Abstract: The present invention in general relates to an intravaginal delivery system as well as uses thereof and methods for manufacturing and use of the same. In particular the present invention relates to an intravaginal delivery system for the controlled release of one or more organic acids, such as lactic acid; said intravaginal delivery system being characterized in that it comprises a combination of ethylene vinyl acetate (EVA) copolymers and carboxylic polymers, such as for example methacrylic acid-methacrylic ester copolymers.

Abstract: The present invention discloses a composition comprising a polyelectrolyte complex and a polyol, characterised in that said polyol is in amorphous form. Optionally, the composition further comprises one or more drugs, wherein each drug has a molecular weight of at least 1000 Dalton. Said compositions are obtainable by spray-drying. The compositions may be prepared in particle form and as a suspension of particles. Pharmaceutical compositions are also provided for use in extracellular drug delivery. Pharmaceutical compositions are also provided that exhibit a controlled dual drug release.

Abstract: A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from above about 20% to 50% by weight of the composition, said pharmaceutical or veterinary granule composition providing a drug release of at least 70% within 10 minutes in water, (ii) a first excipient being a maltodextrin representing from 40% by weight to 85% by weight of said composition, (iii) a wetting amount of a second excipient being a polyethylene glycol having a weight number molecular weight between 300 and 5,000, said second excipient comprising a solid fraction and a liquid fraction, and representing from 15% to 40% by weight of said composition, and optionally one or more pharma-ceutically acceptable fillers selected from the group consisting of hydrocolloids, glidants, lubricants, surfactants and diluents, wherein the weight ratio of said first excipien

Abstract: A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from 0.

Abstract: This patent pertains to the use of debranched starch in the preparation of pharmaceutical pellets by extrusion spheronization. Such excipients are useful in any dry dosage form, including tablets and capsules, for either immediate or sustained release.

Abstract: Vaginal use compositions comprising pellets prepared from a debranched starch. Pellets may be conveniently prepared via extrusion/spheronization.

Abstract: An apparatus for wet granulating a powder material comprises:—a barrel having a granulation chamber and being provided with a first inlet (1) for receiving said powder material and for supplying it to said granulation chamber and with a second inlet (2) for receiving a granulating liquid and for supplying it to said granulation chamber, said granulation having an aperture (9) for discharge of granules from said barrel, and—a transporting means (S) for advancing said powder material toward the end of said granulation chamber while granulating it with the aid of said granulating liquid, said transporting means (S) comprising a first transport zone (4) at its rear end, an agglomeration zone (5) downstream from the first transport zone (4) and a second transport zone (8) at its front end, said first inlet (1) and said second inlet (2) being positioned above the first transport zone (4), wherein said aperture (9) has a shape tightly fitting the terminal portion of the transporting means (S) for directly dischargin

Abstract: Aqueous gel-free two-phase coacervate compositions including a coacervate phase and an equilibrium water phase, comprising a mixture of: (a) a poorly water-soluble bio-active agent, (b) a tensio-active system consisting of non-ionic tensio-active agents, (c) one or more water-soluble carriers for said poorly water-soluble bio-active agent, said carriers being selected from the group consisting of maltodextrins and polyols, and (d) water. Such coacervate compositions may be dried into solid dosage forms from which rapid release of the bio-active agent can be obtained.

Abstract: This invention provides a dry powder composition for poultry vaccination via inhalation comprising an effective amount of a poultry vaccine agent, and a supporting amount of carriers for said poultry vaccine agent, said carriers comprising a combination of a reducing or non-reducing sugar and a biocompatible polymer, said dry powder composition being in the form of particles having an average particle size from 2 to 30 ?m and a particle size polydispersity from 1.1 to 4.0. This invention also relates to a method for producing said dry powder compositions and a system for vaccination of poultry by inhalation.

