Abstract: CNS metastases are a major cause of cancer deaths with few therapeutic options for treatment. Monoclonal anti-body-based therapy is one of the most successful therapeutic strategies for cancer; however, its efficacy is limited against CNS metastases due to insufficient CNS delivery. Here, we show significantly improved antibody delivery to the CNS using novel timed-release nanocapsules that encapsulate individual antibodies within a crosslinked phosphorylcholine polymer and gradually release cargo through hydrolysable crosslinkers. A single course of rituximab (RTX) nanocapsule treatment elevates RTX levels in the CNS by nearly 10-fold compared to native RTX. We improved control of CNS metastases in a murine xenograft model of non-Hodgkin lymphoma; moreover, using a xenograft humanized BLT mouse model, lymphomas were eliminated with a single course of RTX nanocapsule treatment. This approach is useful for treatment of cancers with CNS metastases and is generalizable for delivery of any antibody to the CNS.

Abstract: An armrest storage box assembly has an armrest box body comprising a first storage space having a first opening, and an armrest connected to the armrest box body, the armrest moving between a first closed position and a first open position to open and close the first opening. The armrest comprises an armrest body, comprising a second storage space having a second opening, and a cover connected to the armrest body, the cover moving between a second closed position at which the second opening is closed and a second open position at which the second opening is opened to open and close the second opening.

Abstract: A method, system, and computer program product for detecting and monitoring a signal is provided. The method includes detecting an alignment point for a periodic signal segment of a periodic signal generated by an apparatus being monitored for standard functionality In response, the apparatus is activated from a period prior to the alignment point to an end point of the periodic signal segment and a first point of the periodic signal segment is located. Likewise, a second point of an additional periodic signal segment of the periodic signal is located. The periodic signal is normalized based on results of locating the first point and the second point.

Abstract: The present invention provides a magnetic-control measurement system, comprises a reaction container and a programable magnetron measurement unit.

Abstract: A suppression method of high-frequency resonance for VSC-HVDC (Voltage Source Converter-High Voltage Direct Current Transmission) system based on nonlinear filter in voltage feed-forward control. It includes that the nonlinear filter is used for the voltage feed-forward link in the current inner loop control. The specific method is to extract each sequence component of the AC (Alternating Current) voltage, calculate the average value of the sequence component at N sample points, compare the current average value with the output result of nonlinear filter in the previous period, and output the result of nonlinear filter in the current period. After corrected, the result is a fixed value varying according to gradient which acts on the voltage feed-forward link of the inner loop.

Abstract: The invention relates to the technical field of electric vehicles, and discloses a transformable electric vehicle.

Abstract: The utility model relates to the technical field of a cushion structure of an electric vehicle, and discloses a variable-form cushion structure of electric vehicle. The variable-form cushion structure specifically comprises a chassis with sliding rails, and a cushion unit, wherein, the chassis is arranged longitudinally, and the sliding rails extend longitudinally; the cushion unit comprises a support plate and a seat plate, and the lower end of the seat, plate is hinged to the upper end of the support plate; the lower end of the support plate is fixedly arranged, and the upper end of the seat plate is connected in a movable way with the sliding rails; when the upper end of the seat plate is located at the upper parts of the sliding rails, the seat plate is obliquely arranged relatively to the ground; and when the upper end of the seat plate moves to the lower parts of the sliding rails, the seat, plate is arranged, horizontally.

Abstract: Microelectronic devices include a stack structure with a vertically alternating sequence of insulative structures and conductive structures arranged in tiers. A series of slit structures extends through the stack structure and devices the stack structure into a series of blocks. In a progressed portion of the series of blocks, each block comprises an array of pillars extending the through the stack structure of the block. Also, each block—in the progressed portion—has a different block width than a block width of a neighboring block of the progressed portion of the series of blocks. At least one pillar, of the pillars of the array of pillars in the progressed portion, exhibits bending. Related methods and electronic systems are also disclosed.

Abstract: According to one embodiment, a method, computer system, and computer program product for memory corruption diagnosis is provided. The present invention may include generating a pattern expression (PE) header file, wherein a plurality of common datatypes associated with a software program are pre-defined. The invention may further include generating a PE for each of the plurality of common datatypes, and generating a PE table by merging the generated PEs for each of the plurality of common datatypes. Upon discovery that memory corruption has occurred, the invention may include transmitting a recorded state of the software program as a core dump file to a server, and using a dump utility to identify overlay content of the core dump file. Lastly, the invention may include identifying a possible source program of the memory corruption by matching the PE tables against the illegally-written overlay content.

