, establishing a traffic redirect such that the traffic and additional traffic associated with the second communication session is sent from the second computing resource to the first computing resource.

Abstract: Examples described herein include systems and methods for dynamically determining a server for enrollment with a management system. An example method can include receiving user input at an application executing on a user device, such as a portal application that provides access to and authentication for other applications through a catalogue of application icons. If the user input includes a first URL but that URL produces an error when used in conjunction with extensions associated with a management server, the application can automatically use extensions associated with an application-support server. The application can then retrieve a second URL from the application-support server and use it for performing enrollment steps at the management server. The enrollment steps can include authenticating the user at an identity service and determining the user's group ID for enrollment, for example.

Abstract: Methods and architecture for load-correcting requests for serverless functions to reduce latency of serverless computing are provided. An example technique exploits knowledge that a given server node does not have a serverless function ready to run or is overloaded. Without further processing overhead or communication, the server node shifts the request to a predetermined alternate node without assessing a current state of the alternate node, an efficient decision based on probability that a higher chance of fulfillment exists at the alternate node than at the current server, even with no knowledge of the alternate node. In an implementation, the server node refers the request but also warms up the requested serverless function, due to likelihood of repeated requests or in case the request is directed back. An example device has a front-end redirecting server and a backend serverless system in a single component.

Abstract: This disclosure describes techniques and mechanisms for using a domain-specific language (DSL) to express and compile serverless network functions, and optimizing the deployment location for the serverless network functions on network devices. In some examples, the serverless network functions may be expressed entirely in the DSL (e.g., via a text-based editor, a graphics-based editor, etc.), where the DSL is a computer language specialized to a particular domain, such as a network function domain. In additional examples, the serverless network functions may be expressed and compiled using a DSL in combination with a general-purpose language (GSL). Once the serverless network function have been expressed and/or compiled, the techniques of this disclosure further include determining an optimized network component on which the serverless network function is to execute, and deploying the serverless function to the optimized network component.

Abstract: The instant disclosure relates to methods for converting mammalian definitive endoderm (DE) cells into specific tissue(s) or organ(s) through directed differentiation. In particular, the disclosure relates to formation of gastric fundus tissue and/or organoids formed from differentiated definitive endoderm.

Abstract: This disclosure describes techniques for providing multiple namespace support to application(s) in containers under Kubernetes without breaking containment boundaries or escalating privileges of the application(s). A namespace service executing on a physical server may communicate with contained processes executing on the physical server by utilizing a Unix Domain Socket (UDS) endpoint in the filesystem of each of the containers. the namespace service may execute on the physical server with escalated privileges, allowing the namespace service to create a socket in a namespace and provide access and rights to utilize the socket to process(es) in a separate namespace.

Abstract: Methods and architecture for load-correcting requests for serverless functions to reduce latency of serverless computing are provided. An example technique exploits knowledge that a given server node does not have a serverless function ready to run or is overloaded. Without further processing overhead or communication, the server node shifts the request to a predetermined alternate node without assessing a current state of the alternate node, an efficient decision based on probability that a higher chance of fulfillment exists at the alternate node than at the current server, even with no knowledge of the alternate node. In an implementation, the server node refers the request but also warms up the requested serverless function, due to likelihood of repeated requests or in case the request is directed back. An example device has a front-end redirecting server and a backend serverless system in a single component.

Abstract: The disclosure is related to antibodies and antibody fragments that specifically bind the CUB domain-containing protein 1 (CDCP1) and their methods and uses in treating and detecting cancers.

Abstract: Disclosed is an electric bed with an adjustable bed length, containing an upper head bed frame, an upper foot bed frame, a lower bed frame, and a plurality of bedboards, wherein at least one of the plurality of bedboards is pivotable relative to the lower bed frame, wherein either of the upper head bed frame and the upper foot bed frame is fixed/immobile relative to the lower bed frame while the other contains a moving component which moves back and forth relative to the lower bed frame between a rest position and an extension position, wherein the at least pivotable bedboard keeps horizontal and the upper head bed frame is away from the upper foot bed frame by Distance 1 when the moving component is located at the rest position, while the at least one pivotable bedboard pivots and there is Distance 2 between the upper head bed frame and the upper fool bed frame when the moving part is located at the extension position, wherein Distance 2 is longer than Distance 1.

