Abstract: A medical device is configured to sense a cardiac electrical signal and determine from the cardiac electrical signal at least one of a maximum peak amplitude of a positive slope of the cardiac electrical signal and a maximum peak time interval from a pacing pulse to the maximum peak amplitude. The device is configured to determine a capture type of the pacing pulse based on at least one or both of the maximum peak amplitude and the maximum peak time interval.

Abstract: A preparation method of an anti-PD-1/PD-L1 monoclonal antibody (mAb)-induced autoimmune myocarditis model is provided, including: mediating a model with adeno-associated virus 9 (AAV9) to achieve the high expression of PDL1 in a myocardial tissue, and applying an anti-PD-1/PD-L1 mAb to the model with high PDL1 expression in the myocardial tissue for modeling. The present disclosure also provides use of an animal model prepared by the preparation method. The model prepared by the present disclosure truly simulates the pathogenesis and clinical course of autoimmune myocarditis in a patient administered with an anti-PD1/PD-L1 mAb, is close to a pathophysiological status of a clinical patient, has a high modeling rate, and can be dynamically monitored.

Abstract: A collector 2-cyano-N-(substituted carbamoyl)acetamide compound in flotation of calcium-bearing minerals and a highly selective flotation reagent for the calcium-bearing minerals are provided. The highly selective flotation reagent includes the 2-cyano-N-(substituted carbamoyl)acetamide compound and an auxiliary collector. The 2-cyano-N-(substituted carbamoyl)acetamide compound has an excellent effect on flotation separation of the calcium-bearing minerals and a foaming performance. Dosage is further reduced and a flotation performance is improved by compounding the compound with the auxiliary collector. The flotation reagent can preferably separate fluorite from calcite by flotation, efficiently separates the fluorite and the calcite from scheelite under neutral condition (pH is about 7), effectively purifies rough scheelite concentrate and improves grade of scheelite concentrate. Meanwhile, the neutral flotation reduces influence on the environment.

Abstract: A method for handling a read error on a block of a memory device is disclosed. In response to a read failure indicating that at least one error handling mechanism has handled the read error on the block and fails to read data stored in the block, a memory test is trigged to be performed on the block. The memory test is configured to determine whether the block malfunctions.

Abstract: A medical device is configured to detect an atrial tachyarrhythmia episode. The device senses a cardiac signal, identifies R-waves in the cardiac signal attendant ventricular depolarizations and determines classification factors from the R-waves identified over a predetermined time period. The device classifies the predetermined time period as one of unclassified, atrial tachyarrhythmia and non-atrial tachyarrhythmia by comparing the determined classification factors to classification criteria. A classification criterion is adjusted from a first classification criterion to a second classification criterion after at least one time period being classified as atrial tachyarrhythmia. An atrial tachyarrhythmia episode is detected by the device in response to at least one subsequent time period being classified as atrial tachyarrhythmia based on the adjusted classification criterion.

Abstract: Various embodiments of a ventricular assist system and a method of using such system are disclosed. The system includes a pump adapted to be connected to a heart of a patient, an outflow cannula including a first end adapted to be connected to an outlet of the pump and a second end adapted to be connected to an artery of the patient, and an electrode disposed on an outer surface of the outflow cannula and adapted to be disposed adjacent to an exterior wall of the heart. The system further includes a controller electrically connected to the pump and the electrode, where the controller is adapted to provide a pacing signal to the electrode.

Abstract: A media Parameter-modified method for realizing an adaptive expression of an arbitrary discontinuous surface, comprising the following steps: importing an initial forward model, importing anisotropic parameters; and setting a space step and a time step according to the initial forward model parameters; and then starting a stepped discretization of a free surface of the initial forward model; and using a corrected constitutive relationship to correct a first level parameter of the initial forward model; and bringing the corrected constitutive relationship into a displacement stress equation, and the influence of the free surface can be introduced in the case of the anisotropic media after series of operation. The present disclosure can make an accurate numerical simulation of a wave field near the discontinuous surface, and the accurate numerical simulation will contribute to the extraction and analysis of information from the seismic data.

Abstract: An implantable medical device system is configured to sense cardiac events in response to a cardiac electrical signal crossing a cardiac event sensing threshold. A control circuit is configured to determine a drop time interval based on a heart rate and control a sensing circuit to hold the cardiac event sensing threshold at a threshold value during the drop time interval.

Abstract: The present disclosure provides a method of data protection for a three-dimensional NAND memory. The method includes programming a memory cell of the 3D NAND memory according to programming data; and backing up a portion of the programming data associated with the memory cell in response to a program loop count (PLC) that is larger than a threshold value, where the PLC tracks a repeated number of the programming of the memory cell. A previous PLC can be set as the threshold value, where the previous PLC was used by a previous programming operation and was collected after the memory cell was programmed successfully to a previous target logic state.

Abstract: Implantable medical electrical leads having electrodes arranged such that a defibrillation coil electrode and a pace/sense electrode(s) are concurrently positioned substantially over the ventricle when implanted as described. The leads include an elongated lead body having a distal portion and a proximal end, a connector at the proximal end of the lead body, a defibrillation electrode located along the distal portion of the lead body, wherein the defibrillation electrode includes a first electrode segment and a second electrode segment proximal to the first electrode segment by a distance. The leads may include at least one pace/sense electrode, which in some instances, is located between the first defibrillation electrode segment and the second defibrillation electrode segment.

