Patents by Inventor Jennifer Lewis
Jennifer Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11472102Abstract: In one aspect, the present disclosure provides a nozzle for 3-D printing. The nozzle may include a first nozzle tip defining a first outlet, where the first nozzle tip includes a first channel extending therethrough. The nozzle may further include a second nozzle tip defining a second outlet, where the second nozzle tip includes a second channel extending therethrough, and where the first channel surrounds the second outlet. The second nozzle tip may be retracted longitudinally with respect to the first nozzle tip such that the second outlet of the second nozzle tip is located in the first channel.Type: GrantFiled: December 5, 2017Date of Patent: October 18, 2022Assignees: President and Fellows of Harvard College, ETH Zurich (Swiss Federal Institute of Technology)Inventors: Jennifer A. Lewis, Jochen Mueller, Jordan R. Raney, Kristina Shea
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Publication number: 20220280993Abstract: A modular roller hemming system having a base assembly, a replaceable anvil, a spider arm assembly, a plurality of support arms for supporting the spider arm assembly, and a plurality of repositionable unit tools. The anvil is 3-D printed of a polymer composite material and may be replaced with similarly manufactured anvils having different form factors for receiving various shaped and dimensioned workpiece assemblies. The plurality of support arms are repositionable on the base assembly, the spider arm assembly is reconfigurable, and the plurality of unit tools are moveable to accommodate various anvils having different form factors. The support arms includes an upper segment that is detachable from the lower segment to facilitate the changeover of anvils.Type: ApplicationFiled: March 2, 2021Publication date: September 8, 2022Inventors: Jennifer Lewis, Ronald J. Leslie, Lawrence A. Adamski, Malini Dusey
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Publication number: 20220176694Abstract: A subwavelength resonator for acoustophoretic printing comprises a hollow resonator body for local enhancement of an acoustic field integrated with a nozzle body for delivery of an ink into the acoustic field. The nozzle body has a first end outside the hollow resonator body and a second end inside the hollow resonator body, and includes a fluid channel extending between a fluid inlet at the first end and a fluid outlet at the second end. The fluid channel passes through a side wall of the hollow resonator body and includes at least one bend. During acoustophoretic printing, an ink delivered through the fluid channel of the nozzle body and out of the fluid outlet is exposed to a high-intensity acoustic field.Type: ApplicationFiled: March 23, 2020Publication date: June 9, 2022Applicant: President and Fellows of Harvard CollegeInventors: Daniele FORESTI, Aleksandra MARKOVIC, Jennifer A. LEWIS
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Patent number: 11267981Abstract: A 3-D printed device comprising one or more interconnect structures, the interconnect structures comprising a plurality of conductive particles and one or more diblock or triblock copolymers; the diblock or triblock copolymers having an A-B, A-B-A, or A-B-C block-type structure in which the A-blocks and C-blocks are an aromatic-based polymer or an acrylate-based polymer and the B-blocks are an aliphatic-based polymer. These 3-D printed devices may be formed using a method that comprises providing a conductive ink composition; applying the conductive ink composition to a substrate in a 3-D solvent cast printing process to form one or more interconnect structures; and drying the one or more interconnect structures formed from the conductive ink composition. The dried interconnect structures exhibit a conductivity equal to or greater than 1×105 S/m without having to be subjected to any post-processing sintering treatment.Type: GrantFiled: March 29, 2019Date of Patent: March 8, 2022Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard CollegeInventors: Bradley P. Duncan, Maxwell E. Plaut, Theodore H. Fedynyshyn, Jennifer A. Lewis
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Patent number: 11214768Abstract: Methods of tissue engineering, and more particularly methods and compositions for generating various vascularized 3D tissues, such as 3D vascularized embryoid bodies and organoids are described. Certain embodiments relate to a method of generating functional human tissue, the method comprising embedding an embryoid body or organoid in a tissue construct comprising a first vascular network and a second vascular network, each vascular network comprising one or more interconnected vascular channels; exposing the embryoid body or organoid to one or more biological agents, a biological agent gradient, a pressure, and/or an oxygen tension gradient, thereby inducing angiogenesis of capillary vessels to and/or from the embryoid body or organoid; and vascularizing the embryoid body or organoid, the capillary vessels connecting the first vascular network to the second vascular network, thereby creating a single vascular network and a perfusable tissue structure.Type: GrantFiled: March 3, 2016Date of Patent: January 4, 2022Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Jennifer A. Lewis, Mark A. Skylar-Scott, David B. Kolesky, Kimberly A. Homan, Alex H. M. Ng, George M. Church
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Patent number: 11207831Abstract: A 3D printed core-shell filament comprises an elongated core radially surrounded by an outer shell with a barrier layer in between, where the elongated core comprises a ductile polymer and the outer shell comprises a stiff polymer having a Young's modulus higher than that of the ductile polymer. A lightweight lattice structure may comprise a plurality of the 3D printed core-shell filaments deposited in layers.Type: GrantFiled: December 5, 2017Date of Patent: December 28, 2021Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, ETH ZURICH (SWISS FEDERAL INSTITUTE OF TECHNOLOGY)Inventors: Jennifer A. Lewis, Jochen Mueller, Jordan R. Raney, Kristina Shea
