Abstract: A system may be configured to generate an estimate of value at risk and may include a processor to process instructions that cause the system to generate a rolling time series of value data having a plurality of dimensions, perform rotation transform of the time series, perform variance scaling and correlation scaling on transformed time series, reverse transform the results of the scaling, and estimate of a value-at-risk for the value data.

Abstract: The present disclosure provides tissue-specific Wnt signal enhancing molecules, and related methods of using these molecules to increase Wnt signaling in targeted tissues.

Abstract: The present disclosure provides novel compositions and methods for collectively transforming or genetically modifying a population of distinct germplasm of different germplasms or having different genotypes. The compositions of the present disclosure may include a population of distinct germplasm, such as embryo explants, and a heterologous polynucleotide molecule, a ribonucleoprotein, or a site-specific nuclease. The methods of the present disclosure may include one or more steps of explant preparation, explant rehydration, Rhizobiales bacterium inoculation and co-culture or particle bombardment, bud induction, extended bud induction, and/or regeneration or development of genetically modified plants or plant parts. The methods provided herein may include transforming at least one plant cell of the embryo explants with a heterologous polynucleotide.

Abstract: A fabric care composition is provided including water; a modified carbohydrate polymer having a weight average molecular weight of <500,000 Daltons and a Kjeldahl nitrogen content corrected for ash and volatiles, TKN, of ?0.5 wt %; and a cleaning surfactant; wherein the modified carbohydrate polymer is a carbohydrate polymer functionalized with quaternary ammonium moieties; wherein the quaternary ammonium moieties on the modified carbohydrate polymer include: trimethyl ammonium moieties having formula (I) and dimethyl(alkyl) ammonium moieties having formula (II) wherein each R is independently selected from a C8-22 alkyl group.

Abstract: The present disclosure provides methods, computing device readable medium, devices, and systems having a dental attachment formation structures. One dental appliance includes a body having a first surface shaped to abut an exterior surface of a tooth and a well portion of the first surface shaped to form an attachment that is to be attached to the exterior surface of the tooth, a release layer formed over a surface of the well to allow the attachment to be removed from the well, and an attachment material that is used to form the attachment positioned within the well.

Abstract: In some examples, a system may include a first computing device communicatively coupled to a second computing device. Additionally, the first computing device is configured to obtain, from the second computing device, check-in data indicating an arrival of the user of the second computing device at a first location, and in response to obtaining the check-in data, determine current wait times. Moreover, the first computing device is configured to determine a first number of customers waiting for service, determine a first number of associates available to assist the first number of customers, and determine an expected wait time for the user operating the second computing device based at least on the current wait times. In some examples, the first number of customers waiting for service, and the first number of associates available. Further, the first computing device is configured to transmit the expected wait time to the second computing device.

Abstract: An electronic device may be provided with a flexible printed circuit and a rigid printed circuit mounted to the flexible printed circuit using a board-to-board (B2B) connector. The flexible printed circuit may include signal conductors coupled to one or more antennas on the rigid printed circuit through the B2B connector. A given one of the signal conductors may include a phase shifter segment on the flexible printed circuit and/or a thick impedance matching segment on the rigid printed circuit that help to form a smooth impedance transition from the flexible printed circuit to the rigid printed circuit and the antenna(s). The B2B connector may include signal contacts interleaved with a ground contacts. The B2B connector may include ground bars laterally surrounding the signal and ground contacts to maximize the strength of mechanical coupling between the flexible printed circuit and the rigid printed circuit.

Abstract: Implementations described herein relate to causing emoji(s) that are associated with a given emotion class expressed by a spoken utterance to be visually rendered for presentation to a user at a display of a client device of the user. Processor(s) of the client device may receive audio data that captures the spoken utterance, process the audio data to generate textual data that is predicted to correspond to the spoken utterance, and cause a transcription of the textual data to be visually rendered for presentation to the user via the display. Further, the processor(s) may determine, based on processing the textual data, whether the spoken utterance expresses a given emotion class. In response to determining that the spoken utterance expresses the given emotion class, the processor(s) may cause emoji(s) that are stored in association with the given emotion class to be visually rendered for presentation to the user via the display.

Abstract: A user device incorporates a user interface platform that combines user notifications and various operational settings as part of a common display region. The notifications and settings are separated from one another, and the user interface dynamically adjusts the arrangement of these features to make it convenient for a user to quickly see the information and to manage it. The setting information may incorporate user logins, network and communication data, display and audio information, as well as other settings. And the application-related notifications may include information about active applications such as an email account, audio or video calls, texting apps, social media platforms, calendars, music players, video players, and the like. In response to a new notification, the system may consolidate the operational settings into core settings information. The system may also auto collapse (or expand) the notification list when a new notification is received.

