Patents by Inventor Joachim Klein
Joachim Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090205186Abstract: A method for separating a bearing channel of a housing by cracking. The bearing covers of the bearing channel are separated from the housing by cracking by means of a cracking mandrel. The steps include clamping the housing at the top thereof so that the bearing channel is downwardly oriented, i.e., towards a supporting or clamping surface of the housing and supporting the bearing cover during separation by cracking by means of a counter bracket.Type: ApplicationFiled: January 27, 2006Publication date: August 20, 2009Inventors: Siegfried Gruhler, Joachim Klein, Bernhard Wössner
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Publication number: 20080305526Abstract: New vectors expressible in a host comprising the promoter region of the melibiose operon operably linked to a transcriptional unit that includes nucleic acid sequence which is heterologous to the host. The expression of the nucleic acid sequence is controlled by the promoter region of the melibiose operon. The new vector can be used for the regulated heterologous expression of a nucleic acid sequence in a prokaryotic host. There is an isolated and purified nucleic acid sequence expressible in a host comprising the promoter region of the melibiose operon operably linked to a transcriptional unit that includes a nucleic acid sequence which is heterologous to the host. The expression of the nucleic acid sequence is controlled by the promoter region of the melibiose operon. A prokaryotic host is transformed with the vector or the isolated and purified nucleic acid sequence. There is a method for producing a polypeptide in a host using the vector.Type: ApplicationFiled: December 5, 2005Publication date: December 11, 2008Inventors: Johann Brass, Joachim Klein, Ralf Ostendorp
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Publication number: 20080206817Abstract: Vectors expressible in a host that is the rhaBAD promoter region of the L-rhamnose operon operably linked to a transcriptional unit that is: a) a nucleic acid sequence which is heterologouse to the host, and b) a prokaryotic signal sequence operably linked to the nucleic acid sequence. The prokaryotic signal sequence is selected from signal peptides of periplasmatic binding proteins for sugars, amino acids, vitamins and ions. The expression of the nucleic acid sequence is controlled by the promoter region. The vector is used for the regulated heterologous expression of a nucleic acid sequence in a prokaryotic host. This is an isolated and purified nucleic acid sequence expressible in a host is the promoter region of the L-rhamnose operon. There is a method for producing a polypeptide in a host using the vector.Type: ApplicationFiled: December 5, 2005Publication date: August 28, 2008Inventors: Johann Brass, Christoph Kiziak, Joachim Klein, Ralf Ostendorp
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Patent number: 6152684Abstract: A process for operating a hydraulic machine, especially a hydro-turbine, includes the step of detecting an actual machine state during operation of the machine by ascertaining operating data. The ascertained operating data includes flow through the turbine (if present), effective and reactive power fed into the electric mains, guide vane opening, pressure before the machine and at the suction pipe exit, headwater level, and tailwater level. The method further includes the step of processing at least one state characteristic values of a first cavitation characteristic value (indicative of cavitation intensity), a second cavitation characteristic value (indicative of an abrupt rise in cavitation manifestations), vibration characteristic values, suction pipe pressure, sand concentration, air pressure, water temperature, and generator temperature (for example winding temperature).Type: GrantFiled: April 21, 1998Date of Patent: November 28, 2000Assignee: Voith Hydro, Inc.Inventors: Jean-Marc Ferme, Joachim Klein, Eberhard Kopf
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Patent number: 6119507Abstract: A helium supply unit (1) supplies helium from a high pressure storage (21) to fill a test chamber (6) which encloses a sample holder (5) to be examined for leaks by measuring device (2) including a mass spectrometer (3) and a control unit (4). The test gas is recovered after the testing by a pressure difference between a low pressure storage (18) and the test chamber (6). The test chamber is evacuated prior to receipt of the test gas by a vacuum pump (27) and after testing by a vacuum pump (34) for more complete helium recovery. The recovered test gas is then transmitted back to the high pressure storage (21) through a compressor (19), which raises the pressure of the recovered gas to a predetermined pressure, from the low pressure storage (18). The control unit (4) also controls a pure test gas supply (37) and a release valve (44).Type: GrantFiled: January 13, 1999Date of Patent: September 19, 2000Assignee: Leybold Vakuum GmbHInventors: Rudolf Flosbach, Joachim Klein, Markus Nothhelfer
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Patent number: 5588809Abstract: Metering pumps for the metered feed of liquids are fitted with an intake valve built into an intake line from an intake container, a pump chamber downstream of it with a pumping component altering its displacement volume, a pressure valve leading to the metering connector and a vent and by-pass valve built into a return line leading to the intake container. In order to keep the quality of by-passed metering liquid as small as possible while maintaining adequate venting, there is valve chamber between the pressure valve and the pump chamber and separated from the latter by a return valve and a movable control wall, in which is incorporated the vent controlled by the control wall, opening on the suction stroke of the pumping component and closing on its delivery stroke. .There is also preferably in the valve chamber a prestressed displacement wall altering the volume of the valve chamber in the opposite direction to that of the control wall.Type: GrantFiled: August 7, 1995Date of Patent: December 31, 1996Assignee: Lang Apparatebau GmbHInventors: Joachim Klein, Herbert Hunklinger
