Abstract: The present invention relates to compounds of formulae I and H, or pharmaceutically acceptable salts or esters thereof. Further aspects of the invention relate to pharmaceutical compositions and therapeutic uses of said compounds in the treatment of diseases of uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, inappropriate cellular inflammatory responses, or neurodegenerative disorders, preferably tauopathies, even more preferably, Alzheimer's disease.

Abstract: The present invention relates to compounds of formulae I, or pharmaceutically acceptable salts or esters thereof, wherein: R1 is selected from H and CO—NR8R9, wherein R8 and R9 are each independently selected from H, alkyl, cycloalkyl and mono or bicyclic heterocycloalkyl, wherein said alkyl group is optionally substituted by one or more R12 groups, and said heterocycloalkyl is optionally substituted by R10 or R12; or R8 and R9 are linked, together with the nitrogen to which they are attached, to form a heterocycloalkyl group optionally containing one or more additional heteroatoms, and optionally substituted by one or more groups select from R10 and (CH2)mR12; R2 is selected from H and alkyl, wherein said alkyl group is optionally substituted by one or more R12 groups; R3 is selected from alkyl, cycloalkyl and heterocycloalkyl, each of which may be optionally substituted by halo, OH or alkoxy; Z1, Z2, Z3 and Z4 are all C; R4, R5, R6 and R7 are each independently selected from H, alkyl, CN, NO2,OH, alkoxy, NH

Abstract: A 3-D printer includes a development station positioned to electrostatically transfer layers of material to an intermediate transfer surface, and a transfer station adjacent the intermediate transfer surface. The transfer station is positioned to receive the layers as the intermediate transfer surface moves past the transfer station. Also, a platen is included that moves relative to the intermediate transfer surface. The intermediate transfer surface transfers a layer of the material to the platen each time the platen contacts one of the layers on the intermediate transfer surface at the transfer station to successively form a freestanding stack of the layers on the platen. A fusing station is positioned to apply light to each layer, after each layer is transferred from the transfer station to the platen. The fusing station selectively applies the light to sinter a portion of the material within the layer.

Abstract: An object surface treatment system facilitates the treatment of articles of manufacture before they are printed. The system includes a chamber having walls and a lid configured to close the chamber, a flexible member mounted to the lid of the chamber, a vacuum source operatively connected to an interior volume of the chamber, and a plurality of actuators. A controller is configured to operate the actuators and vacuum source to move the applicator to apply a chemical to the flexible member, move the lid to close the chamber, produce a vacuum within the chamber and move a portion of the surface of the flexible member into engagement with a surface of an object within the chamber, cease operation of the vacuum source to enable the flexible member to return to a position adjacent the lid, and remove the lid from the chamber for removal of the object from the chamber.

Abstract: In 3-D printing a platen moves toward an intermediate transfer belt (ITB) to have a sheet positioned on the platen contact the ITB to electrostatically transfer a layer of different materials to the sheet, and then the platen moves to a heater to join the layer to the sheet. This processing is repeated to have the sheet repeatedly contact the ITB (with intervening heating at the heater) to successively form layers of the materials on the sheet. The sheet having the layers thereon moves to a rinsing station, where a liquid is applied to dissolve the sheet and leave a freestanding stack of the layers. The freestanding stack is fed to a platform to successively form a 3-D structure of freestanding stacks of the layers. Light and/or heat are applied to the 3-D structure to bond the freestanding stacks to one another on the platform.

Abstract: In 3-D printing a platen moves toward an intermediate transfer belt (ITB) to have a sheet positioned on the platen contact the ITB to electrostatically transfer a layer of different materials to the sheet, and then the platen moves to a stabilization station to join the layer to the sheet. This processing is repeated to have the sheet repeatedly contact the ITB (with intervening stabilization at the stabilization station) to successively form layers of the materials on the sheet. The freestanding stack is fed to a platform to successively form a 3-D structure of freestanding stacks of the layers. Heat and/or pressure and/or light are applied to the 3-D structure to bond the freestanding stacks to one another through the sheets of collapsible media on the platform.

Abstract: A cruise control for a vehicle having a mounted rotatable accelerator sleeve and throttle housing which is mounted to a handlebar. The cruise control mounts entirely to the accelerator sleeve and rotates in perfect unity with the throttle when it is rotated. The cruise control is mounted between the throttle housing and the rubber/plastic grip's inner end, directly onto the accelerator sleeve. When the single button of the cruise control is pressed, the cruise control engages and uses friction against the surface of the throttle housing to hold the throttle in place. The operator can force the throttle to rotate by overpowering the friction caused by the cruise control, or preferably, they can disengage the cruise control by pressing the single button again, resetting the cruise control to be engaged again by pressing the single button.

Abstract: Currently there is no apparatus or method to exercise mental agility by the simultaneous and/or independent control from the hands, feet, and eyes. As depicted in FIGS. 1-7, the eye detects that the foot is slower than the hand and the information is sent immediately from the eye to the brain. Subsequently, the brain will instantaneously instruct the foot to speed up and stay on track in the template. The method can be repeated to ensure that the cursors have reached the target at the same time. Repetition enhances the coordination and reflection of the user.

Abstract: Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein R1 is methyl or ethyl; R2 is selected from methyl, ethyl, methoxy and ethoxy; R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl; R4 is selected from methyl, ethyl and —CH2OCH3; R5 and R6 are each individually methyl or hydrogen; and R7 is selected from methyl, ethyl, —(CH2)2OH and —(CH2)2OCH3, or a pharmaceutically acceptable salt thereof.

