Abstract: A container for a stick product utilizes a novel inner body that has no gaps along its top perimeter. As a result, significant advantages in assembly and operation are realized. Containers according to the present invention may be useful for all types of stick products that are applied by drawing the product across a surface.

Abstract: Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.

Abstract: A dual-ended stick mechanism comprises a dual-ended holder cup that holds two stick products; a single inner body with longitudinal shaft; a single cam sleeve a with helical groove; two A-shell members; and two overcaps. When either overcap is rotated with respect to the opposite A-shell, the holder cup moves up and down. A register feature alerts the user that the holder cup has reached its neutral position.

Abstract: Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen. Vectors, compositions and vaccines comprising one or more nucleic acid sequences that encode a mutated WT1 antigen are disclosed. Methods of treating an individual who has a WT1-expressing tumor and methods of preventing a WT1-expressing tumor are disclosed. Mutated WT1 antigen is disclosed.

Abstract: Disclosed herein are compositions comprising optimized consensus TERT antigens and methods for treating cancer and in particular immunogenic compositions that treat and provide protection against tumor.

Abstract: Provided herein are methods of treating brain cancer in a subject, comprising evaluating one or more biological samples from a subject who has brain cancer for the presence of a miRNAs and administering interleukin-12 (IL-12); an immunogenic composition of human telomerase reverse transcriptase (hTERT), Wilms Tumor-1 (WT-1), and prostate specific membrane antigen (PSMA); and an anti-programmed cell death receptor 1 (PD-1) antibody to said subject if the subject has an increased expression level of the mIR-331-3p miRNA or isomiRs thereof and the miR-1537-3p miRNA or isomiRs thereof relative to a control population of subjects.

Abstract: The present invention relates to a nutritional composition comprising at least one human milk oligosaccharide comprising 3? sialyllactose (3-SL), 6? sialyllactose (6-SL), 3-fucosyllactose and any combination thereof for improving language development in a subject, preferably born from a A-tetrasaccharide positive mother and/or the subject fed with a mother's milk rich in A-tetrasaccharide

Abstract: Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing cancer.

Abstract: The use of anti-HPV immunogens and nucleic acid molecules that encode them for the treatment and prevention of RRP are disclosed. Pharmaceutical composition, recombinant vaccines comprising DNA plasmid and live attenuated vaccines are disclosed as well methods of inducing an immune response to treat or prevent RRP are disclosed.

Abstract: Provided herein are methods of inducing an immune response against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) in a subject in need thereof by administering an immunogenic composition to the subject, wherein the subject exhibits: an increase in antigen-specific cellular immune response as measured by Interferon-gamma (IFN-?) Enzyme-linked Immunospot (ELISpot) assay relative to baseline; and/or an increase in neutralizing antibody response as measured by a pseudovirus neutralizing assay relative to baseline.

Abstract: A cosmetic container, such as a compact, that comprises a lid hingedly connected to a base, and a lighting circuit. Some embodiments of the invention comprises a one-way mirror, while others comprise a variable transparency film. Preferred embodiments, however, comprise both a one-way mirror and a variable transparency film that work cooperatively to provide a lid that is see through when viewed from the outside, and reflective when viewed from the inside.

Abstract: Disclosed herein are compositions comprising optimized consensus TERT antigens and methods for treating cancer and in particular immunogenic compositions that treat and provide protection against tumor.

Abstract: A refillable dispenser for a stick product according to the present invention comprises a holder cup, an A-shell and an inner base. Preferably, the dispenser will also comprise an outer base and a closure. The holder cup and A-shell form a cartridge subassembly for a stick product that can be bottom filled, and removed and replaced as needed. The dispenser requires no lubricant.

Abstract: Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated consensus LEMD1 antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a mutated consensus LEMD1 antigen are disclosed. Methods of treating a subject with a LEMD1-expressing tumor and methods of preventing a LEMD1-expressing tumor are disclosed. Mutated consensus LEMD1 antigen is disclosed.

Abstract: Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated consensus PRAME antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a mutated consensus PRAME antigen are disclosed. Methods of treating a subject with a PRAME-expressing tumor and methods of preventing a PRAME-expressing tumor are disclosed. Mutated consensus PRAME antigen is disclosed.

Abstract: Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens. Also provided herein are methods of making the vaccine compositions, methods of preparing, and methods of use thereof.

Abstract: The present application relates to the field of energy storage materials, and particularly, to an electrolytic solution and a battery using the electrolytic solution. The electrolytic solution of the present application contains an additive, the additive including a multi-cyano compound represented by formula (I). The multi-cyano compound of the present application has a stronger complexation with a transition metal on the surface of a positive electrode material, and therefore a protective film can be formed on the surface of the positive electrode material, and the dissolution of the transition metal is effectively suppressed; the surface activity of the positive electrode material is reduced, thereby suppressing side reactions, such as the decomposition of the electrolytic solution on the surface of the positive electrode material; and the cycle performance and storage performance of a battery under wide range of working voltage and wide range of operating temperature conditions are thus improved.

Abstract: A dispensing pump mechanism is provided. The pump comprises integrally molded temper-evidence part between a container collar and a spout; said collar has multiple off-centre outlet channel for dispensing one or more products from the container; said collar also comprises an integrated air vent to be blocked and opened by the rotation of the spout. The whole pump can be over-molded one-piece structure with elastic parts as being actuating parts. The pump improves the functions of the pump, such as lower restitution rate, less structural parts, lower cost, water/dust proof, lightweight, easy assembly.