Abstract: The present invention relates to therapeutic agents, particularly to therapeutic polypeptides and nucleic acids having the capacity for selective expression under conditions of hypoxia, cells incorporating the nucleic acids and their use in therapy, in particular in methods requiring selective expression under conditions of hypoxia, such as typically found in solid cancers. The nucleic acids encode novel hypoxia-responsive chimeric antigen receptors (CARs). The invention also relates to hypoxia-responsive regulatory nucleic acids.

Abstract: A display system comprises a plurality of displays each comprising an array of light-emitting elements to display a corresponding message, a primary controller that controls the array of light-emitting elements of each display to control the content of each message, a communication network to transmit control signals from the primary controller to the displays, a remote manager in communication with the primary controller via a primary manager communication link, and a redundant controller configured and able to control the array of light-emitting elements of each display to control the content of each message if it is determined that there is a malfunction of the primary controller, an interruption in the communication network between the primary controller and at least one of the displays, or an interruption in the primary communication link.

Abstract: A display system comprises a plurality of displays each comprising an array of light-emitting elements to display a corresponding message, a primary controller that controls the array of light-emitting elements of each display to control the content of each message, a communication network to transmit control signals from the primary controller to the displays, a remote manager in communication with the primary controller via a primary manager communication link, and a redundant controller configured and able to control the array of light-emitting elements of each display to control the content of each message if it is determined that there is a malfunction of the primary controller, an interruption in the communication network between the primary controller and at least one of the displays, or an interruption in the primary communication link.

Abstract: An eccentric assembly for a crusher is disclosed. The eccentric assembly attaches both an eccentric and a counterweight to an underlying rotatable gear that supplies rotational force to the assembly. The eccentric includes an eccentric barrel and an eccentric flange, and the sides of the eccentric are disproportionately weighted. Similarly, the counterweight is disproportionately weighted in an inverse configuration to the eccentric. The eccentric and the counterweight are bolted, pinned, keyed, screwed, nailed, or otherwise fastened to an upper side of the gear. Additionally, the eccentric and the gear both have fluid channels disposed therein for transporting lubricant, such as oil, through the crusher. In particular, the gear may include internally bored fluid passages or external drains for receiving and dispelling the lubricant.

Abstract: The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.

Abstract: The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.

Abstract: A breakaway separation prevention safety device that provides warning indicators reminding users to replace a fuel nozzle after dispensing fuel. The safety warning system reminds users of a fuel pump to replace the nozzle into the nozzle mount. The system is activated as the user removes the nozzle from the nozzle mount. An audio and visual warning is emitted as a reminder for the user.

Abstract: A breakaway separation prevention safety device that provides warning indicators reminding users to replace a fuel nozzle after dispensing fuel. The safety warning system reminds users of a fuel pump to replace the nozzle into the nozzle mount. The system is activated as the user removes the nozzle from the nozzle mount. An audio and visual warning is emitted as a reminder for the user.

Abstract: A paint protection apparatus includes a body formed from paint-impermeable material configured in a wound and tubular configuration, and having integrally coupled outer and inner layers covering an entire surface area thereof. The inner layer is formed from an adhesive material. A plurality of perforations passes through the layers, and extends along the entire longitudinal length of the body. A mechanism separates the body along a linear axis registered orthogonal to a longitudinal length of the body while the body is separated along at least one of the perforations. A mechanism unwinds and dispenses the body while one user hand remains spaced from the unwinding and dispensing mechanism during operating conditions. The separating mechanism is slidably positioned along a longitudinal length of the unwinding and dispensing mechanism.

Abstract: A user who is connected to an unprotected network via a protected network is able to browse the Internet without concern that unauthorized code will execute within their local workstation as the result of a vulnerability within the browser executing on a special virtual machine or a browser module. Any unauthorized code will only affect one of a special virtual machine or a browser module.

Abstract: Systems and methods for managing calls, both inbound and outbound, for available agents over a plurality of lines, where each call received or placed is pre-identified to be connected to one specific agent and upon the automatic detection of the call being received or answered, the call is either connected to the specific agent or placed in a queue for that specific agent.

Abstract: Systems and methods for detecting false signals on a telephone line. The devices provide an additional verification for outbound calls which result in a disconnected or not in service signal that such signals are valid and not false tones being emitted by a device or service employed by the call recipient, The type of additional verification of the outbound call is dependent on the telephone network on which the outbound call is placed. For example, on an analog telephone network a drop in loop current may be detected indicting a connected call which is contrary to the disconnected or not in service signals being received. Such connected signals can be detected on digital networks by monitoring dedicated control data channels or through the use of data received through the use of in-band signaling.

