Abstract: A time-ordered series of measurements of a polymer made during translocation of the polymer through a Nanopore are analysed. The measurements are dependent on the identity of k-mers in the Nanopore, a k-mer bring k polymer units of the polymer, where k is a positive integer. The method involves deriving, from the series of measurements, a feature vector of time-ordered features representing characteristics of the measurements; and determining similarity between the derived feature vector and at least one other feature vector.

Abstract: There is disclosed system for oxygenating a patient in relation to anaesthesia using high flow gas delivery. The system has a flow source, and a controller for determining oxygenation requirements of the patient before or during anaesthesia. A method of oxygenating a patient in relation to anaesthesia using high flow gas delivery is also disclosed. The method determines oxygenation requirements of the patient before or during anaesthesia.

Abstract: A thermodynamic apparatus (10) comprising a compressor module (100), a turbine module (200), and a regenerative heat exchanger (300) centred on a central axis (12). The compressor module (100), turbine module (200) and regenerative heat exchanger (300) are arranged in series along the central axis (12) such that the regenerative heat exchanger (300) is provided between the compressor module (100) and the turbine module (200).

Abstract: Systems and methods can determine respiratory rates of a patient using a respiratory device by performing one or more frequency analyses of a signal from the gases flow. The signal from the gases flow can be one that varies with the patient's breathing. The system can include a non-sealed patient interface, such as a nasal cannula in a nasal high flow therapy, or any other patient interfaces. The respiratory system can also detect whether the patient has taken off the patient interface and/or whether the patient connected to the patient interface is talking or eating. Data of the patient's use of the respiratory system and the patient's respiratory rates can provide therapy compliance and long-term trend of use information and/or progress in the patient's respiratory functions and/or other physiological functions.

Abstract: A method of manufacturing a pressure vessel (10) comprising the steps of dividing a wall (104) of a section (100) of the pressure vessel (10) into a first segment (120) and a second segment (150), separating the first segment (120) from the second segment (150), fitting apparatus (400) onto the first segment (120), and then re-attaching the first segment (120) and the second segment (150).

Abstract: A method performed by a computing device includes generating a comparative query entigen group set based on a comparative query in accordance with identigen rules, where the comparative query entigen group set represents a most likely interpretation of the comparative query. The method further includes obtaining a first response entigen group from a knowledge database based on a first comparative query entigen group of the comparative query entigen group set, where the first response entigen group substantially includes the first comparative query entigen group. The method further includes obtaining a second response entigen group from the knowledge database based on a second comparative query entigen group of the comparative query entigen group set, where the second response entigen group substantially includes the second comparative query entigen group. The method further includes generating a comparative response based on the first response entigen group and the second response entigen group.

Abstract: This disclosure describes a distributed automated mobile vehicle (“automated mobile vehicle”) system for autonomously delivering orders of items to various delivery locations and/or autonomously returning items to a return location. In some implementations, each user may own or be assigned their own automated mobile vehicle that is associated with the user and an automated mobile vehicle control system maintained by the user. When the user orders an item, the user owned or controlled automated mobile vehicle navigates to a materials handling facility, retrieves the ordered item and delivers it to the user.

Abstract: The door sill includes a sill deck and a rail carrier assembly having a function of height adjustment. The rail carrier assembly is configured on the sill deck. The rail carrier assembly includes a rail cap, a rail carrier, an adjustment nut and an adjustment screw. The rail cap is snapped onto an upper end of the rail carrier. A groove is formed in the sill deck for the rail carrier to fit in. A nut installation hole is formed in the rail carrier. The adjustment nut is assembled at the nut installation hole, and is in threaded fit with the adjustment screw. The adjustment screw drives the adjustment nut to move up or down in an axial direction of the adjustment screw through rotation, thereby altering the height of the rail carrier fitted in the groove and altering the height of the rail cap.

Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A humidification system for delivering humidified gases to a user can include a heater base, humidification chamber having an inlet, outlet, and associated fluid conduit, and breathing circuit including a supply conduit, inspiratory conduit, and optional expiratory conduit. The humidification system can include various features to help make set-up less difficult and time-consuming. For example, the supply conduit, inspiratory conduit, and optional expiratory conduit can be coupled into a one-piece circuit to aid set-up. Various components can be color-coded and can have corresponding structures to indicate which components should be connected to one another during set-up. Such features can also help make the set-up process more intuitive for an operator, which can reduce the need for specialized training and reduce the number of potential errors.

Abstract: A system for heat treating a part includes an oven chamber, a first infrared (IR) emitter configured to deliver a first amount of IR energy to a first region of the part, a second IR emitter configured to deliver a second amount of IR energy different from the first amount of energy to a second region of the part, and a receiver with an outer surface configured to contact a second surface of the part and shield the second surface of the part from infrared radiation. The part can be heat treated by delivering different amounts of IR energy to the first and second regions of the part. The system can be used to heat treat different thicknesses of a part without overheating a thinner region, or to apply different heat treatments to the different regions.

Abstract: Examples of the disclosure include a method comprising receiving information-technology-device information indicative of IT equipment and including information-technology-device-location information and temperature information; determining, based on the information-technology-device information, an IT-equipment-cooling assessment; receiving cooling-unit information indicative of air output by the IT equipment to the cooling units and/or provided by the cooling units to the IT equipment; determining, based on the cooling-unit information, a cooling-airflow-return effectiveness indicative of how effectively the cooling units capture air output by the IT equipment and/or a cooling-airflow-supply effectiveness indicative of how effectively the cooling units provide air to the IT equipment; and displaying a simulation display depicting the IT equipment, an effectiveness indicator for the cooling-airflow-return effectiveness and/or the cooling-airflow-supply effectiveness, and a respective IT indicator for each IT-

Abstract: Surgical staplers and methods of their use are provided. In one embodiment, a surgical stapler includes a tubular shaft having a proximal end and a distal end, a handle extending from the proximal end of the tubular shaft, a head assembly extending from the distal end of the tubular shaft, and an insertion guide configured to extend through the head assembly. The insertion guide includes an expandable member configured to move between a collapsed configuration and an expanded configuration and a camera configured to be positioned at least partially within the expandable member.

Abstract: Described are methods and devices for modulating the brain activity of a person using stimulation pulses, where the pulse amplitude is variable and approximates a sine-wave. This results in a stimulation pulse that comprises energy at multiple frequencies.

Abstract: An aerosol delivery device is provided that includes a user interface including a pushbutton and a display. A control component contained coupled to the user interface controls operation of at least one functional element of the aerosol delivery device. The control component controls the display to present a menu including a plurality of menu items selectable using only the pushbutton. Each menu item of the plurality of menu items is associated with a respective functional element of the aerosol delivery device, and the control component is configured to navigate the plurality of menu items, and select a currently-presented menu item of the plurality of menu items for control of the respective functional element, in response to respective first and second types of presses of the pushbutton, the first and second types of presses being of different durations.

Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.

Abstract: A method for scoring and reporting electroencephalogram (EEG) data for use in transcranial magnetic stimulation (TMS) therapy. The method may include removing artifacts from the EEG data and determining EEG metrics from the EEG data. The method may further include determining a Brain Synchrony Index from the EEG metrics by applying a predetermined transfer function to the EEG metrics, and reporting the Brain Synchrony Index graphically.

Abstract: A shell extractor tool for removing a jammed ammunition shell from a firearm comprises a handle portion and a shaft portion. The shaft portion is adapted to be inserted through a firearm port and terminates at a proximal end and wherein the proximal end is angled relative to a remainder of the shaft portion to permit engagement of the jammed ammunition shell in a chamber of a firearm. The handle portion is adapted to be grasped by a user and to apply leverage to the jammed ammunition shell, to allow removal of the ammunition shell from the firearm with the shell extractor tool. The shell extractor tool may be provided with a sheath to provide a shell extractor tool kit. The sheath comprises a first structural portion and a second structural portion. The first structural portion and second structural portion are secured together to form a pocket to receive and reversibly secure the extractor tool. The sheath may optionally comprise a third structural portion.

Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.