Patents by Inventor Jan Bergstrom
Jan Bergstrom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11915308Abstract: A system and method are provided for transacting data on a network. The system includes a data submission interface, the data submission interface configured to enable one or more data generators to register data with the network, the data being stored in a location accessible to data consumers accessing the network. The system also includes a data consumer interface to enable one or more data consumers to find data on the network and transact with the one or more data generators to obtain access to and/or ownership of data submitted to the network. The system also includes a blockchain network for storing at least a ledger associated with data registered with the network via the data submission interface to provide an immutable assignment of ownership rights of the data to the respective one or more data generators, and to provide an immutable record of data transactions.Type: GrantFiled: May 10, 2019Date of Patent: February 27, 2024Assignee: Miovision Technologies IncorporatedInventors: Justin A. Eichel, Kurtis N. McBride, Jean-Pierre Bhavnani, Jan Bergstrom
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Patent number: 11439926Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.Type: GrantFiled: December 3, 2019Date of Patent: September 13, 2022Assignee: Cytiva BioProcess R&D ABInventors: Jan Bergstrom, Gunnar Glad, Bo-Lennart Johansson, Jean-Luc Maloisel, Nils Norrman, Tobias E. Soderman
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Publication number: 20220266170Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.Type: ApplicationFiled: May 10, 2022Publication date: August 25, 2022Inventors: Jan Bergstrom, Gunnar Glad, Bo-Lennart Johansson, Jean-Luc Maloisel, Nils Norrman, Tobias E. Soderman
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Publication number: 20210097602Abstract: A system and method are provided for transacting data on a network. The system includes a data submission interface, the data submission interface configured to enable one or more data generators to register data with the network, the data being stored in a location accessible to data consumers accessing the network. The system also includes a data consumer interface to enable one or more data consumers to find data on the network and transact with the one or more data generators to obtain access to and/or ownership of data submitted to the network. The system also includes a blockchain network for storing at least a ledger associated with data registered with the network via the data submission interface to provide an immutable assignment of ownership rights of the data to the respective one or more data generators, and to provide an immutable record of data transactions.Type: ApplicationFiled: May 10, 2019Publication date: April 1, 2021Applicant: Miovision Technologies IncorporatedInventors: Justin A. EICHEL, Kurtis N. MCBRIDE, Jean-Pierre BHAVNANI, Jan BERGSTROM
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Publication number: 20200101398Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.Type: ApplicationFiled: December 3, 2019Publication date: April 2, 2020Applicant: GE Healthcare BioProcess R&D ABInventors: JAN BERGSTROM, GUNNAR GLAD, BO-LENNART JOHANSSON, JEAN-LUC MALOISEL, NILS NORRMAN, TOBIAS E. SODERMAN
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Patent number: 10562007Abstract: The present invention relates to a separation matrix, which comprises a support; extenders coupled to an outer part of said support; and ligands coupled to said extenders, wherein the part of the support to which the extenders are coupled constitutes less than 50% of the volume of the separation matrix. The invention also embraces a method of preparing such a separation matrix, as well as a process wherein the separation media is used.Type: GrantFiled: July 22, 2008Date of Patent: February 18, 2020Assignee: GE Healthcare BioProcess R&D ABInventors: Andreas Axen, Jan Bergstrom, Gunnar Glad, Bo-Lennart Johansson, Nils Norrman
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Patent number: 10493380Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.Type: GrantFiled: June 15, 2016Date of Patent: December 3, 2019Assignee: GE Healthcare BioProcess R&D ABInventors: Jan Bergstrom, Gunnar Glad, Bo-Lennart Johansson, Jean-Luc Maloisel, Nils Norrman, Tobias E. Soderman
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Patent number: 9917442Abstract: A system for management of distributed control and real-time data for an electric utility network having remote devices and legacy subsystems includes a distributed communications network and a plurality of nodes coupled to the distributed communications network. Each of the nodes includes a multi-protocol interface having a boundary protocol convertor comprising a protocol validation engine to validate messages and commands from the remote devices and an in-field distributed data analyzer. The multi-protocol interface provides a standard data model for the remote devices.Type: GrantFiled: March 12, 2014Date of Patent: March 13, 2018Assignee: Prolucid Technologies Inc.Inventors: Graham Beauregard, Tarun Tuli, Robert Leigh, Jan Bergstrom
