Patents by Inventor Jay West
Jay West has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230220377Abstract: Provided herein are compositions and methods for accurate and scalable Primary Template-Directed Amplification (PTA) nucleic acid amplification and sequencing methods, and their applications for mutational analysis in research, diagnostics, and treatment. Further provided herein are multiomics methods for parallel analysis of DNA, RNA, and/or proteins from single cells. Provided herein are methods of multiomic single-cell analysis comprising: (a) isolating a single cell from a population of cells; (b) sequencing a cDNA library comprising polynucleotides amplified from mRNA transcripts from the single cell; and (c) sequencing a genome of the single cell.Type: ApplicationFiled: July 30, 2020Publication date: July 13, 2023Inventors: Jay A.A. WEST, Charles GAWAD
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Publication number: 20230129100Abstract: Provided herein are compositions and methods for detecting nucleic acids. Further provided are methods using Primary Template-Directed Amplification (PTA) to detect trace nucleic acids. Such methods in some instances are applied to diagnostics, biotechnology and pharmaceutical manufacturing, and food safety.Type: ApplicationFiled: May 5, 2021Publication date: April 27, 2023Inventors: Charles GAWAD, Jay A.A. WEST, Siddhartha KADIA
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Publication number: 20230095295Abstract: Provided herein are compositions and methods using mutant Phi29 polymerases for nucleic acid amplification. Further provided herein are methods for accurate and scalable Primary Template-Directed Amplification (PTA) nucleic acid amplification and sequencing methods, and their applications for mutational analysis in research, diagnostics, and treatment using mutant Phi29 polymerases.Type: ApplicationFiled: February 9, 2021Publication date: March 30, 2023Inventors: Charles GAWAD, Jay A.A. WEST, Paul MCEWAN
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Patent number: 11511132Abstract: Systems and methods for tracking a target volume, e.g., tumor, in real-time during radiation treatment are provided. The system includes a memory to store a pre-acquired 3D image of the anatomy of interest in a first reference frame and a processor, operative coupled with the memory, to receive, from an ultrasound probe, a set-up ultrasound image of the anatomy of interest in a second reference frame. The processor further to establish a transformation between the first and second reference frames by registering the set-up ultrasound image with the pre-acquired 3D image and receive, from the ultrasound probe, an intrafraction ultrasound image of the anatomy of interest. The processor further to register the intrafraction ultrasound image with the set-up ultrasound image and track motion of the anatomy of interest based on the registered intrafraction ultrasound image.Type: GrantFiled: June 24, 2020Date of Patent: November 29, 2022Assignee: Accuray IncorporatedInventors: Calvin R. Maurer, Jay West, Petr Jordan
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Publication number: 20220277805Abstract: Provided herein are compositions and methods for accurate and scalable Primary Template-Directed Amplification (PTA) nucleic acid amplification and sequencing methods, and their applications for mutational analysis in research, diagnostics, and treatment. Such methods and compositions facilitate highly accurate amplification of target (or “template”) nucleic acids, which increases accuracy and sensitivity of downstream applications, such as Next-Generation Sequencing.Type: ApplicationFiled: July 30, 2020Publication date: September 1, 2022Inventors: Jay A.A. WEST, Charles GAWAD, Sivaraman NATARAJAN, Robert CARTER, Veronica GONZALES-PENA
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Publication number: 20200316403Abstract: Systems and methods for tracking a target volume, e.g., tumor, in real-time during radiation treatment are provided. The system includes a memory to store a pre-acquired 3D image of the anatomy of interest in a first reference frame and a processor, operative coupled with the memory, to receive, from an ultrasound probe, a set-up ultrasound image of the anatomy of interest in a second reference frame. The processor further to establish a transformation between the first and second reference frames by registering the set-up ultrasound image with the pre-acquired 3D image and receive, from the ultrasound probe, an intrafraction ultrasound image of the anatomy of interest. The processor further to register the intrafraction ultrasound image with the set-up ultrasound image and track motion of the anatomy of interest based on the registered intrafraction ultrasound image.Type: ApplicationFiled: June 24, 2020Publication date: October 8, 2020Inventors: Calvin R. Maurer, Jay West, Petr Jordan
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Patent number: 10702712Abstract: Systems and methods for tracking a target volume, e.g., tumor, in real-time during radiation treatment are provided. Under one aspect, a system includes an ultrasound probe, an x-ray imager, a processor, and a computer-readable medium that stores a 3D image of the tumor in a first reference frame and instructions for causing the processor to: instruct the x-ray imager and ultrasound probe to substantially simultaneously obtain inherently registered x-ray and set-up ultrasound images of the tumor in a second reference frame; establish a transformation between the first and second reference frames by registering the 3D image and the x-ray image; instruct the ultrasound probe to obtain an intrafraction ultrasound image of the tumor; registering the intrafraction ultrasound image with the set-up ultrasound image; and track target volume motion based on the registered intrafraction ultrasound image.Type: GrantFiled: July 15, 2015Date of Patent: July 7, 2020Assignee: ACCURAY INCORPORATEDInventors: Calvin R. Maurer, Jay West, Petr Jordan