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Patent number: 5492449Abstract: A piston diaphragm pump operable for delivering doses of liquids such as surfactants, or wetting agents, for example, includes a pump piston that is reciprocally moveable within a pump tube that encloses a pump pressure chamber. The pump piston is electromagnetically driven against the force of a return spring by a magnetic coil that surrounds the pump tube. In addition, a pump diaphragm is rigidly clamped about an inner circumference to a portion of an upper end of the pump piston. The outer circumference of the pump diaphragm is rigidly clamped about its periphery between upper and middle housing sections. One side of the diaphragm faces a suction chamber, and the other side faces a pressure chamber. A longitudinal bore, that encloses a pump piston provided with a piston valve, extends centrally through the pump diaphragm and links the pressure chamber to the suction chamber.Type: GrantFiled: May 11, 1994Date of Patent: February 20, 1996Assignee: Lang Apparatebau Gesellschaft mit beschraenkter HaftungInventors: Herbert Hunklinger, Joachim Klein
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Patent number: 5480790Abstract: A water-soluble protein conjugate modified by saccharides is covalently bound to a carbohydrate backbone via a saccharide group. Such protein conjugates modified by saccharides can be produced in a simple way by polymerizing a vinylsaccharide and conjugating in a known way the poly(vinylsaccharide) obtained in this way with the protein, which is preferably an enzyme. The protein conjugates according to the present invention are stable over long time periods at a high enzymatic activity and also in aqueous solution and are thus particularly suitable for use in test kits.Type: GrantFiled: April 4, 1991Date of Patent: January 2, 1996Assignees: Boehringer Mannheim GmbH, Gesellschaft fur Biotechnologische Forschung mbHInventors: Wilhelm Tischer, Joachim Klein, Rolf-Joachim Muller, Stephan Engelke
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Patent number: 5266608Abstract: Novel non-elastomeric biomedical adhesive compositions for calcified tissues, are described. The compositions are characterized by a network structure which is obtained by the reaction of a polyisocyanate having at least two isocyanate groups with at least one polyol which possesses surface wetting properties with the participation of compounds selected from calcium and phosphorus, optional in the presence of a catalyst. The polyisocyanate is selected from aliphatic, alicyclic and aromatic compounds and preferred amounts are in the range of 20% to 80% by weight of the total amount of reactants. The polyol is selected from polyalkylene ether glycols and polyester glycols containing between 25 to 75 carbon atoms and preferred amounts are in the range of 10% to 80% by weight of the total amount of reactants. The adhesive compositions were found to produce a fast bonding of the calcified tissues, with a joint strength of above 0.5 N/sq.mm.Type: GrantFiled: June 27, 1991Date of Patent: November 30, 1993Assignees: Technion Research & Dev't Foundation, Ltd., GBF Gesellschaft fur Biotechnologische ForschungInventors: Dov Katz, Esther Brandeis, Joachim Klein
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Patent number: 4869873Abstract: The measuring probe is equipped with a pellistor and renders possible directly determining in a trouble-free manner volatile constituents which are contained in a liquid medium to be investigated and which can be chemically converted with an accompanying heat effect. Heating devices are provided and, due to the prevention of condensate formation, greatly contribute to obtaining high measuring precision. The response time of the measuring probe can also be significantly reduced by heating a membrane which separates a measuring space containing the pellistor from the liquid medium to be investigated. The measuring probe can be used with advantage for monitoring microbiological processes, for example, in a fermenter.Type: GrantFiled: August 2, 1987Date of Patent: September 26, 1989Assignee: Dr. W. Ingold AGInventors: Joachim Klein, Klaus-Dieter Vorlop, Jurgen W. Becke
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Patent number: 4843154Abstract: According to the present invention, in the first instance, new aminopolyols, which can be obtained from the disaccharides isomaltose, isomaltulose and .alpha.-D-glucopyranosyl (1.fwdarw.1)-D-fructose, are prepared. These compounds, designated as isomaltamines and having the formulae: ##STR1## as well as mixtures of the same, are produced by the reductive amination of the aforementioned saccharides by means of ammonia or hydrazine compounds in the presence of catalysts, such as Raney nickel, and hydrogen, or by means of complex metallic hydrides, such as sodium borohydride, in solution or suspension. The invention relates, furthermore, to the N-acyl derivatives of the individual isomaltamines or their mixtures as well as to the production of the N-acylates by a selective N-acylation. Depending upon the nature of the acyl radical, these acylates can be used for example, as surfactants or (similarly to N-acrylamide) for the production of polymers.Type: GrantFiled: July 31, 1987Date of Patent: June 27, 1989Assignee: Sueddeutsche Zucker-AktiengesellschaftInventors: Joachim Klein, Wolfgang Behrens, Markwart Kunz