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Publication number: 20170050121Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.Type: ApplicationFiled: June 15, 2016Publication date: February 23, 2017Inventors: JAN BERGSTROM, GUNNAR GLAD, BO-LENNART JOHANSSON, JEAN-LUC MALOISEL, NILS NORRMAN, TOBIAS E. SODERMAN
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Patent number: 9278297Abstract: The present invention relates to a method for running ion exchange chromatography on a media comprising shell beads having an inner porous core and an outer shell, wherein the inner core is provided with ligands whose charge changes with pH and the shell is provided with charged ion exchange ligands, the method comprising the following steps: a) adsorbing sample molecules on the shell ligands at a first pH; b) causing a discharge of the inner core ligands at a second pH by addition of a buffer substance that is able to increase its charge having the same sign/type as that of the core ligands, which at the same time causes release of ions from the inner core ligands and thereby an increase in ionic strength that displaces the sample molecules from the shell ligands i.e. causes an elution.Type: GrantFiled: June 28, 2011Date of Patent: March 8, 2016Assignee: GE Healthcare Bio-Sciences ABInventors: Jan Bergstrom, Bo-Lennart Johansson
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Patent number: 9259729Abstract: The present invention relates to a method and means to produce chromatography media having improved pressure-flow properties. More closely, the invention relates to bimodal particle size distribution and the use of layer functionalization as means to change pressure-flow properties of chromatography media. The invention relates to a method for production of chromatography media having improved pressure-flow properties, comprising mixing large beads/particles, comprising an inner core and an outer functionalized shell/lid, with smaller beads/particles, wherein the ratio of the particle size of large and small beads: [D50V for large particles/D50V for small particles]>1.2, and wherein the volume ratio of large and small beads in the column: [Total volume of large beads/Total volume beads] is in the range 0.05-0.9.Type: GrantFiled: April 20, 2011Date of Patent: February 16, 2016Assignee: GE Healthcare Bio-Sciences ABInventors: Jan Bergstrom, Bo-Lennart Johansson
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Publication number: 20160043549Abstract: A system for management of distributed control and real-time data for an electric utility network having remote devices and legacy subsystems includes a distributed communications network and a plurality of nodes coupled to the distributed communications network. Each of the nodes includes a multi-protocol interface having a boundary protocol convertor comprising a protocol validation engine to validate messages and commands from the remote devices and an in-field distributed data analyzer. The multi-protocol interface provides a standard data model for the remote devices.Type: ApplicationFiled: March 12, 2014Publication date: February 11, 2016Inventors: Graham Beauregard, Tarun Tuli, Robert Leigh, Jan Bergstrom
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Patent number: 8574437Abstract: The present invention relates to a method of producing novel chromatography media and use thereof for purification of biomolecules, such as proteins. The chromatography media comprises shell beads having an inner porous core and an outer shell. The method comprises providing buffering ligands in the core of the beads, and providing binding ligands aimed for biomolecule binding in the outer shell of the beads. This method makes it possible to optimize binding properties and buffering properties independently of each other which is especially to advantageous for production of chromatofocusing media.Type: GrantFiled: February 16, 2011Date of Patent: November 5, 2013Assignee: GE Healthcare Bio-Sciences ABInventors: Jan Bergstrom, Bo-Lennart Johansson
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Publication number: 20130244229Abstract: The present invention relates to a buffering composition, more closely a composition comprising porous matrix-enclosed buffering agent(s) giving a stabilisation of pH when applied in for example aqueous environment. The composition comprises buffering agent(s) enclosed in a first porous matrix with an impenetrability corresponding to a fractionation range for globular proteins and peptides of <10000 g/mol, preferably <5000 g/mol, more preferably <700 g/mol.Type: ApplicationFiled: November 29, 2011Publication date: September 19, 2013Inventors: Jan Bergstrom, Bo-Lennart Johansson
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Publication number: 20130115709Abstract: The present invention relates to a method for running ion exchange chromatography on a media comprising shell beads having an inner porous core and an outer shell, wherein the inner core is provided with ligands whose charge changes with pH and the shell is provided with charged ion exchange ligands, the method comprising the following steps: a) adsorbing sample molecules on the shell ligands at a first pH; b) causing a discharge of the inner core ligands at a second pH by addition of a buffer substance that is able to increase its charge having the same sign/type as that of the core ligands, which at the same time causes release of ions from the inner core ligands and thereby an increase in ionic strength that displaces the sample molecules from the shell ligands i.e. causes an elution.Type: ApplicationFiled: June 28, 2011Publication date: May 9, 2013Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Jan Bergstrom, Bo-Lennart Johansson
