Patents by Inventor James Raymond Brown

James Raymond Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolated nucleic acid encoding nucleotide pyrophosphorylase
    Patent number: 6268177
    Abstract: The invention provides ndp polypeptides and polynucleotides encoding ndp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ndp polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: July 31, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B Mathie, Richard Lloyd Warren, Magdalena Zalacain
  • Guaa
    Patent number: 6261817
    Abstract: The invention provides guaA polypeptides and polynucleotides encoding guaA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing guaA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: July 17, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Lisa Kathleen Shilling, Richard Lloyd Warren, Magdalena Zalacain
  • tRNA methyltransferase from Streptococcus pneumoniae
    Patent number: 6245542
    Abstract: The invention provides yfjO polypeptides and polynucleotides encoding yfjO polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yfjO polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: June 12, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, Alexander Bryant, James Raymond Brown, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Chi Young So, Stephanie Van Horn, Richard Lloyd Warren, Magdalena Zalacain
  • nusB polypeptides and polynucleotides and methods thereof
    Patent number: 6245891
    Abstract: The invention provides nusB polypeptides and polynucleotides encoding nusB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nusB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: June 12, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Chi Young So, Richard Lloyd Warren, Magdalena Zalacain
  • metK from Streptococcus pneumoniae
    Patent number: 6228625
    Abstract: The invention provides metK polypeptides and polynucleotides encoding metK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing metK polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: May 8, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Chi Young So, Richard Lloyd Warren, Magdalena Zalacain
  • murF2
    Patent number: 6225457
    Abstract: The invention provides murF2 polypeptides and polynucleotides encoding murF2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing murF2 polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: May 1, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin K R Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B Mathie, Richard Lloyd Warren, Magdalena Zalacain
  • spoIIIE from Steptococcus pneumoniae
    Patent number: 6222016
    Abstract: The invention provides spoIIIE polypeptides and DNA (RNA) encoding spoIIIE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spoIIIE polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 12, 1999
    Date of Patent: April 24, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Alison Frances Chalker, Maria Magdalena Zalacain Feliu, James Raymond Brown, Alexander Philip Bryant
  • MurB
    Patent number: 6218528
    Abstract: The invention provides MurB polypeptides and polynucleotides encoding MurB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 14, 1998
    Date of Patent: April 17, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicola G Wallis, Min Wang, Magdalena Zalacain, Sanjoy Biswas, James Raymond Brown, Alison Frances Chalker, David John Holmes, Karen A Ingraham, Deborah D Jaworski, Jennifer Ray, Lisa K Shilling
  • LacC from streptococcus pneumoniae
    Patent number: 6171840
    Abstract: The invention provides lacC polypeptides and DNA (RNA) encoding lacC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lacC polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: January 9, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: James Raymond Brown, Magdalena Zalacain
  • Polynucleotides encoding tRNA methyl transferases from Streptococcus pneumoniae
    Patent number: 6165764
    Abstract: The invention provides tRNA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing trmD polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 23, 1999
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: David John Holmes, Karen Anne Ingraham, Thomas B Mathie, Richard Lloyd Warren, Magdalena Zalacain, Sanjoy Biswas, James Raymond Brown, Chi Young So, Alison Francis Chalker
  • Sensor histidine kinase of Streptococcus pneumoniae
    Patent number: 6165991
    Abstract: The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase Polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase Polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 19, 1998
    Date of Patent: December 26, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Sanjoy Biswas, John P Throup, Nicola G Wallis, Magdalena Zalacain, James Raymond Brown
  • Ornithine carbamoyltransferase
    Patent number: 6165763
    Abstract: The invention provides ornithine carbamoyltransferase polypeptides and DNA (RNA) encoding ornithine carbamoyltransferase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ornithine carbamoyltransferase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: James Raymond Brown, Magdalena Zalacain
  • DNA encoding adenine phosphoribosyltransferase from Streptococcus pneumoniae
    Patent number: 6165762
    Abstract: The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: December 26, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Arthur Lonetto, Richard Oakley Nicholas, James Raymond Brown, David Justin Charles Knowles, Michael Terence Black, John Edward Hodgson, Robert King Stodola, Magdalena Zalacain
  • aroA
    Patent number: 6160094
    Abstract: The invention provides aroA polypeptides and DNA (RNA) encoding aroA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing aroA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: December 12, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: James Raymond Brown, Alison Frances Chalker, David John Payne, Lisa Kathleen Shilling, Christopher Michael Traini
  • infB
    Patent number: 6110685
    Abstract: The invention provides infB polypeptides and polynucleotides encoding in polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing infB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: August 29, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, Richard Lloyd Warren, Magdalena Zalacain, Chi Young So, Christopher M Traini, David John Holmes, Karen Anne Ingraham, Thomas B Mathie
  • DNA encoding streptococcus pneumoniae trigger factor polypeptides
    Patent number: 6100069
    Abstract: The invention provides tig polypeptides and polynucleotides encoding tig polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tig polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: August 8, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Christine Debouck, Deborah Dee Jaworski, Elizabeth Jane Lawlor, Jeffrey Mooney, Lisa Kathleen Katz, Min Wang, Richard Lloyd Warren, Magdalena Zalacain, Yi Yi Zhong
  • Spoiiie
    Patent number: 5888770
    Abstract: The invention provides spoIIIE polypeptides and DNA (RNA) encodig spoIIIE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utlizng spoIIIE polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: March 30, 1999
    Assignee: Smithkline Beecham Corporation
    Inventors: Alison Frances Chalker, Maria Magdalena Zalacain Feliu, James Raymond Brown, Alexander Philip Bryant
  • PhoH
    Patent number: 5885804
    Abstract: The invention provides phoh polypeptides and DNA (RNA) encoding phoh polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: March 23, 1999
    Assignee: Smithkline Beecham Corporation
    Inventors: Magdalena Zalacain, James Raymond Brown
  • aroA
    Patent number: 5883239
    Abstract: The invention provides aroA polypeptides and DNA (RNA) encoding aroA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing aroA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 18, 1997
    Date of Patent: March 16, 1999
    Assignee: Smithkline Beecham Corporation
    Inventors: James Raymond Brown, Alison Frances Chalker, David John Payne, Lisa Kathleen Shilling, Christopher Michael Traini
  • Amps
    Patent number: 5866369
    Abstract: The invention provides ampS polypeptides and DNA (RNA) encoding ampS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ampS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: February 2, 1999
    Assignee: Smithkline Beecham Corporation
    Inventors: Magdalena Zalacain, James Raymond Brown