Patents by Inventor Johannes van den Boom

Johannes van den Boom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Processes for Non-Invasive Assessment of Genetic Variations
    Publication number: 20240161866
    Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations that make use of nucleic acid fragment length information.
    Type: Application
    Filed: September 1, 2023
    Publication date: May 16, 2024
    Applicant: SEQUENOM, INC.
    Inventors: Chen ZHAO, Cosmin DECIU, Dirk Johannes VAN DEN BOOM
  • Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions
    Patent number: 11827928
    Abstract: Provided herein are optimized methods for performing multiplexed detection of a plurality of sequence variations. Also provided are methods for performing multiplexed amplification of target nucleic acid.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: November 28, 2023
    Assignee: AGENA BIOSCIENCE, INC.
    Inventors: Martin Beaulieu, Dirk Johannes Van den Boom
  • Methods and processes for non-invasive assessment of genetic variations
    Patent number: 11783911
    Abstract: Methods for non-invasive assessment of genetic variations that make use of nucleic acid fragment length information, in particular length of fragments in circulating cell-free nucleic acids and compares the number of counts from fragments with different length.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: October 10, 2023
    Assignee: SEQUENOM, INC
    Inventors: Chen Zhao, Cosmin Deciu, Dirk Johannes Van Den Boom
  • METHODS FOR HIGH LEVEL MULTIPLEXED POLYMERASE CHAIN REACTIONS AND HOMOGENEOUS MASS EXTENSION REACTIONS
    Publication number: 20220106637
    Abstract: Provided herein are optimized methods for performing multiplexed detection of a plurality of sequence variations. Also provided are methods for performing multiplexed amplification of target nucleic acid.
    Type: Application
    Filed: August 6, 2021
    Publication date: April 7, 2022
    Inventors: Martin BEAULIEU, Dirk Johannes VAN DEN BOOM
  • Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions
    Patent number: 11111530
    Abstract: Provided herein are optimized methods for performing multiplexed detection of a plurality of sequence variations. Also provided are methods for performing multiplexed amplification of target nucleic acid.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: September 7, 2021
    Assignee: Agena Biosciences, Inc.
    Inventors: Martin Beaulieu, Dirk Johannes Van Den Boom
  • METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS
    Publication number: 20210238669
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Application
    Filed: April 9, 2021
    Publication date: August 5, 2021
    Inventors: Dirk Johannes VAN DEN BOOM, Charles R. CANTOR, Sung Kyun KIM, Zeljko DZAKULA, Cosmin DECIU
  • Methods and processes for non-invasive assessment of genetic variations
    Patent number: 11001884
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: May 11, 2021
    Assignee: Sequenom, Inc.
    Inventors: Dirk Johannes Van Den Boom, Charles R. Cantor, Sung Kyun Kim, Zeljko Dzakula, Cosmin Deciu
  • Radiation shielding device and apparatus comprising such shielding device
    Patent number: 10877384
    Abstract: An apparatus comprising a heat-sensitive device (F); a radiative element (RE), the radiative element in operation generating first electromagnetic radiation (ER), the first radiation propagating towards the heat-sensitive device; and a radiation-shielding device (20) arranged between the radiative element and the heat-sensitive device such that, in operation, the first radiation impinges on the radiation-shielding device. The radiation-shielding device comprises a first shield element (21) having a first fluid channel (215) arranged therein, the first shield element having a first surface (213) and a second surface (214), the first surface being arranged closer to the radiative element than the second surface; and a second shield element (22) having a second fluid channel (225) arranged therein, the second shield element having a third surface (223) and a fourth surface (224), the third surface being arranged closer to the radiative element than the fourth surface.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: December 29, 2020
    Assignee: ASML Netherlands B.V.
    Inventors: Franciscus Johannes Joseph Janssen, Philippe Jacqueline Johannes Hubertus Anthonius Habets, Güneş Nakiboğlu, Roger Wilhelmus Antonius Henricus Schmitz, Remco Van de Meerendonk, Joris Dominicus Bastiaan Johannes Van den Boom, Nicholas Peter Waterson
  • RADIATION SHIELDING DEVICE AND APPARATUS COMPRISING SUCH SHIELDING DEVICE
    Publication number: 20200401058
    Abstract: An apparatus comprising a heat-sensitive device (F); a radiative element (RE), the radiative element in operation generating first electromagnetic radiation (ER), the first radiation propagating towards the heat-sensitive device; and a radiation-shielding device (20) arranged between the radiative element and the heat-sensitive device such that, in operation, the first radiation impinges on the radiation-shielding device. The radiation-shielding device comprises a first shield element (21) having a first fluid channel (215) arranged therein, the first shield element having a first surface (213) and a second surface (214), the first surface being arranged closer to the radiative element than the second surface; and a second shield element (22) having a second fluid channel (225) arranged therein, the second shield element having a third surface (223) and a fourth surface (224), the third surface being arranged closer to the radiative element than the fourth surface.
