Abstract: The disclosure provides novel chemical compounds useful as activators of PKR. PKR activating compounds are useful in the treatment of disease and disorders associated with modulation of PKR and/or PKM2, such as pyruvate kinase deficiency (PKD).

Abstract: A retaining ring can be shaped by machining or lapping the bottom surface of the ring to form a shaped profile in the bottom surface. The bottom surface of the retaining ring can include flat, sloped and curved portions. The lapping can be performed using a machine that dedicated for use in lapping the bottom surface of retaining rings. During the lapping the ring can be permitted to rotate freely about an axis of the ring. The bottom surface of the retaining ring can have curved or flat portions.

Abstract: Provided is a display substrate. The display substrate includes: a base substrate including a display region and a non-display region surrounding the display region; a gate drive circuit disposed in the non-display region; a plurality of first signal lines disposed in the peripheral region and connected to the gate drive circuit; and a plurality of second signal lines disposed in the non-display region and connected to the gate drive circuit; wherein each of the first signal line and the second signal line is configured to supply a signal to the gate drive circuit, and a frequency of the signal supplied by the first signal line is lower than a frequency of the signal supplied by the second signal line.

Abstract: This disclosure relates to compositions and methods for inhibiting mutant IDH1, useful in treatment of mIDH1 cancers including AML, as well as mIDH1-positive solid tumors such as glioma.

Abstract: The present disclosure provides an X-ray detecting device, and a manufacturing method of an X-ray detecting panel. The present disclosure also provides an X-ray detecting panel including a main bias voltage signal line and a photodiode. A cathode of the photodiode is electrically connected to the main bias voltage signal line. The X-ray detecting panel further includes at least one auxiliary bias voltage signal line electrically connected to the main bias voltage signal line.

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.

Abstract: The embodiments of the present disclosure provide a display substrate, a display panel, and a display device. The display substrate includes: a first base substrate, wherein a plurality of sub-pixel regions arranged in an array are provided on the first base substrate; and a reflective layer provided on one side of the first base substrate, wherein a surface of the reflective layer away from the first base substrate is formed to include a plurality of first bumps and a plurality of second bumps, and the first bump has a size greater than that of the second bump.

Abstract: Provided are a display panel and a driving method thereof, and a display device. The display panel includes: a base substrate; and multiple subpixels provided at the base substrate, at least one of the multiple subpixels including a reflective electrode, wherein the reflective electrode at least includes a first reflective electrode and a second reflective electrode insulated and spaced apart from each other, the first reflective electrode is provided with a first through hole, the second reflective electrode is provided with a second through hole, and an area of the first through hole is different from an area of the second through hole.

Abstract: A smart deodorization device with a cover plate includes a reaction chamber having a reaction cavity; an air extraction unit, configured for extracting odor in or near a toilet pool into the reaction cavity; and a water supply unit, configured for supplying water to the reaction cavity. When working, the air extraction unit extracts the odor into the reaction cavity, and the odor is mixed with the water in the reaction cavity to be converted into purified gas and then discharged from the reaction cavity. By using the characteristic that ammonia molecules in the odor are easily soluble in water, the odor and water are mixed in the reaction cavity and then discharged to realize the gas purification. Thus, the device has obvious effects, simple structures, lower costs, and convenience to use without need of replacing filtering materials.

Abstract: An array substrate and a touch display device. The array substrate includes a touch signal line, a common electrode and a first pixel electrode on a substrate. The first pixel electrode includes a first edge and a second edge arranged along the first direction and extending along the second direction, the touch signal line extends along the second direction, and the touch signal line is located between the first edge and the second edge. The via hole connection part of the touch signal line is electrically connected to the common electrode through the touch line via hole, and a size of the via hole connection part in the first direction is greater than a size of a portion of the touch signal line in the first direction, and the portion of the touch signal line is adjacent to the via hole connection part.