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Patent number: 4639423Abstract: An apparatus for the production of biocatalyst beads comprises an immobilization vessel (10) which is provided at its lower end with discharge pipes (23) which extend through a pressure chamber (25) in which a gas pressure prevails. The pressure chamber (25) is terminated by a plate (24) exhibiting holes which coaxially surround the discharge pipes (23). At the lower end of the immobilization vessel (10) is provided a connecting nozzle (30) which is connected in germproof sealing manner to the wall of a collecting vessel (11) which contains a solution of a cross-linking agent or a reprecipitation bath. The collecting vessel (11) may be constructed as a fermenter and provided with an agitator. Both of the vessels may be jointly sterilized.Type: GrantFiled: November 1, 1984Date of Patent: January 27, 1987Assignee: Intermedicat GmbHInventors: Wolfgang Kahlert, Joachim Klein, Hans-Jurgen Steinert, Claus Vorlop
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Patent number: 4522952Abstract: The present invention relates to a process for preparation of a highly fluorinated polymer by converting a polymer containing the recurring unit R--S'--X.sub.m, in which R denotes a base unit forming the matrix, X denotes identical or different functional groups, with the exception of halogen, and S' is an aromatic or araliphatic radical with m+1 free valencies, m being at least 1, into a highly fluorinated polymer by fluorination with elementary fluorine. The process is particularly useful for the preparation of cation exchangers, such as those which contain the unit ##STR1## in which C.sub.6 F.sub.10 represents a perfluorinated cyclohexyl ring.Type: GrantFiled: November 8, 1983Date of Patent: June 11, 1985Assignee: Hoechst AktiengesellschaftInventors: Joachim Klein, Hartmut Widdecke, Frank Doscher, Fritz Pohl
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Patent number: 4334027Abstract: Immobilized enzymatically-active substance is prepared by forming a combination of an enzymatically-active substance and an aqueous polyelectrolyte solution containing a substantial amount of alginate, adding the combination to an aqueous precipitation both containing a source of multivalent ion to form beads of gel containing the enzymatically-active substance, drying the gel beads under controlled conditions to significantly reduce the diameter of the beads and cause hardening of the beads to provide increased mechanical strength, and adding the dried beads to a precipitation both containing a multivalent ion to effect further hardening of the beads. The combination of enzymatically active substance and polyelectrolyte solution may contain an epoxy prepolymer. After further hardening in the polyelectrolyte solution, the beads may be suspended in a buffer solution to dissolve the polyelectrolyte and form porous beads.Type: GrantFiled: February 25, 1980Date of Patent: June 8, 1982Inventors: Joachim Klein, Fritz Wagner
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Patent number: 4118127Abstract: A web of paper or foil to be investigated is optically scanned line by line transversely to its direction of movement by a stationary scanning device and read off in reflection. The length of scanning line is greater than or equal to the width of the web of material under investigation. At least one time mark is formed electronically within a scanning line, which mark, starting from one end of the scanning range, is shifted forwards by a constant step with each scanning movement until the other end of the scanning range has been reached. The instantaneous value of reflected signal appearing in each case at the time mark is then averaged out over a cycle consisting of several scanning movements. A fault is only indicated if there is a deviation from the average value.Type: GrantFiled: March 14, 1977Date of Patent: October 3, 1978Assignee: AGFA-Gevaert AktiengesellschaftInventors: Hans-Joachim Klein, Manfred Rupprecht, Heinz Wonneberg, Julius Geiger, Gunter Masa
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Patent number: 4095904Abstract: The device is based on an optical transmission arrangement in which a signal change occurs when a foreign body is present in the liquid. By means of a rotating device the cylindrical container to be tested is set in rotation and subsequently braked. Then optical testing is carried out. The light beams passing through the container are picked up by a plurality of photo electric detectors arranged above one another. The photodetectors are divided into groups, which are each switched on sequentially be a programme control unit from top to bottom to effect the measurement, with one photodector group being switched on when the vortex of liquid occurring as a result of the container rotation has subsided after the standstill of the container and disappeared from the field of view of the photodector group.Type: GrantFiled: May 19, 1976Date of Patent: June 20, 1978Assignee: Bayer AktiengesellschaftInventors: Hans Joachim Klein, Fritz Henze, Bernhard Vinzelberg, deceased, by Susanne Klein nee Vinzelberg, heir
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Patent number: 3972624Abstract: In a process for detecting longitudinally orientated faults on moving webs of paper or film, the web is optically scanned line by line transversely to its direction of movement and read by reflection. The scanning line is moved to and fro across the whole web at constant velocity and during a given number of scanning movements the instantaneous value of the reflected signal is interrogated at two fixed time marks within the scanning line and stored and the average values over a scanning cycle are formed separately for each of the two time marks. The average values ae indicated and recorded as faults only if a value different from the average noise value is obtained from both time marks in succession.Type: GrantFiled: December 11, 1974Date of Patent: August 3, 1976Assignee: AGFA-Gevaert, A.G.Inventors: Hans Joachim Klein, Manfred Rupprecht, Heinz Wonneberg, Julius Geiger