Abstract: A nasal spray system for dispensing medicaments and vaccines through nasal passages is described comprising three elements; a standard syringe, a disposable pre-filled nasal spray tip, and a disposable snap cap that protects the nasal spray tip from contamination. To dispense medicaments and vaccines, the disposable snap cap is removed and the syringe mated to the nasal spray tip. Upon insertion into a nasal passage, the syringe plunger is pushed forward dispensing the atomized liquid. The nasal spray tip is discarded and a new spray tip mated with the syringe for insertion into the other nasal passage.

Abstract: A dropper assembly comprising a pipette portion, having a proximate end and a distal end, the distal end of said pipette having an opening through which fluid is adapted to flow in the pipette pr9otion; a cap portion having a top wall, the proximate end of the said pipette portion being integrally formed with the top wall of said cap portion on one side thereof; a bulb portion having a flange at one end thereof, said cap portion having an annular wall extending axially outwardly from the opposite side of the top wall thereof, the flange of said bulb portion being positioned on said opposite side of said top wall, and said annular wall being swaged over the flange of said bulb portion, to thereby integrally connect said bulb portion to said cap portion.

Abstract: A limited pour neck finish bottle wherein a plurality of radially inwardly extending flexible fingers are integral with the peripheral edge portion of the open end of the neck of a bottle and extend across the open end of the neck to restrict or interfere with the flow of liquid from the bottle if an attempt is made to pour the liquid from the bottle rather than employing an exact dose dispensing device. The bottle is made by molding a plurality of axially extending flexible fingers on the peripheral edge portion at the open end of the neck simultaneously with the molding of the bottle, and then bending the fingers downwardly to the radially inwardly extending position.

Abstract: A one-piece pipette/dropper assembly comprising a pipette portion, a threaded cap portion, and a bulb portion, said cap portion having a top wall including a top surface and a bottom surface, said bulb portion having a first end integrally formed with the top wall of the cap on the upper surface thereof, said pipette portion having a first end integrally formed with the top wall of the cap on the lower surface thereof, said bulb portion communicating with said pipette portion through said first end and an opening in a second end on said pipette for receiving and discharging fluid.

Abstract: A limited pour neck finish bottle wherein a plurality of radially inwardly extending flexible fingers are integral with the peripheral edge portion of the open end of the neck of a bottle and extend across the open end of the neck to restrict or interfere with the flow of liquid from the bottle if an attempt is made to pour the liquid from the bottle rather than employing an exact dose dispensing device. The bottle is made by molding a plurality of axially extending flexible fingers on the peripheral edge portion at the open end of the neck simultaneously with the molding of the bottle, and then bending the fingers downwardly to the radially inwardly extending position.

Abstract: A dropper assembly comprising a pipette portion, having a proximate end and a distal end, the distal end of said pipette having an opening through which fluid is adapted to flow in the pipette pr9otion; a cap portion having a top wall, the proximate end of the said pipette portion being integrally formed with the top wall of said cap portion on one side thereof; a bulb portion having a flange at one end thereof, said cap portion having an annular wall extending axially outwardly from the opposite side of the top wall thereof, the flange of said bulb portion being positioned on said opposite side of said top wall, and said annular wall being swaged over the flange of said bulb portion, to thereby integrally connect said bulb portion to said cap portion.

Abstract: A dosage dispenser assembly for containers to dispense liquids in the containers. The assembly includes elongated hollow barrel and an arrangement for removably mounting the barrel over the discharge opening in the container so that the port in the barrel in the seated position is disposed adjacent the bottom of the container. A stop sleeve of generally tubular configuration engages internally of the barrel and has at least two key ways of different axial depth defining cam follower surfaces. A plunger engages in the barrel having a lug element and is rotatable relative to the stop sleeve between a position wherein the plunger tip is fully seated in the barrel and another position wherein the plunger may be activated axially to draw a predetermined dosage of liquid contents into the barrel.

Abstract: The present invention provides improved oral dosage form formulations of efavirenz that are useful in the inhibition of human immunodeficiency virus (HIV), the prevention or treatment of infection by HIV, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS). In particular, the present invention relates to compressed tablets or capsules comprising efavirenz that contain one or more disintegrants that enhance the dissolution rate of the efavirenz in the gastrointestinal tract thereby improving the rate and extent of absorption of efavirenz in the body. The present invention also relates to the process of making such tablets or capsules.

Abstract: The present invention provides improved oral dosage form formulations of efavirenz that are useful in the inhibition of human immunodeficiency virus (HIV), the prevention or treatment of infection by HIV, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS). In particular, the present invention relates to compressed tablets or capsules comprising efavirenz that contain one or more disintegrants that enhance the dissolution rate of the efavirenz in the gastrointestinal tract thereby improving the rate and extent of absorption of efavirenz in the body. The present invention also relates to the process of making such tablets or capsules.

