Publication number: 20230142654
Abstract: The present invention relates to a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing the same as an active ingredient. The method for preparing a biomaterial to which a compound represented by formula 2 is coupled, of the present invention, allows the compound represented by formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient.
Type:
Application
Filed:
January 15, 2021
Publication date:
May 11, 2023
Inventors:
Chun Young IM, Sang Hyun MIN, Ji Hoon YU, Eun Bi KO, So Young KIM, Seungyeon LEE, Dong Kyu CHOI, Heejin LEE, Ga Young PARK, Doohyun LEE, Eunmi HONG, Hui-Jeon JEON, Young-Hoon PARK, Ye Ri HAN, Nam Hui KIM, Jun Woo KIM, Bae Jun OH, Jeong-Eun PARK, Chang Hoon SEO, Minsoo SONG, Seonggu RO, Dongkyu SHIN