Patents by Inventor Johannes Ludescher

Johannes Ludescher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline beta-lactam intermediate
    Publication number: 20020065262
    Abstract: Crystalline 7-[2-(2-formylaminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-methoxymethyl-3-cephem-4-carboxylic acid-1-(isopropoxycarbonyloxy)ethyl ester and its use.
    Type: Application
    Filed: October 31, 2001
    Publication date: May 30, 2002
    Inventors: Julia Greil, Johannes Ludescher, Klaus Totschnig, Siegfried Wolf
  • Crystalline amine salt of cefdinir
    Patent number: 6350869
    Abstract: Cefdinir in the form of a salt with dicyclohexylamine, a process for its production and its use in the purification of impure cefdinir.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: February 26, 2002
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Hubert Sturm, Siegfried Wolf, Johannes Ludescher
  • Process for the purification of a 3-cephem-4-carboxylic acid derivative
    Patent number: 6333409
    Abstract: The invention relates to a new process for the depletion of 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-[(Z)-1-propen-1-yl]-3-cephem-4-carboxylic acid and 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-[(z/E)-1-propen-1-yl]-3-cephem-4-carboxylic acid or by adsorption chromatography.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: December 25, 2001
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Bernhard Prager, Siegfried Wolf
  • Purification process
    Publication number: 20010044533
    Abstract: Processes for the depletion of 7-ADCA in mixtures of vinyl-ACA with 7-ADCA via novel salts of vinyl-ACA or via chromatography.
    Type: Application
    Filed: June 13, 2001
    Publication date: November 22, 2001
    Inventors: Johannes Ludescher, Werner Veit
  • Purification process
    Patent number: 6313289
    Abstract: Crystalline 2-(amninothiazol-4-yl)-2-(tert.butoxycarbonylmethoxyimino)acetic acid-S-mercapto-benzo-thiazolylester in form of an N,N-dimethylacetamide solvate; a crystalline salt of a 7-[2-(aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid with an amine of formula N(R1)(R2)(R3), wherein R1, R2, and R3 have various meanings, a crystalline sulphuric acid addition salt of a 7-[2-(2-aminothiazol-4-yl)-2-carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid; and the use of these salts in the production of cefixime, e.g. in form of a trihydrate.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: November 6, 2001
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Ludwig Miller, Hubert Sturm, Werner Veit, Martin Decristoforo, Siegfried Wolf
  • Purification process
    Publication number: 20010037019
    Abstract: Processes for the depletion of 7-ADCA in mixtures of vinyl-ACA with 7-ADCA via novel salts of vinyl-ACA or via chromatography.
    Type: Application
    Filed: May 25, 2001
    Publication date: November 1, 2001
    Inventors: Johannes Ludescher, Werner Veit
  • Vinyl-ACA purification process
    Patent number: 6284888
    Abstract: A process for purification of vinyl-ACA of formula from a mixture of vinyl-ACA and 7-ADCA of formula is provided. The process comprises a) producing a mixture of a salt of vinyl-ACA and a salt of 7-ADCA in a solvent in which the salt of 7-ADCA has a higher solubility than the salt of vinyl-ACA, and b) subjecting the mixture to crystallization to obtain a precipitate of the salt of vinyl-ACA. A process of purifying vinyl-ACA from a mixture of vinyl-ACA and 7-ADCA via chromatography, particularly adsorption chromatography is also provided.
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: September 4, 2001
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Werner Veit
  • Separation of cephalosporin isomers
    Publication number: 20010016581
    Abstract: Process of depleting 7-amino-3-[(E)-2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid in Z/E mixtures of 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid
    Type: Application
    Filed: January 23, 2001
    Publication date: August 23, 2001
    Inventors: Johannes Ludescher, Harald Summer, Siegfried Wolf
  • Process for the production of 3-vinyl cephalosporins
    Publication number: 20010007029
    Abstract: A process for the production of 3-vinylcephalosporin compounds of formula 1
    Type: Application
    Filed: February 23, 2001
    Publication date: July 5, 2001
    Inventors: Josef Wieser, Gerd Ascher, Johannes Ludescher, Herbert Sturm
  • Intermediates and process for the production of 3-vinyl cephalosporins
    Patent number: 6248881
    Abstract: A process for the production of a 3-vinylcephalosporin compound of formula I wherein R1 and R2 may be the same or different and denote hydrogen or an organic radical, which comprises subjecting a 3-iodomethyl-cephalosporin to a Wittig reaction in the presence of a weak base.
    Type: Grant
    Filed: March 31, 1997
    Date of Patent: June 19, 2001
    Assignee: Biochemie GmbH
    Inventors: Josef Wieser, Gerd Ascher, Johannes Ludescher, Herbert Sturm
  • Separation of cephalosporin isomers
    Patent number: 6235897
    Abstract: Process of depleting 7-amino-3-[(E)-2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid in Z/E mixtures of 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid a) by subjecting an amine salt of a Z/E mixture of 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid to crystallization and converting this amine salt into 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid, or b) by subjecting the Z/E mixture to chromatography.