Abstract: In certain aspects, a controller for controlling a memory device includes a memory and a processor. The memory is configured to store instructions. The processor is coupled to the memory and configured to execute the instructions to perform a process including receiving data describing a read failure of a set of error handling mechanisms, where the read failure indicates that the set of error handling mechanisms handles a read error on a block of the memory device and fails to read data stored in the block; and responsive to the read failure of the set of error handling mechanisms, performing a memory test on the block to determine whether the block malfunctions.

Abstract: A preparation method of an anti-PD-1/PD-L1 monoclonal antibody (mAb)-induced autoimmune myocarditis model is provided, including: mediating a model with adeno-associated virus 9 (AAV9) to achieve the high expression of PDL1 in a myocardial tissue, and applying an anti-PD-1/PD-L1 mAb to the model with high PDL1 expression in the myocardial tissue for modeling. The present disclosure also provides use of an animal model prepared by the preparation method. The model prepared by the present disclosure truly simulates the pathogenesis and clinical course of autoimmune myocarditis in a patient administered with an anti-PD1/PD-L1 mAb, is close to a pathophysiological status of a clinical patient, has a high modeling rate, and can be dynamically monitored.

Abstract: An assembly system includes a positioning unit adapted to clamp and position a cable, a supply unit adapted to supply a connector, and an insertion unit adapted to insert an end of the cable into the connector by moving the connector. The supply unit includes a conveyor belt having a side to which ends of a plurality of connectors in a row of connectors are connected, a cutting device configured to cut each connector of the row of connectors from the conveyor belt, and a conveyor configured to move the conveyor belt, so as to move the connectors individually to the cutting device.

Abstract: An extra-cardiovascular implantable cardioverter defibrillator senses R-waves from a first cardiac electrical signal by a first sensing channel and stores a time segment of a second cardiac electrical signal in response to each sensed R-wave. The ICD determines intervals between successively sensed R-waves and, in response to at least a predetermined number of the intervals being less than a tachyarrhythmia detection interval, analyzes at least a portion of the time segment of the second cardiac electrical signal corresponding to a most recent one of the sensed R-waves to confirm the most recent one of the R-waves. The ICD updates an unconfirmed beat count in response to the most recent one of the R-waves not being confirmed and withholds detection of a tachyarrhythmia episode in response to the unconfirmed beat count being equal to or greater than a rejection threshold.

Abstract: A hot pressing machine for continuously hot pressing a flexible flat cable includes a plurality of hot pressing units arranged at intervals along a feeding direction of the flexible flat cable. A central controller of the machine is operably connected to the plurality of hot pressing units and is configured to control the plurality of hot pressing units to synchronously hot press the flexible flat cable located in the plurality of hot pressing units.

Abstract: Computer-implemented systems and methods forecast network resource and/or infrastructure needs for an enterprise computer system that employs network servers to host resources that are requested by network users. Based on the forecasts, the network resources can be scaled or provisioned accordingly. The state of the networkservers can be dynamically adjusted to meet the request needs of the users while reducing excess capacity. The forecasting techniques are also applicable to cloud computing environments. Based on the forecasts, the cloud server pool can be scaled dynamically, so that the system's scale satisfies the changing requests and avoids wasting resources when the system is under low load.

Abstract: An implantable medical device system capable of sensing cardiac electrical signals includes a sensing circuit, a therapy delivery circuit and a control circuit. The sensing circuit is configured to receive a cardiac electrical signal and sense a cardiac event in response to the signal crossing a cardiac event sensing threshold. The therapy delivery circuit is configured to deliver an electrical stimulation therapy to a patient's heart via the electrodes coupled to the implantable medical device. The control circuit is configured to control the sensing circuit to set a starting value of the cardiac event sensing threshold and hold the starting value constant for a sense delay interval. The control circuit is further configured to detect an arrhythmia based on cardiac events sensed by the sensing circuit and control the therapy delivery circuit to deliver the electrical stimulation therapy in response to detecting the arrhythmia.

Abstract: An implantable medical device system includes an extracardiac sensing device and an intracardiac pacemaker. The sensing device senses a P-wave attendant to an atrial depolarization of the heart via housing-based electrodes carried by the sensing device when the sensing device is implanted outside the cardiovascular system and sends a trigger signal to the intracardiac pacemaker in response to sensing the P-wave. The intracardiac pacemaker detects the trigger signal and schedules a ventricular pacing pulse in response to the detected trigger signal.

Abstract: In certain aspects, a controller for controlling a memory device includes a memory and a processor. The memory is configured to store instructions. The processor is coupled to the memory and configured to execute the instructions to perform a process including receiving data describing a read failure of a set of error handling mechanisms, where the read failure indicates that the set of error handling mechanisms handles a read error on a block of the memory device and fails to read data stored in the block; and responsive to the read failure of the set of error handling mechanisms, performing a memory test on the block to determine whether the block malfunctions.

Abstract: Implementations of the present disclosure provide a memory apparatus that includes a plurality of memory cells stored with memory data in N dies. Each of the N dies includes M planes. Each of the M planes includes a memory block. The apparatus also includes a controller configured to determine J layers in the memory block in each of the M planes and in each of the N dies, each of the J layers comprising a pair of adjacent gate conductive layers. The controller is also configured to determine M sets of stripes. Each of the M sets of stripes comprising a plurality of data portions stored in a respective one of the M planes. The controller is further configured to determine M sets of parity data portions. The controller is further configured to control a temporary storage unit to store the M sets of parity data portions.