Patents by Inventor Jinhua Chen
Jinhua Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9144756Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions provide both strong aromatic and hydrophobic interactions with components of a sample. Moreover, the invention provides compositions of new silanes, their immobilization on a solid substrate, such as silica, to form new stationary phases.Type: GrantFiled: May 19, 2011Date of Patent: September 29, 2015Assignee: Dionex CorporationInventors: Xiaodong Liu, Jinhua Chen, Christopher A. Pohl
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Publication number: 20140370614Abstract: The present invention provides an agglomerated multimodal chromatographic medium. the medium of the invention includes groups active in anion exchange, cation exchange and hydrophilic interaction chromatographic modalities. The invention provides methods of making these media and using them in separations of analytes. Also provided are separations devices incorporating the medium and systems incorporating these separations devices.Type: ApplicationFiled: June 14, 2013Publication date: December 18, 2014Inventors: Xiaodong LIU, Christopher A. POHL, Jinhua CHEN
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Publication number: 20130237112Abstract: With respect to the anionic polymer ion-exchange material used in an alkaline fuel cell, an electrodialysis apparatus, water treatment industry, catalyst industry, and the like, there are provided an anionic polymer ion-exchange material having both excellent ionic conductivity and excellent mechanical strength, as compared to the materials conventionally used, and a method for producing the same. An anionic polymer ion-exchange material having a polymer base material mainly made of an amide resin having both an aromatic structure and an aliphatic chain in the principal chain thereof, wherein the polymer base material has an anionic monomer graft-polymerized on the aliphatic chain in the principal chain of the amide resin, wherein the anionic monomer has an aromatic structure and a quaternary ammonium structure.Type: ApplicationFiled: February 27, 2013Publication date: September 12, 2013Applicant: JAPAN ATOMIC ENERGY AGENCYInventors: Jinhua CHEN, Masaharu ASANO, Yasunari MAEKAWA
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Patent number: 8372558Abstract: A vinyl monomer is graft polymerized on an aromatic hydrocarbon-based polymer film substrate to introduce graft chains into the substrate and thereafter a functional monomer represented by the following formula and having sulfonic acid groups or functional groups capable of conversion to sulfonic acid groups is graft polymerized to introduce the sulfonic acid groups or the functional groups capable of conversion to sulfonic acid groups: where R is an aromatic ring or an aliphatic chain; X is (1) —OH, (2) —OLi, —ONa or —OK, (3) —F or —Cl, or (4) —OCnH2n+1 where n is an integer of 1 to 7. Since the graft chains obtained by graft polymerization of the vinyl monomer can also be utilized as scaffold polymers, the graft polymerizability of the functional monomer to the aromatic hydrocarbon-based polymer film substrate is sufficiently improved to enable the preparation of a polymer electrolyte membrane that excels not only in proton conductivity and mechanical strength but also in dimensional stability.Type: GrantFiled: August 22, 2008Date of Patent: February 12, 2013Assignee: Japan Atomic Energy AgencyInventors: Jinhua Chen, Yasunari Maekawa, Masaharu Asano, Masaru Yoshida
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Patent number: 8283088Abstract: An object is to provide an electrolyte membrane that maintains excellent cell characteristics for a long time under high temperature and low water retention, as this is the most important point in fuel cells. A process for producing a polymer electrolyte membrane for fuel cells is provided, which process comprises in sequence: forming graft molecular chains by graft-polymerization of a vinyl silane coupling agent on a polymer film substrate that has phenyl groups capable of holding sulfonic acid groups; introducing sulfonic acid groups into phenyl groups contained in the graft molecular chains; and hydrolyzing and condensing alkoxy groups contained in the graft molecular chains so that a silane crosslinked structure is introduced between the graft molecular chains. A polymer electrolyte membrane produced by the process is also provided.Type: GrantFiled: September 5, 2007Date of Patent: October 9, 2012Assignees: Japan Atomic Energy Agency, Nitto Denko CorporationInventors: Masaru Yoshida, Masaharu Asano, Jinhua Chen, Yasunari Maekawa, Toshimitsu Tachibana, Yozo Nagai, Soji Nishiyama