Abstract: An apparatus for wet granulating a powder material comprises:—a barrel having a granulation chamber and being provided with a first inlet (1) for receiving said powder material and for supplying it to said granulation chamber and with a second inlet (2) for receiving a granulating liquid and for supplying it to said granulation chamber, said granulation having an aperture (9) for discharge of granules from said barrel, and—a transporting means (S) for advancing said powder material toward the end of said granulation chamber while granulating it with the aid of said granulating liquid, said transporting means (S) comprising a first transport zone (4) at its rear end, an agglomeration zone (5) downstream from the first transport zone (4) and a second transport zone (8) at its front end, said first inlet (1) and said second inlet (2) being positioned above the first transport zone (4), wherein said aperture (9) has a shape tightly fitting the terminal portion of the transporting means (S) for directly dischargin

Abstract: An apparatus for wet granulating a powder material comprises: —a barrel having a granulation chamber and being provided with a first inlet (1) for receiving said powder material and for supplying it to said granulation chamber and with a second inlet (2) for receiving a granulating liquid and for supplying it to said granulation chamber, said granulation having an aperture (9) for discharge of granules from said barrel, and —a transporting means (S) for advancing said powder material toward the end of said granulation chamber while granulating it with the aid of said granulating liquid, said transporting means (S) comprising a first transport zone (4) at its rear end, an agglomeration zone (5) downstream from the first transport zone (4) and a second transport zone (8) at its front end, said first inlet (1) and said second inlet (2) being positioned above the first transport zone (4), wherein said aperture (9) has a shape tightly fitting the terminal portion of the transporting means (S) for directly discharg

Abstract: A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from above about 20% to 50% by weight of the composition, said pharmaceutical or veterinary granule composition providing a drug release of at least 70% within 10 minutes in water, (ii) a first excipient being a maltodextrin representing from 40% by weight to 85% by weight of said composition, (iii) a wetting amount of a second excipient being a polyethylene glycol having a weight number molecular weight between 300 and 5,000, said second excipient comprising a solid fraction and a liquid fraction, and representing from 15% to 40% by weight of said composition, and optionally one or more pharma-ceutically acceptable fillers selected from the group consisting of hydrocolloids, glidants, lubricants, surfactants and diluents, wherein the weight ratio of said first excipien

Abstract: A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from 0.

Abstract: The invention provides bioadhesive composition having increased bioadhesive properties, decreased irritation, and the capacity for higher drug loading. The compositions of the invention comprise intimate mixtures of a polysaccharide and a polycarboxylated polymer, and optionally also an absorption enhancer.

Abstract: Vaginal use compositions comprising pellets prepared from a debranched starch. Pellets may be conveniently prepared via extrusion/spheronization.

Abstract: This invention provides a process for preparing a solid dosage form, comprising:—preparing an aqueous slurry, solution or suspension of (a) a powder material, and (b) a mixture of one or more polyols and one or more maltodextrins, and—spray drying the resultant aqueous slurry, solution or suspension, thereby obtaining particles which are directly compressible into a solid dosage form being able to disintegrate in an aqueous medium within no more than 15 minutes.

Abstract: The present invention provides a combination of: a N-containing drug molecule salt, wherein said drug molecule is selected from the group consisting of quinine and quinidine, and an aromatic mono- or dicarboxylic acid salt, e.g. quinine pamoate, which is useful for a pharmaceutical formulation such as a pediatric suspension, especially in the treatment of malaria.

Abstract: This invention provides a dry powder composition for poultry vaccination via inhalation comprising an effective amount of a poultry vaccine agent, and a supporting amount of carriers for said poultry vaccine agent, said carriers comprising a combination of a reducing or non-reducing sugar and a biocompatible polymer, said dry powder composition being in the form of particles having an average particle size from 2 to 30 ?m and a particle size polydispersity from 1.1 to 4.0. This invention also relates to a method for producing said dry powder compositions and a system for vaccination of poultry by inhalation.

Abstract: The present invention relates to a pharmaceutical composition comprising a non-viable cell lysate and at least one antiflocculant and/or antisedimentation agent(s). The pharmaceutical composition of the present invention comprising the cell lysate is in the form of a solution or a suspension or a lyophilisate, in particular, the homogenized cell lysate compositions are in the form of solutions or suspensions or lyophilisates. The present invention further discloses processes for the production and the use of the pharmaceutical composition.

Abstract: The present invention relates to a pharmaceutical composition comprising a non-viable cell lysate and at least one antiflocculant and/or antisedimentation agent(s). The pharmaceutical composition of the present invention comprising the cell lysate is in the form of a solution or a suspension or a lyophilisate, in particular, the homogenized cell lysate compositions are in the form of solutions or suspensions or lyophilisates. The present invention further discloses processes for the production and the use of the pharmaceutical composition.