Patents by Inventor John D. Buehler
John D. Buehler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150150819Abstract: Compositions containing opioid antagonists are disclosed, particularly alvimopan and its active metabolite in solid dosage forms, where the drug is uniformly distributed, achieves the desired bioavailability, and is stable. Methods of preparing and using the compositions containing opioid antagonists are also disclosed. The results are achieved by a combination of processing techniques and component selection.Type: ApplicationFiled: February 12, 2015Publication date: June 4, 2015Inventor: John D. Buehler
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Publication number: 20140303211Abstract: Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.Type: ApplicationFiled: June 19, 2014Publication date: October 9, 2014Inventor: John D. Buehler
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Publication number: 20140057947Abstract: Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.Type: ApplicationFiled: November 1, 2013Publication date: February 27, 2014Applicant: Adolor CorporationInventor: John D. BUEHLER
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Publication number: 20140014611Abstract: An improved child-resistant closure for dispensers of liquid medicaments, the closure being of a two-part construction. The closure has an outer cap with a quantity of shoulder lugs and skirt lugs and an inner cap with a quantity of shoulder lugs and flexible beams. The closure has equal quantities of shoulder lugs on the inner and outer caps, equal quantities of skirt lugs and flexible beams, flexible beams having an arcuate underside, shoulder lugs having a depth to prevent hyper-flexion of the flexible beams, and an ideal overlap when the faces of the shoulder lugs are aligned. Additionally, provided are methods for attaching and removing the cap from a pre-existing bottle.Type: ApplicationFiled: July 12, 2013Publication date: January 16, 2014Inventors: John D. Buehler, John B. Daly, Kevin A. DiPlacido, Redd J. Harold, David T. Kershner, David A. Manera, Timothy K. Stangle, Russ Granato
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Patent number: 8598207Abstract: Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.Type: GrantFiled: May 22, 2012Date of Patent: December 3, 2013Assignee: Adolor CorporationInventor: John D. Buehler
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Patent number: 8517997Abstract: A dispenser assembly for liquid products is disclosed. Such an assembly may include an elongated barrel, and an elongated plunger having a flexible sealing lip disposed at an end thereof. The sealing lip may have an outer diameter in a relaxed state that is greater than an internal cross-sectional diameter of the barrel. When the plunger and barrel are actuated axially relative to one another, the sealing lip flexes inwardly and provides the sole contact between the plunger and the barrel.Type: GrantFiled: February 12, 2008Date of Patent: August 27, 2013Assignee: Comar, Inc.Inventors: David A. Manera, John D. Buehler
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Patent number: 8459312Abstract: An adapter to be pressed into the neck of a bottle to receive a syringe for accessing the bottle contents by a syringe. The adapter has a distal end that extends into the bottle and a normally closed valve located at that distal end to prevent the contents from leaking out of the bottle if the bottle is inverted. An upper flange of the adapter seats against the top of the bottle and is recessed into the top of the bottle to prevent easy access to pry the adapter out of the bottle. A cap is also disclosed that is adapted to be pressed into the neck of a bottle. The cap has an upper lid that is hinged to a lower body to allow the upper hinge to move between a closed position sealing the bottle and an open position where the bottle is accessible by a syringe.Type: GrantFiled: June 29, 2010Date of Patent: June 11, 2013Assignee: Comar, Inc.Inventors: David A. Manera, Victoria Moore O'Brien, Brian Myers, Daniel R. Hoffman, John D. Buehler
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Publication number: 20120232114Abstract: Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.Type: ApplicationFiled: May 22, 2012Publication date: September 13, 2012Applicant: Adolor CorporationInventor: John D. Buehler
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Publication number: 20100327010Abstract: An adapter to be pressed into the neck of a bottle to receive a syringe for accessing the bottle contents by a syringe. The adapter has a distal end that extends into the bottle and a normally closed valve located at that distal end to prevent the contents from leaking out of the bottle if the bottle is inverted. An upper flange of the adapter seats against the top of the bottle and is recessed into the top of the bottle to prevent easy access to pry the adapter out of the bottle. A cap is also disclosed that is adapted to be pressed into the neck of a bottle. The cap has an upper lid that is hinged to a lower body to allow the upper hinge to move between a closed position sealing the bottle and an open position where the bottle is accessible by a syringe.Type: ApplicationFiled: June 29, 2010Publication date: December 30, 2010Inventors: David A. Manera, Victoria Moore O'Brien, Brian Myers, Daniel R. Hoffman, John D. Buehler
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Publication number: 20100240690Abstract: Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.Type: ApplicationFiled: March 22, 2010Publication date: September 23, 2010Applicant: Adolor CorporationInventor: John D. Buehler
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Patent number: 7700626Abstract: Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.Type: GrantFiled: June 2, 2005Date of Patent: April 20, 2010Assignee: Adolor CorporationInventor: John D. Buehler
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Publication number: 20090062749Abstract: A dispenser assembly for liquid products is disclosed. Such an assembly may include an elongated barrel, and an elongated plunger having a flexible sealing lip disposed at an end thereof. The sealing lip may have an outer diameter in a relaxed state that is greater than an internal cross-sectional diameter of the barrel. When the plunger and barrel are actuated axially relative to one another, the sealing lip flexes inwardly and provides the sole contact between the plunger and the barrel.Type: ApplicationFiled: February 12, 2008Publication date: March 5, 2009Applicant: Comar, Inc.Inventors: David A. Manera, John D. Buehler
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Patent number: 7438552Abstract: A dispenser assembly for liquid products comprising an elongated, generally cylindrical barrel of a predetermined internal cross-sectional diameter having a discharge opening at one end and open at its opposite end, an elongated, generally cylindrical hollow plunger having an outer diameter less than the barrel internal diameter and a circumferentially extending axially directed sealing lip adjacent the tip portion having an outer diameter greater than the internal diameter of the barrel in the relaxed state to thereby flex the lip inwardly against its bias and providing the sole sliding contact between the plunger and barrel when the plunger and barrel are actuated axially relative to one another.Type: GrantFiled: January 10, 2006Date of Patent: October 21, 2008Assignee: Comar, Inc.Inventors: David A. Manera, John D. Buehler
