Patents by Inventor Jan Marik

Jan Marik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMAGING METHODS USING DEUTERATED COMPOUNDS
    Publication number: 20230218782
    Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
    Type: Application
    Filed: November 18, 2022
    Publication date: July 13, 2023
    Applicant: Genentech, Inc.
    Inventors: Jan MARIK, Joseph P. LYSSIKATOS, Simon Peter WILLIAMS
  • Deuterated compounds
    Patent number: 11504440
    Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: November 22, 2022
    Assignee: Genentech, Inc.
    Inventors: Jan Marik, Joseph P. Lyssikatos, Simon Williams
  • DEUTERATED COMPOUNDS AND USES THEREOF
    Publication number: 20200297875
    Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
    Type: Application
    Filed: June 8, 2020
    Publication date: September 24, 2020
    Applicant: Genentech, Inc.
    Inventors: Jan Marik, Joseph P. Lyssikatos, Simon Williams
  • Deuterated compounds and uses thereof
    Patent number: 10675367
    Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: June 9, 2020
    Assignee: Genentech Inc.
    Inventors: Jan Marik, Joseph P. Lyssikatos, Simon Williams
  • DEUTERATED COMPOUNDS AND USES THEREOF
    Publication number: 20190201561
    Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
    Type: Application
    Filed: July 31, 2018
    Publication date: July 4, 2019
    Applicant: Genentech, Inc.
    Inventors: Jan Marik, Joseph P. Lyssikatos, Simon Williams
  • Deuterated compounds and uses thereof
    Patent number: 10076581
    Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: September 18, 2018
    Assignee: Genentech, Inc.
    Inventors: Jan Marik, Joseph P. Lyssikatos, Simon Williams
  • IMMUNO-PET IMAGING OF ANTIBODIES AND IMMUNOCONJUGATES AND USES THEREFOR
    Publication number: 20170121424
    Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
    Type: Application
    Filed: October 10, 2016
    Publication date: May 4, 2017
    Applicant: Genentech, Inc.
    Inventors: Mark DENNIS, Jan MARIK, Paul POLAKIS, Bonnee RUBINFELD, Simon WILLIAMS
  • Methods and compositions for radiohalogen protein labeling
    Patent number: 9486546
    Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: November 8, 2016
    Assignee: GENENTECH, INC.
    Inventors: Charles Andrew Boswell, Leslie A. Khawli, Jan Marik, Simon Williams
  • DEUTERATED COMPOUNDS AND USES THEREOF
    Publication number: 20160250358
    Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
    Type: Application
    Filed: January 26, 2016
    Publication date: September 1, 2016
    Applicant: Genentech, Inc.
    Inventors: Jan Marik, Joseph P. Lyssikatos, Simon Williams
  • Methods and compositions for radiohalogen protein labeling
    Patent number: 9393327
    Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: July 19, 2016
    Assignee: GENENTECH, INC.
    Inventors: Charles Andrew Boswell, Leslie A Khawli, Jan Marik, Simon Williams
  • IMMUNO-PET IMAGING OF ANTIBODIES AND IMMUNOCONJUGATES AND USES THEREFOR
    Publication number: 20160168261
    Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
    Type: Application
    Filed: November 30, 2015
    Publication date: June 16, 2016
    Applicant: Genentech, Inc.
    Inventors: Mark DENNIS, Jan MARIK, Paul POLAKIS, Bonnee RUBINFELD, Simon WILLIAMS
  • METHODS AND COMPOSITIONS FOR RADIOHALOGEN PROTEIN LABELING
    Publication number: 20160002121
    Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.
    Type: Application
    Filed: July 31, 2015
    Publication date: January 7, 2016
    Applicant: GENENTECH, INC.
    Inventors: Charles Andrew Boswell, Leslie A. Khawli, Jan Marik, Simon Williams
  • Fluorine-18 and carbon-11 labeled radioligands for positron emission tomography (PET) imaging for LRRK2
    Patent number: 9139566
    Abstract: A method for positron emission tomography (PET) imaging of LRRK2 in tissue of a subject, the method comprising: administering a compound of formula I, formula II or formula III, or a pharmaceutically acceptable salt thereof to the subject, wherein the compound includes at least one C11 or F18 label thereon; allowing the compound to penetrate into the tissue of the subject; and collecting a PET image of the CNS or brain tissue of the subject.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: September 22, 2015
    Assignee: Genentech, Inc.
    Inventors: Jan Marik, Zachary Kevin Sweeney, Bryan K. Chan, Anthony Estrada
  • IMMUNO-PET IMAGING OF ANTIBODIES AND IMMUNOCONJUGATES AND USES THEREFOR
    Publication number: 20150056132
    Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
    Type: Application
    Filed: May 27, 2014
    Publication date: February 26, 2015
    Applicant: Genentech, Inc.
    Inventors: Mark DENNIS, Jan Marik, Paul Polakis, Bonnee Rubinfeld, Simon Williams
  • ZIRCONIUM-RADIOLABELED, CYSTEINE ENGINEERED ANTIBODY CONJUGATES
    Publication number: 20150017094
    Abstract: Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody fragments (ThioFab). Methods of design, preparation, screening, and selection of the cysteine engineered antibodies are provided. Cysteine engineered antibodies (Ab) are conjugated with one or more zirconium complex (Z) labels through a linker (L) to form cysteine engineered zirconium-labeled antibody conjugates having Formula I: Ab-(L-Z)p??I where p is 1 to 4. Imaging methods and diagnostic uses for zirconium-radiolabeled, cysteine engineered antibody conjugate compositions are disclosed.
    Type: Application
    Filed: June 10, 2014
    Publication date: January 15, 2015
    Inventors: Herman Gill, Jagath R. Junutula, Henry B. Lowman, Jan Marik, Jeff Tinianow, Simon Williams
  • Methods and compositions for protein labelling
    Patent number: 8865122
    Abstract: A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: October 21, 2014
    Assignee: Genentech, Inc.
    Inventors: Herman Gill, Jan Marik, Jeff Tinianow, Simon Williams
  • Immuno-PET imaging of antibodies and immunoconjugates and uses therefor
    Patent number: 8771966
    Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: July 8, 2014
    Assignee: Genentech, Inc.
    Inventors: Mark Dennis, Jan Marik, Paul Polakis, Bonnee Rubinfeld, Simon Williams
  • METHODS AND COMPOSITIONS FOR RADIOHALOGEN PROTEIN LABELING
    Publication number: 20140170064
    Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.
    Type: Application
    Filed: December 18, 2013
    Publication date: June 19, 2014
    Applicant: Genentech, Inc.
    Inventors: Charles Andrew Boswell, Leslie A. Khawli, Jan Marik, Simon Williams
  • Methods and compositions for protein labelling
    Patent number: 8435488
    Abstract: A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: May 7, 2013
    Assignee: Genentech, Inc.
    Inventors: Herman Gill, Jan Marik, Jeff Tinianow, Simon Williams
  • METHODS AND COMPOSITIONS FOR PROTEIN LABELLING
    Publication number: 20100221176
    Abstract: A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.
    Type: Application
    Filed: February 25, 2010
    Publication date: September 2, 2010
    Inventors: Herman Gill, Jan Marik, Jeff Tinianow, Simon Williams