Abstract: A 3-D printer includes a development station positioned to electrostatically transfer layers of material to an intermediate transfer surface, and a transfer station adjacent the intermediate transfer surface. The transfer station is positioned to receive the layers as the intermediate transfer surface moves past the transfer station. Also, a platen is included that moves relative to the intermediate transfer surface. The intermediate transfer surface transfers a layer of the material to the platen each time the platen contacts one of the layers on the intermediate transfer surface at the transfer station to successively form a freestanding stack of the layers on the platen. A fusing station is positioned to apply light to each layer, after each layer is transferred from the transfer station to the platen. The fusing station selectively applies the light to sinter a portion of the material within the layer.

Abstract: In 3-D printing a platen moves toward an intermediate transfer belt (ITB) to have a sheet positioned on the platen contact the ITB to electrostatically transfer a layer of different materials to the sheet, and then the platen moves to a stabilization station to join the layer to the sheet. This processing is repeated to have the sheet repeatedly contact the ITB (with intervening stabilization at the stabilization station) to successively form layers of the materials on the sheet. The freestanding stack is fed to a platform to successively form a 3-D structure of freestanding stacks of the layers. Heat and/or pressure and/or light are applied to the 3-D structure to bond the freestanding stacks to one another through the sheets of collapsible media on the platform.

Abstract: Layers of build and support material on an intermediate transfer surface are exposed to a solvent using a solvent application station to make the build material tacky, without affecting the support material. Then, the intermediate transfer surface moves past a transfuse station (the transfuse station is positioned to receive the layers after exposure to the solvent) and a platen moves relative to the intermediate transfer surface to contact the platen to one of the layers on the intermediate transfer surface. The intermediate transfer surface transfers a layer of the build material and the support material to the platen each time the platen contacts the layers on the intermediate transfer surface at the transfuse station to successively form a freestanding stack of the layers of build and support material on the platen.

Abstract: In 3-D printing a platen moves toward an intermediate transfer belt (ITB) to have a sheet positioned on the platen contact the ITB to electrostatically transfer a layer of different materials to the sheet, and then the platen moves to a heater to join the layer to the sheet. This processing is repeated to have the sheet repeatedly contact the ITB (with intervening heating at the heater) to successively form layers of the materials on the sheet. The sheet having the layers thereon moves to a rinsing station, where a liquid is applied to dissolve the sheet and leave a freestanding stack of the layers. The freestanding stack is fed to a platform to successively form a 3-D structure of freestanding stacks of the layers. Light and/or heat are applied to the 3-D structure to bond the freestanding stacks to one another on the platform.

Abstract: Systems and methods are provided for managing a print job archive. The system includes a plurality of databases that store print job properties, wherein at least one database is designated to record the print job properties as a function of a predetermined characteristic of the print job. The system also includes an interface that receives multiple print jobs, and a data distribution module coupled with the plurality of databases and the interface. For each of the multiple print jobs, the data distribution module categorizes the print job based on at least one predetermined characteristic, identifies a database among the plurality of databases that is designated for the print jobs as a function of the at least one predetermined characteristic, and stores the print jobs in the identified database as a function of the at least one predetermined characteristic.

Abstract: Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein R1 is methyl or ethyl; R2 is selected from methyl, ethyl, methoxy and ethoxy; R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl; R4 is selected from methyl, ethyl and —CH2OCH3; R5 and R6 are each individually methyl or hydrogen; and R7 is selected from methyl, ethyl, —(CH2)2OH and —(CH2)2OCH3, or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods are disclosed for intelligent data caching behavior. In an embodiment, a method may comprise receiving a read or write command for specific data, determining related data associated with the specific data, and directing the related data be stored to a cache. In another embodiment, a system may comprise a host device, and at least one driver operating on the host device. The at least one driver may be configured to intercept read or write command from the host device to a data storage device regarding specific data, obtain information from the host device to determine associated data related to the specific data, and direct the data storage device to store the associated data to a cache memory.

Abstract: Method and server in a business intelligence analysis system for building a response to a client request. The response includes information regarding the response in an updated server context. The updated server context is round tripped to the client and included in a subsequent request. After being received from the client, the subsequent request is optimized based on the included updated server context.

Abstract: Systems and methods are disclosed for intelligent data caching behavior. In an embodiment, a method may comprise receiving an indication a user has selected specific data for caching, and storing the specific data to a cache memory. In another embodiment, a system may comprise a host device including a driver configured to monitor the system for an indication a user has selected specific data for caching, and store the specific data to a cache memory. In yet another embodiment, an apparatus may a data storage device including a nonvolatile data storage medium, a cache memory, and a processor. The Processor may be configured to receive an indication a user has selected specific data for caching, and copy the specific data form the nonvolatile data storage medium to the cache memory.

Abstract: Disclosed is a method for managing the triboelectric charge potential of a two-component xerographic developer over a wide range of variables. In particular, the present embodiments uses the addition of second and third carrier particles to a developer comprising toner particles and first carrier particles to adjust the tribo electric charge potential of the developer. Various parameters (system responses), including Vmag, laser power, relative humidity, toner and carrier age, and image scan data, are used to determine the requisite amounts of the second and third carrier to achieve a desired shift in tribo electric charge potential of the developer.

Abstract: A cruise control for a vehicle having a mounted rotatable accelerator sleeve and throttle housing which is mounted to a handlebar. The cruise control mounts entirely to the accelerator sleeve and rotates in perfect unity with the throttle when it is rotated. The cruise control is mounted between the throttle housing and the rubber/plastic grip's inner end, directly onto the accelerator sleeve. When the single button of the cruise control is pressed, the cruise control engages and uses friction against the surface of the throttle housing to hold the throttle in place. The operator can force the throttle to rotate by overpowering the friction caused by the cruise control, or preferably, they can disengage the cruise control by pressing the single button again, resetting the cruise control to be engaged again by pressing the single button.