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Publication number: 20130040809Abstract: The present invention relates to a method and means to produce chromatography media having improved pressure-flow properties. More closely, the invention relates to bimodal particle size distribution and the use of layer functionalisation as means to change pressure-flow properties of chromatography media. The invention relates to a method for production of chromatography media having improved pressure-flow properties, comprising mixing large beads/particles, comprising an inner core and an outer functionalized shell/lid, with smaller beads/particles, wherein the ratio of the particle size of large and small beads: [D50V for large particles/D50V for small particles]>1.2, and wherein the volume ratio of large and small beads in the column: [Total volume of large beds/Total volume beads] is in the range 0.05-0.9.Type: ApplicationFiled: April 20, 2011Publication date: February 14, 2013Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Jan Bergstrom, Bo-Lennart Johansson
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Publication number: 20120309618Abstract: The present invention relates to a method of producing novel chromatography media and use thereof for purification of biomolecules, such as proteins. The chromatography media comprises shell beads having an inner porous core and an outer shell. The method comprises providing buffering ligands in the core of the beads, and providing binding ligands aimed for biomolecule binding in the outer shell of the beads. This method makes it possible to optimize binding properties and buffering properties independently of each other which is especially to advantageous for production of chromatofocusing media.Type: ApplicationFiled: February 16, 2011Publication date: December 6, 2012Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Jan Bergstrom, Bo-Lennart Johansson
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Patent number: 8092682Abstract: The present invention relates to a separation matrix comprised of a support to the surfaces of which polymer chains have been coupled, wherein each polymer chain presents recurring proton-donating groups and at least the surface of the support is substantially hydrophilic. In the most advantageous embodiment, the support is porous cross-linked agarose, the polymers are poly(acrylic acid) and the proton-donating groups are carboxyl groups. The matrix is useful e.g. to remove PEG from pegylated and/or native compounds in a liquid. Accordingly, the invention also encompasses a method, such as a chromatographic method, wherein the separation matrix according to the invention is used, for example as a pre-treatment of a reaction mixture that comprises unreacted PEG, pegylated proteins and native proteins.Type: GrantFiled: July 21, 2009Date of Patent: January 10, 2012Assignee: GE Healthcare Bio-Sciences ABInventors: James Van Alstine, Jan Bergstrom, Henrik Ihre, Tobias Soderman
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Patent number: 8093373Abstract: The present invention relates to a method of isolating at least one plasmid from other components of a liquid, which method comprises the steps of providing a separation matrix comprised of one or more porous carriers, which carrier(s) present anion exchange groups on external surfaces as well as pore surfaces and a pore size distribution that does not allow access of plasmids to pore surfaces; contacting said matrix with the liquid to allow adsorption of the plasmids to ligands present on the separation matrix; contacting an eluent with the separation matrix to release the plasmids and recovering plasmids from a fraction of said eluent. Thus, the present method allows the plasmids to adsorb to the external surfaces of the matrix, while other components such as RNA is adsorbed onto the pore surfaces. In one embodiment, the matrix presents a DNA exclusion limit of at least about 270 base pairs; such as at least about 1,000 base pairs.Type: GrantFiled: February 21, 2005Date of Patent: January 10, 2012Assignee: GE Healthcare Bio-Sciences ABInventors: James Van Alstine, Jan Bergström, Dag Lindström, Joachim Stadler
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Patent number: 8070958Abstract: The present invention relates to a separation matrix comprised of ligands coupled to the surfaces of a porous support, such as one or more porous particles, wherein the ligands provide at least one chemical gradient within the support. In the most advantageous embodiment, the chemical gradient is a ligand density gradient. The invention also relates to a method of providing a separation matrix comprising ligands coupled to the surfaces of a porous support, in which method at least one ligand density gradient is provided by solvent-controlled diffusion of at least one reagent into the porous support.Type: GrantFiled: January 25, 2010Date of Patent: December 6, 2011Assignee: GE Healthcare Bio-Sciences ABInventors: Jan Bergstrom, Gunnar Glad, Bo-Lennart Johansson, Anders Ljunglof, Jean-Luc Maloisel