Abstract: This invention relates to polynucleotides comprising optimized SUMF1 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for deliver) of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a SUMF1 gene or aberrant activity of a SUMF1 gene product in the subject, such as SUMF1 disease.

Abstract: Methods and devices for the tailored restraint of two separate bones, in which the bones are generally permitted to rotate relative to one another, or move toward each other, but are restrained from separating beyond a predetermined, fixed distance. In some embodiments, the restraint is provided by compressing a tether into a notched groove.

Abstract: A system includes a plug assembly having a housing configured to be positioned within a first passageway formed in a wellhead component. A channel is formed in the housing, and the channel is configured to enable fluid to flow from a bore of the wellhead component into the channel. A sensor is supported by the housing and is configured to measure a condition of the fluid within the channel. An annular seal is configured to extend between an outer surface of the housing and an inner surface of a second passageway formed in a flange that circumferentially surrounds at least part of the plug assembly while the flange is coupled to the wellhead component.

Abstract: Described herein is a coupling device, associated parts and a method of use thereof. In one aspect, a coupling device is described comprising a sleeve with an inner surface that encloses at least part of at least one elongated element to be coupled; and at least one deformation means fitted with interference between, and causing local deformation about, at least part of the inner surface of the sleeve and/or an adjacent outer surface of the at least one elongated element. A deformation means insertion tool, a coupling sleeve, a deformation means, and a method of coupling at least one element are also described. The described coupling device, associated parts and a method of use offer the ability to couple together different elements in a strong and/or ductile manner, coupling being tuneable as needed to suit the preferred application. The coupling described may overcome art issues associated with bulky size of coupling, in particular, radial protrusion.

Abstract: Methods and devices for the tailored restraint of two separate bones, in which the bones are generally permitted to rotate relative to one another, or move toward each other, but are restrained from separating beyond a predetermined, fixed distance. In some embodiments, the restraint is provided by compressing a tether into a notched groove.

Abstract: Described herein is a coupling device, associated parts and a method of use thereof. In one aspect, a coupling device is described comprising a sleeve with an inner surface that encloses at least part of at least one elongated element to be coupled; and at least one deformation means fitted with interference between, and causing local deformation about, at least part of the inner surface of the sleeve and/or an adjacent outer surface of the at least one elongated element. A deformation means insertion tool, a coupling sleeve, a deformation means, and a method of coupling at least one element are also described. The described coupling device, associated parts and a method of use offer the ability to couple together different elements in a strong and/or ductile manner, coupling being tuneable as needed to suit the preferred application. The coupling described may overcome art issues associated with bulky size of coupling, in particular, radial protrusion.

Abstract: A system for generating entity-specific security-related inquiries and determining a frequency for invoking the inquiries based on integration of external security-related data and internal security related data. Specifically, a security threat level is determined for an entity and the components which comprise the security threat are identified. The components signify areas of focus for generating the entity-specific security-related inquiries. In further embodiments of the invention analytics are implemented to logically analyze the external security-related data and internal security related data and the results of which further refine the generation of the entity-specific security-related inquiries and/or determination of the frequency for invoking the inquiries.

Abstract: This invention relates to polynucleotides comprising optimized GALC open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a GALC gene or aberrant activity of a GALC gene product in the subject, such as Krabbe disease (i.e., globoid cell leukodystrophy (GLD)).

Abstract: Described herein is a coupling device, associated parts and a method of use thereof. In one aspect, a coupling device is described comprising a sleeve with an inner surface that encloses at least part of at least one elongated element to be coupled; and at least one deformation means fitted with interference between, and causing local deformation about, at least part of the inner surface of the sleeve and/or an adjacent outer surface of the at least one elongated element. A deformation means insertion tool, a coupling sleeve, a deformation means, and a method of coupling at least one element are also described. The described coupling device, associated parts and a method of use offer the ability to couple together different elements in a strong and/or ductile manner, coupling being tuneable as needed to suit the preferred application. The coupling described may overcome art issues associated with bulky size of coupling, in particular, radial protrusion.

Abstract: This invention relates to polynucleotides comprising optimized FIG4 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a FIG4 gene or aberrant activity of a FIG4 gene product in the subject, such as CMT4J.

Abstract: This invention relates to polynucleotides comprising optimized aspartylglucosaminidase (AGA) open reading frames and vectors and cells comprising the same. The invention further relates to methods of using the same for delivery of the open reading frame to a cell or a subject and methods for treating aspartylglucosaminuria (AGU) in a subject.

Abstract: A combination of knowledge representation and retrieval, assessments and personalization for a tutoring platform that provides an automated phased word exposition method for vocabulary learning and enable learners to learn words (or any learning objective) with sufficient proficiency and without excessive repetition. The phased learning objective method implements a moving average model that models the learner across multiple dimensions (e.g. reading, listening, writing, speaking) such that the platform is confident of the learner's understanding, while using minimal assessment doses, and such that the understanding transfers across experiences. The method implemented provides for multiple learning and assessment activities for a learning objective and leverages the same learner model for each learning dimension. Each word of a word set passes through learning and assessment-only phases for statistically significant evidence of learning.

Abstract: This invention relates to polynucleotides comprising optimized CLN7 open reading frame (ORF) sequences, viral vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of CLN7, such as variant late infantile neuronal ceroid lipofuscinoses (vLINCL; CLN7 disease).

Abstract: A parallelogram suspension in a bicycle, the parallelogram suspension comprising a first swing arm rotatably coupled to a seat post at a first end of the first swing arm; a second swing arm rotatably coupled to the seat post at a first end of the second swing arm; a linkage rotatably coupled between a second end of the first swing arm and a second end of the second swing arm; a deformable support disposed in a volume defined between the first swing arm, the second swing arm, and the linkage; and a release configured to selectively open the volume to release the deformable support.

Abstract: Personalized video interjections based on a learner model and a learning objective. A method for adding interjections to a video includes analyzing the content of a plurality of videos based on a set of learning objectives, selecting a video based on a learning objective, determining types of video interjections using an analytics engine that compares a learner model and the learning objective, determining a location for the video interjections using the analytics engine, generating a video interjection for each video interjection type and inserting the video interjections into the video at the determined locations.

Abstract: This invention relates to polynucleotides comprising optimized CLNS open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a CLNS gene or aberrant activity of a CLNS gene product in the subject, such as CLNS disease.

Abstract: This invention relates to feedback-enabled synthetic genes, polynucleotide target cassettes, vectors, and pharmaceutical compositions for the purpose of providing transgene expression in target tissues that is capable of endogenous regulation for treating disorders such as dose-sensitive intellectual ability disorders, as well as methods of making and methods of using the same.

Abstract: An elastomer support for a parallelogram suspension in a bicycle, the deformable support comprising a deformable body defining an opening, wherein the deformable body is configured to be disposed within a volume defined by the parallelogram suspension; and an insert removably insertable into the opening of the deformable body.

Abstract: A process for thermal cracking of a feedstock of plastic materials, in particular waste materials, includes the steps of melting the feedstock, conveying melted feedstock in a pyrolysis chamber where the melted feedstock is heated in a substantially oxygen purged environment, to convert it into pyrolysis gases, the process further comprising the steps of: driving pyrolysis gases from the pyrolysis chamber into a tray reflux column comprising a partial condenser at its upper extremity, returning pyrolysis gases condensed in the tray reflux column into the pyrolysis chamber, distilling pyrolysis gases exiting the partial condenser of the reflux column, to provide one or more fuel products.