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Patent number: 10603512Abstract: Systems and methods for tracking a target volume, e.g., tumor, during radiation treatment are provided. Under one aspect, a system includes an ultrasound probe, an x-ray imager, a processor, and a computer-readable medium that stores a 3D image of the tumor in a first reference frame and instructions to cause the processor to: instruct the x-ray imager and ultrasound probe to substantially simultaneously obtain inherently registered x-ray and set-up ultrasound images of the tumor in a second reference frame; establish a transformation between the first and second reference frames by registering the 3D image and the x-ray image; instruct the ultrasound probe to obtain an intrafraction ultrasound image of the tumor; registering the intrafraction ultrasound image with the set-up ultrasound image; and track target volume motion based on the registered intrafraction ultrasound image.Type: GrantFiled: July 13, 2015Date of Patent: March 31, 2020Assignee: ACCURAY INCORPORATEDInventors: Calvin R. Maurer, Jay West, Petr Jordan
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Publication number: 20150314138Abstract: Systems and methods for tracking a target volume, e.g., tumor, in real-time during radiation treatment are provided. Under one aspect, a system includes an ultrasound probe, an x-ray imager, a processor, and a computer-readable medium that stores a 3D image of the tumor in a first reference frame and instructions for causing the processor to: instruct the x-ray imager and ultrasound probe to substantially simultaneously obtain inherently registered x-ray and set-up ultrasound images of the tumor in a second reference frame; establish a transformation between the first and second reference frames by registering the 3D image and the x-ray image; instruct the ultrasound probe to obtain an intrafraction ultrasound image of the tumor; registering the intrafraction ultrasound image with the set-up ultrasound image; and track target volume motion based on the registered intrafraction ultrasound image.Type: ApplicationFiled: July 15, 2015Publication date: November 5, 2015Inventors: Calvin R. Maurer, Jay West, Petr Jordan
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Publication number: 20150314137Abstract: Systems and methods for tracking a target volume, e.g., tumor, during radiation treatment are provided. Under one aspect, a system includes an ultrasound probe, an x-ray imager, a processor, and a computer-readable medium that stores a 3D image of the tumor in a first reference frame and instructions to cause the processor to: instruct the x-ray imager and ultrasound probe to substantially simultaneously obtain inherently registered x-ray and set-up ultrasound images of the tumor in a second reference frame; establish a transformation between the first and second reference frames by registering the 3D image and the x-ray image; instruct the ultrasound probe to obtain an intrafraction ultrasound image of the tumor; registering the intrafraction ultrasound image with the set-up ultrasound image; and track target volume motion based on the registered intrafraction ultrasound image.Type: ApplicationFiled: July 13, 2015Publication date: November 5, 2015Inventors: Calvin R. Maurer, Jay West, Petr Jordan
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Systems and methods for real-time tumor tracking during radiation treatment using ultrasound imaging
Patent number: 9108048Abstract: Systems and methods for tracking a target volume, e.g., tumor, in real-time during radiation treatment are provided. Under one aspect, a system includes an ultrasound probe, an x-ray imager, a processor, and a computer-readable medium that stores a 3D image of the tumor in a first reference frame and instructions for causing the processor to: instruct the x-ray imager and ultrasound probe to substantially simultaneously obtain inherently registered x-ray and set-up ultrasound images of the tumor in a second reference frame; establish a transformation between the first and second reference frames by registering the 3D image and the x-ray image; instruct the ultrasound probe to obtain an intrafraction ultrasound image of the tumor; registering the intrafraction ultrasound image with the set-up ultrasound image; and track target volume motion based on the registered intrafraction ultrasound image.Type: GrantFiled: August 5, 2011Date of Patent: August 18, 2015Assignee: Accuray IncorporatedInventors: Calvin R. Maurer, Jr., Jay West, Petr Jordan -
Publication number: 20140151297Abstract: In a reverse osmosis fluid purification system, an input fluid is received at an input of the purification system, and a fluid purification run cycle is performed on the input fluid. The fluid purification cycle includes pumping the input fluid through a membrane with a pump at a first pressure and first flow rate to generate product fluid and waste fluid. The product fluid is provided to an external system and the waste fluid is provided to a drain port. The membrane is then rinsed after performing the fluid purification run cycle by providing the input fluid to the pump and pumping the input fluid through the membrane at a second pressure less than the first pressure and a second flow rate greater than the first flow rate for a predetermined period of time.Type: ApplicationFiled: November 27, 2013Publication date: June 5, 2014Inventors: Clinton William Hulme, Sean Jay West, Kelly Dean Ross
