Abstract: An organ perfusion system comprises: a perfusion fluid circuit (16) arranged to circulate perfusion fluid through the organ; a surrogate organ (126) arranged to be connected into the circuit in place of the organ so that the circuit can circulate fluid through the surrogate organ; and organ sensing means arranged to distinguish between the presence of the organ in the circuit and the presence of the surrogate organ in the circuit. The sensing means may comprise one or more pressure sensors (136, 137, 138), or a flow meter (125). Further aspects relate to adjusting the content of at least one component, such as oxygen or a nutrient, in the perfusion fluid. Bubble detection means (113), and means (74) to measure the amount of fluid secreted by or leaked from the organ, may also be provided.

Abstract: Provided are an artificial intelligence (AI) system simulating a function of a human brain, such as cognition and judgment, using a machine learning algorithm, such as deep learning, and an application thereof. Also, provided is a method, performed by an electronic apparatus, of refining an artificial intelligence (AI) model, the method including: detecting information about a context of an electronic apparatus used to refine a local model stored in the electronic apparatus being changed; determining a gradient for refining the local model based on the changed information about the context; refining the local model based on the determined gradient; transmitting the gradient to a server; receiving, from the server, information about a global model refined based on the gradient; and refining the local model based on the received information.

Abstract: This document relates to materials and methods for treating cancer. For example, this document provides materials and methods for using PD-L1 targeting domains in bispecific chimeric polypeptides, chimeric transmembrane polypeptides, genetically modified viruses, nucleic acid vectors, and/or fusion-inducing cells to treat cancer.

Abstract: Disclosed herein are systems, methods, and device for performing external counterpulsation. The external counterpulsation device can include a cuff including a body, a first end, and a second end. In some examples, the external counterpulsation device includes a removable tubular connector, a removably attached bladder, and a securing material extending across a length of the body of the cuff. The external counterpulsation device also includes a u-shaped buckle having a first arm, a second arm, and an opening. The first arm is configured to extend through the opening of the first end of the cuff and the second arm is configured to form a roller. The opening of the buckle is formed between the first arm and the second arm and is configured to allow the body of the cuff to extend through the u-shaped buckle.

Abstract: Provided herein are methods of administering a KRAS G12C inhibitor to a cancer subject.

Abstract: A method at a network element, the method including receiving at least one message at the network element, the at least one message being one or both of: an update status information message from an updates server; and an anomaly detection status information message from anomaly detection server; determining, based on the receiving the at least one message, a dynamic cybersecurity posture indication for an intelligent transportation system entity; and providing the dynamic cybersecurity posture indication for the intelligent transportation system entity to an Enrolment Authority, wherein the dynamic cybersecurity posture indication can be included in a certificate relating to the intelligent transportation system entity.

Abstract: An improved poultry production method comprising providing dry hydrogen peroxide (DHP) to poultry eggs, chicks and birds, and devices for providing DHP to poultry production during laying, incubating, hatching, and growing.

Abstract: This document relates to methods and materials for virotherapy. For example, this document provides methods and materials for treating cancer using a recombinant mumps virus as an oncolytic agent.

Abstract: Devices that include a low sensitivity bulk acoustic wave (BAW) resonator sensor including a surface to which a low recognition component is immobilized, the low recognition component being configured to selectively bind the analyte, an analyte molecule to which a tag is linked, or a tag, or any one of these molecules to which an amplification element-linked second recognition component is bound; a high sensitivity BAW resonator sensor including a surface to which a high recognition component is immobilized, the high recognition component being configured to selectively bind the analyte, an analyte molecule to which a tag is linked, or a tag, or any one of these molecules to which an amplification element-linked second recognition component is bound; one or more containers housing an amplification molecule, the amplification element-linked second recognition component, and optionally one or both of the tag and the analyte molecule.

Abstract: The invention relates to production of a yeast strain with increased mannan oligosaccharides, amino acids, and complex carbohydrates. The invention further relates to the process to propagate and ferment such yeast. The invention further relates to methods of use of the yeast as a feed additive for animals and a food product for humans.