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Patent number: 8129074Abstract: A crosslinked nano-inorganic particle/polymer electrolyte membrane composed of a polymer film substrate, graft molecular chains bound to the backbone skeleton of the polymer film substrate and comprising a vinyl monomer graft-polymerized, sulfonic groups bound to the graft molecular chains, and an inorganic material as nano-scale particles uniformly dispersed within a crosslinked structure ascribed to the backbone skeleton of the polymer film substrate and the graft molecular chains, wherein the backbone skeleton of the polymer film substrate, the graft molecular chains, and the nano-inorganic particles mutually construct a crosslinked structure.Type: GrantFiled: November 16, 2006Date of Patent: March 6, 2012Assignees: Japan Atomic Energy Agency, Nitto Denko CorporationInventors: Jinhua Chen, Masaru Yoshida, Masaharu Asano, Tetsuya Yamaki, Toshimitsu Tachibana, Soji Nishiyama, Yozo Nagai
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Publication number: 20110284465Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions provide both strong aromatic and hydrophobic interactions with components of a sample. Moreover, the invention provides compositions of new silanes, their immobilization on a solid substrate, such as silica, to form new stationary phases.Type: ApplicationFiled: May 19, 2011Publication date: November 24, 2011Applicant: Dionex CorporationInventors: Xiaodong Liu, Jinhua Chen, Christopher A. Pohl
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Patent number: 7993793Abstract: By performing photograft polymerization of functional monomers such that grafted chains will be introduced from the surface of a polymer base film into its interior without deteriorating its inherent characteristics and also by creating a multiplex crosslinked structure between the grafted chains and the base film under such conditions as to cause preferential radiation-induced crosslinking reaction, there is produced a polymer electrolyte membrane having high enough oxidation resistance and proton conductivity to be suitable for use in fuel cells.Type: GrantFiled: March 23, 2007Date of Patent: August 9, 2011Assignees: Japan Atomic Energy Agency, Nitto Denko CorporationInventors: Masaru Yoshida, Masaharu Asano, Jinhua Chen, Yasunari Maekawa, Toshimitsu Tachibana, Yozo Nagai, Soji Nishiyama
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Patent number: 7932245Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.Type: GrantFiled: October 22, 2003Date of Patent: April 26, 2011Assignee: Abbott LaboratoriesInventors: Youssef L. Bennani, William H. Bunnelle, Sou-Jen Chang, Sanjay R. Chemburkar, Jinhua Chen, Michael J. Dart, Dilinie P. Fernando, Yi-Yin Ku, Mark Lockwood, Lei Wang
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Publication number: 20100190875Abstract: An aromatic polymer film substrate, or a grafted aromatic polymer film substrate having a monomer introduced therein as graft chains is irradiated with ionizing radiation to impart a crosslinked structure. The aromatic polymer film substrate or the grafted aromatic polymer film substrate, provided with the crosslinked structure, is directly sulfonated to obtain a crosslinked aromatic polymer electrolyte membrane. The crosslinked aromatic polymer electrolyte membrane has low water uptake, high proton conductivity, low methanol permeability, high chemical stability, and excellent mechanical characteristics.Type: ApplicationFiled: April 1, 2010Publication date: July 29, 2010Applicant: JAPAN ATOMIC ENERGY AGENCYInventors: Jinhua Chen, Yasunari Maekawa, Masaharu Asano, Masaru Yoshida
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Patent number: 7714027Abstract: An aromatic polymer film substrate, or a grafted aromatic polymer film substrate having a monomer introduced therein as graft chains is irradiated with ionizing radiation to impart a crosslinked structure. The aromatic polymer film substrate or the grafted aromatic polymer film substrate, provided with the crosslinked structure, is directly sulfonated to obtain a crosslinked aromatic polymer electrolyte membrane. The crosslinked aromatic polymer electrolyte membrane has low water uptake, high proton conductivity, low methanol permeability, high chemical stability, and excellent mechanical characteristics. A method for producing the crosslinked aromatic polymer electrolyte membrane is also provided.Type: GrantFiled: January 31, 2008Date of Patent: May 11, 2010Assignee: Japan Atomic Energy AgencyInventors: Jinhua Chen, Yasunari Maekawa, Masaharu Asano, Masaru Yoshida
