Abstract: Systems and methods for providing quantitative measurements of global glymphatic flow of cerebrospinal fluid (“CSF”) using magnetic resonance imaging (“MRI”) are described. In general, images are obtained from a subject using flow-sensitive MRI techniques that are designed to be particularly sensitive to the glymphatic flow of CSF. Measures of glymphatic flow can be obtained while the subject is in an awake state and again while the subject is in a sleep state. Based on these two measurements, a biomarker that indicates a neurological state or disease can be generated.

Abstract: Realtime magnetic resonance imaging (MRI) uses cardiac and respiratory monitoring tools to avoid or minimize motion-induced image artifacts. A series of initial MR images are associated with the physiological data from the cardiac, respiratory, or other monitoring tools. The tools provide physiological data in conjunction with anatomic or spatial information such that the optimal gating times (i.e., for acquiring MR image data) in the cardiac and respiratory cycles can be identified and the optimal acquisition durations are identified relative to the physiological data. The process then uses MRI with the identified optimal gating times and acquisition durations to produce a high quality output image of the anatomy of interest. The high quality image can be one or more of the following: a two-dimensional (2D) with a higher signal-to-noise ratio (i.e.

Abstract: Realtime magnetic resonance imaging (MRI) uses cardiac and respiratory monitoring tools to avoid or minimize motion-induced image artifacts. A series of initial MR images are associated with the physiological data from the cardiac, respiratory, or other monitoring tools. The tools provide physiological data in conjunction with anatomic or spatial information such that the optimal gating times (i.e., for acquiring MR image data) in the cardiac and respiratory cycles can be identified and the optimal acquisition durations are identified relative to the physiological data. The process then uses MRI with the identified optimal gating times and acquisition durations to produce a high quality output image of the anatomy of interest. The high quality image can be one or more of the following: a two-dimensional (2D) with a higher signal-to-noise ratio (i.e.