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Patent number: 7070581Abstract: A dispenser assembly for liquid products comprising an elongated, generally cylindrical barrel of a predetermined internal cross-sectional diameter having a discharge opening at one end and open at its opposite end, an elongated, generally cylindrical hollow plunger having an outer diameter less than the barrel internal diameter and a circumferentially extending axially directed sealing lip adjacent the tip portion having an outer diameter greater than the internal diameter of the barrel in the relaxed state to thereby flex the lip inwardly against its bias and providing the sole sliding contact between the plunger and barrel when the plunger and barrel are actuated axially relative to one another.Type: GrantFiled: April 4, 2003Date of Patent: July 4, 2006Assignee: Comar, Inc.Inventors: David A. Manera, John D. Buehler
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Publication number: 20040040985Abstract: A container-closure assembly comprising a container having a body portion and a neck finish having external threads, a cap of cup-like form having a top and a skirt with internal threads to mate with the container threads for application and removal of the cap from the container, an elongated tubular dispensing member having a discharge opening at one end and mounting a bulbous member at the other end to draw liquid products in the container into the dispensing member, the body portion of the container having a downwardly dished bottom defining the lowest point at about the center of the bottom and means defining a series of circumferentially spaced protrusions projecting downwardly from the bottom wall defining support pads for supporting the container on a flat surface, the lowest point of the pads disposed in a common plane transverse to the longitudinal axis of the container and wherein the peak or apex of the slanted bottom wall is disposed above said common plane.Type: ApplicationFiled: June 9, 2003Publication date: March 4, 2004Inventors: Brian Michael Gatton, John D. Buehler
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Publication number: 20040007556Abstract: A container-closure assembly comprising a cap of cup-like form having a circumferentially expending skirt and a circumferentially extending flange depending from the top and spaced radially inwardly from the skirt and a series of radially inwardly directed circumferentially re-spaced lugs on the inner periphery of the skirt, the container having a neck portion with a discharge opening, the outer peripheral surface of the container being tapered upwardly and inwardly whereby the flexible flange engages the tapered surface when the cap is positioned over the container means defining a series of circumferentially re-spaced hook portions only on the container neck including a downwardly facing notched recess and a tapered face, said lugs position below a plain through the tip of the taper only hooks when the flexible flange lightly engages the tapered finish on the neck of the container.Type: ApplicationFiled: May 23, 2003Publication date: January 15, 2004Inventors: David A. Manera, John D. Buehler
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Publication number: 20040010238Abstract: A dispenser assembly for liquid products comprising an elongated, generally cylindrical barrel of a predetermined internal cross-sectional diameter having a discharge opening at one end and open at its opposite end, an elongated, generally cylindrical hollow plunger having an outer diameter less than the barrel internal diameter and a circumferentially extending axially directed sealing lip adjacent the tip portion having an outer diameter greater than the internal diameter of the barrel in the relaxed state to thereby flex the lip inwardly against its bias and providing the sole sliding contact between the plunger and barrel when the plunger and barrel are actuated axially relative to one another.Type: ApplicationFiled: April 4, 2003Publication date: January 15, 2004Inventors: David A. Manera, John D. Buehler
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Patent number: 6589484Abstract: The present invention provides a one-piece pipette/dropper assembly that includes a pipette portion, a threaded cap portion, and bulb portion. The cap potion has a top wall including a top and bottom surface and the bulb portion has a first end integrally formed with the top wall of the cap on the top surface. The pipette portion has a first end integrally formed with the top wall of the cap on the bottom surface thereof. The bulb potion communicates with the pipette potion through the first end of the pipette portion and the pipette portion has an opening in a second end for receiving and discharging a fluid.Type: GrantFiled: December 28, 2000Date of Patent: July 8, 2003Inventor: John D. Buehler
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Patent number: 6565543Abstract: A drop dispenser having a sleeve carrying a closure and resilient dosage receiving fitting. The sleeve is treadably mounted on a fluid containing container having a nipple thereon. The closure on the sleeve has a configuration corresponding to the configuration of the nipple for sealing the nipple in the closed position. The fitting is filled with fluid from the container by turning the sleeve in a direction away from the closed position on the nipple to an open position to thereby establish fluid communication between the container and fitting. The fluid is dispensed from the fitting by squeezing the fitting after the closure has been returned to the closed position on the nipple, thereby preventing fluid from flowing from the resilient fitting back into the container. Cooperating stop members are provided between the sleeve and bottle neck to limit the movement of the sleeve relative to the bottle neck.Type: GrantFiled: September 28, 2000Date of Patent: May 20, 2003Assignee: Comar, Inc.Inventor: John D. Buehler
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Patent number: 6555133Abstract: The present invention provides improved oral dosage form formulations of efavirenz that are useful in the inhibition of human immunodeficiency virus (HIV), the prevention or treatment of infection by HIV, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS). In particular, the present invention relates to compressed tablets or capsules comprising efavirenz that contain one or more disintegrants that enhance the dissolution rate of the efavirenz in the gastrointestinal tract thereby improving the rate and extent of absorption of efavirenz in the body. The present invention also relates to the process of making such tablets or capsules.Type: GrantFiled: April 2, 2001Date of Patent: April 29, 2003Assignee: Bristol-Myers Squibb CompanyInventors: William T. Makooi-Morehead, John D. Buehler, Brian R. Landmann