Patents by Inventor James C. Nurse
James C. Nurse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150008129Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: ApplicationFiled: September 8, 2014Publication date: January 8, 2015Inventors: Charles S. Vann, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Publication number: 20140374259Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: ApplicationFiled: September 5, 2014Publication date: December 25, 2014Inventors: Charles S. Vann, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Publication number: 20140251811Abstract: A device having a first substrate and a second substrate separated from the first substrate to form a volume between the first and second substrates, electrodes disposed on the first and second substrates and facing the volume, each substrate comprising at least one electrode, and a first insulating layer disposed on the first substrate and a second insulating layer disposed on the second substrate to separate the electrodes from the volume.Type: ApplicationFiled: April 28, 2014Publication date: September 11, 2014Applicant: APPLIED BIOSYSTEMS LLCInventors: Charles S. VANN, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Publication number: 20140090716Abstract: An apparatus for controlling flow in a fluid flow path can include a chamber containing an expandable material, the expandable material being configured to expand out of the chamber into a portion of the fluid flow path so as to at least partially block the fluid flow path. The apparatus also can include at least one structure providing flow communication between the chamber and the fluid flow path. The at least one structure can be configured to pass the expandable material from the chamber to the portion of the fluid flow path during expansion so as to control a rate at which the expandable material expands into the portion of the fluid flow path.Type: ApplicationFiled: September 19, 2013Publication date: April 3, 2014Applicant: APPLIED BIOSYSTEMS, LLCInventors: James C. Nurse, John R. Van Camp
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Publication number: 20140001202Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: ApplicationFiled: May 10, 2013Publication date: January 2, 2014Applicant: APPLIED BIOSYSTEMS, LLCInventors: Charles S. Vann, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Patent number: 8470149Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: GrantFiled: December 5, 2011Date of Patent: June 25, 2013Assignee: Applied Biosystems, LLCInventors: Charles S. Vann, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Patent number: 8337777Abstract: A device and methods for sample distribution through a channel in which an expandable valve provides a mechanism to regulate flow through the channel. The valve may be configured to exert a force on a membrane layer so as to substantially block a portion of the channel to retain the sample in a desired location and prevent flow past the valve mechanism between the channel and a chamber.Type: GrantFiled: June 25, 2007Date of Patent: December 25, 2012Assignee: Applied Biosystems, LLCInventors: James C. Nurse, Douglas P. Greiner, Nigel P. Beard
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Publication number: 20120138462Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: ApplicationFiled: December 5, 2011Publication date: June 7, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Charles S. Vann, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Publication number: 20110171748Abstract: Various embodiments described in the application relate to an apparatus, system, and method for generating, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The system can comprise an apparatus comprising at least one conduit operatively connected to one or more pumps for providing discrete volumes separated from one another by a fluid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil.Type: ApplicationFiled: March 22, 2011Publication date: July 14, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: David M. COX, Willy WIYATNO, Mark F. OLDHAM, James C. NURSE, Douglas P. GREINER, Sam L. WOO, Richard T. REEL, Dennis A. LEHTO, Linda G. LEE, Janusz B. WOJTOWICZ
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Publication number: 20110164862Abstract: A heating apparatus comprising a support base and a microplate having a first surface and an opposing second surface. The microplate is positioned adjacent the support base and comprises a plurality of wells formed in the first surface thereof. Each of the plurality of wells is sized to receive an assay therein. A sapphire crystalline transparent window is positioned adjacent the microplate opposing the support base. A heating device heats the transparent window in response to a control system.Type: ApplicationFiled: October 1, 2010Publication date: July 7, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Kirk M. Hirano, Jason E. Babcoke, Albert L. Carrillo, Douwe D. Haga, Pin Kao, Patrick D. Kinney, James C. Nurse
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Publication number: 20110146418Abstract: A device for sample processing can include at least one chamber having an egress, said chamber being configured to receive a sample for processing, a filter through which at least some sample portions in the at least one chamber flow, and a barrier member disposed in a first state to contain sample in the at least one chamber. Upon sufficient conditions, the barrier member can be alterable to a second state to permit flow of at least some sample portions contained in the chamber in a flow direction toward the egress and through the filter.Type: ApplicationFiled: October 1, 2010Publication date: June 23, 2011Inventors: Maxim G. BREVNOV, James C. Nurse, James Stray
