Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens. Also provided herein are methods of making the vaccine compositions, methods of preparing, and methods of use thereof.

Abstract: Nucleic acid molecules and compositions comprising: a nucleic acid sequence that encodes IL-12 p35 subunit or a functional fragment thereof and/or a nucleic acid sequence that encodes IL12 p40 subunit or a functional fragment thereof, are disclosed. The nucleic acid molecules and compositions further comprising a nucleic acid sequence that encodes an immunogen are also disclosed. Method of modulating immune response and methods of inducing an immune response against an immunogen are disclosed. Therapeutic and prophylactic vaccination methods are also disclosed.

Abstract: A dispensing pump mechanism is provided. The pump comprises integrally molded temper-evidence part between a container collar and a spout; said collar has multiple off-centre outlet channel for dispensing one or more products from the container; said collar also comprises an integrated air vent to be blocked and opened by the rotation of the spout. The whole pump can be over-molded one-piece structure with elastic parts as being actuating parts. The pump improves the functions of the pump, such as lower restitution rate, less structural parts, lower cost, water/dust proof, lightweight, easy assembly.

Abstract: Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated consensus PRAME antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a mutated consensus PRAME antigen are disclosed. Methods of treating a subject with a PRAME-expressing tumor and methods of preventing a PRAME-expressing tumor are disclosed. Mutated consensus PRAME antigen is disclosed.

Abstract: Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated consensus LEMD1 antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a mutated consensus LEMD1 antigen are disclosed. Methods of treating a subject with a LEMD1-expressing tumor and methods of preventing a LEMD1-expressing tumor are disclosed. Mutated consensus LEMD1 antigen is disclosed.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing colorectal cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens, and/or (iv) express one or more tumor fitness advantage mutations, including but not limited to driver mutations. Also provided herein are methods of making and preparing the colorectal cancer vaccine compositions and methods of use thereof.

Abstract: A fluid control device comprising including a body having an inlet, an outlet, and a fluid flow path between the inlet and the outlet, a seat, and a control element that is coupled to a stem. The control element and the stem are movable relative to a longitudinal axis and biased toward a closed position, in which the control element engages the seat. An actuator assembly is operatively coupled to the stem and includes a planetary gear transmission mechanism configured to receive a first rotational velocity and to deliver a second rotational velocity different than the first rotational velocity. A shaft has a first end coupled to the transmission mechanism and a second end coupled to valve stem. The second rotational velocity is transmitted to the valve stem to move the control element between the closed position and an open position.

Abstract: The present disclosure provides a portable seafloor drill rig for a submersible for multi-point core drilling, including a power head, a reduction gear box, an emergency jettison device, a drilling tool, and a temperature and pressure-retaining device. a water supply connector and the power head are arrange on a top plate of the reduction gear box. An output shaft of the power head is connected to an input shaft of the reduction gear box, and an output shaft of the reduction gear box is provided with a central hole, which is in communication with a water inlet hole of the water supply connector. An output shaft of the reduction gear box is connected to the emergency jettison device, and the temperature and pressure-retaining device can perform temperature and pressure-retaining storage of the core drilled by the drilling tool.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing breast cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens, and/or (iv) express one or more tumor fitness advantage mutations, including but not limited to driver mutations. Also provided herein are methods of making and preparing the breast cancer vaccine compositions and methods of use thereof.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing cancer.

Abstract: A dual-ended stick mechanism comprises a dual-ended holder cup that holds two stick products; a single inner body with longitudinal shaft; a single cam sleeve a with helical groove; two A-shell members; and two overcaps. When either overcap is rotated with respect to the opposite A-shell, the holder cup moves up and down. A register feature alerts the user that the holder cup has reached its neutral position.

Abstract: A glue-free lipstick case that comprises an A-shell and cam sleeve with no glue in between. The cam sleeve is provided with one or more flexible tabs on its outer surface. The flexible tabs bias in a radially outward direction. The A-shell member fits snugly over the cam sleeve and flexible tabs, such that the outward pressure exerted by the tabs on the inner surface of the cam sleeve helps to ensure that the two members move as one.

Abstract: Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a modified consensus MUC16 antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a modified consensus MUC16 antigen are disclosed. Methods of treating a subject with a MUC16-expressing tumor and methods of preventing a MUC16-expressing tumor are disclosed. Modified consensus MUC16 antigen is disclosed.

Abstract: Embodiments of this application disclose a collective communication method, apparatus, and system. The method includes: A first network device receives a first packet; the first network device receives at least one second packet; and the first network device sends a third packet based on the first packet and the at least one second packet. When no connection is established between the first network device and a terminal device, the first network device may aggregate and distribute collective communication packets by using a connection between the first terminal device and another terminal device.

Abstract: Nucleic acid molecules and compositions comprising: a nucleic acid sequence that encodes IL-12 p35 subunit or a functional fragment thereof and/or a nucleic acid sequence that encodes IL12 p40 subunit or a functional fragment thereof, are disclosed. The nucleic acid molecules and compositions further comprising a nucleic acid sequence that encodes an immunogen are also disclosed. Method of modulating immune response and methods of inducing an immune response against an immunogen are disclosed. Therapeutic and prophylactic vaccination methods are also disclosed.

Abstract: Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a modified consensus MUC16 antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a modified consensus MUC16 antigen are disclosed. Methods of treating a subject with a MUC16-expressing tumor and methods of preventing a MUC16-expressing tumor are disclosed. Modified consensus MUC16 antigen is disclosed.

Abstract: A cosmetic container, such as a compact, that comprises a lid hingedly connected to a base, and a lighting circuit. Some embodiments of the invention comprises a one-way mirror, while others comprise a variable transparency film. Preferred embodiments, however, comprise both a one-way mirror and a variable transparency film that work cooperatively to provide a lid that is see through when viewed from the outside, and reflective when viewed from the inside.

Abstract: Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.

Abstract: A method of realizing an interactive virtual experiment is provided. A teacher may drags a minimum experimental unit into a demonstration area using a mouse. The above operational action is described as digital data in a panoramic learning platform. The data is transmitted to a student client. The same minimum experimental unit is automatically placed in the same position of the demonstration area of the virtual experiment subsystem of the student client according to the data. The teacher may operates the minimum experimental unit. The operational action is described as digital data in the panoramic learning platform. The data is sent to the student client. The same operational action is automatically performed in the student client based on the above data. The demonstration is performed on the minimum experimental units in the demonstration areas of the teacher client and the student client.