Abstract: Disclosed are a display panel and a driving method therefor, and a display device. Two adjacent rows of sub-pixels are taken as a row group, and the row group is provided with a first sub row group and a second sub row group that are arranged in a column direction; a gate electrode of a first transistor in the first sub row group is electrically connected to a first gate line; a gate electrode of a second transistor in the second sub row group is electrically connected to a second gate line; two adjacent sub-pixels in the column direction share one third transistor, and a gate electrode of the third transistor in the row group is electrically connected to a third gate line; and the first transistor and the second transistor in one column of sub-pixels are electrically connected to a data line by means of the shared third transistor.

Abstract: An electronic paper display screen and a manufacturing method therefor, and a display device. The electronic paper display screen includes a first electronic paper screen and a second liquid crystal display layer which are stacked; the first electronic paper screen is an electrophoretic electronic paper screen, the second liquid crystal display layer is a cholesteric liquid crystal display screen, and the second liquid crystal display layer includes a first substrate, a second substrate and a control drive circuit; the first substrate is provided with multiple first electrodes arranged in a first direction, and the second substrate is provided with multiple second electrodes arranged in a second direction; and at least one of the first substrate and the second substrate is further provided with multiple metal wires, the metal wires are respectively connected to the control drive circuit and the electrodes of the substrate to which the metal wires belong.

Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.

Abstract: The present invention related to a brain tumor-targeting peptide, a coding nucleic acid thereof, and a vector and host cell comprising the coding nucleic acid. The targeting peptide linked to a diagnostic marker can be used in brain tumor diagnosis, especially in brain tumor imaging; and the targeting peptide when linked to a therapeutic drug can carry the drug directly to a brain tumor lesion so as to achieve brain tumor treatment.

Abstract: Provided are an antibody that binds to Staphylococcus aureus alpha-hemolysin or a fragment thereof, and the use of the antibody or the fragment thereof for preventing or treating Staphylococcus aureus infections. The antibody is obtained through screening by means of the strategies of attenuated immunity and virulent screening of alpha-hemolysin, and the antibody has high affinity to alpha-hemolysin, can effectively block the hemolysis effect of alpha-hemolysin, has proved significant protective or therapeutic effects in the alpha-hemolysin sepsis model, MRSA bacteremia model and MRSA lung infection model, and has a synergistic effect with antibiotics, which is a beneficial supplement to existing antibiotic therapy for Staphylococcus aureus.

Abstract: A display panel and a driving method thereof, and a display device. The display panel includes a substrate and a plurality of pixel circuits arranged in an array on the substrate, each of the plurality of pixel circuits includes a pixel driving chip and at least one light-emitting element electrically connected to the pixel driving chip, and the pixel driving chip is configured to receive and store a data signal and drive the at least one light-emitting element to emit light according to the data signal.

Abstract: The present invention relates to a metal-organic hybrid lattice material and the application in the detection of radiation sources. In the invention, a water-soluble thorium salt and 2,2?:6?,2?-terpyridine-4?-carboxylic acid are subjected to a solvothermal reaction in water and an organic mixed solvent to obtain a metal-organic hybrid lattice material. The crystalline material produces radiation-induced discoloration and photoluminescence change under ultraviolet light, X-ray, ?-ray, ?-ray, and so on. The material is useful for qualitative and quantitative detection and calibration after high-dose irradiation. Compared with the traditional radiation-induced color change indicator labels, the material achieves the visual qualitative and quantitative detection and has strong radiation stability, high reuse rate, wide detection range, and good linear relationship, to solve the problem of traditional materials relying on professional optical equipment to quantify the radiation dose.

Abstract: A system for determining an assessment of at least one exercise performed by a user is described. The system includes an input device, and a computing device. The input device is configured to monitor at least one exercise performed by a user. The computing device includes processors and a memory. The memory is coupled to the processors and stores program instructions that when executed by the processors cause the processors to: (1) generate a user interface displaying a content; (2) provide an instruction associated with the at least one exercise; (3) determine an indication of movement associated with the at least one exercise; (4) in response to a determination of the indication of movement, determine an assessment of the at least one exercise; and (5) in response to a determination of the assessment of the at least one exercise, perform an operation.

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3?, R4, R5, X1, X2, X3, X4, and n are described herein.