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Patent number: 7955864Abstract: Various embodiments described in the application relate to an apparatus, system, and method for generating, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The system can comprise an apparatus comprising at least one conduit operatively connected to one or more pumps for providing discrete volumes separated from one another by a fluid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil.Type: GrantFiled: August 22, 2006Date of Patent: June 7, 2011Assignee: Life Technologies CorporationInventors: David M. Cox, Willy Wiyatno, Mark F. Oldham, James C. Nurse, Douglas P. Greiner, Sam L. Woo, Richard T. Reel, Dennis A. Lehto, Linda G. Lee, Janusz B. Wojtowicz
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Publication number: 20100236930Abstract: A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.Type: ApplicationFiled: February 19, 2010Publication date: September 23, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Charles S. Vann, Debjyoti Banerjee, Timothy G. Geiser, James C. Nurse, Nigel P. Beard
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Publication number: 20090285719Abstract: An apparatus for sealing a microplate, wherein the apparatus comprises a microplate having a first surface and an opposing second surface. A plurality of wells is formed in the first surface of the microplate, wherein each of the plurality of wells is sized to receive an assay therein. A sealing cover is disposed over the microplate adjacent the plurality of wells and is compliant to accommodate variations between the sealing cover and the microplate and/or distribute loads evenly therebetween.Type: ApplicationFiled: May 22, 2009Publication date: November 19, 2009Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Kirk M. Hirano, James C. Nurse, Albert L. Carrillo, Mike Y. Lu, Adrian Fawcett
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Publication number: 20090224482Abstract: Various embodiments of a custom gasket for use in a flow cell assembly are disclosed. In various embodiments of a custom gasket for a flow cell assembly, the gasket may have a compressible wedge providing a fluid-tight seal at a gasket-fluid interface. In various embodiments of a custom gasket for a flow cell assembly, the gasket may provide a zero dead volume flow path in a flow cell, enabling features such as decreased fluid carry-over and decreased flow cell wash time in comparison to conventional flow cell gaskets.Type: ApplicationFiled: March 4, 2009Publication date: September 10, 2009Applicant: Life Technologies CorporationInventor: James C. Nurse
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Publication number: 20090081768Abstract: An assay card and devices and methods for isolating chambers on the assay card are described. The assay card comprises a substrate formed of one or more materials, e.g., plastic, having a softening temperature, the substrate defining channels communicating with respective reaction chambers. The assay card may be heated in a region of the channels to at least the softening temperature. The softened plastic may be deformed, e.g., with a tool which may or may not also provide the heat for softening the substrate. In this manner, the plastic of the substrate may be caused to at least partially obstruct the channels, thereby isolating the reaction chambers. The invention also relates to a method of manufacturing a tool device that includes pins for heating and deforming an assay card.Type: ApplicationFiled: September 21, 2007Publication date: March 26, 2009Applicant: Applera CorporationInventors: Joon Mo Yang, David M. Liu, Yuh-Min Chiang, Carol Schrembri, Aldrich N.K. Lau, Umberto Ulmanella, Nigel P. Beard, Maryam Shariati, James C. Nurse, Douwe D. Haga, Ian A. Harding, Julio P. Focaracci
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Publication number: 20080163945Abstract: An apparatus for controlling flow in a fluid flow path can include a chamber containing an expandable material, the expandable material being configured to expand out of the chamber into a portion of the fluid flow path so as to at least partially block the fluid flow path. The apparatus also can include at least one structure providing flow communication between the chamber and the fluid flow path. The at least one structure can be configured to pass the expandable material from the chamber to the portion of the fluid flow path during expansion so as to control a rate at which the expandable material expands into the portion of the fluid flow path.Type: ApplicationFiled: December 19, 2007Publication date: July 10, 2008Applicant: Applera CorporationInventors: James C. Nurse, John R. Van Camp
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Publication number: 20080003145Abstract: A device and methods for sample distribution through a channel in which an expandable valve provides a mechanism to regulate flow through the channel. The valve may be configured to exert a force on a membrane layer so as to substantially block a portion of the channel to retain the sample in a desired location and prevent flow past the valve mechanism between the channel and a chamber.Type: ApplicationFiled: June 25, 2007Publication date: January 3, 2008Applicant: Applera CorporationInventors: James C. Nurse, Douglas P. Greiner, Nigel P. Beard
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Patent number: 6022671Abstract: Disclosed is a hybrid waveguide structure, wherein a core or cladding has a hybrid section or "button" of a different optical property such as refractive index from the major portion of the core or cladding, respectively. The hybrid section can be made of a passive material or an electro-optic material. Methods of making a hybrid waveguide structure are also disclosed. These methods include rib-based methods and trench-based methods, and in either of these methods, a temporary filler is used in many instances to incorporate the hybrid section into the hybrid waveguide structure.Type: GrantFiled: March 11, 1997Date of Patent: February 8, 2000Assignee: Lightwave Microsystems CorporationInventors: Edward S. Binkley, James C. Nurse