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Publication number: 20100040927Abstract: An object is to provide an electrolyte membrane that maintains excellent cell characteristics for a long time under high temperature and low water retention, as this is the most important point in fuel cells. A process for producing a polymer electrolyte membrane for fuel cells is provided, which process comprises in sequence: forming graft molecular chains by graft-polymerization of a vinyl silane coupling agent on a polymer film substrate that has phenyl groups capable of holding sulfonic acid groups; introducing sulfonic acid groups into phenyl groups contained in the graft molecular chains; and hydrolyzing and condensing alkoxy groups contained in the graft molecular chains so that a silane crosslinked structure is introduced between the graft molecular chains. A polymer electrolyte membrane produced by the process is also provided.Type: ApplicationFiled: September 5, 2007Publication date: February 18, 2010Inventors: Masaru Yoshida, Masaharu Asano, Jinhua Chen, Yasunari Maekawa, Toshimitsu Tachibana, Yozo Nagai, Soji Nishiyama
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Publication number: 20090277838Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions include a porous solid support (e.g., silica gels, silica monoliths or synthetic organic resins) having an exterior surface and pore openings defined by “interior walls”. To the solid support are covalently bound organic ion-exchange ligands (e.g., silyl ligands), which incorporate at least one ion-exchange group (e.g., ionic or ionizable group). The compositions further include micro-particles (e.g., latex particles) incorporating ion-exchange groups having a charge that is opposite to the charge found on the support. The micro-particles are bound to the exterior surface of the support (e.g., via electrostatic forces).Type: ApplicationFiled: May 9, 2008Publication date: November 12, 2009Applicant: Dionex CorporationInventors: Xiaodong Liu, Christopher A. Pohl, Jinhua Chen, L. Andy Woodruff
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Patent number: 7557232Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC). The compositions include a substrate (e.g., silica gel), covalently bound to a compound, which includes both a hydrophobic moiety and a hydrophilic moiety, which is preferably a 1,2-diol moiety. The hydrophobic moiety is sufficiently hydrophobic for the compositions to exhibit reversed phase characteristics and typically incorporates at least 5 carbon atoms in sequence. Based on having both hydrophilic and hydrophobic functionalities, the new stationary phases exhibit unique chromatographic properties. For example, these media can be used in either hydrophilic (HILIC) mode, in which the mobile phase includes a high percentage of an organic solvent, or in reversed phase mode, in which the mobile phase contains a higher percentage of an aqueous solvent.Type: GrantFiled: May 25, 2007Date of Patent: July 7, 2009Assignee: Dionex CorporationInventors: Xiaodong Liu, Christopher A. Pohl, Jinhua Chen
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Publication number: 20090068534Abstract: A vinyl monomer is graft polymerized on an aromatic hydrocarbon-based polymer film substrate to introduce graft chains into the substrate and thereafter a functional monomer represented by the following formula and having sulfonic acid groups or functional groups capable of conversion to sulfonic acid groups is graft polymerized to introduce the sulfonic acid groups or the functional groups capable of conversion to sulfonic acid groups: where R is an aromatic ring or an aliphatic chain; X is (1) —OH, (2) —OLi, —ONa or —OK, (3) —F or —Cl, or (4) —OCnH2n+1 where n is an integer of 1 to 7. Since the graft chains obtained by graft polymerization of the vinyl monomer can also be utilized as scaffold polymers, the graft polymerizability of the functional monomer to the aromatic hydrocarbon-based polymer film substrate is sufficiently improved to enable the preparation of a polymer electrolyte membrane that excels not only in proton conductivity and mechanical strength but also in dimensional stability.Type: ApplicationFiled: August 22, 2008Publication date: March 12, 2009Applicant: JAPAN ATOMIC ENERGY AGENCYInventors: Jinhua Chen, Yasunari Maekawa, Masaharu Asano, Masaru Yoshida
