Patents by Inventor James C. Nurse
James C. Nurse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230201839Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.Type: ApplicationFiled: December 21, 2022Publication date: June 29, 2023Inventors: Michael C. Pallas, James C. Nurse, Gary Lim, Theodore E. Straub, Eliodor Ghenciu, Evan Foster, Jorge Fonseca, Kevin Maher
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Patent number: 11590506Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.Type: GrantFiled: May 30, 2019Date of Patent: February 28, 2023Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Michael C. Pallas, James C. Nurse, Gary Lim, Theodore E. Straub, Eliodor Ghenciu, Evan Foster, Jorge Fonseca, Kevin Maher
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Patent number: 10739307Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: GrantFiled: January 25, 2019Date of Patent: August 11, 2020Assignee: APPLIED BIOSYSTEMS, LLCInventors: Charles S. Vann, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Patent number: 10627420Abstract: A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade, and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further, in various embodiments the liquid sample has an advancing contact angle of 85+/?15 degrees with the first and second blade. Furthermore, loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action.Type: GrantFiled: March 15, 2013Date of Patent: April 21, 2020Assignee: Life Technologies CorporationInventors: Michael C. Pallas, James C. Nurse, Gary Lim, Theodore E. Straub, Evan W. Foster
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Publication number: 20190381502Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.Type: ApplicationFiled: May 30, 2019Publication date: December 19, 2019Inventors: Michael C. Pallas, James C. Nurse, Gary Lim, Theodore E. Straub, Eliodor Ghenciu, Evan Foster, Jorge Fonseca, Kevin Maher
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Publication number: 20190293598Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: ApplicationFiled: January 25, 2019Publication date: September 26, 2019Inventors: Charles S. VANN, Debjyoti BANERJEE, Timothy G. GEISER, James C. NURSE, Nigel P. BEARD
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Patent number: 10215730Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: GrantFiled: June 5, 2017Date of Patent: February 26, 2019Assignee: APPLIED BIOSYSTEMS, LLCInventors: Charles S. Vann, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Publication number: 20180128778Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: ApplicationFiled: June 5, 2017Publication date: May 10, 2018Inventors: Charles S. VANN, Debjyoti BANERJEE, Timothy G. GEISER, James C. NURSE, Nigel P. BEARD
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Patent number: 9671365Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: GrantFiled: August 4, 2015Date of Patent: June 6, 2017Assignee: Applied Biosystems, LLCInventors: Charles S. Vann, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Publication number: 20150338373Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: ApplicationFiled: August 4, 2015Publication date: November 26, 2015Inventors: Charles S. VANN, Debjyoti BANERJEE, Timothy G. GEISER, James C. NURSE, Nigel P. BEARD
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Publication number: 20150338372Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: ApplicationFiled: August 4, 2015Publication date: November 26, 2015Inventors: Charles S. VANN, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Patent number: 9132400Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: GrantFiled: September 8, 2014Date of Patent: September 15, 2015Assignee: Applied Biosystems, LLCInventors: Charles S. Vann, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Patent number: 9126169Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: GrantFiled: September 5, 2014Date of Patent: September 8, 2015Assignee: Applied Biosystems, LLCInventors: Charles S. Vann, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Publication number: 20150219534Abstract: A device according to various embodiments can include a first chamber and a second chamber configured to contain at least one biological sample. A triturating element is interdisposed between the first chamber and the second chamber and provides fluid communication between the first chamber and the second chamber.Type: ApplicationFiled: February 4, 2015Publication date: August 6, 2015Inventors: Nigel P. Beard, James C. Nurse
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Patent number: 9061262Abstract: A device having a first substrate and a second substrate separated from the first substrate to form a volume between the first and second substrates, electrodes disposed on the first and second substrates and facing the volume, each substrate comprising at least one electrode, and a first insulating layer disposed on the first substrate and a second insulating layer disposed on the second substrate to separate the electrodes from the volume.Type: GrantFiled: April 28, 2014Date of Patent: June 23, 2015Assignee: Applied Biosystems, LLCInventors: Charles S. Vann, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Patent number: 9044724Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: GrantFiled: May 10, 2013Date of Patent: June 2, 2015Assignee: Applied Biosystems, LLCInventors: Charles S. Vann, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Publication number: 20150080247Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.Type: ApplicationFiled: March 15, 2013Publication date: March 19, 2015Inventors: Michael C. Pallas, James C. Nurse, Gary Lim, Theodore E. Straub, Eliodor Ghenciu, Evan W. Foster, Jorge Fonseca, Kevin Maher
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Publication number: 20150072897Abstract: A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade, and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further, in various embodiments the liquid sample has an advancing contact angle of 85+/?15 degrees with the first and second blade. Furthermore, loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action.Type: ApplicationFiled: March 15, 2013Publication date: March 12, 2015Inventors: Michael C. Pallas, James C. Nurse, Gary Lim, Theodore E. Straub, Evan W. Foster
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Publication number: 20150044686Abstract: An article for holding a plurality of biological samples includes a substrate a substrate comprising a first surface and an opposing second surface and a plurality of reaction sites in the substrate. Each of the reaction sites extends from an opening in the first surface to an opening in the second surface. The reaction sites comprise a hexagonal shape and are configured to provide sufficient surface tension by capillary action to hold respective biological samples. The reaction sites have a density over at least a portion of the surfaces that is at least 170 holes per square millimeter. At least one of the surfaces may have a surface roughness characterized by an arithmetic average roughness (Ra) that is less than or equal to 5 nanometers.Type: ApplicationFiled: March 15, 2013Publication date: February 12, 2015Applicant: Life Technologies CorporationInventors: Michael Pallas, James C. Nurse, Kevin Maher, Jorge Fonseca, Eliodor Ghenciu, Evan Foster
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Patent number: 8931501Abstract: An apparatus for controlling flow in a fluid flow path can include a chamber containing an expandable material, the expandable material being configured to expand out of the chamber into a portion of the fluid flow path so as to at least partially block the fluid flow path. The apparatus also can include at least one structure providing flow communication between the chamber and the fluid flow path. The at least one structure can be configured to pass the expandable material from the chamber to the portion of the fluid flow path during expansion so as to control a rate at which the expandable material expands into the portion of the fluid flow path.Type: GrantFiled: December 19, 2007Date of Patent: January 13, 2015Assignee: Applied Biosystems, LLCInventors: James C. Nurse, John R. Van Camp