Abstract: An application and a method of compounds inhibiting synthesis of very long chain fatty acids (VLCFAs) in preventing and controlling microbial pathogens are provided, which relate to the technical field of plant pathology and plant disease prevention and control. In particular, an application method of a compound for inhibiting the synthesis of VLCFAs in preventing and treating microbial pathogens is provided. Research results associated with the methods show that taking the synthesis of VLCFAs as the target, microbial pathogens can be inhibited by using compounds that inhibit the synthesis of VLCFAs. Therefore, the compounds inhibiting the synthesis of VLCFAs can be used in preventing and treating microbial pathogens diseases, which provides a new idea or strategy for the prevention and treatment of microbial pathogens diseases, and provides more choices for the types of drugs for the prevention and treatment of pathogenic diseases.

Abstract: The present invention discloses a fast inflating air pump, including a housing, an inflating tube, an inlet tube, a motor, a transmission assembly and a controller housed in the housing. A blower is arranged in the inlet tube for increasing air pressure to the inflating port. A piston is at least partially contained in the inflating tube, and the piston is driven by the motor via the transmission assembly so as to slide back and forth linearly for increasing air pressure in the inflating tube. A one-way valve is installed in the communicating pipe for only allowing air flow into the inflating tube. The controller instructs the motor to drive the piston to slide back and forth in the inflation tube on condition that the blower stops working until the air inflation pressure increases to a predetermined threshold, then the controller instructs the motor to stop operating.

Abstract: Data storage of workloads is migrated from a local computing environment to a cloud computing environment. The workloads are first executed in a runtime environment that have been deployed within a first virtual machine running in the local computing environment, according to a blueprint that defines a data storage path for the workloads. The data storage of the workloads is migrated by copying contents of a first file, which corresponds to a virtual disk of the first virtual machine, to a second file, modifying the blueprint to change the data storage path to a path that specifies a file path to the second file, and deploying a runtime environment within a second virtual machine running in the cloud computing environment, according to the modified blueprint. After transitioning the data storage of the workloads in this manner, the workloads are executed in the runtime environment deployed within the second virtual machine.

Abstract: An electrolytic eluent generator includes an electrolyte reservoir, an eluent generation chamber, and an ion exchange membrane stack. The electrolyte reservoir includes a chamber containing an aqueous electrolyte solution including an electrolyte and a surfactant; and a first electrode. The eluent generation chamber including a second electrode. The ion exchange connector includes an ion exchange membrane stack, and a compression block.

Abstract: An anion exchange for separating a plurality of carbohydrates includes a negatively charged substrate particle. A base polymer layer includes a first plurality of quaternary amines. The polyalkylpolyamine polymer layer is covalently attached to the base condensation polymer layer. The polyalkylpolyamine polymer layer includes a polymeric branch structure that includes a second plurality of quaternary amines. A density of the second plurality of quaternary amines increases in a direction away from the base condensation polymer layer. The anion exchange stationary phase does not have a hydroxy group spaced apart from any one of the first or the second plurality of quaternary amines by an ethyl group.

Abstract: Data storage of workloads is migrated from a local computing environment to a cloud computing environment. The workloads are first executed in a runtime environment that have been deployed within a first virtual machine running in the local computing environment, according to a blueprint that defines a data storage path for the workloads. The data storage of the workloads is migrated by copying contents of a first file, which corresponds to a virtual disk of the first virtual machine, to a second file, modifying the blueprint to change the data storage path to a path that specifies a file path to the second file, and deploying a runtime environment within a second virtual machine running in the cloud computing environment, according to the modified blueprint. After transitioning the data storage of the workloads in this manner, the workloads are executed in the runtime environment deployed within the second virtual machine.

Abstract: The invention relates generally to disulfide drug conjugates wherein a linker comprising a sulfur-bearing carbon atom substituted with at least one hydrocarbyl or substituted hydrocarbyl is conjugated by a disulfide bond to a cysteine sulfur atom of a targeting carrier, and wherein the linker is further conjugated to a drug moiety. The invention further relates to activated linker-drug conjugates suitable for conjugation to a targeting carrier by a disulfide bond. The invention further relates to methods for preparing hindered disulfide drug conjugates.

Abstract: An anion exchange for separating a plurality of carbohydrates includes a negatively charged substrate particle. A base polymer layer includes a first plurality of quaternary amines. The polyalkylpolyamine polymer layer is covalently attached to the base condensation polymer layer. The polyalkylpolyamine polymer layer includes a polymeric branch structure that includes a second plurality of quaternary amines. A density of the second plurality of quaternary amines increases in a direction away from the base condensation polymer layer. The anion exchange stationary phase does not have a hydroxy group spaced apart from any one of the first or the second plurality of quaternary amines by an ethyl group.