Abstract: Systems and methods for detecting call blocking devices or services. The devices monitor outbound call connections to determine if a connected call has been answered by a call blocking device or service rather than a person or answering machine. The verification is a comparison between the connection of an outbound call and a predefined parameter of data associated with that connection. For example, the predefined timing parameter may require detecting a connection before the first ring, or a connection occur within a predetermine period of time from when the outbound call is placed, or a connection occurring after a certain number of rings, etc. Which predefined parameter is associated with a particular outbound call may depend on the call blocking device or service the call center placing the outbound call expects to encounter on a particular connection attempt of a particular phone number.

Abstract: Systems and methods for allowing a call center to accept and schedule callback appointments for the service of inbound calls at times which are convenient for the inbound caller as well as automatically placing an outbound call at the scheduled callback time. The system collects information from the caller when scheduling a callback time which assists the agent with servicing the scheduled callback more efficiently than the original incoming call. The system also uses algorithms and various system parameters to determine how many agents are needed to service all scheduled callbacks at a given time while maximizing the efficiency of the agents by avoiding having agents service callbacks which fail to reach the person to be serviced for various reasons. When not enough agents are available to handle the scheduled callbacks and current incoming calls the called back individual is automatically connected to the next available agent avoiding the line of incoming calls entirely.

Abstract: A gas administering method for administering gas to an airway of a patient having a nasal vestibule and for use with a gas administering apparatus comprises a primary gas source that is operable to provide gas and a nasal vestibular portion arranged so as to receive the gas from the primary gas source. Further, the nasal vestibular portion is capable of releasing the primary gas into the nasal vestibule. The method comprises inserting the nasal vestibular portion into the nasal vestibule, forming a seal between the nasal vestibular portion and an inner surface of the nasal vestibule, administering an amount of a gas from the primary gas source at a constant flow rate into the nasal vestibule via the nasal vestibular portion, and administering an anesthetic to the patient. The anesthetic induces depression of a portion of the nervous system of the patient.

Abstract: A gas administering method for administering gas to an airway of a patient having a nasal vestibule and for use with a gas administering apparatus comprises a primary gas source that is operable to provide gas and a nasal vestibular portion arranged so as to receive the gas from the primary gas source. Further, the nasal vestibular portion is capable of releasing the primary gas into the nasal vestibule. The method comprises inserting the nasal vestibular portion into the nasal vestibule, forming a seal between the nasal vestibular portion and an inner surface of the nasal vestibule, administering an amount of a gas from the primary gas source at a constant flow rate into the nasal vestibule via the nasal vestibular portion, and administering an anesthetic to the patient. The anesthetic induces depression of a portion of the nervous system of the patient.

Abstract: A gas administering method for administering gas to an airway of a patient having a nasal vestibule and for use with a gas administering apparatus comprises a primary gas source that is operable to provide gas and a nasal vestibular portion arranged so as to receive the gas from the primary gas source. Further, the nasal vestibular portion is capable of releasing the primary gas into the nasal vestibule. The method comprises inserting the nasal vestibular portion into the nasal vestibule, forming a seal between the nasal vestibular portion and an inner surface of the nasal vestibule, administering an amount of a gas from the primary gas source at a constant flow rate into the nasal vestibule via the nasal vestibular portion, and administering an anesthetic to the patient. The anesthetic induces depression of a portion of the nervous system of the patient.

Abstract: A gas administering method for administering gas to an airway of a patient having a nasal vestibule and for use with a gas administering apparatus comprises a primary gas source that is operable to provide gas and a nasal vestibular portion arranged so as to receive the gas from the primary gas source. Further, the nasal vestibular portion is capable of releasing the primary gas into the nasal vestibule. The method comprises inserting the nasal vestibular portion into the nasal vestibule, forming a seal between the nasal vestibular portion and an inner surface of the nasal vestibule, administering an amount of a gas from the primary gas source at a constant flow rate into the nasal vestibule via the nasal vestibular portion, and administering an anesthetic to the patient. The anesthetic induces depression of a portion of the nervous system of the patient.

Abstract: A gas administering method for administering gas to an airway of a patient having a nasal vestibule and for use with a gas administering apparatus comprises a primary gas source that is operable to provide gas and a nasal vestibular portion arranged so as to receive the gas from the primary gas source. Further, the nasal vestibular portion is capable of releasing the primary gas into the nasal vestibule. The method comprises inserting the nasal vestibular portion into the nasal vestibule, forming a seal between the nasal vestibular portion and an inner surface of the nasal vestibule, administering an amount of a gas from the primary gas source at a constant flow rate into the nasal vestibule via the nasal vestibular portion, and administering an anesthetic to the patient. The anesthetic induces depression of a portion of the nervous system of the patient.

Abstract: A microprocessor assembly is located on a daughterboard, which is configured to be physically and electrically coupled to a motherboard. One of the electrical terminals in an electrical connector between the daughterboard/motherboard is coupled to either a ground or a voltage supply Vdd on the daughterboard, depending on the type of microprocessor used. The electrical connector passes either the ground or Vdd signal to a semiconductor device on the motherboard to automatically identify the type of microprocessor on the daughterboard.