Abstract: The present disclosure discloses a color matching evaluation method combining similarity measure and visual perception. The method includes: firstly, constructing an image database with rich color information; extracting main colors from an acquired image using an improved clustering method for color matching; generating a corresponding palette using an intelligent color matching recommendation system, and evaluating a palette similarity using a minimum color difference model; then, recoloring the corresponding image using the generated palette through an image recoloring technology to obtain a recolored image, and calculating a structural similarity between the source image and the recolored image; performing feature level adaptive weighted fusion on the palette similarity and the structural similarity, and performing an eye movement tracking experiment on the source image and the recolored image to obtain visual perception data of the images.

Abstract: A multiplexed line scanning LiDAR system generates a line scan of an object based on the distance of various point measurements to the object. The multiplexed line scanning LiDAR utilizes at least one set of light source emissions to a fiber optic laser element to form a line scan pattern to determine a distance and velocity of an object.

Abstract: Embodiments disclosed include systems, devices, and methods for analysis of samples containing particles used for gene delivery to determine a quality of the sample and/or an indication that the gene delivery particles are in a full, partial, and/or empty state. The present disclosure also relates to determining a protein and/or NA content in samples with known proportions of gene delivery particles in a full, partial, and/or empty state and based on the determination, establish a relationship between NA content and proportions of gene delivery particles in a full state. The present disclosure also relates to using such an established relationship to predict a proportion of the gene delivery particles in a full, partial, and/or empty state in test samples having the gene delivery particles in an unknown state.

Abstract: A liquid metal (LM) dispensing apparatus and method for design and fabrication thereof. Components of the LM dispensing apparatus are designed and tooled based on a target pinout (e.g., a number of, arrangement of, and dimensions of, holes in a substrate to have LM injected therein) and desired LM material. Embodiments employ detachably attached needles using a locking means to provide leak-free interchangeability of the needles. The flexibility with needles makes replacing damaged needles more perfunctory. Embodiments contour the LM reservoir to enhance uniform LM flow to the needles and dispense or inject LM from multiple detachably attached needles concurrently.

Abstract: Embodiments disclosed include systems, devices, and methods for analysis of samples containing particles used for gene delivery to determine a quality of the sample and/or an indication that the gene delivery particles are in a full, partial, and/or empty state. The present disclosure also relates to determining a protein and/or NA content in samples with known proportions of gene delivery particles in a full, partial, and/or empty state and based on the determination, establish a relationship between NA content and proportions of gene delivery particles in a full state. The present disclosure also relates to using such an established relationship to predict a proportion of the gene delivery particles in a full, partial, and/or empty state in test samples having the gene delivery particles in an unknown state.

Abstract: In one embodiment, a direct injection device includes a head, a plunger, a reservoir, and multiple needles. The head controls extrusion of liquid stored in the reservoir of the direct injection device. For example, the head causes the plunger to compress the liquid in the reservoir, which causes the liquid to be extruded through the needles.

Abstract: In one embodiment, an integrated circuit apparatus comprises a substrate that includes electrical contacts on a first side of the substrate to couple the substrate to an integrated circuit die, a passivation layer on a second side of the substrate opposite the first side, metal pads on the second side of the substrate and within openings defined by the passivation layer, and solder bumps on the metal pads. The solder bumps are a material that is resistant to Gallium-based liquid metal embrittlement.

Abstract: Embodiments disclosed include systems, devices, and methods for analysis of samples containing particles used for gene delivery to determine a quality of the sample and/or an indication that the gene delivery particles are in a full, partial, and/or empty state. The present disclosure also relates to determining a protein and/or NA content in samples with known proportions of gene delivery particles in a full, partial, and/or empty state and based on the determination, establish a relationship between NA content and proportions of gene delivery particles in a full state. The present disclosure also relates to using such an established relationship to predict a proportion of the gene delivery particles in a full, partial, and/or empty state in test samples having the gene delivery particles in an unknown state.

Abstract: Embodiments disclosed include systems, devices, and methods for analysis of samples containing particles used for gene delivery to determine a quality of the sample and/or an indication that the gene delivery particles are in a full, partial, and/or empty state. The present disclosure also relates to determining a protein and/or NA content in samples with known proportions of gene delivery particles in a full, partial, and/or empty state and based on the determination, establish a relationship between NA content and proportions of gene delivery particles in a full state. The present disclosure also relates to using such an established relationship to predict a proportion of the gene delivery particles in a full, partial, and/or empty state in test samples having the gene delivery particles in an unknown state.

Abstract: Embodiments include systems, apparatuses, and methods to efficiently separate analytes in a sample and elute fractions of the separated analytes. In some embodiments, a method includes introducing a sample in a capillary with a first end ionically coupled to a first running buffer and a second end ionically coupled to a second running buffer to form a pH gradient. The method includes applying a voltage between the first running buffer and the second running buffer, to separate a plurality of analytes in the sample. The method includes disposing the second end of the capillary in a collection well including a chemical mobilizer and applying a voltage to elute one or more analytes from the plurality of analytes in the sample, that have been separated, into the collection well. Embodiments include detection methods to monitor separation of analytes, mobilization of analytes, and/or elution of fractions containing analytes.