Abstract: Orthodontic systems and related methods are disclosed for designing and providing improved or more effective tooth moving systems for eliciting a desired tooth movement and/or repositioning teeth into a desired arrangement. Methods and orthodontic systems include the generation of an overcorrection in the tooth-receiving cavities of an appliance worn in the dentition. The overcorrection may provide an improved and more accurately applied force or moment applied to a tooth. The overcorrected force or moment can move a tooth closer to a desired position than if not overcorrected as sufficient force can still applied to the tooth as it gets closer to the desired position. The overcorrected force or moment may also better target the root of the tooth where the biological response to tooth movement occurs. The overcorrection may be calculated in various ways as described herein.

Abstract: Appliances for orthodontic treatment are provided. In some embodiments, an orthodontic appliance includes a shell having a plurality of teeth-receiving cavities shaped to reposition a patient’s teeth from a first arrangement toward a second arrangement. The shell can have a first elasticity. The appliance can include an attachment-receiving well formed in the shell. The attachment-receiving well can be configured to engage an attachment coupled to a tooth of the patient. The appliance can further include at least one tactile object coupled to the attachment-receiving well. The at least one tactile object can include an elongate body that extends toward the attachment when the shell is worn on the patient’s teeth. The at least one tactile object can have a second elasticity greater than the first elasticity.

Abstract: Methods, systems, and apparatus's for improving orthodontic treatments. In an embodiment, an orthodontic system including a tactile object is provided for modulating an engagement between a tooth attachment and an orthodontic appliance.

Abstract: Orthodontic systems and related methods are disclosed for designing and providing improved or more effective tooth moving systems for eliciting a desired tooth movement and/or repositioning teeth into a desired arrangement. Methods and orthodontic systems include the generation of an overcorrection in the tooth-receiving cavities of an appliance worn in the dentition. The overcorrection may provide an improved and more accurately applied force or moment applied to a tooth. The overcorrected force or moment can move a tooth closer to a desired position than if not overcorrected as sufficient force can still applied to the tooth as it gets closer to the desired position. The overcorrected force or moment may also better target the root of the tooth where the biological response to tooth movement occurs. The overcorrection may be calculated in various ways as described herein.

Abstract: In some examples, a system may include a first computing device communicatively coupled to a second computing device. Additionally, the first computing device is configured to obtain, from the second computing device, check-in data indicating an arrival of the user of the second computing device at a first location, and in response to obtaining the check-in data, determine current wait times. Moreover, the first computing device is configured to determine a first number of customers waiting for service, determine a first number of associates available to assist the first number of customers, and determine an expected wait time for the user operating the second computing device based at least on the current wait times. In some examples, the first number of customers waiting for service, and the first number of associates available. Further, the first computing device is configured to transmit the expected wait time to the second computing device.

Abstract: A system is provided and generally includes a server, an associate computing device, and a customer computing device. The server may receive data from the customer computing device indicating that a customer is picking up items from a predetermined location. The server may compute an estimated wait time for the customer based on one or more machine learning processes. In some examples, a number of unexpected customers that may arrive is determined. The machine learning process may compute the estimated wait time based on the number of unexpected customers. The machine learning process may be trained with historical data. The estimated wait time is transmitted to the customer computing device, and is displayed to the customer. In some examples, the server sends a list of customers waiting to be serviced to the associate computing device. The list may be prioritized based on estimated wait times for those customers.

Abstract: The present invention is directed to the filed of gene therapy. In particular, compositions and methods are disclosed that repair gene microduplication mutations by reversion to a wild type sequence. For example, the creation of a double stranded break by a programmable nuclease protein within a microduplication induces the microhomology mediated end joining DNA repair pathway that in the process of DNA repair removes the microduplication mutation and restores the wild type sequence.

Abstract: A system is provided and generally includes a server, an associate computing device, and a customer computing device. The server may receive data from the customer computing device indicating that a customer is picking up items from a predetermined location. The server may compute an estimated wait time for the customer based on one or more machine learning processes. In some examples, a number of unexpected customers that may arrive is determined. The machine learning process may compute the estimated wait time based on the number of unexpected customers. The machine learning process may be trained with historical data. The estimated wait time is transmitted to the customer computing device, and is displayed to the customer. In some examples, the server sends a list of customers waiting to be serviced to the associate computing device. The list may be prioritized based on estimated wait times for those customers.

Abstract: Methods, systems, and apparatus's for improving orthodontic treatments. In an embodiment, an orthodontic system including a tactile object is provided for modulating an engagement between a tooth attachment and an orthodontic appliance.

Abstract: Methods, systems, and apparatus's for improving orthodontic treatments. In an embodiment, an orthodontic system including a tactile object is provided for modulating an engagement between a tooth attachment and an orthodontic appliance.

Abstract: A haptic device comprises a signal generator that is configured to receive an input word that is a unit of a language. The signal generator converts the input word into one or more phonemes of the input word. The signal generator further converts the one or more phonemes into a sequence of actuator signals. The sequence of actuator signals is formed from a concatenation of sub-sequences of actuator signals. Each phoneme corresponding to a unique sub-sequence of actuator signals. The haptic device further comprises a two dimensional array of cutaneous actuators configured to receive the sequence of actuator signals from the signal generator, each of the actuator signals mapped to a cutaneous actuator of the two dimensional array of cutaneous actuators.