Abstract: A welding fixture comprises a suction assembly, a drive assembly, and a positioning assembly. The suction assembly comprises a fixing member and a suction member slidably coupled to the fixing member. The drive assembly couples the fixing member to the suction member. The suction assembly comprises a positioning member slidably coupled to the fixing member, a flange protruding from the positioning member, and an elastic member sleeved on the positioning member. The elastic member is configured to bias the flange away from a side of the fixing member. The drive assembly can move the suction member and thereby moving the workpiece towards the positioning member, so that the weldment makes contact with the workpiece via the positioning member.

Abstract: The invention relates to methods of enhancing normal melanocortin-4 receptor (MC4R) activity, and to enhancing activity of an MC4R having a mutation which affects protein folding and/or processing of the MC4R. The invention provides a method of treating an individual having a condition in which increased activity of an MC4R at the cell surface would be beneficial, for example in obesity, by administering an effective amount of a pharmacological chaperone for the MC4R. The invention provides MC4R pharmacological chaperones which enhance the activity of MC4R. The invention further provides a method of screening to identify pharmacological chaperones which enhance folding of an MC4R in the endoplasmic reticulum (ER), in order to enhance the activity of the MC4R at the cell surface.

Abstract: A gluing nozzle can include a base defining a receiving cavity, and a tube coupled to the base. The tube can include a straight portion mounted to the base, and a bent portion bent from the straight portion. The tube can define a channel fluidly communicating with the receiving cavity, the straight portion, and the bent portion. The channel can extend through an outlet of the bent portion. A distal end of the bent portion can form an annular surface surrounding the outlet. The annular surface can be substantially parallel to an axis of the straight portion.

Abstract: Disclosed herein is a method of assembling an array of light emitting diode (LED) dies on a substrate comprising: positioning dies in fluid; exposing the dies to a magnetic force to attract the dies onto magnets that are arranged at pre-determined locations either on or near the substrate; and forming permanent connections between the dies and the substrate thereby constituting an array of LED dies on a substrate.

Abstract: The present invention relates to methods for treating obstructive sleep apnea (OSA), alleviating a negative OSA symptom, reducing snoring, or improving quality of life in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising pyridostigmine before sleep. Also provided are related medicaments as well as methods for preparing the medicaments.

Abstract: A foam affixing mechanism employed to affix foam to a workpiece, includes a robot arm, a foam supplying assembly and a clamping assembly. The foam supplying assembly is located adjacent to the robot arm to supply foam pieces. The clamping assembly is mounted on the robot arm. The clamping assembly includes a fixing frame, a driving member, a pair of fixing members, and a pair of clamping subassemblies. The driving member is mounted on the fixing frame, the pair of fixing members are fixed to the fixing frame. The clamping subassembly includes a first linking member rotatably connected to the driving member and a second linking member rotatably connected to the first linking member. The second linking member is rotatably connected to the fixing member by a middle portion thereof, the second linking member includes a clamping portion at an end. The present invention further discloses a clamping assembly.

Abstract: A method of enhancing the activity of lysosomal ?-Galactosidase A (?-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.

Abstract: Disclosed is a portable fire extinguishing device, which comprises a casing (1) and a cartridge (2) provided inside the casing (1). The device is characterized in that: the casing (1) comprises a first half casing (4), a second half casing (5) fitted to the first half casing (4), a fastening ring (6) and a bottom cover (7); the first half casing (4) and the second half casing (5) are butted; the fastening ring (6) is provided on the top ends of the first half casing (4) and the second half casing (5) so as to fasten the both; and the bottom cover (7) is provided at the bottoms of the both. The first half casing, the second half casing, the fastening ring and the bottom cover are clamped and fixedly connected with each other to form a whole casing so that the whole wall thickness of the casing is uniform, thus improving injection moulding processes, reducing the difficulty in manufacturing a mould, saving plastic resources, and facilitating installation and disassembly.

Abstract: An explosion-venting method for an aerosol fire suppression apparatus, comprising the following steps: 1) when the aerosol fire suppression apparatus explodes, an explosion-venting device matching the aerosol fire suppression apparatus generating a limited displacement along a direction that a hot air stream of the aerosol fire suppression apparatus is jetting towards; 2) when an extremity of the explosion-venting device reaches an edge of the aerosol fire suppression apparatus, being limited, the explosion-venting apparatus stops the displacement along the direction that the hot air stream of the aerosol fire suppression apparatus is jetting towards, thus achieving for the aerosol fire suppression apparatus the effects of explosion-venting and reduced recoil force.

