Abstract: A single-tier blockchain-based system and method for document transformation and accountability is provided. Transaction documents including document templates relating to a transfer of real property are maintained. Each template includes form elements. The form elements are each associated with a data field identifier and a data value. A data model is maintained for the transaction documents and includes the data field identifiers and the data values for the form elements. A request is received for the transaction documents. The form elements of the transaction documents are automatically populated with the data values via the data model in response to the request. Compliance checking is performed on the data values populating the form elements. A cryptographic hash of the transaction documents is committed to a blockchain copy stored by one or more network nodes in a single-tier when no errors are identified in the data values during the compliance checking.

Abstract: The present disclosure provides bifunctional compounds of Formula (I), and pharmaceutically acceptable salts, isotopic forms, isolated stereoisomers, or mixtures of stereoisomers thereof, as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.

Abstract: A frequency multiplier circuit includes a first multiplier circuit to generate a first digital value representing a received reference signal having a reference frequency and reference phase, the multiplier circuit to multiply the first digital value by a multiplier value. Comparison circuitry compares the first digital value to an output digital value representing an output signal having an output frequency and an output phase, the comparison circuitry to generate an error signal based on the comparison. A programmable loop filter generates a control signal based at least in part on the error signal. A frequency generation circuit produces the output signal having the output frequency and phase. A phase-to-digital converter generates and feeds the output digital value to the phase comparison circuitry. A programmable transition controller controls a transitioning frequency relationship between a first signal frequency of a first locked output signal and a desired second signal frequency.

Abstract: A system and method for document transformation is provided. An address is received. A document set is generated based on the address. Each document includes data fields and an identifier for each data field. A transaction number is assigned to the document set. Data values are received for population of the data fields in one of the documents. The data values and the identifier for the data field in which each data value is populated is stored with the transaction number. The remaining documents are populated. One of the identifiers is identified for one of the data fields in one of the remaining documents. One of the data fields is determined in one of the remaining documents. The data value associated with the data field is identified based on the identifier and the transaction number. The data fields in the remaining documents are populated with the determined data value.

Abstract: A system and method for document transformation and recordation is provided. Documents for a transaction of real property are identified based on a jurisdiction in which the real property is located. Each document includes a plurality of data fields and each data field is associated with a data field identifier. A data value is received in at least one of the data fields of one or more of the documents. The data fields in the documents associated with the data field identifiers that match the data field identifiers of the data fields in which the data values are received are identified. The identified data fields are automatically populated with the data values based on the data field identifiers associated with the data values. A completeness rule is applied to the documents by verifying whether all required documents for completing the transaction in the jurisdiction are satisfied by the documents.

Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: Waterborne dispersions including crosslinkable multistage polymeric particles useful in coating compositions are provided. The multistage particles have a last-formed layer that includes a diketone functionality that is capable of crosslinking via a dihydrazide component also included in the dispersion. Another embodiment of the waterborne dispersion further includes crosslinkable latex particles having a diketone functionality that are capable of crosslinking with each other and/or the multistage particles via the dihydrazide component. An emulsion polymerization process for forming the multistage particles also is provided. Also provided are coating compositions that contain either embodiment of the waterborne dispersions.

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

Abstract: A method of generating customizable goal representation is disclosed. A request from a user to view a goal representation is received. A flexible goal ontology is accessed that comprises one or more goal entities, one or more goal relationships between the goal entities, or one or more goal properties, the one or more goal properties including one or more metadata attributes relating to the one or more goal entities. A set of mapping rules is obtained that defines mappings between one or more goals. The set of mapping rules is evaluated to assemble a customized goal representation tailored to the user. The customized goal representation is updated based on a revaluation of the mapping rules affected by changes to the one or more goal entities, the one or more goal relationships, or the one or more properties.

Abstract: Systems and methods for document transformation and recordation are provided. Documents for a transaction of real property are identified based on a jurisdiction in which the real property is located. Each document includes a plurality of data fields and each data field is associated with a data field identifier. A data value is received in at least one of the data fields of one or more of the documents. The data fields in the documents associated with the data field identifiers that match the data field identifiers of the data fields in which the data values are received are identified. The identified data fields are automatically populated with the data values based on the data field identifiers. Completeness rules are applied to the documents by verifying all required documents for completing the transaction in the jurisdiction are satisfied. Documents or information pertaining the documents can be stored in a blockchain.

Abstract: The present invention discloses a quantum-dot film, wherein the quantum-dot film comprises a binder and a plurality of quantum dots dispersed in the binder, wherein the plurality of quantum dots are capable of being water-resistant and oxygen-resistant.

Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: Disclosed are morpholino oligonucleotides that can be used to silence expression of MGMT, pharmaceutical compositions that include said morpholino oligonucleotides, and methods of using said morpholino oligonucleotides in the treatment of cancer, particularly methods that involve the use of radiation to deliver said morpholino oligonucleotides.

Abstract: The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.

Abstract: The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.

Abstract: The present invention discloses a quantum-dot composite film comprising: a quantum-dot prism film, comprising a quantum-dot layer and a first plurality of prisms disposed over the quantum-dot layer, wherein a first optical prism film and a second optical prism film are disposed over the quantum-dot prism film for increasing the brightness level of the quantum-dot prism film.

Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: A composite quantum-dot optical film comprises a quantum-dot layer and a composite structure disposed on the quantum-dot layer, wherein the composite structure comprises a first substrate, a second substrate, and a first barrier layer, wherein each of the first substrate and the second substrate comprises a polymer material, wherein the barrier layer being made of organic material and capable of being water-resistant is disposed between the first substrate and the second substrate.

Abstract: The present application discloses a bending-resistant polyester film and its production method thereof. The chemical structure of the bending-resistant polyester composition comprises monomers having elastic conformation. The film made from the composition of polyester of the present invention through production processes such as melt extrusion and biaxial drawing still has excellent flexibility and optical properties.