Abstract: The invention relates to mutant forms of CsgG. The invention also related to analyte detection and characterisation using CsgG.

Abstract: An apparatus is described. The apparatus includes a semiconductor chip that includes logic circuitry, embedded dynamic random access memory (DRAM) cells and embedded ferroelectric random access memory (FeRAM) cells.

Abstract: Provided are radiopaque compositions comprising one or more of yttrium (Y), strontium (Sr), gallium (Ga), and silicon, or oxides and salts thereof. The composition can comprise a combination of Y2O3, SrO, Ga2O3, and SiO2, and optionally MnO2, and TiO2. Other compositions comprise SrO, Ga2O3, TiO2, MnO2, and SiO2. The composition can be a particulate material. The compositions are useful for radioembolization to treat tumors.

Abstract: The backside of a planar view lamella is prepared from a sample extracted from a workpiece. The sample includes multiple device layers and a substrate layer. After removing at least a part of the substrate layer covering a final device layer to obtain a sample surface, a region of interest (ROI) relative to the sample surface is alternately scanned with an electron beam and spontaneously etched until the final device layer within the ROI is exposed. One or more device layers may be removed from the sample backside after the final device layer is exposed to obtain the backside of the planar view lamella.

Abstract: A base station for an audio headset system is provided which is able to communicate with a remote device. The base station is configured to be convertible such that it facilitates communication with remote devices over a range of different communication protocols, in accordance with varying user preference.

Abstract: Described herein is a system and method for embedding an electronic file in a document canvas of an application. User input of an electronic file to be embedded in a document canvas of an application is received. Information regarding the electronic file to be embedded, a target page and/or a user is analyzed to determine parameter(s) regarding representation of the electronic file in the document canvas. The electronic file is embedded in the document canvas of the application in accordance with the determined at least one parameter regarding representation of the electronic file in the document canvas.

Abstract: This disclosure provides methods of treating cancer or eliciting an anti-tumor response in a subject by administering an effective amount of a population of T-cells that exhibits higher or lower than baseline expression of one or more genes. In other aspects, methods are provided to diagnose cancer and determine prognosis of cancer patients. Also provided are methods to identify the antigens or antigen receptors associated with the isolated and/or purified cell populations that elicit a more positive prognosis.

Abstract: The subject of the invention is an insurance claim and/or financial transaction processing system for parametric risk related claims and/or performance warranty related transactions that can be processed using transparency and in a rapid manner wherein the performance or insurance is transacted using sensors and/or analytics. The invention also includes a marketplace where parties can enter or leave, buy or sell, a transaction or transactions associated with an insurance or financial transaction. The system enables aggregation and/or distribution of risk, performance obligations or investments, and aggregation/distribution and/or syndication of insurers or bankers, crowdsourcing/crowdfunding and/or participation of individuals and small groups within the transaction system. The integration of investment, insurance risk conditionalities and performance guarantees within a single exchangeable system is also envisioned. Transaction re-risking and de-risking and associated payments or payouts is also envisioned.

Abstract: Apparatus and methods are disclosed for sample preparation, suitable for online or offline use with multilayer samples. Ion beam technology is leveraged to provide rapid, accurate delayering with etch stops at a succession of target layers. In one aspect, a trench is milled around a region of interest (ROI), and a conductive coating is developed on an inner sidewall. Thereby, reliable conducting paths are formed between intermediate layers within the ROI and a base layer, and stray current paths extending outside the ROI are eliminated, providing better quality etch progress monitoring, during subsequent etching, from body or scattered currents. Ion beam assisted gas etching provides rapid delayering with etch stops at target polysilicon layers. Uniform etching at deep layers can be achieved. Variations and results are disclosed.

Abstract: A qubit assembly includes a first superconducting loop comprising a first Josephson junction and a second Josephson junction, a second superconducting loop comprising the second Josephson junction and a third Josephson junction, and a third superconducting loop comprising the third Josephson junction and a fourth Josephson junction. A flux source is configured to provide a control flux to the second superconducting loop, such that the effective commutation relations between a first quantum operator corresponding to current in the first superconducting loop and a second quantum operator corresponding to current in the third superconducting loop can be changed by changing a magnitude of the control flux provided to the second superconducting loop by the flux source.

Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: A power distribution system such as a marine power distribution and propulsion system. The system includes an ac busbar and a plurality of active front end power converters. Each AFE power converter includes a first active rectifier/inverter connected to the busbar and a second active rectifier/inverter connected to an electrical load such as an electric propulsion motor. Power sources are connected to the dc link of the AFE power converters and can be operated under the control of a power management controller or power management system.