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Systems and Methods for Real-Time Tumor Tracking During Radiation Treatment Using Ultrasound Imaging
Publication number: 20120035462Abstract: Systems and methods for tracking a target volume, e.g., tumor, in real-time during radiation treatment are provided. Under one aspect, a system includes an ultrasound probe, an x-ray imager, a processor, and a computer-readable medium that stores a 3D image of the tumor in a first reference frame and instructions for causing the processor to: instruct the x-ray imager and ultrasound probe to substantially simultaneously obtain inherently registered x-ray and set-up ultrasound images of the tumor in a second reference frame; establish a transformation between the first and second reference frames by registering the 3D image and the x-ray image; instruct the ultrasound probe to obtain an intrafraction ultrasound image of the tumor; registering the intrafraction ultrasound image with the set-up ultrasound image; and track target volume motion based on the registered intrafraction ultrasound image.Type: ApplicationFiled: August 5, 2011Publication date: February 9, 2012Inventors: Calvin R. Maurer, JR., Jay West, Petr Jordan -
Patent number: 7953204Abstract: Method and systems are disclosed for radiating a moving target inside a heart. The method includes acquiring sequential volumetric representations of an area of the heart and defining a target tissue region and/or a radiation sensitive structure region in 3D for a first of the representations. The target tissue region and/or radiation sensitive structure region are identified for another of the representations by an analysis of the area of the heart from the first representation and the other representation. Radiation beams to the target tissue region are fired in response to the identified target tissue region and/or radiation sensitive structure region from the other representation.Type: GrantFiled: March 16, 2009Date of Patent: May 31, 2011Assignees: Cyberheart, Inc., Accuray IncorporatedInventors: Thilaka Sumanaweera, Patrick Maguire, Ed Gardner, Jay West
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Publication number: 20090257557Abstract: Method and systems are disclosed for radiating a moving target inside a heart. The method includes acquiring sequential volumetric representations of an area of the heart and defining a target tissue region and/or a radiation sensitive structure region in 3D for a first of the representations. The target tissue region and/or radiation sensitive structure region are identified for another of the representations by an analysis of the area of the heart from the first representation and the other representation. Radiation beams to the target tissue region are fired in response to the identified target tissue region and/or radiation sensitive structure region from the other representation.Type: ApplicationFiled: March 16, 2009Publication date: October 15, 2009Applicants: CyberHeart, Inc., Accuray IncorporatedInventors: Thilaka Sumanaweera, Patrick Maguire, Ed Gardner, Jay West
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Patent number: 7524672Abstract: Disclosed are systems that include a manifold in fluid communication with a microfluidic chip having a microarray, an illuminator, and a detector in optical communication with the microarray. Methods for using these systems for biological detection are also disclosed.Type: GrantFiled: September 22, 2004Date of Patent: April 28, 2009Assignee: Sandia CorporationInventors: Jay A. A. West, Kyle W. Hukari, Gary A. Hux
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Publication number: 20080264842Abstract: Disclosed herein are micropurification cards, systems, systems and methods, backspace. A micropurification cards include a plurality of fluidic components capable of extracting molecules from samples. Samples include biological cells and the extracted molecules include nucleic acids.Type: ApplicationFiled: October 11, 2007Publication date: October 30, 2008Applicant: Arcxis Biotechnologies, LLCInventors: Kyle W. Hukari, Matthew J. Bartosiewicz, Seth R. Stern, Michael C. DeRenzi, Fabien M. Van De Graaf, Jesse B. Thompson, Jay A.A. West
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Publication number: 20080011945Abstract: Systems and methods for automatically determining a beam parameter at each of a plurality of treatment nodes are disclosed. The beam parameter may include a beam shape, beam size and/or beam orientation. Systems and methods for automatically selecting multiple collimators in a radiation treatment system are also disclosed.Type: ApplicationFiled: March 30, 2007Publication date: January 17, 2008Inventors: Calvin Maurer, Jay West, John Allison
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Publication number: 20080013687Abstract: Systems and methods for automatically determining a beam parameter at each of a plurality of treatment nodes are disclosed. The beam parameter may include a beam shape, beam size and/or beam orientation. Systems and methods for automatically selecting multiple collimators in a radiation treatment system are also disclosed.Type: ApplicationFiled: March 30, 2007Publication date: January 17, 2008Inventors: Calvin Maurer, Jay West, John Allison
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Patent number: D1016945Type: GrantFiled: June 7, 2021Date of Patent: March 5, 2024Assignee: Dakine IP Holdings LPInventors: Zachary West, John Martin, Brian Fletcher, Mirona Motoc, Jay Willet, Aaron Ambuske