Abstract: Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R4, X3, X4, X5, X6, X7 and Ring A are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

Abstract: The discovery of distinct modes of asymmetric catalysis has the potential to rapidly advance chemists' ability to build enantioenriched molecules. As an example, the use of chiral cation salts as phase-transfer catalysts for anionic reagents has enabled a vast set of enantioselective transformations. A largely overlooked analogous mechanism wherein a chiral anionic catalyst brings a cationic species into solution is itself a powerful method. The concept is broadly applicable to a number of different reaction pathways, including to the enantioselective fluorocyclization of olefins, and dearomatization of aromatic systems with a cationic electrophile-transferring (e.g., fluorinating) agent and a chiral phosphate catalyst. The reactions proceed in high yield and stereoselectivity. The compounds and methods of the invention are of particular value, especially considering the scarcity of alternative approaches.

Abstract: Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Z2, Z3, and Z5 are as described herein, compositions thereof, and uses thereof.

Abstract: Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.

Abstract: A load indicator for use with a fall protection apparatus having a line and a connector for connecting to a user includes a housing having a pass-through opening and a covered indicator region. At least a portion of the housing is configured for connecting to the line. The load indicator also includes a shear pin supported by the housing and extending across the pass-through opening, and a saddle extending across at least a portion of the pass-through opening and supported by at least a portion of the shear pin. The saddle is configured for connecting to at least a portion of the connector. The saddle is movable relative to the housing between a first position and a second position when a force exceeding a predetermined threshold value is applied on the saddle causing the shear pin to shear or break. At least a portion of the indicator region is uncovered in the second position of the saddle when the shear pin shears or breaks.

Abstract: Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.

Abstract: A scheduling system and method for data cleansing may be used to optimize clinical scheduling. The present disclosure describes receiving clinical record data, in an agnostic manner, from a system including a source scheduling database containing the clinical record data; mapping the clinical record data to a desired format; conforming the clinical record data to standardized scheduling elements of the scheduling system; cleansing, in a manner configurable by a user, the clinical record data to purge portions of the clinical record data; providing the clinical record data to an optimization engine for optimization of the clinical record data; optimizing the clinical record data by applying configurable logic to the clinical record data; and uploading one or more newly defined optimized scheduling templates via an outbound connection back to the scheduling system.

Abstract: A bracket for attaching a lifting/lowering device to a support member of a safety structure, the bracket including: a body configured to at least partially contact or envelop a support member of a safety structure, wherein at least one surface of the body has at least one cut-out that includes at least one shaped end for contacting a support member pin inserted into the support member of the safety structure, and wherein the body includes at least one surface for mounting or securing the bracket to a lifting/lowering device. A bracket and lifting/lowering device assembly and method of installation are also disclosed.

Abstract: A scheduling system and method for data cleansing may be used to optimize clinical scheduling. The present disclosure describes receiving clinical record data, in an agnostic manner, from a system including a source scheduling database containing the clinical record data; mapping the clinical record data to a desired format; conforming the clinical record data to standardized scheduling elements of the scheduling system; cleansing, in a manner configurable by a user, the clinical record data to purge portions of the clinical record data; providing the clinical record data to an optimization engine for optimization of the clinical record data; optimizing the clinical record data by applying configurable logic to the clinical record data; and uploading one or more newly defined optimized scheduling templates via an outbound connection back to the scheduling system.

Abstract: Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Z2, Z3, and Z5 are as described herein, compositions thereof, and uses thereof.

Abstract: A personal fall limiter arrangement having a user connection arrangement, including: a body attached to at least a portion of the frame and having a recess configured to receive at least a portion of a user connector; at least one tab pivotally attached to a first portion of the body; and at least one biasing member engaged with the at least one tab and configured to urge the at least one tab towards a locked (or closed) position; wherein, in operation, the at least one tab is pivotal between: (1) an open position to permit passage of at least a portion of the user connector into or out of the recess; and (2) the locked position to prevent passage of at least a portion of the user connector out of the recess.

Abstract: A bracket for attaching a lifting/lowering device to a support member of a safety structure, the bracket including: a body configured to at least partially contact or envelop a support member of a safety structure, wherein at least one surface of the body has at least one cut-out that includes at least one shaped end for contacting a support member pin inserted into the support member of the safety structure, and wherein the body includes at least one surface for mounting or securing the bracket to a lifting/lowering device. A bracket and lifting/lowering device assembly and method of installation are also disclosed.

Abstract: Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.

Abstract: The discovery of distinct modes of asymmetric catalysis has the potential to rapidly advance chemists' ability to build enantioenriched molecules. As an example, the use of chiral cation salts as phase-transfer catalysts for anionic reagents has enabled a vast set of enantioselective transformations. A largely overlooked analogous mechanism wherein a chiral anionic catalyst brings a cationic species into solution is itself a powerful method. The concept is broadly applicable to a number of different reaction pathways, including to the enantioselective fluorocyclization of olefins, and dearomatization of aromatic systems with a cationic electrophile-transferring (e.g., fluorinating) agent and a chiral phosphate catalyst. The reactions proceed in high yield and stereoselectivity. The compounds and methods of the invention are of particular value, especially considering the scarcity of alternative approaches.

Abstract: The present invention features a method of treating pores on the skin by applying to skin in need of such treatment a device including a housing having a skin contacting surface, a first conductive electrode, a second conductive electrode, and a carrier; wherein the first conductive electrode is in electric communication with the second conductive electrode, wherein the first conductive electrode is in ionic communication with the carrier, wherein the carrier is in communication with the skin contacting surface, and wherein the skin contacting surface is placed in contact with the skin.

Abstract: A personal fall limiter arrangement having a user connection arrangement, including: a body attached to at least a portion of the frame and having a recess configured to receive at least a portion of a user connector; at least one tab pivotally attached to a first portion of the body; and at least one biasing member engaged with the at least one tab and configured to urge the at least one tab towards a locked (or closed) position; wherein, in operation, the at least one tab is pivotal between: (1) an open position to permit passage of at least a portion of the user connector into or out of the recess; and (2) the locked position to prevent passage of at least a portion of the user connector out of the recess.

Abstract: Compounds of formula I, wherein R1, X1, X2 and A, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.

Abstract: Compounds of formula I, wherein R1, R2, R3, X and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.

Abstract: This invention relates to shine control cleansing compositions, which are capable of controlling the appearance of oily and shiny skin for an extended period of time.

Abstract: This invention relates to shine control cleansing compositions, which are capable of controlling the appearance of oily and shiny skin for an extended period of time.