Abstract: This document provides methods and materials related to vesicular stomatitis viruses. For example, vesicular stomatitis viruses, nucleic acid molecules encoding VSV polypeptides, methods for making vesicular stomatitis viruses, and methods for using vesicular stomatitis viruses to treat cancer are provided.

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

Abstract: A location awareness system including a communication network, and a network operating element coupled to the communication network. At least one anchor network gateway is coupled to the communication network, the at least one anchor network gateway configured to generate a wireless anchor network. A plurality of anchors are configured to couple to one of the at least one anchor network gateway via its respective wireless anchor network. A plurality of tags is each configured to communicate with at least one anchor to provide ranging information for determination of a position of the tag within an area covered by the system.

Abstract: This document provides methods and materials related to CDV H and/or CDV F polypeptides. For example, CDV H polypeptides, CDV F polypeptides, recombinant viruses (e.g., vesicular stomatitis viruses (VSVs)) containing CDV H polypeptides and/or CDV F polypeptides, nucleic acid molecules encoding a CDV H polypeptide and/or CDV F polypeptide, methods for making recombinant viruses (e.g., VSVs) containing CDV H polypeptides and/or CDV F polypeptides, and methods for using recombinant viruses (e.g., VSVs) containing CDV H polypeptides and/or CDV F polypeptides to treat cancer or infectious diseases are provided.

Abstract: An injection setup kit can include a manifold connector, a first packaging container, and a fluid line. The first packaging container can define a first closed interior volume that includes a patient interface connector having a patient interface inlet, a first patient interface outlet, and a valve configured to selectively permit fluid communication through the patient interface connector. The patient interface inlet can be fluidly connected to the manifold outlet. The fluid line can have a first fluid line end and a second fluid line end. The first fluid line end can be connected to the patient interface inlet within the first closed interior volume. The second fluid line end can extend outside of the first closed interior volume and be connected to a manifold outlet outside of the first closed interior volume.

Abstract: A scaffolding assembly adapted to be releasably attached to an elongate support member such as an overhead pipe. The scaffolding assembly has a split collar and a platform assembly adapted to be releasably attached to the split collar. The split collar comprises at least two segments which can encircle the pipe and be secured to one another. The platform assembly which includes a platform deck has a connector formation which extends laterally outwardly from the deck to an extent that it can engage a receiving formation on the collar assembly and thereby attach the platform assembly to the collar assembly.

Abstract: A communication system and method for supporting a plurality of vehicle-to-everything radio access technologies (V2X RATs) is provided. The communication system configured to support multiple V2X RATs transmits, using a first V2X RAT, an indication of its availability to support an interworking function between the plurality of V2X RATs. The communication system receives an instruction to provide the interworking function between different V2X RATs. The interworking function may be incorporated in a vehicle that is joined to a platoon configured to use a first V2X RAT, and provide the interworking function between the first and a second V2X RAT. The interworking function may be used to add further vehicles to the platoon that communicate using only the second V2X RAT.

Abstract: A method for determining the density of particles includes passing a carrier fluid and particles through a fractionation cell at a predetermined rate, where the carrier fluid has a predetermined density, the fractionation cell has a housing including a first axial end and a second axial end and the fractionation cell defines an interior carrier fluid flow-through channel, and an upper fluid outlet and a lower fluid outlet positioned below the upper fluid outlet, passing the carrier fluid and the particles through the upper fluid outlet and the lower fluid outlet, measuring a first concentration of particles passing through the upper fluid outlet, measuring a second concentration of particles passing through the lower fluid outlet, and determining a density of the particles based at least in part on the first concentration and the second concentration of particles.

Abstract: Methods, apparatuses, and systems for analyzing complete microorganism strains in complex heterogeneous communities, determining functional relationships and interactions thereof, and synthesizing bioreactive modificators based thereon are disclosed. Methods for identifying and utilizing pathways and functionalities of interest based thereon are also disclosed.

Abstract: There is provided a computer-implemented method and apparatus for determining temporal behaviour of an object. The method comprises receiving track data indicative of a plurality of tracks. Each track identifies an association between features corresponding to an object in each of a plurality of images forming image data representative of one or more objects. The method further comprises identifying, in at least some of the plurality of tracks, one or more faults, wherein each fault is associated with at least one respective fault image of the image data. The method further comprises iteratively performing a correction process on the track data.

