Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: Examples disclosed herein relate to a device that has a chassis that can transition from a factory security state to a production security state. A visible object can be removed from the outside of the chassis to trigger the change in state. A BMC can change the state from the factory security state to the production security state based on detection of a physical trigger. The factory security state includes an application programming interface (API) that is enabled and the production security state has the API disabled.

Abstract: Embodiments described herein include systems and methods for providing a management interface for controlling multiple households. The management interface may be provided as an application on a mobile device or as an Internet webpage. An example implementation involves a device displaying representations of: a plurality of households; an indication of a selected household; one or more zones within the selected household; and a representation of media being played by a selected zone of the one or more zones. While displaying the representations, the device receives, from a server, data indicating updated information associated with the plurality of households; and, in response, updates the graphical display to display at least an updated representation of media being played by the selected zone.

Abstract: The present invention relates to a combination treatment which comprises (a) at least one ERK inhibitor preferably Compound B as described herein, and (b) a c-RAF inhibitor or a pharmaceutically acceptable salt thereof, preferably Compound A, which may be combined into a single pharmaceutical composition or prepared for separate or sequential administration. It includes a c-RAF inhibitor and an ERK inhibitor prepared for simultaneous, separate or sequential administration for the treatment of a proliferative disease, particularly an advanced solid tumor that harbors a Mitogen-activated protein kinase (MAPK) alteration, and includes methods of using these compounds in combination as well as a commercial package comprising such combination.

Abstract: The present invention relates to anti-FGFR2 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: Embodiments described herein include systems and methods for providing a management interface for controlling multiple households. The management interface may be provided as an application on a mobile device or as an Internet webpage. An example implementation involves a device displaying representations of: a plurality of households; an indication of a selected household; one or more zones within the selected household; and a representation of media being played by a selected zone of the one or more zones. While displaying the representations, the device receives, from a server, data indicating updated information associated with the plurality of households; and, in response, updates the graphical display to display at least an updated representation of media being played by the selected zone.

Abstract: A technology is described for distributing a configuration file to network addressable devices. An example method may include receiving a configuration customization that is to be applied to the configuration settings of a non-configured network addressable device. A configuration file may be updated with the configuration customization. A request may be received to transmit the configuration file so that the configuration file may be applied to the configuration settings of the non-configured network addressable device.

Abstract: Systems and methods for facilitating reservations of shared desks, phone booths, and other spaces or areas within a workspace for members of the workspace are described. For example, a space reservation system receives a request to reserve a space for a member and selects a space suitable for the member based on one or more work environment characteristics associated with the space. The system also presents various interfaces for displaying available spaces and facilitating interactions between the member and the space.

Abstract: Embodiments described herein include systems and methods for providing a social interface for sharing media experience information between households in a community. Users of different households may form the community. The social interface may be provided as an application on a mobile device or an Internet webpage as a portal to the community. An example implementation involves a device displaying representations of: a plurality of households; an indication of a selected household; one or more zones within the selected household; and a representation of media being played by a selected zone of the one or more zones. While displaying the representations, the device receives, from a server, data indicating updated information associated with the plurality of households; and, in response, updates the graphical display to display at least an updated representation of media being played by the selected zone.

Abstract: In an embodiment, an apparatus for sensing soil characteristics comprises a circular wheel frame that is capable of rotation in an agricultural field; at least one first arcuate tread segment that is affixed to an outer rim of the wheel frame and constitutes a soil contacting bearing surface when the apparatus is in contact with soil; at least one recess in the outer rim of the wheel frame; a circuit board within the wheel frame and having at least a first receptacle that is radially aligned with the at least one recesses; at least one removable sensor comprising one or more first sensing elements, a first plug that mates to the first receptacle of the circuit board, and a second arcuate tread segment and configured to mount in the at least one recess with the second arcuate tread segment aligned with the first arcuate tread segment to form a continuous tread; a power supply coupled to the at least one removable sensor through the connector; means coupled to the power supply for wirelessly transmitting data o