Abstract: Disclosed herein is a method of assembling an array of light emitting diode (LED) dies on a substrate comprising: positioning dies in fluid; exposing the dies to a magnetic force to attract the dies onto magnets that are arranged at pre-determined locations either on or near the substrate; and forming permanent connections between the dies and the substrate thereby constituting an array of LED dies on a substrate.

Abstract: A feeding device includes a bottom plate defining a feeding hole, at least one first feeding mechanism, and at least one second feeding mechanism. The first feeding mechanism includes a first driving member mounted on the bottom plate, a first connection member connected to the first driving member, and a plurality of first support members. The first support member is mounted on the first connection member spaced from each other along a longitudinal direction of the first connection member, for supporting the workpieces. The second feeding mechanism has a similar structure to that of the first feeding mechanism. The first connection member and the second connection member are positioned above the bottom plate adjacent to each other. Each second support member is staggeredly positioned above one corresponding first support member.

Abstract: A fixed fire extinguishing apparatus, comprising a housing (2), a cartridge (1) and an activation controller connected to the cartridge (1), wherein the cartridge (1) is numbered at least two and arrayed in the housing (2). A plurality of cartridges (1) can be simultaneously activated via one activation controller (5), thus greatly enhancing the fire extinguishing performance of the fire extinguishing apparatus. In addition, the fixed fire extinguishing apparatus has a small overall size thus occupies less space.

Abstract: A workpiece marking device operating automatically includes a support member, a transmission member, a feeding mechanism, a discharging mechanism, a driving mechanism, a positioning tool, and a marking mechanism. The transmission member conveys a workpiece, the feeding mechanism includes a driving assembly coupled to the support member and a lifting member coupled to the driving assembly. The discharging mechanism is positioned on the support member and above the transmission member. The discharging mechanism includes a driving assembly coupled to the support member and a lifting member coupled to the driving assembly of the discharging mechanism to move workpieces away after marking.

Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxymojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.

Abstract: A data storage system and associated method of use may generally be directed to a memory cache that stores a plurality of pending read and write requests. A processor can be configured to prioritize the read requests in the memory cache in response to a sensed acoustic or mechanical vibration in a data storage medium.

Abstract: A size inspection device includes a detecting platform, a positioning assembly, four first detecting assemblies, four second detecting assemblies, a third detecting assembly, and a controller. The detecting platform includes a mounting plate. The positioning assembly is detachably mounted on the mounting plate for holding the workpiece on the detecting platform. The controller is electronically connected to the first detecting assemblies, the second detecting assemblies, and the third detecting assembly. The four first detecting assemblies and the four second detecting assemblies are slidably mounted on the mounting plate and are capable of obtaining a first moving distance and a second moving distance respectively. The third detecting assembly is mounted on the mounting plate and is capable of obtaining a third moving distance. The controller obtains the moving distances and determines whether or not the workpiece is of passing or failing quality.

Abstract: A height measuring includes a mounting base, a measuring mechanism, and a controller. The measuring mechanism includes a driving member, a measuring member, and a sensor. The driving member is mounted onto the mounting base. The sensor is positioned on the driving member. The measuring member is movably positioned on the driving member and passes through the sensor. The driving member is configured to drive the measuring member to move until it contacts a workpiece in a jig. The controller is electrically connected to the sensor and prestores a moving distance range. The sensor is configured to sense a moving distance of the measuring member and transmit the moving distance to the controller. The controller is configured to judge whether or not the workpiece reaches a proper height relative to the jig by comparing the moving distance data with the prestored distance range.

Abstract: Implementations disclosed herein provide a method comprising determining used shingled data tracks adjacent to a target track using a track usage monitoring scheme, and reading the used shingled data tracks to perform a write operation to the target track.

Abstract: Systems and methods are disclosed for performing band rewrites on shingled storage media based on error scan counts. In one embodiment, a device may comprise a data storage medium including a first band and a processor. The first band may include a plurality of tracks storing data in a shingled manner where a first track at least partially overlaps a second track. The processor may be configured to receive a write command directed to the first band, increment a first rewrite count of the first band based on the write command, and when the first rewrite count exceeds a first rewrite threshold, perform a read-modify-write (RMW) operation for all of the first band. In some embodiments, a device may maintain write counts for sections of a band, and perform RMW operations on less than all of the band.