Abstract: A field spectral radiometer includes a support structure and a remote sensing head disposed on the support structure. The remote sensing head includes a central axis, a first optical element disposed on a first side of the central axis and defining a first optical path for a first optical channel, and a second optical element disposed on a second side of the central axis and defining second optical path for a second optical channel. An instrumentation assembly disposed on the support structure. the instrumentation assembly includes a first detection path associated with the first optical channel and a second detection path associated with the second optical channel, the first and second detection path include optical indexers for manipulating the first and second optical channels. The field spectral radiometer may include a calibration assembly disposed on the base. The calibration assembly may include a calibrating light source for calibrating the remote sensing head.

Abstract: In aspects, a system includes an on-board storage containing a synthetic quality control material, a plurality of sub-systems having a plurality of operating parameters and including a material analyzer, a database storing quality control results that include results of the material analyzer analyzing the synthetic quality control material over time, one or more processors, and at least one memory storing instructions which, when executed by the one or more processors, cause the system to, automatically without user intervention: generate a control chart based on the quality control results, determine that a parameter of the plurality of operating parameters is out-of-tolerance based on the control chart, and adjust at least one of the plurality of sub-systems without user intervention to bring the out-of-tolerance parameter to within tolerance.

Abstract: A head-mounted device may have a head-mounted housing containing rear-facing displays that display images for a user when the head-mounted housing is worn by the user. The head-mounted device housing may have housing structures such as elongated housing members with protruding posts. A headband may be removably coupled to the head-mounted device housing. The headband may have a strap with openings configured to receive the posts. Releasable latches may be provided to allow selective engagement and disengagement between the headband and the housing. The latches may contain movable latch members that are biased using magnetic biasing mechanisms, spring-based biasing mechanisms, or other biasing mechanisms. To release each latch, a tab, button, toggle lever, slider, or other release mechanisms may be actuated by a user. This moves the movable latch member from a closed latch position to an open latch position that releases the headband from the housing.

Abstract: There is provided a method and device for provisioning emergency number information on a user equipment. When a dialed number matches an emergency number from the provisioned emergency number information, the user equipment selects either the circuit switched domain or the packet switched domain and executes a call setup procedure for that domain.

Abstract: Systems (100) for assembling stiffened composite structures comprise a layup mandrel (102) and a network (104) of fluid lines (116) configured to be selectively and fluidically coupled to string bladders (118) positioned relative to the layup mandrel (102).

Abstract: This disclosure describes methods and devices that assist in forming biosensors. Specifically, features that align solutions containing molecules to be immobilized on biosensors. A retaining structure may be disposed at least partially around a target surface of a substrate. A resonating structure may be disposed on the target surface. A droplet of functionalized material may be disposed on the resonating structure and the target surface, which may be auto-aligned and retained by the retaining structure on the target surface to consistently cover the resonating structure.

Abstract: Computer-implemented methods and systems are provided for automatically performing a task on a remote computer. During a registration stage, the system receives personal information of a human user, obtains an IP address and a device configuration for a computing device, and stores the personal information, IP address, and the device configuration in record in a database. The system receives a request to interact with a remote website to perform a task, the request including the personal information of the human user. The system then retrieves the record from the database using the personal information. The system creates a virtual machine based on the device configuration for the computing device, selects one of a geographically distributed set of proxy servers having an IP geographically address resembling the IP address for the computing device, and executes instructions causing the virtual machine to interact with the remote website using the proxy server to perform the task.

Abstract: This document relates to methods and materials involved in treating cancer. For example, methods and materials for using one or more oncolytic viruses (e.g., one or more replicating oncolytic viruses) to treat cancer in a mammal (e.g., a human) identified as having a cancer likely to respond to oncolytic virotherapy are provided.

Abstract: This document provides methods and materials related to vesicular stomatitis viruses. For example, replication-competent vesicular stomatitis viruses, nucleic acid molecules encoding replication-competent vesicular stomatitis viruses, methods for making replication-competent vesicular stomatitis viruses, and methods for using replication-competent vesicular stomatitis viruses to treat cancer or infectious diseases are provided.