    Type: Grant
    Filed: March 25, 1997
    Date of Patent: May 22, 2001
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Harald Summer, Siegfried Wolf
  • Process for the production of cephalosporines
    Patent number: 6169180
    Abstract: The invention relates to a new economical and simple process, using a new intermediate compound, for the production of 3′-substituted 7-amino-3-propenyl-4-cephem-carboxylic acid derivatives of formula wherein R is hydrogen, a negative charge or a silyl protecting group, Ro is hydrogen or methoxy, R1 is hydrogen or a silyl protecting group and X is the radical of a nucleophile, and their acid addition salts.
    Type: Grant
    Filed: October 8, 1997
    Date of Patent: January 2, 2001
    Assignee: Biochemie Gesellschaft
    Inventors: Johannes Ludescher, Hubert Sturm, Josef Wieser
  • Process for the purification of a 3-cephem-4-carboxylic acid derivative
    Patent number: 6136967
    Abstract: The invention relates to a new process for the depletion of 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-[(Z)-1-propen-1-yl]-3-cephem-4-carboxylic acid and 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-[(Z/E)-1-propen-1-yl]-3-cephem-4-carboxylic acid or by adsorption chromatography.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: October 24, 2000
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Bernhard Prager, Siegfried Wolf
  • Production of a crystalline salt of amoxicillin
    Patent number: 6103897
    Abstract: A process for the production of a crystalline salt of amoxicillin utilizing ethanol as a solvent, and crystallizing the salt of amoxicillin in the presence of a salifying compound.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: August 15, 2000
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Joan Cabre, Jose Diago, Asuncion Esteve, Johannes Ludescher
  • Cephalosporin compounds
    Patent number: 6093813
    Abstract: Cephalosporin derivatives of formula II ##STR1## wherein R.sup.a denotes hydrogen or a silyl group; R.sup.b denotes a group of formula --OR.sup.e, wherein R.sup.e denotes hydrogen or alkyl; and R.sup.c and R.sup.d together denote a bond; in free form or in salt form.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: July 25, 2000
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gerd Ascher, Johannes Ludescher, Hubert Sturm, Josef Wieser
  • Cephalosporin synthesis
    Patent number: 6063917
    Abstract: A process for the production of a compound of formula ##STR1## wherein R.sup.a denotes hydrogen or silyl;R.sup.b denotes a group of formula --OR.sup.e, whereinR.sup.e denotes hydrogen or alkyl; andR.sup.c and R.sup.d together denote a bond;in free form or in salt form,which process comprises the step of spitting, in the presence of ozone, the double bond in position 3 of the ring structure of a compound of formula III ##STR2## wherein R.sub.2 and R.sub.3 are the same or different and independently of each other denote hydrogen or an organic group, and X.sup.- denotes the anion of an inorganic or organic acid and optionally silylating the amine group in position 7 of the ring system.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: May 16, 2000
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gerd Ascher, Johannes Ludescher, Hubert Sturm, Josef Wieser
  • 3-imino-cephalosporins
    Patent number: 6034237
    Abstract: 3-Imino-cephalosporin derivatives of formula II ##STR1## wherein Y denotes alkyl, aryl or heterocyclyl; and R.sup.a and R.sup.d denote hydrogen or a silyl group; in free form or in salt form, and methods of preparation.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: March 7, 2000
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gerd Ascher, Johannes Ludescher, Hubert Sturm, Josef Wieser
  • Silylation process
    Patent number: 5998610
    Abstract: A process for the silylation of 6-aminopenicillanic acid or 7-amino-desacetoxy-cephalosporanic acid by silylation in certain carboxylic acid esters and its use in the production of 6-alpha-aminoacyl-penicillins and 7-alpha-aminoacyl-desacetoxy-cephalosporins.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: December 7, 1999
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Victor Centellas, Jose Diago, Johannes Ludescher
  • Process for the purification of a 3-cephem-4-carboxylic acid derivative
    Patent number: 5869648
    Abstract: The invention relates to a new process for the depletion of 7-amino-3-?(E)-1-propen-1-yl!-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-?(Z)-1-propen-1-yl!-3-cephem-4-carboxylic acid and 7-amino-3-?(E)-1-propen-1-yl!-3-cephem-4 carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-?(Z/E)-1-propen-1-yl!-3-cephem-4-carboxylic acid or by adsorption chromatography.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 9, 1999
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Bernhard Prager, Siegfried Wolf
  • Purification of a cephalosporin salt
    Patent number: 5861508
    Abstract: A p-toluenesulphonic acid salt of 7-?2-(2-aminothiazol-4-yl)-2-(Z)-hydroximino-acetamido!-3-N,N-dimethylcarb amoyloxymethyl-3-cephem-4-carboxylic acid (isopropoxycarbonyloxy)ethylester, e.g. of formula ##STR1## its use in the production of other salts and a pharmaceutical composition containing it.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: January 19, 1999
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Rainer Pucher, Siegfried Wolf