Abstract: Apparatus, systems, and methods for protecting a vehicle from a radiation source (e.g., the sun) are provided. One apparatus includes a set of first wires and a set of second wires located proximate to the set of first wires. The set of first wires maintains a positive voltage and the set of second wires maintains a negative voltage. The set of first wire and the set of second wires are arranged to generate an electrostatic field (ESF) between the vehicle and the radiation source. A system includes a spacecraft and a field generator that generates an ESF between the spacecraft and a radiation source. A method includes tracking a location of a spacecraft relative to a radiation source and generating an ESF between the spacecraft and the radiation source.

Abstract: The present disclosure relates to quality control for point-of-care medical diagnostic systems. In various embodiments, the system includes an on-board storage containing a synthetic quality control material, a plurality of sub-systems having a plurality of operating parameters and including a material analyzer, a database storing quality control results that include results of the material analyzer analyzing the synthetic quality control material over time, one or more processors, and at least one memory storing instructions which, when executed by the one or more processors, cause the system to, automatically without user intervention: generate a control chart based on the quality control results, determine that a parameter of the plurality of operating parameters is out-of-tolerance based on the control chart, and adjust at least one of the plurality of sub-systems without user intervention to bring the out-of-tolerance parameter to within tolerance.

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

Abstract: There is provided a method and device for provisioning emergency number information on a user equipment. When a dialed number matches an emergency number from the provisioned emergency number information, the user equipment selects either the circuit switched domain or the packet switched domain and executes a call setup procedure for that domain.

Abstract: An electronic device is provided. The device includes a processor configured to receive, from a first external device, a list of a first number of items generated based on a request of a user, and a first score of each of the first number of items, identify a first relevancy between each element of a first feature set and each of the first number of items and a second relevancy between each element of the set and the user, identify a first list of a second number of items, identify, for at least one item of the first list, a third relevancy between a first feature of the set which satisfies a condition and the at least one item and a fourth relevancy between the first feature and the user, based on the first relevancy and the second relevancy, and output the third relevancy and the fourth relevancy with the first list.

Abstract: Provided herein are methods of administering a KRAS G12C inhibitor to a cancer subject.

Abstract: An excavator (1) having a lifting device (2) for lifting a pallet comprising a chassis (3) having a boom (4) mounted thereon and a dipper arm (5) pivotally coupled to a distal end of said boom to which an implement, such as a bucket, may be attached, said lifting device comprising a mast (12) upon which is slideably mounted a carriage (20), a pair of spaced tines (21, 22) being provided on said carriage for supporting a pallet thereon, wherein said mast is mounted on said dipper arm of said excavator to be arranged in a vertical or substantially vertical operative orientation such that, in use, said carriage can be moved between lowered and raised positions on said mast when the mast is mounted on said boom, wherein at least one ground engaging load bearing member (28, 29) is provided at a lower end of said mast.

Abstract: A method at a network element, the method including receiving at least one message at the network element, the at least one message being one or both of: an update status information message from an updates server; and an anomaly detection status information message from anomaly detection server; determining, based on the receiving the at least one message, a dynamic cybersecurity posture indication for an intelligent transportation system entity; and providing the dynamic cybersecurity posture indication for the intelligent transportation system entity to an Enrolment Authority, wherein the dynamic cybersecurity posture indication can be included in a certificate relating to the intelligent transportation system entity.

Abstract: This document relates to materials and methods for treating cancer. For example, this document provides materials and methods for using PD-L1 targeting domains in bispecific chimeric polypeptides, chimeric transmembrane polypeptides, genetically modified viruses, nucleic acid vectors, and/or fusion-inducing cells to treat cancer.

Abstract: Devices that include a low sensitivity bulk acoustic wave (BAW) resonator sensor including a surface to which a low recognition component is immobilized, the low recognition component being configured to selectively bind the analyte, an analyte molecule to which a tag is linked, or a tag, or any one of these molecules to which an amplification element-linked second recognition component is bound; a high sensitivity BAW resonator sensor including a surface to which a high recognition component is immobilized, the high recognition component being configured to selectively bind the analyte, an analyte molecule to which a tag is linked, or a tag, or any one of these molecules to which an amplification element-linked second recognition component is bound; one or more containers housing an amplification molecule, the amplification element-linked second recognition component, and optionally one or both of the tag and the analyte molecule.