Abstract: The present invention is to a novel process for the preparation of a compound of the formula: ##STR1## wherein p is 0, or 2;Ar is an optionally substituted phenyl or naphtyl; andinter alia R4 is an optionally susbtituted phenyl, naphth-1-yl, naphth-2-yl, or a heteroaryl ring;which process comprises reacting together an aldehyde of the formula:R.sub.4 --CHO;wherein R.sub.4 is as defined above;a compound of the formula:ArS(O)pH;wherein Ar, and p are as defined above;with formamide, an acid catalyst, and optionally a dehydrating agent.

Abstract: The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Methods for improving the tissue inductive activity of a morphogenic protein in a mammal using those compositions are provided. This invention also provides implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Methods for inducing local tissue formation from a progenitor cell in a mammal using those devices are also provided. A method for accelerating allograft repair in a mammal using morphogenic devices is provided.

Abstract: The present invention is directed to the novel intermediate compounds of the formula: ##STR1## wherein, interalia, R.sub.4 is a substituted phenyl or an optionally substituted napthyl derivative.

Abstract: This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.

Abstract: The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Methods for improving the tissue inductive activity of a morphogenic protein in a mammal using those compositions are provided. This invention also provides implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Methods for inducing local tissue formation from a progenitor cell in a mammal using those devices are also provided. A method for accelerating allograft repair in a mammal using morphogenic devices is provided.

Abstract: Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.

Abstract: The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Methods for improving the tissue inductive activity of a morphogenic protein in a mammal using those compositions are provided. This invention also provides implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Methods for inducing local tissue formation from a progenitor cell in a mammal using those devices are also provided. A method for accelerating allograft repair in a mammal using morphogenic devices is provided.

Abstract: The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Methods for improving the tissue inductive activity of a morphogenic protein in a mammal using those compositions are provided. This invention also provides implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Methods for inducing local tissue formation from a progenitor cell in a mammal using those devices are also provided. A method for accelerating allograft repair in a mammal using morphogenic devices is provided.

Abstract: This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.

Abstract: This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.

Abstract: As cytokine inhibitors 2,4,5-triarylimidazole compounds and compositions for use as cytokine inhibitors.

Abstract: Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.

Abstract: A system and method of remotely recording a telephone message at a selected recording device connected to a telephone receiver by an RF link may include a base station having an RF transmitter connected to a telephone receiver, and plural paging/recording devices, each with an RF receiver and a message recorder. The paging/recording devices may be contained within suitable children's toys. A caller calls the telephone receiver and when the telephone connection has been made provides a first code signal to the telephone receiver to gain access to the RF transmitter, and then provides a second code signal to identify a particular paging/recording device that is to receive and record the message.

Abstract: A system and method of remotely recording a telephone message at a selected recording device connected to a telephone receiver by an RF link may include a base station having an RF transmitter connected to a telephone receiver, and plural paging/recording devices, each with an RF receiver and a message recorder. The paging/recording devices may be contained within suitable children's toys, or within pager-like packages. A caller calls the telephone receiver and when the telephone connection has been made provides a first code signal to the telephone receiver to gain access to the RF transmitter, and then provides a second code signal to identify a particular paging/recording device that is to receive and record the message.

Abstract: A self-watering and self-drying planter assembly with a water reservoir open to the air and a top downward system for supplying water into the soil through built-in water-feeding channels, each having a water-transfer control lever for controlling the quantity of water supplied to the soil in the planter.The planter assembly automatically controls the amount of water and nutrients supplied to said plant by controlling the periods of water feeding and the intervening dry periods. There is an inner container assembly including an inner container for receiving a plant and soil, an outer container spaced from and surrounding the inner container and defining therebetween a water-receiving chamber, and a water-supplying chamber below for receiving water from said water-receiving chamber. A float assembly automatically supplies water from the water-receiving chamber to the water-supplying chamber in response to the water level in said water-supplying chamber.

Abstract: The invention relates to an apparatus of unitary construction to fine-finish gear teeth. The apparatus is a worm having first and second end portions and first and second outer surfaces. The first and second surfaces define a common tooth profile. The first end portion is adapted for grinding and the second end portion is adapted for finishing.

Abstract: A method of inhibiting the production of interleukin-1 by monocytes and/or macrophages in a human in need thereof which comprises administering to such a human an effective, interleukin-1 production inhibiting amount of a diaryl-substituted imidazole fused to a second heterocyclic ring containing a nitrogen bridgehead atom wherein said second ring may also contain sulfur, oxygen or an additional nitrogen atom, and may contain additional unsaturation.This invention relates to a method of inhibiting the production of Tumor Necrosis Factor (TNF) by monocytes or macrophages in a human in need thereof which comprises administering to such mammal an effective, TNF production inhibiting amount of a compound of Formula (I) as described herein. The compounds of Formula (II) are generally described as diaryl-substituted imidazole fused to a second heterocyclic ring containing a nitrogen bridgehead wherein said ring may also contain sulfur, oxygen, or an additional nitrogen atom, and may contain additional unsaturation.

Abstract: This new invention, the water column floating pump, is a fluid pump which uses a rotationally symmetric container to pump fluid from an inlet reservoir to the outlet end of the rotationally symmetric container. The rotationally symmetric container is adapted to float with its axis of rotation vertical in a pump flotation chamber. The rotationally symmetric container floats and rotates in the fluid being pumped and uses the buoyancy of the fluid to carry its weight. A plurality of helically spiralling conduits proximate the periphery of the symmetric container forms a system of vacuum suction tubes designed to suck water from the inlet reservoir, proximate the bottom of the fluid pump, to the outlet end proximate the top of the container. The rotationally symmetric container operates at low rotational speed and requires a small horsepower motor to overcome water friction and water pressure.

Abstract: A mantel device for storing and dispensing fuel for insert-type pellet stoves having a continuous feed hopper. A pellet stove mantel has a hopper inside the mantel. The mantel hopper is attachable to the continuous feed hopper of the pallet stove and provides hopper to hopper fuel feed. The mantel device has the appearance of a zero clearance fireplace including a flush mounted mantel, a pedestal lift attached to the main frame of the mantel and a hearth mat is fastened to the main frame of the mantel and the pedestal lift. The mantel hopper is located in the upper portion of the mantel and has a plurality of angled sides forming a funnel. The mantel also has a cap at the top with an opening covered by a lid which provides an access to the hopper.

Abstract: A method of inhibiting the 5-lipoxygenase pathway in an animal in need thereof which comprises administering an effective, 5-lipoxygenase pathway inhibiting amount of a diaryl-substituted imidazole fused to a thiazole pyrrolidine, thiazide or piperidine ring to such animal.