Abstract: A canister for launching a missile having a cylindrical outer tube with a hemispherical head releaseably secured to its lower end connected through stiffeners to an inner tubular member to form a passage for the gases generated when the missile is fired. A restraint mechanism secures the missile to a base plate, which is itself mounted on shock absorbers, with a release mechanism responsive to the firing of the missile for disabling the restraint mechanism.

Abstract: A drop dispenser having a sleeve carrying a closure and resilient dosage receiving fitting. The sleeve is treadably mounted an a fluid containing container having a nipple thereon. The closure on the sleeve has a configuration corresponding to the configuration of the nipple for sealing the nipple in the closed position. The fitting is filled with fluid from the container by turning the sleeve in a direction away from the closed position on the nipple to an open position to thereby establish fluid communication between the container and fitting. The fluid is dispensed from the fitting by squeezing the fitting after the closure has been returned to the closed position on the nipple, thereby preventing fluid from flowing from the resilient fitting back into the container. Cooperating stop members are provided between the sleeve and bottle neck to limit the movement of the sleeve relative to the bottle neck.

Abstract: A limited pour neck finish bottle wherein a plurality of radially inwardly extending flexible fingers are integral with the peripheral edge portion of the open end of the neck of a bottle and extend across the open end of the neck to restrict or interfere with the flow of liquid from the bottle if an attempt is made to pour the liquid from the bottle rather than employing an exact dose dispensing device. The bottle is made by molding a plurality of axially extending flexible fingers on the peripheral edge portion at the open end of the neck simultaneously with the molding of the bottle, and then bending the fingers downwardly to the radially inwardly extending position.

Abstract: A dispensing bulb having a squeezable body portion and integral squeezable neck portion having a pair of diametrically disposed vent holes. An adaptor is mounted in the neck portion and is provided with a cylindrical portion extending into the bulb neck portion beyond the vent holes and spaced radially inwardly therefrom. A dispensing tube is connected to the adaptor and communicates with the interior of the bulb. The neck portion of the bulb is squeezed to draw liquid into the tube, and the cylindrical portion of the adaptor limits the squeezing of the neck portion to prevent liquid from being drawn through the tube into the body portion of the bulb.

Abstract: A pharmaceutical composition including magnesium alginate and an antacid material useful in the treatment of reflux esophagitis.

Abstract: A mixing container and an adapter to interconnect the mixing container to a second container to permit intermixing of the contents of the containers. The mixing container has a neck with a plurality of raised circumferential ribs thereon. The adapter has a central cylindrical sleeve. A first end of the sleeve is surrounded by a cylindrical skirt. The interior surface of the first end of the sleeve has a plurality of circumferential grooves which enable the adapter to engage the ribs on the neck of the mixing container. The interior surface of the cylindrical skirt has a screw thread to enable the adapter to engage a conventional threaded container neck. The opposite, or second, end of the sleeve has a cutting sleeve therein, concentric with the sleeve. The cutting sleeve is adapted to pierce a seal on the mixing container. The second end of the sleeve frictionally engages the raised circumferential ribs on the mixing container during the mixing operation.

Abstract: A first container having a first material therein has a piercing tip on a dispensing member which is movable relative to the container to control flow from the container. The first container has a movable portion for facilitating introduction of air into the container. A second container having a second material therein has an inlet and an outlet. The inlet is closed and adapted to be pierced by said tip to facilitate introduction of the first material into the second container.

Abstract: This invention relates to an improvement comprising coating agitated particles of substantially anhydrous antacid with a solvent-free mixture of electronegatively charged material in a non-toxic inert substantially water insoluble oil.

Abstract: Simethicone is entrapped in solid, discrete particles of a matrix composition of glycerol and corn syrup solids. A mixture of these particles and a therapeutic antacid overcomes the incompatability of the simethicone and the antacid, due to the shielding action of the matrix composition.

Abstract: This invention describes a method of lowering the viscosity of aqueous gels of agents used in pharmaceutical preparations and of aqueous suspensions used as pharmaceutical preparations. Particular gels and suspensions and the viscosity lowering ingredients which are most useful are also described.

Abstract: A dispensing bulb having a squeezable body portion and integral squeezable neck portion having a pair of diametrically disposed vent holes. An adaptor is mounted in the neck portion and is provided with a cylindrical portion extending into the bulb neck portion beyond the vent holes and spaced radially inwardly therefrom. A dispensing tube is connected to the adaptor and communicates with the interior of the bulb. The neck portion of the bulb is squeezed to draw liquid into the tube, and the cylindrical portion of the adaptor limits the squeezing of the neck portion to prevent liquid from being drawn through the tube into the body portion of the bulb.