Abstract: A vehicle engine compartment assembly includes an upper longitudinal beam and a front subframe disposed under the upper longitudinal beam. The vehicle engine compartment assembly further includes a middle longitudinal beam and a connecting supporting member. The middle longitudinal beam is disposed between the upper longitudinal beam and the front subframe. The connecting supporting member is connected to each of the middle longitudinal beam, the upper longitudinal beam and the front subframe. In the vehicle engine compartment assembly, the middle longitudinal beam is added between the upper longitudinal beam and the front subframe, and the upper longitudinal beam, the middle longitudinal beam and the front subframe are connected together to form a stable structure having a shape of “”. When the vehicle suffers collision at a high speed, the impact force is transferred through three load transfer paths to improve the energy absorption effect.

Abstract: Provided are a new aromatic cyanogen compound and a preparation method thereof. The present invention also relates to the use of such compound in antiviral drugs, in particular the use thereof in anti-HCV drugs.

Abstract: An atomizer compartment structure includes an oil storage compartment and a heating core support. The upper end of the oil storage tank is a closed end, and the lower end of the oil storage tank has a tubular oil conduit and an air conduit, and the external wall of the oil storage compartment has a latch buckle disposed at an end near the air conduit. The upper end of the heating core support has an oil filling hole corresponsive to the oil conduit and an air guide hole corresponsive to the air conduit, and the external wall of the heating core support has an engaging slot for engaging the latch buckle. When the oil storage compartment and the heating core support are latched tightly, the oil conduit extends into the oil filling hole and the air conduit extends into the air guide hole.

Abstract: An atomizer compartment structure includes an oil storage compartment and a heating core support. The upper end of the oil storage tank is a closed end, and the lower end of the oil storage tank has a tubular oil conduit and an air conduit, and the external wall of the oil storage compartment has a latch buckle disposed at an end near the air conduit. The upper end of the heating core support has an oil filling hole corresponsive to the oil conduit and an air guide hole corresponsive to the air conduit, and the external wall of the heating core support has an engaging slot for engaging the latch buckle. When the oil storage compartment and the heating core support are latched tightly, the oil conduit extends into the oil filling hole and the air conduit extends into the air guide hole.

Abstract: Provided are a new aromatic cyanogen compound and a preparation method thereof. The present invention also relates to the use of such compound in antiviral drugs, in particular the use thereof in anti-HCV drugs.

Abstract: A vehicle engine compartment assembly includes an upper longitudinal beam and a front subframe disposed under the upper longitudinal beam. The vehicle engine compartment assembly further includes a middle longitudinal beam and a connecting supporting member. The middle longitudinal beam is disposed between the upper longitudinal beam and the front subframe. The connecting supporting member is connected to each of the middle longitudinal beam, the upper longitudinal beam and the front subframe. In the vehicle engine compartment assembly, the middle longitudinal beam is added between the upper longitudinal beam and the front subframe, and the upper longitudinal beam, the middle longitudinal beam and the front subframe are connected together to form a stable structure having a shape of “”. When the vehicle suffers collision at a high speed, the impact force is transferred through three load transfer paths to improve the energy absorption effect.

Abstract: An apparatus for delivering devices. The apparatus comprises a catheter with an elongated shaft having a first lumen and a second lumen extending therethrough. The apparatus further comprises a distal section with a lumen in communication with a port in a distal end of the catheter and with the first lumen and the second lumen. The first lumen is configured for a first device and the second lumen is configured for a second device to be disposed therein. The apparatus further comprises a proximal adapter coupled to the elongated shaft with a first port in communication with the first lumen and a second port in communication with the second lumen.

Abstract: The invention relates generally to disulfide drug conjugates wherein a linker comprising a sulfur-bearing carbon atom substituted with at least one hydrocarbyl or substituted hydrocarbyl is conjugated by a disulfide bond to a cysteine sulfur atom of a targeting carrier, and wherein the linker is further conjugated to a drug moiety. The invention further relates to activated linker-drug conjugates suitable for conjugation to a targeting carrier by a disulfide bond. The invention further relates to methods for preparing hindered disulfide drug conjugates.

Abstract: The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions include a porous solid support (e.g., silica gels, silica monoliths or synthetic organic resins) having an exterior surface and pore openings defined by “interior walls”. To the solid support are covalently bound organic ion-exchange ligands (e.g., silyl ligands), which incorporate at least one ion-exchange group (e.g., ionic or ionizable group). The compositions further include micro-particles (e.g., latex particles) incorporating ion-exchange groups having a charge that is opposite to the charge found on the support. The micro-particles are bound to the exterior surface of the support (e.g., via electrostatic forces).

Abstract: The present invention provides an agglomerated multimodal chromatographic medium. the medium of the invention includes groups active in anion exchange, cation exchange and hydrophilic interaction chromatographic modalities. The invention provides methods of making these media and using them in separations of analytes. Also provided are separations devices incorporating the medium and systems incorporating these separations devices.

Abstract: An apparatus for delivering devices. The apparatus comprises a catheter with an elongated shaft having a first lumen and a second lumen extending therethrough. The apparatus further comprises a distal section with a lumen in communication with a port in a distal end of the catheter and with the first lumen and the second lumen. The first lumen is configured for a first device and the second lumen is configured for a second device to be disposed therein. The apparatus further comprises a proximal adapter coupled to the elongated shaft with a first port in communication with the first lumen and a second port in communication with the second lumen.