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Publication number: 20210299943Abstract: A method of printing a cellular solid (120) by direct bubble writing comprises introducing an ink formulation (102) comprising a polymerizable monomer and a gas (104) into a nozzle (106), which includes a core flow channel (108) radially surrounded by an outer flow channel (110). The ink formulation is directed into the outer flow channel (110) and the gas is directed into the core channel (108). The ink formulation (102) and the gas (104) are ejected out of the nozzle (106) as a stream of bubbles (112), where each bubble includes a core (114) comprising the gas and a liquid shell (116) overlying the core that comprises the ink formulation. After ejection, the polymerizable monomer is polymerized to form a solid polymeric shell (118) from the liquid shell (116), and the bubbles are deposited on a substrate (122) moving relative to the nozzle (106). Thus, a polymeric cellular solid (120) having a predetermined geometry is printed.Type: ApplicationFiled: August 2, 2019Publication date: September 30, 2021Applicant: UNIVERSITEIT TWENTEInventors: Claas Willem VISSER, Dahlia Ningrum AMATO, Jennifer A. Lewis, Jochen MUELLER
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Patent number: 11117091Abstract: Method and apparatus for separating a target substance from a fluid or mixture. Capsules having a coating and stripping solvents encapsulated in the capsules are provided. The coating is permeable to the target substance. The capsules having a coating and stripping solvents encapsulated in the capsules are exposed to the fluid or mixture. The target substance migrates through the coating and is taken up by the stripping solvents. The target substance is separated from the fluid or mixture by driving off the target substance from the capsules.Type: GrantFiled: July 16, 2018Date of Patent: September 14, 2021Assignees: Lawrence Livermore National Security, LLC, The Board of Trustees of the University of IllinoisInventors: Roger D. Aines, Christopher M. Spadaccini, Joshuah K. Stolaroff, William L. Bourcier, Jennifer A. Lewis, Eric B. Duoss, John J. Vericella
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Publication number: 20210154998Abstract: A method of acoustophoretic printing comprises generating an acoustic field at a first end of an acoustic chamber fully or partially enclosed by sound-reflecting walls. The acoustic field interacts with the sound-reflecting walls and travels through the acoustic chamber. The acoustic field is enhanced in a chamber outlet at a second end of the acoustic chamber. An ink is delivered into a nozzle positioned within the acoustic chamber. The nozzle has a nozzle opening projecting into the chamber outlet. The ink travels through the nozzle and is exposed to the enhanced acoustic field at the nozzle opening, and a predetermined volume of the ink is ejected from the nozzle opening and out of the acoustic chamber.Type: ApplicationFiled: January 6, 2021Publication date: May 27, 2021Applicant: President and Fellows of Harvard CollegeInventors: Daniele Foresti, Jennifer A. Lewis, Armand Kurum
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Patent number: 10946588Abstract: A present disclosure relates to a system for automatic design and manufacturing of 3D printing units and 3D products. The system is configured to obtain specification of a target structure corresponding to a 3D product; automatically determine a design and a printing path of a 3D printing unit based on the specification of the target structure, wherein the 3D printing unit is a micronozzle unit configured to print the target structure of the 3D product; automatically determine a manufacturing procedure to print the 3D printing unit based on the specification of the target structure; and instruct a 3D printer to print the 3D printing unit according to the manufacturing procedure and the printing path of the 3D printing unit.Type: GrantFiled: March 3, 2017Date of Patent: March 16, 2021Assignee: President and Fellows of Harvard UniversityInventors: Jennifer A. Lewis, Mark Andrew Skylar-Scott, Jochen Mueller, David Kolesky
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Publication number: 20210008789Abstract: A method of 3D printing a battery includes extruding a first electrode ink formulation through a first deposition nozzle moving relative to a substrate, and depositing one or more continuous filaments comprising the first electrode ink formulation on the substrate to print a first electrode. A separator ink formulation is extruded through a second deposition nozzle moving relative to the substrate, and one or more continuous filaments comprising the separator ink formulation is deposited on the first electrode to print a separator precursor, which is then cured to form a separator. A second electrode ink formulation is extruded through a third deposition nozzle moving relative to the substrate, and one or more continuous filaments comprising the second electrode ink formulation is deposited to print a second electrode on the separator. The first and second electrodes and the separator are enclosed in a package, thereby forming a battery with thick electrodes.Type: ApplicationFiled: February 11, 2019Publication date: January 14, 2021Applicant: President and Fellows of Harvard CollegeInventors: Teng-Sing Wei, Jennifer A. Lewis