    Type: Application
    Filed: February 21, 2019
    Publication date: December 24, 2020
    Inventors: Franciscus Johannes Joseph Janssen, Philippe Jacqueline Johannes Hubertus Anthonius Habets, Günes Nakiboglu, Roger Wilhelmus Antonius Henricus Schmitz, Remco Van de Meerendonk, Joris Dominicus Bastiaan Johannes Van den Boom, Nicholas Peter Waterson
  • Products and processes for multiplex nucleic acid identification
    Patent number: 10604791
    Abstract: Provided herein are products and processes for detecting the presence or absence of multiple target nucleic acids. Certain methods include amplifying the target nucleic acids, or portion thereof; extending oligonucleotides that specifically hybridize to the amplicons, where the extended oligonucleotides include a capture agent; capturing the extended oligonucleotides to a solid phase via the capture agent; releasing the extended oligonucleotide by competition with a competitor; detecting the extended oligonucleotide, and thereby determining the presence or absence of each target nucleic acid by the presence or absence of the extended oligonucleotide.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: March 31, 2020
    Assignee: Agena Bioscience, Inc.
    Inventors: Christiane Honisch, Dirk Johannes Van Den Boom, Michael Mosko, Anders Nygren
  • METHODS FOR HIGH LEVEL MULTIPLEXED POLYMERASE CHAIN REACTIONS AND HOMOGENEOUS MASS EXTENSION REACTIONS
    Publication number: 20180245146
    Abstract: Provided herein are optimized methods for performing multiplexed detection of a plurality of sequence variations. Also provided are methods for performing multiplexed amplification of target nucleic acid.
    Type: Application
    Filed: January 5, 2018
    Publication date: August 30, 2018
    Inventors: Martin BEAULIEU, Dirk Johannes VAN DEN BOOM
  • Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions
    Patent number: 9896724
    Abstract: Provided herein are optimized methods for performing multiplexed detection of a plurality of sequence variations. Also provided are methods for performing multiplexed amplification of target nucleic acid.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: February 20, 2018
    Assignee: Agena Bioscience, Inc.
    Inventors: Martin Beaulieu, Dirk Johannes van den Boom
  • METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS
    Publication number: 20180030528
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Application
    Filed: July 11, 2017
    Publication date: February 1, 2018
    Inventors: Dirk Johannes VAN DEN BOOM, Charles R. CANTOR, Sung Kyun KIM, Zeljko DZAKULA, Cosmin DECIU
  • METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS
    Publication number: 20170351811
    Abstract: Methods for non-invasive assessment of genetic variations that make use of nucleic acid fragment length information, in particular length of fragments in circulating cell-free nucleic acids and compares the number of counts from fragments with different length.
    Type: Application
    Filed: July 29, 2015
    Publication date: December 7, 2017
    Inventors: Chen ZHAO, Cosmin DECIU, Dirk Johannes VAN DEN BOOM
  • METHODS FOR HIGH LEVEL MULTIPLEXED POLYMERASE CHAIN REACTIONS AND HOMOGENEOUS MASS EXTENSION REACTIONS
    Publication number: 20160102347
    Abstract: Provided herein are optimized methods for performing multiplexed detection of a plurality of sequence variations. Also provided are methods for performing multiplexed amplification of target nucleic acid.
    Type: Application
    Filed: May 22, 2015
    Publication date: April 14, 2016
    Inventors: Martin Beaulieu, Dirk Johannes van den Boom
  • METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS
    Publication number: 20160034640
    Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations that make use of nucleic acid fragment length information.
    Type: Application
    Filed: July 29, 2015
    Publication date: February 4, 2016
    Inventors: Chen ZHAO, Cosmin Deciu, Dirk Johannes Van Den Boom
  • Base specific cleavage of methylation-specific amplification products in combination with mass analysis
    Patent number: 9249456
    Abstract: Methods, combinations and kits are provided for identifying the methylation state of a target nucleic acid molecule, the methylation state of a nucleotide locus in a target nucleic acid molecule, or for identifying the locus of one or more methylated or unmethylated nucleotides in a target nucleic acid molecule. Methylation state identification is performed by treating a methylated target nucleic acid molecule with a reagent that modifies one or more nucleotides in the target nucleic acid molecule as a function of the methylation state of the target nucleic acid molecule, methylation specifically amplifying treated target nucleic acid molecule, fragmenting amplified products, and detecting one or more fragments to thereby identify the methylation state of a target nucleic acid molecule, the methylation state of a nucleotide locus in a target nucleic acid molecule, or the locus of one or more methylated or unmethylated nucleotides in a target nucleic acid molecule.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: February 2, 2016
    Assignee: AGENA BIOSCIENCE, INC.
    Inventors: Mathias Ehrich, Dirk Johannes Van Den Boom
  • Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions
    Patent number: 9068223
    Abstract: Provided herein are optimized methods for performing multiplexed detection of a plurality of sequence variations. Also provided are methods for performing multiplexed amplification of target nucleic acid.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: June 30, 2015
    Assignee: Agena Bioscience, Inc.
    Inventors: Martin Beaulieu, Dirk Johannes Van Den Boom
  • Detection and quantification of biomolecules using mass spectrometry
    Patent number: 9051608
    Abstract: The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5? to 3? nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry. This process is easily incorporated into a polymerase chain reaction (PCR) amplification assay. The method also includes embodiments directed to quantitative analysis of target nucleic acids.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: June 9, 2015
    Assignee: AGENA BIOSCIENCE, INC.
    Inventors: Dirk Johannes Van Den Boom, Paul Andrew Oeth, Payam Mahboubi
  • METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS
    Publication number: 20140242588
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Application
    Filed: October 5, 2012
    Publication date: August 28, 2014
    Applicant: SEQUENOM, INC
    Inventors: Dirk Johannes Van Den Boom, Charles R. Cantor, Sung Kyun Kim, Zeljko Dzakula, Cosmin Deciu