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Publication number: 20080312350Abstract: An aromatic polymer film substrate, or a grafted aromatic polymer film substrate having a monomer introduced therein as graft chains is irradiated with ionizing radiation to impart a crosslinked structure. The aromatic polymer film substrate or the grafted aromatic polymer film substrate, provided with the crosslinked structure, is directly sulfonated to obtain a crosslinked aromatic polymer electrolyte membrane. The crosslinked aromatic polymer electrolyte membrane has low water uptake, high proton conductivity, low methanol permeability, high chemical stability, and excellent mechanical characteristics. A method for producing the crosslinked aromatic polymer electrolyte membrane is also provided.Type: ApplicationFiled: January 31, 2008Publication date: December 18, 2008Applicant: JAPAN ATOMIC ENERGY AGENCYInventors: Jinhua Chen, Yasunari Maekawa, Masaharu Asano, Masaru Yoshida
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Publication number: 20080293959Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC). The compositions include a substrate (e.g., silica gel), covalently bound to a compound, which includes both a hydrophobic moiety and a hydrophilic moiety, which is preferably a 1,2-diol moiety. The hydrophobic moiety is sufficiently hydrophobic for the compositions to exhibit reversed phase characteristics and typically incorporates at least 5 carbon atoms in sequence. Based on having both hydrophilic and hydrophobic functionalities, the new stationary phases exhibit unique chromatographic properties. For example, these media can be used in either hydrophilic (HILIC) mode, in which the mobile phase includes a high percentage of an organic solvent, or in reversed phase mode, in which the mobile phase contains a higher percentage of an aqueous solvent.Type: ApplicationFiled: May 25, 2007Publication date: November 27, 2008Applicant: Dionex CorporationInventors: Xiaodong Liu, Christopher A. Pohl, Jinhua Chen
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Publication number: 20080293721Abstract: The present invention provides compounds having the general structure I, or a pharmaceutically acceptable salt thereof: wherein Z is selected from a group consisting of O, C, N, and S; each of Ar1, Ar2, and Ar3 is a moiety selected from a group consisting of an aryl and a substituted aryl; Y is selected from a group consisting of S, O, CH2 and SO2; K is selected from a group consisting CH2, CF2, O, NH, and SO2; each of n1 and n2 is an integer selected from a group consisting of 0, 1, 2, 3, and 4; and each of x, y, m1 and m2 is an integer selected from a group consisting of 0 and 1. Pharmaceutical compositions based on compounds I are also provided for treatment of a neurological disorders, diseases, or pathologies, and for treatment of infectious diseases.Type: ApplicationFiled: April 30, 2008Publication date: November 27, 2008Applicant: Burnham Institute for Medical ResearchInventors: Maurizio Pellecchia, Jinhua Chen, Ziming Zhang
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Patent number: 7165196Abstract: A test system and method for testing a serializer/de-serializer system. The system includes a pair of serializer/de-serializers each having a serial data receive port and a serial data transmit port. The serializer/de-serializers are adapted to be placed in a loop-back mode in response to a loop-back signal to pass data fed to the serial data receive port to the serial data transmit port. A backplane connects the serial data transmit port of one serializer/de-serializer to the serial data receive port of a second one of the serializer/de-serializers. A tester passes data to the first serial data receive port and receives data from the data transmit port of the second one of the serializer/de-serializers with both serializer/de-serializes placed in the loop-back mode.Type: GrantFiled: September 3, 2004Date of Patent: January 16, 2007Assignee: EMC CorporationInventors: Ofer Porat, Jinhua Chen, Marlon Ramroopsingh, Alexander Rabinovich
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Patent number: 7033541Abstract: The present invention relates to compounds and more particularly to compounds which are useful for the determination of bicarbonate and the delivery of bicarbonate to a non-aqueous solution. The invention further relates to an optical sensor for the determination of bicarbonate in a liquid sample.Type: GrantFiled: March 25, 2003Date of Patent: April 25, 2006Inventors: Thomas W. Bell, Jinhua Chen, Alisher B. Khasanov