Abstract: Presented herein are novel phosphotyrosine binding compositions, including antibodies and antibody fragments. The inventors of the present disclosure have resolved the crystal structures of two widely utilized pan-specific pY antibodies, PY20 and 4G10. These two known antibodies, although developed independently from animal immunizations, have surprisingly similar modes of recognition of the phosphate group, and revealed a generic binding structure among pan-specific pY antibodies. Based on this newly discovered convergent structure, engineered CDR-L3 loops were developed that impart greatly improved affinity to pY binding antibodies and other pY binding compositions. The inventions disclosed herein include antibodies and antibody fragments bearing these novel CDR-L3 sequences and methods of using such pY binding compositions for the detection of phosphotyrosine-bearing proteins.

Abstract: Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.

Abstract: The present disclosure relates to self-test circuitry for a system that includes one or more current control subsystems, each current control subsystem having a load terminal for coupling the current control subsystem to a load. The self-test circuitry comprises: a signal path associated with each current control subsystem, each signal path configured to selectively couple a measurement node to the load terminal of the current control subsystem, wherein the measurement node is common to all of the signal paths; voltage detection circuitry; and test voltage source circuitry configured to provide a test voltage to the measurement node. The voltage detection circuitry is operable to output a signal indicative of a fault condition if a voltage detected at the measurement node differs from the test voltage when the measurement node is coupled to the load terminal.

Abstract: Disclosed herein are methods of enhancing development of a three-dimensional in vitro model of an intestinal tissue (HIO), which may be derived from a precursor cell. The precursor cell may be, for example, an embryonic stem cell, an induced pluripotent stem cell (iPSC), or the like. The in vitro HIO model may be characterized in that the HIO has a lumen, in which a lengthening device may be inserted to promote development of the HIO. Compositions derived from the disclosed methods are also described.

Abstract: This disclosure describes techniques for providing a distributed scalable architecture for Network Address Translation (NAT) systems with high availability and mitigations for flow breakage during failover events. The NAT servers may include functionality to serve as fast-path servers and/or slow-path servers. A fast-path server may include a NAT worker that includes a cache of NAT mappings to perform stateful network address translation and to forward packets with minimal latency. A slow-path server may include a mapping server that creates new NAT mappings, depreciates old ones, and answers NAT worker state requests. The NAT system may use virtual mapping servers (VMSs) running on primary physical servers with state duplicated VMSs on different physical failover servers.

Abstract: An electric bed with an adjustable bed length, containing an upper head bed frame, an upper foot bed frame, a lower bed frame, and a plurality of bedboards. Wherein at least one of the plurality of bedboards is pivotable relative to the lower bed frame. Wherein either of the upper head bed frame and the upper foot bed frame is fixed/immobile relative to the lower bed frame while the other contains a moving component which moves back and forth relative to the lower bed frame between a rest position and an extension position. Wherein the at least pivotable bedboard keeps horizontal and the upper head bed frame is away from the upper foot bed frame by Distance 1 when the moving component is located at the rest position, while the at least one pivotable bedboard pivots and there is Distance 2 between the upper head bed frame and the upper foot bed frame when the moving part is located at the extension position. Wherein Distance 2 is longer than Distance 1.

Abstract: In one embodiment, a server generates expected levels of capability associated with possible combinations of settings for first and second adjustable parameters for an aspect of a software image feature. The server receives an indication of a desired level of capability for the aspect of the software image feature and, based on the indication, identifies a particular expected level of capability associated with a particular possible combination of the settings for the first and second adjustable parameters. The particular expected level of capability is closer to a desired level of capability for an aspect of a software image feature than the other expected levels of capability associated with the possible combinations of the settings for the first and second adjustable parameters. The server produces a software image that includes the particular possible combination of the settings for the first and second adjustable parameters.

Abstract: A cloud orchestration platform obtains from a policy controller, application flow requirements for an application to be deployed in a container network that includes a plurality of microservices. The cloud orchestration platform determines a path through at least a subset of the plurality of microservices based on the application flow requirements, and computes information describing compute resources for workloads associated with the path through the plurality of microservices needed to support the application flow requirements. The cloud orchestration platform creates and/or reserves the workloads among the plurality of microservices. The cloud orchestration platform communicates scheduling requirements to a scheduling driver function associated with the plurality of microservices, the scheduling deriver function using the scheduling requirements to coordinate scheduling of workloads based on the path.

Abstract: A process for the conversion of a feed comprising a mixture of hydrogen and carbon monoxide to hydrocarbons, the hydrogen and carbon monoxide in the feed being present in a ratio of from 1:9 to 9:1 by volume, the process comprising the step of contacting the feed at elevated temperature and atmospheric or elevated pressure with a catalyst comprising titanium dioxide and co bait wherein the catalyst initially comprises from 30% to 95% metallic cobalt by weight of cobalt.