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification. The compounds are apelin and APJ agonists for treating cardiovascular diseases. Preferred compounds are 2-(1,1?-biphe-1H-benzo[d]imidazole derivatives. The invention further provides compositions comprising the compounds and the compounds for use in methods of medical treatment.

Abstract: Methods and systems are provided that enable single sign-on (SSO) mechanisms on rich clients running hosting applications that include documents with one or more embedded web assets. An embedded web asset may be any resource (e.g., document, image, data, etc.) that is accessed via a browser from within a hosting application. In aspects, authentication of a user identity is required to access an embedded web asset. In particular, an identity management module is provided on a rich client. The identity management module is configured to maintain multiple credentials for multiple user identities that are associated with multiple applications, whether the applications are embedded applications or hosting applications. In this way, a user may access multiple applications, including embedded web assets, associated with each user identity—without signing into each application. That is, a user is able to login a single time for each user identity.

Abstract: Apparatus and methods for controlling the insertion of a membrane channel into a membrane are disclosed. In one arrangement a first bath holds a first liquid in contact with a first surface of a membrane. A second bath holds a second liquid in contact with a second surface of the membrane. The membrane separates the first and second liquids. A first electrode contacts the first liquid. A second electrode contacts the second liquid. A driving unit applies a potential difference across the membrane via the first and second electrodes to promote insertion of a membrane channel into the membrane from the first liquid or the second liquid. A membrane voltage reduction unit is connected in series with the membrane. The driving unit applies a driving voltage across the membrane voltage reduction unit and the membrane, the driving voltage providing the potential difference across the membrane.

Abstract: Described is a method comprising: forming a magnet on a substrate or a template, the magnet having an interface; and forming a first layer of non-magnet conductive material on the interface of the magnet such that the magnet and the layer of non-magnet conductive material are formed in-situ. Described is an apparatus comprising: a magnet formed on a substrate or a template, the magnet being formed under crystallographic, electromagnetic, or thermodynamic conditions, the magnet having an interface; and a first layer of non-magnet conductive material formed on the interface of the magnet such that the magnet and the layer of non-magnet conductive material are formed in-situ.

Abstract: Global transcriptional profiling of CTLs in tumors and adjacent non-tumor tissue from treatment-naive patients with early stage lung cancer revealed molecular features associated with robustness of anti-tumor immune responses. Major differences in the transcriptional program of tumor-infiltrating CTLs were observed that are shared across tumor subtypes. Pathway analysis revealed enrichment of genes in cell cycle, T cell receptor (TCR) activation and co-stimulation pathways, indicating tumor-driven expansion of presumed tumor antigen-specific CTLs. Marked heterogeneity in the expression of molecules associated with TCR activation and immune checkpoints such as 4-1BB, PD1, TIM3, was also observed and their expression was positively correlated with the density of tumor-infiltrating CTLs.

Abstract: Disclosed is a system, apparatus, and business method for using financial instruments to provide investment incentive to fund disaster mitigation projects and/or ecosystem restoration projects triggered by real world events detected at set points by sensors and analyzed by computing devices. The detection of events results in the computational analysis and determination of a characteristics of a resilience bond or ecosystem-service bond to be issued or returned to investors. Examples involve sensors used to detect events, including flood damage mitigation, earthquake damage mitigation, or air quality improvement. In one preferred embodiment of the disclosure an investor may make an initial payment into a financial instrument being a resilience bond used to fund a mitigation project, said financial instrument pays phases to the mitigation project developer at the completion of phases of the project that occur prior to the occurrence of a disaster.

Abstract: An aqueous conversion coating solution comprises a trivalent chromium compound, a zirconate compound, and a dye compound. The trivalent chromium compound can comprise trivalent chromium compounds such as trivalent chromium sulfate. The dye compound can comprise an azo dye, a chromium complex dye, an anthraquinoid dye, and/or a methine dye. The zirconate compound can comprise alkali metal hexafluorozirconate compounds. The conversion coating solution can comprise a phosphorous compound such as an organic amino-phosphonic acid compound. The conversion coating solution can be formed by mixing a dye additive containing the dye with a trivalent chromium conversion coating solution that does not contain a dye. The conversion coating solution can be used to treat metal substrates comprising aluminum, magnesium, and/or zinc.

Abstract: Methods of characterizing an analyte using a nanopore. One aspect features methods for characterizing a double-stranded polynucleotide using a nanopore, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.