Abstract: Embodiments disclosed include systems, devices, and methods for analysis of samples containing particles used for gene delivery to determine a quality of the sample and/or an indication that the gene delivery particles are in a full, partial, and/or empty state. The present disclosure also relates to determining a protein and/or NA content in samples with known proportions of gene delivery particles in a full, partial, and/or empty state and based on the determination, establish a relationship between NA content and proportions of gene delivery particles in a full state. The present disclosure also relates to using such an established relationship to predict a proportion of the gene delivery particles in a full, partial, and/or empty state in test samples having the gene delivery particles in an unknown state.

Abstract: Embodiments include systems, apparatuses, and methods to efficiently separate analytes in a sample and elute fractions of the separated analytes. In some embodiments, a method includes introducing a sample in a capillary with a first end ionically coupled to a first running buffer and a second end ionically coupled to a second running buffer to form a pH gradient. The method includes applying a voltage between the first running buffer and the second running buffer, to separate a plurality of analytes in the sample. The method includes disposing the second end of the capillary in a collection well including a chemical mobilizer and applying a voltage to elute one or more analytes from the plurality of analytes in the sample, that have been separated, into the collection well. Embodiments include detection methods to monitor separation of analytes, mobilization of analytes, and/or elution of fractions containing analytes.

Abstract: Provided herein are IEF focusing methods for determining the number of drug molecules present in at least one antibody-drug conjugate (ADC) species subpopulation. In one embodiment, the method comprises performing free solution isoelectric focusing on a sample comprising at least one ADC species, to obtain a focused sample. The absorbance of the sample at two different wavelengths is then measured, for example, over a range of pI values. Absorbance values at the two different wavelengths are compared at at least one corresponding pI value, where the at least one corresponding pI value is the pI of the ADC subpopulation. The number of drug molecules in the at least one ADC species subpopulation is then determined based on the comparison. The methods provided herein can also be used to determine the number of specific binding pair members bound to its target specific binding pair member.

Abstract: Systems and methods for initiating enrollment of a local device in a cloud environment using a separate device are presented. In an example embodiment, a device identifier for the local device is received from the local device by a separate device that is trusted by a cloud computing system. The separate device causes the displaying of an indicator for the local device. In response to receiving an activation of the indicator for the local device, the separate device issues a request to the cloud computing system to receive credential information enabling the local device to enroll with the cloud computing system. The separate device receives the credential information from the cloud computing system and transmits the credential information to the local device.

Abstract: Approaches for using a device-based authentication certificate to obtain data access to a cloud-based destination application are provided. Using an edge manager device, a token and data access request is received from a machine. The edge manager device is configured to administer data access to one or more cloud-based applications.

Abstract: Data communications are enabled between a machine and a remote service application. When user-based credential data is valid, an authorization code is provided from an authorization service application to the machine. The authorization code and a request for a first access token are received and in response, the first access token is sent from the authorization service application to the first machine. The first machine responsively sends the first access token and an enrollment request to an enrollment service application. The enrollment service application sends machine credential data to the first machine to permit the first machine later access to cloud-based applications.

Abstract: Data communications are enabled between a machine and a remote service application. When user-based credential data is valid, an authorization code is provided from an authorization service application to the machine. The authorization code and a request for a first access token are received and in response, the first access token is sent from the authorization service application to the first machine. The first machine responsively sends the first access token and an enrollment request to an enrollment service application. The enrollment service application sends machine credential data to the first machine to permit the first machine later access to cloud-based applications.

Abstract: Approaches for using a device-based authentication certificate to obtain data access to a cloud-based destination application are provided. Using an edge manager device, a token and data access request is received from a machine. The edge manager device is configured to administer data access to one or more cloud-based applications.

Abstract: Systems and methods for initiating enrollment of a local device in a cloud environment using a separate device are presented. In an example embodiment, a device identifier for the local device is received from the local device by a separate device that is trusted by a cloud computing system. The separate device causes the displaying of an indicator for the local device. In response to receiving an activation of the indicator for the local device, the separate device issues a request to the cloud computing system to receive credential information enabling the local device to enroll with the cloud computing system. The separate device receives the credential information from the cloud computing system and transmits the credential information to the local device.

Abstract: In various example embodiments, systems and methods for administering machine access to a cloud service are presented. A first device or machine can access an enrollment service in a cloud environment using user-based credential data. The enrollment service can request registration of the first device with an authorization service. If the authorization service accepts the request, then the authorization service can provide credential data for the first device to use to access one or more cloud-based services. In an example embodiment, a third party application provides devices and an enrollment service with credential data that can be used to facilitate device enrollment with cloud services.