Abstract: The present disclosure provides an HVAC system for a vehicle having a first heat source and having a primary loop through which a coolant circulates and a secondary loop through which refrigerant circulates. The primary loop having two parallel sub-loops, namely a first sub-loop and a second sub-loop in which the coolant may circulate. The first sub-loop of the primary loop includes the first heat source, a second heat source, and a first heat exchanger. The first sub-loop may partially extend into a case of the HVAC system to place the first heat exchanger adjacent an air heater. The second sub-loop of the primary loop includes the first heat source, the second heat source, and a second heat exchanger. The HVAC system having a plurality of operation modes for efficiently conditioning air in a cabin of the vehicle.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for aggregating requests for resources. In one aspect, a method includes receiving a set of requests for computing resources. Each request specifies one or more computing resources and, for each of the one or more computing resources, a quantity of the computing resource requested. A quantity-based provider condition that a request must meet for inclusion in an allocation process is identified. Each received request that fails to meet the quantity-based provider condition is included in a proper subset. Requests in the proper subset of requests are grouped into one or more groups based at least on the quantity of the one or more resources specified by each request of the proper subset and the quantity-based provider condition. A respective combined request is generated for each group of requests.

Abstract: A thermal management system for a vehicle includes an enclosure containing an air-handling unit, a first circuit, a second circuit, and a control interface module. The air-handling unit includes a housing and a variable speed blower configured to provide a flow of air through the housing. The first circuit includes a compressor, a condenser in thermal communication with the air-handling unit, a receiver-drier, an expansion valve, and a chiller, in series. The second circuit includes a first loop including the chiller of the first circuit, a second loop including a radiator in thermal communication with the air-handling unit, and a third loop including a heater. The control interface module is configured to control each of the air-handling unit, the first circuit, and the second circuit.

Abstract: An antenna with adjustable tilt angle includes: a mounting structure; an antenna mount fixed to the mounting structure; an antenna mounted to the antenna mount, the antenna configured to produce an antenna beam; a remote electrical tilt (RET) unit operatively associated with the antenna to adjust a pointing tilt angle of the antenna beam; a tilt pointing direction sensor mounted to the antenna, the pointing direction tilt sensor configured to detect the a pointing angle of the antenna relative to a baseline standard; and a controller operatively connected with the RET unit and the pointing direction tilt sensor, the controller configured to receive signals from the pointing direction tilt sensor and transmit signals to the RET unit to adjust the tilt pointing angle of the antenna beam based on the detected angle of the antenna.

Abstract: The present invention relates to anti-CDH6 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: Embodiments described herein include systems and methods for providing a social interface for sharing media experience information between households in a community. Users of different households may form the community. The social interface may be provided as an application on a mobile device or an Internet webpage as a portal to the community. An example implementation involves a device displaying representations of: a plurality of households; an indication of a selected household; one or more zones within the selected household; and a representation of media being played by a selected zone of the one or more zones. While displaying the representations, the device receives, from a server, data indicating updated information associated with the plurality of households; and, in response, updates the graphical display to display at least an updated representation of media being played by the selected zone.

Abstract: The present disclosure provides an HVAC system for a vehicle having a first heat source and comprising a primary loop through which a coolant circulates and a secondary loop through which refrigerant circulates. The primary loop having two parallel sub-loops, namely a first sub-loop and a second sub-loop in which the coolant may circulate. The first sub-loop of the primary loop includes the first heat source, a second heat source, and a first heat exchanger. The first sub-loop may partially extend into a case of the HVAC system to place the first heat exchanger adjacent an air heater. The second sub-loop of the primary loop includes the first heat source, the second heat source, and a second heat exchanger. The HVAC system having a plurality of operation modes for efficiently conditioning air in a cabin of the vehicle.

Abstract: Embodiments described herein include systems and methods for providing a social interface for sharing media experience information between households in a community. Users of different households may form the community. The social interface may be provided as an application on a mobile device or an Internet webpage as a portal to the community. An example implementation involves a device displaying representations of: a plurality of households; an indication of a selected household; one or more zones within the selected household; and a representation of media being played by a selected zone of the one or more zones. While displaying the representations, the device receives, from a server, data indicating updated information associated with the plurality of households; and, in response, updates the graphical display to display at least an updated representation of media being played by the selected zone.

Abstract: A marking assembly includes a hollow cannula having a wall extending from a proximal end to a distal end. The wall defines a lumen of the cannula. The wall includes at least one opening at a distal portion of the cannula. A stylet is configured to be received in the lumen of the cannula. The stylet has a wall extending from a proximal end to a distal end. When the stylet is received in the lumen of the cannula, a circumferential space is defined between the wall of the stylet and the wall of the cannula such that fluid entering the circumferential space will exit the cannula through the at least one opening of the cannula.

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.