Patents by Inventor Jan Marik

Jan Marik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ZIRCONIUM-RADIOLABELED, CYSTEINE ENGINEERED ANTIBODY CONJUGATES
    Publication number: 20100111856
    Abstract: Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody fragments (ThioFab). Methods of design, preparation, screening, and selection of the cysteine engineered antibodies are provided. Cysteine engineered antibodies (Ab) are conjugated with one or more zirconium complex (Z) labels through a linker (L) to form cysteine engineered zirconium-labeled antibody conjugates having Formula I: Ab-(L-Z)p??I where p is 1 to 4. Imaging methods and diagnostic uses for zirconium-radiolabeled, cysteine engineered antibody conjugate compositions are disclosed.
    Type: Application
    Filed: November 5, 2009
    Publication date: May 6, 2010
    Inventors: Herman Gill, Jagath R. Junutula, Henry B. Lowman, Jan Marik, Jeff Tinianow, Simon Williams
  • Preparation and application of encoded bead aggregates in combinatorial chemistry
    Publication number: 20040235053
    Abstract: The present invention relates to methods of preparing a library of compounds using encoded bead aggregates. The structural features of the compounds are encoded, and the quantities of compound prepared are sufficient for solution phase studies.
    Type: Application
    Filed: March 25, 2004
    Publication date: November 25, 2004
    Applicant: The Regents of the University of California
    Inventors: Kit S. Lam, Jan Marik