Abstract: A method for skin care and/or maintenance including applying or administering a preparation to a subject is provided. The preparation includes a biomedical composition, and the biomedical composition includes an effective amount of micelle, wherein the micelle includes a hyaluronic acid and/or a derivative thereof and a modified histidine. The modified histidine is grafted to at least one primary hydroxyl group of the hyaluronic acid and/or the derivative thereof, and a graft ratio of the modified histidine is 1-100%. Moreover, the hyaluronic acid and/or the derivative thereof and the modified histidine form the micelle on a weight percentage of 0.2-300:1.

Abstract: Embodiments of the present disclosure provide a method for predicting an occurrence of a tool processing event, thereby determining whether to activate a virtual metrology. In a model-building stage, plural sets of model-building data are used to create at least one classification model in accordance with at least one classification algorithm, in which each classification model includes plural decision trees. Then, probabilities of the decision trees are used to create at least one reliance index model, and the sets of model-building data are used to create at least one similarity index model in accordance with a statistical distance algorithm. In a conjecture stage, a set of processing data of a workpiece is inputted into each classification model, each reliance index model and each similarity index model to determine whether to activate (start) virtual metrology.

Abstract: A computer implemented method, computer system and computer program product are provided for lost detection for paired mobile devices. According to the method, a processor receives behavior data of paired mobile devices from one or more sensors of the paired mobile devices, wherein the behavior data comprising one or more parameters that reflect current status of the paired mobile devices. And the processor compares the received behavior data with human behavior data model. And, in response to the received behavior data being not matched with the human behavior data model, the processor determines that at least one of the paired mobile devices is lost.

Abstract: Disclosed are techniques for migrating the execution of a task from a first host system to a second host system by copying a snapshot of data required for starting the execution of a task from memory of the first host system to memory of a coupling facility, monitoring the execution of the task on the first host system, and, upon detecting failure of the execution of the task on the first host system, initiating execution of the task on the second host system by copying the snapshot of data from the memory of the coupling facility to the memory of the second host system.

Abstract: The invention relates to protein nanocapsules that exhibit material properties that change in different in vivo environments. A zwitterion moiety on the surface of the nanocapsule can protect the protein from opsonization in a first environment, yet uncouples from the protein nanocapsule in a second environment (e.g. at a pH of less than 6.5). In embodiments of the invention, the uncoupled protein nanocarrier is then internalized by mammalian cells (e.g. tumor cells).

Abstract: The present application provides for water capsules, preparation methods of water capsules, a preparation method for lightweight concrete and a structure of lightweight concrete. Each of the water capsules comprises an alkali-sensitive shell and water inside; the water capsules are used to mix with a cementitious matrix, the water capsules can survive during concrete mixing and transportation processes but then gradually rupture in hardened concrete; the water released during the hardening of the concrete is beneficial for the hydration of the concrete. The water capsules and their preparation method, the preparation method for and structure of the lightweight concrete of the present application are of unique design and strong practicability.

Abstract: A graft polymer is provided, which includes a polymer backbone with a plurality of hydroxy groups, protection group modified histidine grafted onto the side of the polymer backbone, and hydrophilic polymer having terminal reactive group grafted onto the side of the polymer backbone. The graft polymer coating can be applied to metal material to form a composite material, which can be implanted into an organism to reduce adhesion problems.

Abstract: A conductive fiber and a method for fabricating the conductive fiber are provided. The method for fabricating the conductive fiber includes the following steps. A first solution is provided, where the first solution includes a spinnable polymer dissolved in a first solvent, wherein the weight ratio of the spinnable polymer to the first solvent is from 5:95 to 20:80. A second solution is provided, wherein the second solution includes a conductive material dispersed in a second solvent, and the weight ratio of the conductive material to the second solvent is from 5:95 to 20:80. The shape of the conductive material is dendritic or snowflake-like. Next, a wet spinning process employing the first solution and the second solution is performed to obtain the conductive fiber.

Abstract: A method for preparing ?-cellulose, a spinning composition, and a fiber material are provided. The method for preparing ?-cellulose includes providing a coffee residue; subjecting the coffee residue to a decolorization treatment, obtaining a white powder; reacting the white powder with an alkaline solution, obtaining a mixture; filtering the mixture to produce a filter cake; and baking the filter cake to obtain ?-cellulose.

Abstract: Embodiments for data deduplication in a data deduplication environment by one or more processors. A data extent, existing on a remote server instance, may be denoted as a virtual base extent to eliminate redundant transfer of the data extent for fast data deduplication in a distributed data protection environment. A synchronization operation is performed to replace the virtual base extent with actual data via a replication process.

Abstract: Embodiments of the present invention provide a two-phase process for searching the root causes of the yield loss in the production line 100. In a first phase, process tools and their process tool types that are likely to cause the yield loss are identified, and in a second phase, the process parameters that are likely to cause the yield loss within the process tool types found in the first phase are identified. In each phase, two different algorithms can be used to generate a reliance index (RIk) for gauge the reliance levels of their search results.