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Publication number: 20210000590Abstract: This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a plurality of spaces between the ribs filled or made with the first material, a different, second material, a combination of the first and a second materials, or a combination of a second material and one or more other different materials. The bilayer graft devices have two components or layers. One component, e.g., the underlay graft device, can include a projection, and the second component, e.g., the overlay graft device, can include an opening that corresponds to the projection (or vice versa) so that the opening and the projection can secure the two layers together in a “lock and key” manner. This disclosure also features methods of making, using, and implanting the three-dimensional artificial tympanic membrane and bilayer graft devices.Type: ApplicationFiled: September 22, 2020Publication date: January 7, 2021Inventors: Aaron K. Remenschneider, Elliott Kozin, Nicole Leah Black, Michael J. McKenna, Daniel J. Lee, Jennifer A. Lewis, John Rosowski, David B. Kolesky, Mark A. Skylar-Scott, Alexander D. Valentine
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Patent number: 10845360Abstract: Aspects of the present invention provide improved methods and apparatus for use in in vitro modeling of the interaction of cells with cellular constructs/parts/axons, including axon mimetics and use of three-dimensional fibers.Type: GrantFiled: April 17, 2019Date of Patent: November 24, 2020Assignees: Massachusetts Institue of Technology, President and Fellows of Harvard CollegeInventors: Krystyn J. Van Vliet, Anna Jagielska, Kimberly Homan, Jennifer A. Lewis, Travis Alexander Busbee
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Publication number: 20200360567Abstract: A 3D printed tubular construct, such as a nephron, with or without embedded vasculature as well as methods of printing tubular tissue constructs are described.Type: ApplicationFiled: May 29, 2020Publication date: November 19, 2020Applicant: President and Fellows of Harvard CollegeInventors: Jennifer A. Lewis, Kimberly A. Homan, David B. Kolesky, Ryan L. Truby, Mark A. Skylar-Scott
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Publication number: 20200353682Abstract: A 3-D printed device comprising one or more structures, the structures comprising a plurality of magnetically responsive particles and one or more diblock or triblock copolymers; the diblock or triblock copolymers having an A-B, A-B-A, or A-B-C block-type structure in which the A-blocks and C-blocks are an aromatic-based polymer or an acrylate-based polymer and the B-blocks are an aliphatic-based polymer. These 3-D printed devices may be formed using a method that comprises providing a magnetic ink composition; applying the magnetic ink composition to a substrate in a 3-D solvent cast printing process to form one or more structures; and drying the one or more structures formed from the magnetic ink composition. The dried structures can exhibit one or more regions of magnetic permeability greater than 1.3×10?6 H/m.Type: ApplicationFiled: May 1, 2020Publication date: November 12, 2020Inventors: Theodore H. Fedynyshyn, Jennifer A. Lewis, Bradley P. Duncan
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Patent number: 10786349Abstract: This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a plurality of spaces between the ribs filled or made with the first material, a different, second material, a combination of the first and a second materials, or a combination of a second material and one or more other different materials. The bilayer graft devices have two components or layers. One component, e.g., the underlay graft device, can include a projection, and the second component, e.g., the overlay graft device, can include an opening that corresponds to the projection (or vice versa) so that the opening and the projection can secure the two layers together in a “lock and key” manner. This disclosure also features methods of making, using, and implanting the three-dimensional artificial tympanic membrane and bilayer graft devices.Type: GrantFiled: March 21, 2016Date of Patent: September 29, 2020Assignees: Massachusetts Eye and Ear Infirmary, President and Fellows of Harvard CollegeInventors: Aaron K. Remenschneider, Elliot Kozin, Nicole Black, Michael J. McKenna, Daniel J. Lee, Jennifer Lewis, John Rosowski, David Kolesky, Mark A. Skylar-Scott, Alexander D. Valentine
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Publication number: 20200289709Abstract: Described are methods for producing tissue constructs, tissue constructs produced by the methods, and their use. The described method of producing a tissue construct comprises providing a granular tissue, depositing one or more filaments on or in the granular tissue, each filament comprising an ink, and gelling or fusing the granular tissue, thereby producing the tissue construct.Type: ApplicationFiled: September 20, 2018Publication date: September 17, 2020Inventors: Mark Skylar-Scott, Sebastien Uzel, Jennifer Lewis
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Publication number: 20200248147Abstract: Described are methods of enhancing development of renal organoids, methods of using the same, and kits.Type: ApplicationFiled: June 8, 2018Publication date: August 6, 2020Applicants: President and Fellows of Harvard College, The Brigham And Women's Hospital, Inc.Inventors: Kimberly A. Homan, Navin R. Gupta, Katharina T. Kroll, David B. Kolesky, Mark Skylar-Scott, Michael T. Valerius, Joseph Bonventre, Ryuji Morizane, Jennifer Lewis
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Patent number: 10702630Abstract: A 3D printed tubular construct, such as a nephron, with or without embedded vasculature as well as methods of printing tubular tissue constructs are described.Type: GrantFiled: May 4, 2016Date of Patent: July 7, 2020Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Jennifer A. Lewis, Kimberly A. Homan, David B. Kolesky, Ryan L. Truby, Mark A. Skylar-Scott
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Publication number: 20200164109Abstract: Described are methods for producing multi-layered tubular tissue structures, tissue structures produced by the methods, and their use.Type: ApplicationFiled: July 20, 2018Publication date: May 28, 2020Applicant: President and Fellows of Harvard CollegeInventors: Katharina Theresa Kroll, Kimberly A. Homan, Mark A. Skylar-Scott, Sebastien G.M. Uzel, David B. Kolesky, Patrick Lustenberger, Jennifer A. Lewis